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Items: 1 to 50 of 57

1.

Clinical and microbiological factors associated with mortality in candidemia in adult patients 2007-2016.

Mari AH, Valkonen M, Kolho E, Friberg N, Anttila VJ.

Infect Dis (Lond). 2019 Sep 11:1-7. doi: 10.1080/23744235.2019.1662941. [Epub ahead of print]

PMID:
31507238
2.

Cytokeratin-supervised deep learning for automatic recognition of epithelial cells in breast cancers stained for ER, PR, and Ki-67.

Valkonen M, Isola J, Isola J, Ylinen O, Muhonen V, Saxlin A, Tolonen T, Nykter M, Ruusuvuori P.

IEEE Trans Med Imaging. 2019 Aug 7. doi: 10.1109/TMI.2019.2933656. [Epub ahead of print]

PMID:
31398111
3.

Influenza and associated co-infections in critically ill immunosuppressed patients.

Martin-Loeches I, Lemiale V, Geoghegan P, McMahon MA, Pickkers P, Soares M, Perner A, Meyhoff TS, Bukan RB, Rello J, Bauer PR, van de Louw A, Taccone FS, Salluh J, Hemelaar P, Schellongowski P, Rusinova K, Terzi N, Mehta S, Antonelli M, Kouatchet A, Klepstad P, Valkonen M, Landburg PP, Barratt-Due A, Bruneel F, Pène F, Metaxa V, Moreau AS, Souppart V, Burghi G, Girault C, Silva UVA, Montini L, Barbier F, Nielsen LB, Gaborit B, Mokart D, Chevret S, Azoulay E; Efraim investigators and the Nine-I study group.

Crit Care. 2019 May 2;23(1):152. doi: 10.1186/s13054-019-2425-6.

4.

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018.

Ianevski A, Zusinaite E, Shtaida N, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Dumpis U, Vitkauskiene A, Stašaitis K, Öhrmalm C, Bondeson K, Bergqvist A, Cox RJ, Tenson T, Merits A, Kainov DE.

Viruses. 2019 Mar 1;11(3). pii: E207. doi: 10.3390/v11030207.

5.

Plasma bradykinin concentrations during septic shock determined by a novel LC-MS/MS assay.

Lindström M, Valkonen M, Tohmola N, Renkonen R, Strandin T, Vaheri A, Itkonen O.

Clin Chim Acta. 2019 Jun;493:20-24. doi: 10.1016/j.cca.2019.02.023. Epub 2019 Feb 22.

PMID:
30802439
6.

Targeting low-normal or high-normal mean arterial pressure after cardiac arrest and resuscitation: a randomised pilot trial.

Jakkula P, Pettilä V, Skrifvars MB, Hästbacka J, Loisa P, Tiainen M, Wilkman E, Toppila J, Koskue T, Bendel S, Birkelund T, Laru-Sompa R, Valkonen M, Reinikainen M; COMACARE study group.

Intensive Care Med. 2018 Dec;44(12):2091-2101. doi: 10.1007/s00134-018-5446-8. Epub 2018 Nov 15.

7.

The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma.

Salmi S, Siiskonen H, Sironen R, Tyynelä-Korhonen K, Hirschovits-Gerz B, Valkonen M, Auvinen P, Pasonen-Seppänen S.

Melanoma Res. 2019 Jun;29(3):237-247. doi: 10.1097/CMR.0000000000000522.

8.

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.

Pickkers P, Mehta RL, Murray PT, Joannidis M, Molitoris BA, Kellum JA, Bachler M, Hoste EAJ, Hoiting O, Krell K, Ostermann M, Rozendaal W, Valkonen M, Brealey D, Beishuizen A, Meziani F, Murugan R, de Geus H, Payen D, van den Berg E, Arend J; STOP-AKI Investigators.

JAMA. 2018 Nov 20;320(19):1998-2009. doi: 10.1001/jama.2018.14283.

9.

A universal gene expression system for fungi.

Rantasalo A, Landowski CP, Kuivanen J, Korppoo A, Reuter L, Koivistoinen O, Valkonen M, Penttilä M, Jäntti J, Mojzita D.

Nucleic Acids Res. 2018 Oct 12;46(18):e111. doi: 10.1093/nar/gky558.

10.

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas.

Valkonen M, Haapasalo H, Rilla K, Tyynelä-Korhonen K, Soini Y, Pasonen-Seppänen S.

BMC Cancer. 2018 Jun 18;18(1):664. doi: 10.1186/s12885-018-4569-1.

11.

Novel activities of safe-in-human broad-spectrum antiviral agents.

Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D.

Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub 2018 Apr 23. Review.

PMID:
29698664
12.

Indoor bacteria and asthma in adults: a multicentre case-control study within ECRHS II.

Pekkanen J, Valkonen M, Täubel M, Tischer C, Leppänen H, Kärkkäinen PM, Rintala H, Zock JP, Casas L, Probst-Hensch N, Forsberg B, Holm M, Janson C, Pin I, Gislason T, Jarvis D, Heinrich J, Hyvärinen A.

Eur Respir J. 2018 Feb 7;51(2). pii: 1701241. doi: 10.1183/13993003.01241-2017. Print 2018 Feb.

13.

Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer.

Ehteshami Bejnordi B, Veta M, Johannes van Diest P, van Ginneken B, Karssemeijer N, Litjens G, van der Laak JAWM; the CAMELYON16 Consortium, Hermsen M, Manson QF, Balkenhol M, Geessink O, Stathonikos N, van Dijk MC, Bult P, Beca F, Beck AH, Wang D, Khosla A, Gargeya R, Irshad H, Zhong A, Dou Q, Li Q, Chen H, Lin HJ, Heng PA, Haß C, Bruni E, Wong Q, Halici U, Öner MÜ, Cetin-Atalay R, Berseth M, Khvatkov V, Vylegzhanin A, Kraus O, Shaban M, Rajpoot N, Awan R, Sirinukunwattana K, Qaiser T, Tsang YW, Tellez D, Annuscheit J, Hufnagl P, Valkonen M, Kartasalo K, Latonen L, Ruusuvuori P, Liimatainen K, Albarqouni S, Mungal B, George A, Demirci S, Navab N, Watanabe S, Seno S, Takenaka Y, Matsuda H, Ahmady Phoulady H, Kovalev V, Kalinovsky A, Liauchuk V, Bueno G, Fernandez-Carrobles MM, Serrano I, Deniz O, Racoceanu D, Venâncio R.

JAMA. 2017 Dec 12;318(22):2199-2210. doi: 10.1001/jama.2017.14585.

14.

Indoor microbiota in severely moisture damaged homes and the impact of interventions.

Jayaprakash B, Adams RI, Kirjavainen P, Karvonen A, Vepsäläinen A, Valkonen M, Järvi K, Sulyok M, Pekkanen J, Hyvärinen A, Täubel M.

Microbiome. 2017 Oct 13;5(1):138. doi: 10.1186/s40168-017-0356-5.

15.

Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort.

Valkonen M, Täubel M, Pekkanen J, Tischer C, Rintala H, Zock JP, Casas L, Probst-Hensch N, Forsberg B, Holm M, Janson C, Pin I, Gislason T, Jarvis D, Heinrich J, Hyvärinen A.

Indoor Air. 2018 Jan;28(1):16-27. doi: 10.1111/ina.12427. Epub 2017 Oct 16.

16.

Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study.

Azoulay E, Pickkers P, Soares M, Perner A, Rello J, Bauer PR, van de Louw A, Hemelaar P, Lemiale V, Taccone FS, Martin Loeches I, Meyhoff TS, Salluh J, Schellongowski P, Rusinova K, Terzi N, Mehta S, Antonelli M, Kouatchet A, Barratt-Due A, Valkonen M, Landburg PP, Bruneel F, Bukan RB, Pène F, Metaxa V, Moreau AS, Souppart V, Burghi G, Girault C, Silva UVA, Montini L, Barbier F, Nielsen LB, Gaborit B, Mokart D, Chevret S; Efraim investigators and the Nine-I study group.

Intensive Care Med. 2017 Dec;43(12):1808-1819. doi: 10.1007/s00134-017-4947-1. Epub 2017 Sep 25.

PMID:
28948369
17.

Plasma anti-FXa concentration after continuous intravenous infusion and subcutaneous dosing of enoxaparin for thromboprophylaxis in critically ill patients. A randomized clinical trial.

Vahtera A, Valkonen M, Huhtala H, Pettilä V, Kuitunen A.

Thromb Res. 2017 Oct;158:71-75. doi: 10.1016/j.thromres.2017.08.014. Epub 2017 Aug 24.

PMID:
28846877
18.

Metastasis detection from whole slide images using local features and random forests.

Valkonen M, Kartasalo K, Liimatainen K, Nykter M, Latonen L, Ruusuvuori P.

Cytometry A. 2017 Jun;91(6):555-565. doi: 10.1002/cyto.a.23089. Epub 2017 Apr 20.

19.

Analysis of spatial heterogeneity in normal epithelium and preneoplastic alterations in mouse prostate tumor models.

Valkonen M, Ruusuvuori P, Kartasalo K, Nykter M, Visakorpi T, Latonen L.

Sci Rep. 2017 Mar 20;7:44831. doi: 10.1038/srep44831.

20.

Expression of Two Novel β-Glucosidases from Chaetomium atrobrunneum in Trichoderma reesei and Characterization of the Heterologous Protein Products.

Colabardini AC, Valkonen M, Huuskonen A, Siika-Aho M, Koivula A, Goldman GH, Saloheimo M.

Mol Biotechnol. 2016 Dec;58(12):821-831.

PMID:
27714589
21.

Protein profiling of nasopharyngeal aspirates of hospitalized and outpatients revealed cytokines associated with severe influenza A(H1N1)pdm09 virus infections: A pilot study.

Fu Y, Gaelings L, Jalovaara P, Kakkola L, Kinnunen MT, Kallio-Kokko H, Valkonen M, Kantele A, Kainov DE.

Cytokine. 2016 Oct;86:10-14. doi: 10.1016/j.cyto.2016.07.003. Epub 2016 Jul 18.

PMID:
27442005
22.

Insight to Nanoparticle Size Analysis-Novel and Convenient Image Analysis Method Versus Conventional Techniques.

Vippola M, Valkonen M, Sarlin E, Honkanen M, Huttunen H.

Nanoscale Res Lett. 2016 Dec;11(1):169. doi: 10.1186/s11671-016-1391-z. Epub 2016 Mar 31.

23.

Feature-based analysis of mouse prostatic intraepithelial neoplasia in histological tissue sections.

Ruusuvuori P, Valkonen M, Nykter M, Visakorpi T, Latonen L.

J Pathol Inform. 2016 Jan 29;7:5. doi: 10.4103/2153-3539.175378. eCollection 2016.

24.

Bacterial Exposures and Associations with Atopy and Asthma in Children.

Valkonen M, Wouters IM, Täubel M, Rintala H, Lenters V, Vasara R, Genuneit J, Braun-Fahrländer C, Piarroux R, von Mutius E, Heederik D, Hyvärinen A.

PLoS One. 2015 Jun 29;10(6):e0131594. doi: 10.1371/journal.pone.0131594. eCollection 2015.

25.

Targeting matrix metalloproteinases with intravenous doxycycline in severe sepsis--A randomised placebo-controlled pilot trial.

Nukarinen E, Tervahartiala T, Valkonen M, Hynninen M, Kolho E, Pettilä V, Sorsa T, Backman J, Hästbacka J.

Pharmacol Res. 2015 Sep;99:44-51. doi: 10.1016/j.phrs.2015.05.005. Epub 2015 May 22.

PMID:
26008138
26.

Predictors of microbial agents in dust and respiratory health in the Ecrhs.

Tischer C, Zock JP, Valkonen M, Doekes G, Guerra S, Heederik D, Jarvis D, Norbäck D, Olivieri M, Sunyer J, Svanes C, Täubel M, Thiering E, Verlato G, Hyvärinen A, Heinrich J.

BMC Pulm Med. 2015 May 2;15:48. doi: 10.1186/s12890-015-0042-y.

27.

Complete Genome Sequences of Influenza A/H1N1 Strains Isolated from Patients during the 2013-2014 Epidemic Season in Finland.

Jalovaara P, Mishel P, Kallio-Kokko H, Valkonen M, Kantele A, Ikonen N, Julkunen I, Kakkola L, Kutsaya A, Vuorinen T, Mattila P, Almusa H, Kainov D.

Genome Announc. 2015 Mar 12;3(2). pii: e01523-14. doi: 10.1128/genomeA.01523-14.

28.

Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells.

Mishel P, Bychkov D, Kallio-Kokko H, Valkonen M, Kantele A, Mattila P, Almusa H, Jalovaara P, Kainov D.

Genome Announc. 2014 Dec 24;2(6). pii: e01349-14. doi: 10.1128/genomeA.01349-14.

29.

Genetic Instability of Influenza pH1N1 Viruses.

Jalovaara P, Bychkov D, Ahtiainen L, Kallio-Kokko H, Valkonen M, Kantele A, Mattila P, Almusa H, Kallioniemi O, Kainov D.

Genome Announc. 2014 Oct 2;2(5). pii: e00841-14. doi: 10.1128/genomeA.00841-14.

30.

Imitation of phase I oxidative metabolism of anabolic steroids by titanium dioxide photocatalysis.

Ruokolainen M, Valkonen M, Sikanen T, Kotiaho T, Kostiainen R.

Eur J Pharm Sci. 2014 Dec 18;65:45-55. doi: 10.1016/j.ejps.2014.08.009. Epub 2014 Sep 9.

PMID:
25220585
31.

Intracellular pH responses in the industrially important fungus Trichoderma reesei.

Valkonen M, Penttilä M, Benčina M.

Fungal Genet Biol. 2014 Sep;70:86-93. doi: 10.1016/j.fgb.2014.07.004. Epub 2014 Jul 19.

PMID:
25046860
32.

Effect of C-terminal protein tags on pentitol and L-arabinose transport by Ambrosiozyma monospora Lat1 and Lat2 transporters in Saccharomyces cerevisiae.

Londesborough J, Richard P, Valkonen M, Viljanen K.

Appl Environ Microbiol. 2014 May;80(9):2737-45. doi: 10.1128/AEM.04067-13. Epub 2014 Feb 21.

33.

Screening of candidate regulators for cellulase and hemicellulase production in Trichoderma reesei and identification of a factor essential for cellulase production.

Häkkinen M, Valkonen MJ, Westerholm-Parvinen A, Aro N, Arvas M, Vitikainen M, Penttilä M, Saloheimo M, Pakula TM.

Biotechnol Biofuels. 2014 Jan 28;7(1):14. doi: 10.1186/1754-6834-7-14.

34.

Noninvasive high-throughput single-cell analysis of the intracellular pH of Saccharomyces cerevisiae by ratiometric flow cytometry.

Valkonen M, Mojzita D, Penttilä M, Bencina M.

Appl Environ Microbiol. 2013 Dec;79(23):7179-87. doi: 10.1128/AEM.02515-13. Epub 2013 Sep 13.

35.

Client-centeredness of Finnish and Estonian nursing students and the support from nursing education to develop it. Students' self-evaluation.

Kalam-Salminen L, Valkonen MR, Aro I, Routasalo P.

Nurse Educ Today. 2013 Oct;33(10):1112-8. doi: 10.1016/j.nedt.2013.02.006. Epub 2013 Mar 13.

PMID:
23498724
36.

Endotoxin, extracellular polysaccharides, and β(1-3)-glucan concentrations in dust and their determinants in four European birth cohorts: results from the HITEA project.

Casas L, Tischer C, Wouters IM, Valkonen M, Gehring U, Doekes G, Torrent M, Pekkanen J, Garcia-Esteban R, Hyvärinen A, Heinrich J, Sunyer J.

Indoor Air. 2013 Jun;23(3):208-18. doi: 10.1111/ina.12017. Epub 2012 Dec 21.

PMID:
23176390
37.

Metabolic engineering of Saccharomyces cerevisiae for bioconversion of D-xylose to D-xylonate.

Toivari M, Nygård Y, Kumpula EP, Vehkomäki ML, Benčina M, Valkonen M, Maaheimo H, Andberg M, Koivula A, Ruohonen L, Penttilä M, Wiebe MG.

Metab Eng. 2012 Jul;14(4):427-36. doi: 10.1016/j.ymben.2012.03.002. Epub 2012 Mar 13.

38.

Determination of bacterial load in house dust using qPCR, chemical markers and culture.

Kärkkäinen PM, Valkonen M, Hyvärinen A, Nevalainen A, Rintala H.

J Environ Monit. 2010 Mar;12(3):759-68. doi: 10.1039/b917937b. Epub 2010 Jan 20.

PMID:
20445866
39.

Spatially segregated SNARE protein interactions in living fungal cells.

Valkonen M, Kalkman ER, Saloheimo M, Penttilä M, Read ND, Duncan RR.

J Biol Chem. 2007 Aug 3;282(31):22775-85. Epub 2007 Jun 5.

40.

An outbreak of gastrointestinal illness and erythema nodosum from grated carrots contaminated with Yersinia pseudotuberculosis.

Jalava K, Hakkinen M, Valkonen M, Nakari UM, Palo T, Hallanvuo S, Ollgren J, Siitonen A, Nuorti JP.

J Infect Dis. 2006 Nov 1;194(9):1209-16. Epub 2006 Sep 27.

PMID:
17041846
41.

Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae.

Arvas M, Pakula T, Lanthaler K, Saloheimo M, Valkonen M, Suortti T, Robson G, Penttilä M.

BMC Genomics. 2006 Feb 22;7:32.

42.

[Q for query, questions and answers concerning Q-fever].

Valkonen M, Seppänen M, Suni J, Siikamäki H.

Duodecim. 2005;121(19):2077-84. Review. Finnish. No abstract available.

PMID:
16300296
43.

Rhabdomyolysis in a patient receiving atorvastatin and fluconazole.

Kahri J, Valkonen M, Bäcklund T, Vuoristo M, Kivistö KT.

Eur J Clin Pharmacol. 2005 Feb;60(12):905-7. Epub 2004 Dec 30. No abstract available.

PMID:
15625612
44.

The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei.

Valkonen M, Penttilä M, Saloheimo M.

Mol Genet Genomics. 2004 Nov;272(4):443-51. Epub 2004 Oct 8.

PMID:
15480788
45.

Rhabdomyolysis associated with concomitant use of simvastatin and clarithromycin.

Kahri AJ, Valkonen MM, Vuoristo MK, Pentikäinen PJ.

Ann Pharmacother. 2004 Apr;38(4):719. Epub 2004 Feb 13. No abstract available.

PMID:
14966253
46.

Characterization of secretory genes ypt1/yptA and nsf1/nsfA from two filamentous fungi: induction of secretory pathway genes of Trichoderma reesei under secretion stress conditions.

Saloheimo M, Wang H, Valkonen M, Vasara T, Huuskonen A, Riikonen M, Pakula T, Ward M, Penttilä M.

Appl Environ Microbiol. 2004 Jan;70(1):459-67.

47.

Improvement of foreign-protein production in Aspergillus niger var. awamori by constitutive induction of the unfolded-protein response.

Valkonen M, Ward M, Wang H, Penttilä M, Saloheimo M.

Appl Environ Microbiol. 2003 Dec;69(12):6979-86.

49.

Activation mechanisms of the HAC1-mediated unfolded protein response in filamentous fungi.

Saloheimo M, Valkonen M, Penttilä M.

Mol Microbiol. 2003 Feb;47(4):1149-61.

50.

[Leptospirosis--an increasingly common zoonosis].

Valkonen M, Klemets P, Nuorti P, Siikamäki H, Valtonen V.

Duodecim. 2002;118(4):379-83. Finnish. No abstract available.

PMID:
12233042

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