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Items: 1 to 50 of 132

1.

Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cells-derived hepatic stem cells.

Fourrier A, Delbos F, Menoret S, Collet C, Thi Thuy LT, Myara A, Petit F, Tolosa L, Laplanche S, Gómez-Lechón MJ, Labrune P, Anegon I, Vallier L, Garnier D, Nguyen TH.

Xenotransplantation. 2019 Jul 25:e12544. doi: 10.1111/xen.12544. [Epub ahead of print]

PMID:
31342573
2.

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.

Ng NHJ, Jasmen JB, Lim CS, Lau HH, Krishnan VG, Kadiwala J, Kulkarni RN, Ræder H, Vallier L, Hoon S, Teo AKK.

iScience. 2019 Jun 28;16:192-205. doi: 10.1016/j.isci.2019.05.032. Epub 2019 May 27.

3.

Tissue-Engineering the Intestine: The Trials before the Trials.

Clevers H, Conder RK, Li VSW, Lutolf MP, Vallier L, Chan S, Grikscheit TC, Jensen KB, De Coppi P.

Cell Stem Cell. 2019 Jun 6;24(6):855-859. doi: 10.1016/j.stem.2019.04.018.

PMID:
31173715
4.

Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.

Tysoe OC, Justin AW, Brevini T, Chen SE, Mahbubani KT, Frank AK, Zedira H, Melum E, Saeb-Parsy K, Markaki AE, Vallier L, Sampaziotis F.

Nat Protoc. 2019 Jun;14(6):1884-1925. doi: 10.1038/s41596-019-0168-0. Epub 2019 May 20.

PMID:
31110298
5.

Use of Biliary Organoids in Cholestasis Research.

Sampaziotis F, Tysoe O, Brevini T, Vallier L.

Methods Mol Biol. 2019;1981:373-382. doi: 10.1007/978-1-4939-9420-5_25.

PMID:
31016668
6.

Conditional Gene Knockout in Human Cells with Inducible CRISPR/Cas9.

Snijders KE, Cooper JD, Vallier L, Bertero A.

Methods Mol Biol. 2019;1961:185-209. doi: 10.1007/978-1-4939-9170-9_12.

PMID:
30912047
7.

A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.

Hurrell T, Segeritz CP, Vallier L, Lilley KS, Cromarty AD.

Sci Rep. 2019 Mar 1;9(1):3270. doi: 10.1038/s41598-019-39400-1.

8.

Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity.

Linker SM, Urban L, Clark SJ, Chhatriwala M, Amatya S, McCarthy DJ, Ebersberger I, Vallier L, Reik W, Stegle O, Bonder MJ.

Genome Biol. 2019 Feb 11;20(1):30. doi: 10.1186/s13059-019-1644-0.

9.

Genome-Wide Epigenetic and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.

Kraiczy J, Ross ADB, Forbester JL, Dougan G, Vallier L, Zilbauer M.

Cell Mol Gastroenterol Hepatol. 2019;7(2):285-288. doi: 10.1016/j.jcmgh.2018.10.008. Epub 2018 Oct 23. No abstract available.

10.

GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation.

Chia CY, Madrigal P, Denil SLIJ, Martinez I, Garcia-Bernardo J, El-Khairi R, Chhatriwala M, Shepherd MH, Hattersley AT, Dunn NR, Vallier L.

Stem Cell Reports. 2019 Jan 8;12(1):57-70. doi: 10.1016/j.stemcr.2018.12.003.

11.

Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics.

Yiangou L, Grandy RA, Morell CM, Tomaz RA, Osnato A, Kadiwala J, Muraro D, Garcia-Bernardo J, Nakanoh S, Bernard WG, Ortmann D, McCarthy DJ, Simonic I, Sinha S, Vallier L.

Stem Cell Reports. 2019 Jan 8;12(1):165-179. doi: 10.1016/j.stemcr.2018.11.020. Epub 2018 Dec 27.

12.

Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop.

Stacey G, Andrews P, Asante C, Barbaric I, Barry J, Bisset L, Braybrook J, Buckle R, Chandra A, Coffey P, Crouch S, Driver P, Evans A, Gardner J, Ginty P, Goldring C, Hay DC, Healy L, Hows A, Hutchinson C, Jesson H, Kalber T, Kimber S, Leathers R, Moyle S, Murray T, Neale M, Pan D, Park BK, Rebolledo RE, Rees I, Rivolta MN, Ritchie A, Roos EJ, Saeb-Parsy K, Schröder B, Sebastien S, Thomas A, Thomas RJ, Turner M, Vallier L, Vitillo L, Webster A, Williams D.

Regen Med. 2018 Dec;13(8):935-944. doi: 10.2217/rme-2018-0120. Epub 2018 Nov 29.

PMID:
30488776
13.

A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.

Serrano F, Bernard WG, Granata A, Iyer D, Steventon B, Kim M, Vallier L, Gambardella L, Sinha S.

Stem Cells Dev. 2019 Jan 15;28(2):81-100. doi: 10.1089/scd.2017.0234. Epub 2018 Dec 18.

14.

Modeling Disease with Human Inducible Pluripotent Stem Cells.

Grandy R, Tomaz RA, Vallier L.

Annu Rev Pathol. 2019 Jan 24;14:449-468. doi: 10.1146/annurev-pathol-020117-043634. Epub 2018 Oct 24.

PMID:
30355153
15.

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

Rashidi H, Luu NT, Alwahsh SM, Ginai M, Alhaque S, Dong H, Tomaz RA, Vernay B, Vigneswara V, Hallett JM, Chandrashekran A, Dhawan A, Vallier L, Bradley M, Callanan A, Forbes SJ, Newsome PN, Hay DC.

Arch Toxicol. 2018 Oct;92(10):3117-3129. doi: 10.1007/s00204-018-2280-2. Epub 2018 Aug 28.

16.

A new assay to evaluate microvesicle plasmin generation capacity: validation in disease with fibrinolysis imbalance.

Cointe S, Harti Souab K, Bouriche T, Vallier L, Bonifay A, Judicone C, Robert S, Armand R, Poncelet P, Albanese J, Dignat-George F, Lacroix R.

J Extracell Vesicles. 2018 Jul 16;7(1):1494482. doi: 10.1080/20013078.2018.1494482. eCollection 2018.

17.

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.

Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L.

J Hepatol. 2018 Oct;69(4):851-860. doi: 10.1016/j.jhep.2018.05.028. Epub 2018 Jun 5.

18.

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A.

Transplantation. 2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217. Review.

PMID:
29781950
19.

Proteomic Comparison of Various Hepatic Cell Cultures for Preclinical Safety Pharmacology.

Hurrell T, Segeritz CP, Vallier L, Lilley KS, Cromarty AD.

Toxicol Sci. 2018 Jul 1;164(1):229-239. doi: 10.1093/toxsci/kfy084.

PMID:
29635369
20.

Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications.

Yiangou L, Ross ADB, Goh KJ, Vallier L.

Cell Stem Cell. 2018 Apr 5;22(4):485-499. doi: 10.1016/j.stem.2018.03.016. Review.

21.

Conditional Manipulation of Gene Function in Human Cells with Optimized Inducible shRNA.

Bertero A, Yiangou L, Brown S, Ortmann D, Pawlowski M, Vallier L.

Curr Protoc Stem Cell Biol. 2018 Feb 28;44:5C.4.1-5C.4.48. doi: 10.1002/cpsc.45.

PMID:
29512130
22.

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency.

Bertero A, Brown S, Madrigal P, Osnato A, Ortmann D, Yiangou L, Kadiwala J, Hubner NC, de Los Mozos IR, Sadée C, Lenaerts AS, Nakanoh S, Grandy R, Farnell E, Ule J, Stunnenberg HG, Mendjan S, Vallier L.

Nature. 2018 Mar 8;555(7695):256-259. doi: 10.1038/nature25784. Epub 2018 Feb 28.

23.

The DSL ligand APX-1 is required for normal ovulation in C. elegans.

McGovern M, Castaneda PG, Pekar O, Vallier LG, Cram EJ, Hubbard EJA.

Dev Biol. 2018 Mar 15;435(2):162-169. doi: 10.1016/j.ydbio.2018.01.009. Epub 2018 Jan 31.

24.

Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.

Ibarra-Soria X, Jawaid W, Pijuan-Sala B, Ladopoulos V, Scialdone A, Jörg DJ, Tyser RCV, Calero-Nieto FJ, Mulas C, Nichols J, Vallier L, Srinivas S, Simons BD, Göttgens B, Marioni JC.

Nat Cell Biol. 2018 Feb;20(2):127-134. doi: 10.1038/s41556-017-0013-z. Epub 2018 Jan 8.

25.

DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.

Kraiczy J, Nayak KM, Howell KJ, Ross A, Forbester J, Salvestrini C, Mustata R, Perkins S, Andersson-Rolf A, Leenen E, Liebert A, Vallier L, Rosenstiel PC, Stegle O, Dougan G, Heuschkel R, Koo BK, Zilbauer M.

Gut. 2019 Jan;68(1):49-61. doi: 10.1136/gutjnl-2017-314817. Epub 2017 Nov 15.

26.

Advances in the generation of bioengineered bile ducts.

Justin AW, Saeb-Parsy K, Markaki AE, Vallier L, Sampaziotis F.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1532-1538. doi: 10.1016/j.bbadis.2017.10.034. Epub 2017 Oct 31. Review.

27.

Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos.

Jennings RE, Berry AA, Gerrard DT, Wearne SJ, Strutt J, Withey S, Chhatriwala M, Piper Hanley K, Vallier L, Bobola N, Hanley NA.

Stem Cell Reports. 2017 Nov 14;9(5):1387-1394. doi: 10.1016/j.stemcr.2017.09.018. Epub 2017 Oct 19.

28.

Erratum: Genome editing reveals a role for OCT4 in human embryogenesis.

Fogarty NME, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim JS, Wells D, Vallier L, Bertero A, Turner JMA, Niakan KK.

Nature. 2017 Nov 9;551(7679):256. doi: 10.1038/nature24292. Epub 2017 Oct 4.

PMID:
28976971
29.

Genome editing reveals a role for OCT4 in human embryogenesis.

Fogarty NME, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim JS, Wells D, Vallier L, Bertero A, Turner JMA, Niakan KK.

Nature. 2017 Oct 5;550(7674):67-73. doi: 10.1038/nature24033. Epub 2017 Sep 20. Erratum in: Nature. 2017 Oct 04;:.

30.

Variability of human pluripotent stem cell lines.

Ortmann D, Vallier L.

Curr Opin Genet Dev. 2017 Oct;46:179-185. doi: 10.1016/j.gde.2017.07.004. Epub 2017 Aug 24. Review.

PMID:
28843810
31.

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J, Eksteen B, Ellinghaus D, Färkkilä M, Festen EAM, Floreani A, Franceschet I, Gotthardt DN, Hirschfield GM, Hoek BV, Holm K, Hohenester S, Hov JR, Imhann F, Invernizzi P, Juran BD, Lenzen H, Lieb W, Liu JZ, Marschall HU, Marzioni M, Melum E, Milkiewicz P, Müller T, Pares A, Rupp C, Rust C, Sandford RN, Schramm C, Schreiber S, Schrumpf E, Silverberg MS, Srivastava B, Sterneck M, Teufel A, Vallier L, Verheij J, Vila AV, Vries B, Zachou K; International PSC Study Group, The UK PSC Consortium, Chapman RW, Manns MP, Pinzani M, Rushbrook SM, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weersma RK.

Gut. 2018 Aug;67(8):1517-1524. doi: 10.1136/gutjnl-2016-313598. Epub 2017 Aug 4.

32.

Platelet function is modified by common sequence variation in megakaryocyte super enhancers.

Petersen R, Lambourne JJ, Javierre BM, Grassi L, Kreuzhuber R, Ruklisa D, Rosa IM, Tomé AR, Elding H, van Geffen JP, Jiang T, Farrow S, Cairns J, Al-Subaie AM, Ashford S, Attwood A, Batista J, Bouman H, Burden F, Choudry FA, Clarke L, Flicek P, Garner SF, Haimel M, Kempster C, Ladopoulos V, Lenaerts AS, Materek PM, McKinney H, Meacham S, Mead D, Nagy M, Penkett CJ, Rendon A, Seyres D, Sun B, Tuna S, van der Weide ME, Wingett SW, Martens JH, Stegle O, Richardson S, Vallier L, Roberts DJ, Freson K, Wernisch L, Stunnenberg HG, Danesh J, Fraser P, Soranzo N, Butterworth AS, Heemskerk JW, Turro E, Spivakov M, Ouwehand WH, Astle WJ, Downes K, Kostadima M, Frontini M.

Nat Commun. 2017 Jul 13;8:16058. doi: 10.1038/ncomms16058.

33.

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L.

Nat Med. 2017 Aug;23(8):954-963. doi: 10.1038/nm.4360. Epub 2017 Jul 3.

34.

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs.

Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, Bala S, Bensaddek D, Casale FP, Culley OJ, Danecek P, Faulconbridge A, Harrison PW, Kathuria A, McCarthy D, McCarthy SA, Meleckyte R, Memari Y, Moens N, Soares F, Mann A, Streeter I, Agu CA, Alderton A, Nelson R, Harper S, Patel M, White A, Patel SR, Clarke L, Halai R, Kirton CM, Kolb-Kokocinski A, Beales P, Birney E, Danovi D, Lamond AI, Ouwehand WH, Vallier L, Watt FM, Durbin R, Stegle O, Gaffney DJ.

Nature. 2017 Jun 29;546(7660):686. doi: 10.1038/nature23012. Epub 2017 Jun 14.

PMID:
28614302
35.

Common genetic variation drives molecular heterogeneity in human iPSCs.

Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, Bala S, Bensaddek D, Casale FP, Culley OJ, Danecek P, Faulconbridge A, Harrison PW, Kathuria A, McCarthy D, McCarthy SA, Meleckyte R, Memari Y, Moens N, Soares F, Mann A, Streeter I, Agu CA, Alderton A, Nelson R, Harper S, Patel M, White A, Patel SR, Clarke L, Halai R, Kirton CM, Kolb-Kokocinski A, Beales P, Birney E, Danovi D, Lamond AI, Ouwehand WH, Vallier L, Watt FM, Durbin R, Stegle O, Gaffney DJ.

Nature. 2017 Jun 15;546(7658):370-375. doi: 10.1038/nature22403. Epub 2017 May 10. Erratum in: Nature. 2017 Jun 29;546(7660):686.

36.

Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes.

Pawlowski M, Ortmann D, Bertero A, Tavares JM, Pedersen RA, Vallier L, Kotter MRN.

Stem Cell Reports. 2017 Apr 11;8(4):803-812. doi: 10.1016/j.stemcr.2017.02.016. Epub 2017 Mar 23.

37.

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.

Sampaziotis F, de Brito MC, Geti I, Bertero A, Hannan NR, Vallier L.

Nat Protoc. 2017 Apr;12(4):814-827. doi: 10.1038/nprot.2017.011. Epub 2017 Mar 23.

38.

Microparticles and Fibrinolysis.

Vallier L, Cointe S, Lacroix R, Bonifay A, Judicone C, Dignat-George F, Kwaan HC.

Semin Thromb Hemost. 2017 Mar;43(2):129-134. doi: 10.1055/s-0036-1592301. Epub 2016 Dec 6. Review.

39.

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs.

Bertero A, Pawlowski M, Ortmann D, Snijders K, Yiangou L, Cardoso de Brito M, Brown S, Bernard WG, Cooper JD, Giacomelli E, Gambardella L, Hannan NR, Iyer D, Sampaziotis F, Serrano F, Zonneveld MC, Sinha S, Kotter M, Vallier L.

Development. 2016 Dec 1;143(23):4405-4418.

40.

The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages.

Zhu L, Gomez-Duran A, Saretzki G, Jin S, Tilgner K, Melguizo-Sanchis D, Anyfantis G, Al-Aama J, Vallier L, Chinnery P, Lako M, Armstrong L.

J Cell Biol. 2016 Oct 24;215(2):187-202. Epub 2016 Oct 17.

41.

The role of hepatocyte nuclear factor 1β in disease and development.

El-Khairi R, Vallier L.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:23-32. doi: 10.1111/dom.12715. Review.

PMID:
27615128
42.

Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.

Forbester JL, Hannan N, Vallier L, Dougan G.

Methods Mol Biol. 2016 Aug 31. [Epub ahead of print]

PMID:
27576565
43.

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Gieseck RL 3rd, Ramalingam TR, Hart KM, Vannella KM, Cantu DA, Lu WY, Ferreira-González S, Forbes SJ, Vallier L, Wynn TA.

Immunity. 2016 Jul 19;45(1):145-58. doi: 10.1016/j.immuni.2016.06.009. Epub 2016 Jul 12.

44.

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

Rouhani FJ, Nik-Zainal S, Wuster A, Li Y, Conte N, Koike-Yusa H, Kumasaka N, Vallier L, Yusa K, Bradley A.

PLoS Genet. 2016 Apr 7;12(4):e1005932. doi: 10.1371/journal.pgen.1005932. eCollection 2016 Apr.

45.

Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D.

Pauklin S, Madrigal P, Bertero A, Vallier L.

Genes Dev. 2016 Feb 15;30(4):421-33. doi: 10.1101/gad.271452.115.

46.

Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells.

Butcher LM, Ito M, Brimpari M, Morris TJ, Soares FAC, Ährlund-Richter L, Carey N, Vallier L, Ferguson-Smith AC, Beck S.

Nat Commun. 2016 Jan 29;7:10458. doi: 10.1038/ncomms10458.

47.

Putting induced pluripotent stem cells to the test.

Vallier L.

Nat Biotechnol. 2015 Nov;33(11):1145-6. doi: 10.1038/nbt.3401. No abstract available.

PMID:
26544143
48.

Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.

Agu CA, Soares FA, Alderton A, Patel M, Ansari R, Patel S, Forrest S, Yang F, Lineham J, Vallier L, Kirton CM.

Stem Cell Reports. 2015 Oct 13;5(4):660-71. doi: 10.1016/j.stemcr.2015.08.012. Epub 2015 Sep 17.

49.

Generation of Hepatocytes from Pluripotent Stem Cells for Drug Screening and Developmental Modeling.

Gieseck RL 3rd, Vallier L, Hannan NR.

Methods Mol Biol. 2015;1250:123-42. doi: 10.1007/978-1-4939-2074-7_9.

PMID:
26272139
50.

Cell Cycle Rules Pluripotency.

Vallier L.

Cell Stem Cell. 2015 Aug 6;17(2):131-2. doi: 10.1016/j.stem.2015.07.019.

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