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Distinct roles for dynein light intermediate chains in neurogenesis, migration, and terminal somal translocation.

Gonçalves JC, Dantas TJ, Vallee RB.

J Cell Biol. 2019 Mar 4;218(3):808-819. doi: 10.1083/jcb.201806112. Epub 2019 Jan 23.


Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture.

de Carvalho ALRT, Strikoudis A, Liu HY, Chen YW, Dantas TJ, Vallee RB, Correia-Pinto J, Snoeck HW.

Development. 2019 Jan 22;146(2). pii: dev171652. doi: 10.1242/dev.171652.


Cdk1 phosphorylation of the dynein adapter Nde1 controls cargo binding from G2 to anaphase.

Wynne CL, Vallee RB.

J Cell Biol. 2018 Sep 3;217(9):3019-3029. doi: 10.1083/jcb.201707081. Epub 2018 Jun 21.


Role of kinesins in directed adenovirus transport and cytoplasmic exploration.

Zhou J, Scherer J, Yi J, Vallee RB.

PLoS Pathog. 2018 May 21;14(5):e1007055. doi: 10.1371/journal.ppat.1007055. eCollection 2018 May.


Nuclear migration in mammalian brain development.

Bertipaglia C, Gonçalves JC, Vallee RB.

Semin Cell Dev Biol. 2018 Oct;82:57-66. doi: 10.1016/j.semcdb.2017.11.033. Epub 2017 Dec 6. Review.


Replication of early and recent Zika virus isolates throughout mouse brain development.

Rosenfeld AB, Doobin DJ, Warren AL, Racaniello VR, Vallee RB.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12273-12278. doi: 10.1073/pnas.1714624114. Epub 2017 Oct 31.


Microcephaly as a cell cycle disease.

Doobin DJ, Dantas TJ, Vallee RB.

Cell Cycle. 2017 Feb;16(3):247-248. doi: 10.1080/15384101.2016.1252591. Epub 2016 Oct 28. No abstract available.


Emerging roles for motor proteins in progenitor cell behavior and neuronal migration during brain development.

Dantas TJ, Carabalona A, Hu DJ, Vallee RB.

Cytoskeleton (Hoboken). 2016 Oct;73(10):566-576. doi: 10.1002/cm.21293. Epub 2016 Apr 4. Review.


Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.

Doobin DJ, Kemal S, Dantas TJ, Vallee RB.

Nat Commun. 2016 Aug 24;7:12551. doi: 10.1038/ncomms12551.


Load-induced enhancement of Dynein force production by LIS1-NudE in vivo and in vitro.

Reddy BJ, Mattson M, Wynne CL, Vadpey O, Durra A, Chapman D, Vallee RB, Gross SP.

Nat Commun. 2016 Aug 4;7:12259. doi: 10.1038/ncomms12259.


Imaging of motor-dependent transport in neuronal and nonneuronal cells at high spatial and temporal resolution.

Yi J, Khobrekar NV, Dantas TJ, Zhou J, Vallee RB.

Methods Cell Biol. 2016;131:453-65. doi: 10.1016/bs.mcb.2015.06.014. Epub 2015 Sep 2.


Cellular and subcellular imaging of motor protein-based behavior in embryonic rat brain.

Baffet AD, Carabalona A, Dantas TJ, Doobin DD, Hu DJ, Vallee RB.

Methods Cell Biol. 2016;131:349-63. doi: 10.1016/bs.mcb.2015.06.013. Epub 2015 Sep 2.


KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration.

Carabalona A, Hu DJ, Vallee RB.

Nat Neurosci. 2016 Feb;19(2):253-62. doi: 10.1038/nn.4213. Epub 2016 Jan 11.


Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.

Taylor SP, Dantas TJ, Duran I, Wu S, Lachman RS; University of Washington Center for Mendelian Genomics Consortium, Nelson SF, Cohn DH, Vallee RB, Krakow D.

Nat Commun. 2015 Jun 16;6:7092. doi: 10.1038/ncomms8092.


Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells.

Baffet AD, Hu DJ, Vallee RB.

Dev Cell. 2015 Jun 22;33(6):703-16. doi: 10.1016/j.devcel.2015.04.022. Epub 2015 Jun 4.


Control of cytoplasmic dynein force production and processivity by its C-terminal domain.

Nicholas MP, Höök P, Brenner S, Wynne CL, Vallee RB, Gennerich A.

Nat Commun. 2015 Feb 11;6:6206. doi: 10.1038/ncomms7206.


Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport.

Tripathy SK, Weil SJ, Chen C, Anand P, Vallee RB, Gross SP.

Nat Cell Biol. 2014 Dec;16(12):1192-201. doi: 10.1038/ncb3063. Epub 2014 Nov 24.


Conformational changes in the adenovirus hexon subunit responsible for regulating cytoplasmic dynein recruitment.

Scherer J, Vallee RB.

J Virol. 2015 Jan 15;89(2):1013-23. doi: 10.1128/JVI.02889-14. Epub 2014 Oct 29.


PKA-dependent dynein switching from lysosomes to adenovirus: a novel form of host-virus competition.

Scherer J, Yi J, Vallee RB.

J Cell Biol. 2014 Apr 28;205(2):163-77. doi: 10.1083/jcb.201307116.


Dynein recruitment to nuclear pores activates apical nuclear migration and mitotic entry in brain progenitor cells.

Hu DJ, Baffet AD, Nayak T, Akhmanova A, Doye V, Vallee RB.

Cell. 2013 Sep 12;154(6):1300-13. doi: 10.1016/j.cell.2013.08.024.


Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy.

Harms MB, Ori-McKenney KM, Scoto M, Tuck EP, Bell S, Ma D, Masi S, Allred P, Al-Lozi M, Reilly MM, Miller LJ, Jani-Acsadi A, Pestronk A, Shy ME, Muntoni F, Vallee RB, Baloh RH.

Neurology. 2012 May 29;78(22):1714-20. doi: 10.1212/WNL.0b013e3182556c05. Epub 2012 Mar 28.


Multiple modes of cytoplasmic dynein regulation.

Vallee RB, McKenney RJ, Ori-McKenney KM.

Nat Cell Biol. 2012 Feb 29;14(3):224-30. doi: 10.1038/ncb2420.


High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport.

Yi JY, Ori-McKenney KM, McKenney RJ, Vershinin M, Gross SP, Vallee RB.

J Cell Biol. 2011 Oct 17;195(2):193-201. doi: 10.1083/jcb.201104076.


Adenovirus recruits dynein by an evolutionary novel mechanism involving direct binding to pH-primed hexon.

Scherer J, Vallee RB.

Viruses. 2011 Aug;3(8):1417-31. doi: 10.3390/v3081417. Epub 2011 Aug 12. Review.


Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin.

McKenney RJ, Weil SJ, Scherer J, Vallee RB.

J Biol Chem. 2011 Nov 11;286(45):39615-22. doi: 10.1074/jbc.M111.289017. Epub 2011 Sep 12.


NudC is required for interkinetic nuclear migration and neuronal migration during neocortical development.

Cappello S, Monzo P, Vallee RB.

Dev Biol. 2011 Sep 15;357(2):326-35. doi: 10.1016/j.ydbio.2011.07.001. Epub 2011 Jul 13.


Live microscopy of neural stem cell migration in brain slices.

Tsai JW, Vallee RB.

Methods Mol Biol. 2011;750:131-42. doi: 10.1007/978-1-61779-145-1_9.


Neuronal migration defects in the Loa dynein mutant mouse.

Ori-McKenney KM, Vallee RB.

Neural Dev. 2011 May 25;6:26. doi: 10.1186/1749-8104-6-26.


Recruitment of dynein to late endosomes and lysosomes through light intermediate chains.

Tan SC, Scherer J, Vallee RB.

Mol Biol Cell. 2011 Feb 15;22(4):467-77. doi: 10.1091/mbc.E10-02-0129. Epub 2010 Dec 17.


A cytoplasmic dynein tail mutation impairs motor processivity.

Ori-McKenney KM, Xu J, Gross SP, Vallee RB.

Nat Cell Biol. 2010 Dec;12(12):1228-34. doi: 10.1038/ncb2127. Epub 2010 Nov 21.


Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells.

Tsai JW, Lian WN, Kemal S, Kriegstein AR, Vallee RB.

Nat Neurosci. 2010 Dec;13(12):1463-71. doi: 10.1038/nn.2665. Epub 2010 Oct 31.


LIS1 and NudE induce a persistent dynein force-producing state.

McKenney RJ, Vershinin M, Kunwar A, Vallee RB, Gross SP.

Cell. 2010 Apr 16;141(2):304-14. doi: 10.1016/j.cell.2010.02.035.


Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes.

Varma D, Dawn A, Ghosh-Roy A, Weil SJ, Ori-McKenney KM, Zhao Y, Keen J, Vallee RB, Williams JC.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3493-8. doi: 10.1073/pnas.0908959107. Epub 2010 Feb 4.


Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit.

Bremner KH, Scherer J, Yi J, Vershinin M, Gross SP, Vallee RB.

Cell Host Microbe. 2009 Dec 17;6(6):523-35. doi: 10.1016/j.chom.2009.11.006.


Asymmetric centrosome inheritance maintains neural progenitors in the neocortex.

Wang X, Tsai JW, Imai JH, Lian WN, Vallee RB, Shi SH.

Nature. 2009 Oct 15;461(7266):947-55. doi: 10.1038/nature08435.


Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration.

Schmoranzer J, Fawcett JP, Segura M, Tan S, Vallee RB, Pawson T, Gundersen GG.

Curr Biol. 2009 Jul 14;19(13):1065-74. doi: 10.1016/j.cub.2009.05.065. Epub 2009 Jun 18.


Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones.

Vallee RB, Seale GE, Tsai JW.

Trends Cell Biol. 2009 Jul;19(7):347-55. doi: 10.1016/j.tcb.2009.03.009. Epub 2009 Jun 11. Review.


Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons.

Sengupta R, Burbassi S, Shimizu S, Cappello S, Vallee RB, Rubin JB, Meucci O.

J Neurosci. 2009 Feb 25;29(8):2534-44. doi: 10.1523/JNEUROSCI.5865-08.2009.


The dynein stalk contains an antiparallel coiled coil with region-specific stability.

Höök P, Yagi T, Ghosh-Roy A, Williams JC, Vallee RB.

Biochemistry. 2009 Mar 31;48(12):2710-3. doi: 10.1021/bi900223x.


Modes and mishaps of neuronal migration in the mammalian brain.

Métin C, Vallee RB, Rakic P, Bhide PG.

J Neurosci. 2008 Nov 12;28(46):11746-52. doi: 10.1523/JNEUROSCI.3860-08.2008. Review.


Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment.

Varma D, Monzo P, Stehman SA, Vallee RB.

J Cell Biol. 2008 Sep 22;182(6):1045-54. doi: 10.1083/jcb.200710106.


Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice.

Takaki E, Fujimoto M, Nakahari T, Yonemura S, Miyata Y, Hayashida N, Yamamoto K, Vallee RB, Mikuriya T, Sugahara K, Yamashita H, Inouye S, Nakai A.

J Biol Chem. 2007 Dec 21;282(51):37285-92. Epub 2007 Oct 27.


NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores.

Stehman SA, Chen Y, McKenney RJ, Vallee RB.

J Cell Biol. 2007 Aug 13;178(4):583-94. Epub 2007 Aug 6.


Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue.

Tsai JW, Bremner KH, Vallee RB.

Nat Neurosci. 2007 Aug;10(8):970-9. Epub 2007 Jul 8.


Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex.

Williams JC, Roulhac PL, Roy AG, Vallee RB, Fitzgerald MC, Hendrickson WA.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10028-33. Epub 2007 Jun 5.


Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth.

Grabham PW, Seale GE, Bennecib M, Goldberg DJ, Vallee RB.

J Neurosci. 2007 May 23;27(21):5823-34.


Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation.

Suzuki SO, McKenney RJ, Mawatari SY, Mizuguchi M, Mikami A, Iwaki T, Goldman JE, Canoll P, Vallee RB.

Acta Neuropathol. 2007 May;113(5):591-9. Epub 2007 Jan 13.


ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?

Vallee RB, Varma D, Dujardin DL.

Cell Cycle. 2006 Nov 1;5(21):2447-51. Epub 2006 Sep 12. Review.


The dynein family at a glance.

Höök P, Vallee RB.

J Cell Sci. 2006 Nov 1;119(Pt 21):4369-71. Review. No abstract available.


The cellular roles of the lissencephaly gene LIS1, and what they tell us about brain development.

Vallee RB, Tsai JW.

Genes Dev. 2006 Jun 1;20(11):1384-93. Review. No abstract available.

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