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Items: 28


A Shared Mechanism for the Folding of Voltage-Gated K+ Channels.

McDonald SK, Levitz TS, Valiyaveetil FI.

Biochemistry. 2019 Mar 26;58(12):1660-1671. doi: 10.1021/acs.biochem.9b00068. Epub 2019 Mar 7.


Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor.

Infield DT, Matulef K, Galpin JD, Lam K, Tajkhorshid E, Ahern CA, Valiyaveetil FI.

Nat Commun. 2018 Nov 29;9(1):5055. doi: 10.1038/s41467-018-07477-3.


A facile approach for the in vitro assembly of multimeric membrane transport proteins.

Riederer EA, Focke PJ, Georgieva ER, Akyuz N, Matulef K, Borbat PP, Freed JH, Blanchard SC, Boudker O, Valiyaveetil FI.

Elife. 2018 Jun 11;7. pii: e36478. doi: 10.7554/eLife.36478.


Patch-Clamp Recordings of the KcsA K+ Channel in Unilamellar Blisters.

Matulef K, Valiyaveetil FI.

Methods Mol Biol. 2018;1684:181-191. doi: 10.1007/978-1-4939-7362-0_14.


A glimpse into the C-type-inactivated state for a Potassium Channel.

Valiyaveetil FI.

Nat Struct Mol Biol. 2017 Oct 5;24(10):787-788. doi: 10.1038/nsmb.3480. No abstract available.


Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy.

Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT.

J Am Chem Soc. 2017 Jul 5;139(26):8837-8845. doi: 10.1021/jacs.7b01594. Epub 2017 May 12.


Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy.

Kratochvil HT, Carr JK, Matulef K, Annen AW, Li H, Maj M, Ostmeyer J, Serrano AL, Raghuraman H, Moran SD, Skinner JL, Perozo E, Roux B, Valiyaveetil FI, Zanni MT.

Science. 2016 Sep 2;353(6303):1040-1044.


Combining in Vitro Folding with Cell Free Protein Synthesis for Membrane Protein Expression.

Focke PJ, Hein C, Hoffmann B, Matulef K, Bernhard F, Dötsch V, Valiyaveetil FI.

Biochemistry. 2016 Aug 2;55(30):4212-9. doi: 10.1021/acs.biochem.6b00488. Epub 2016 Jul 21.


Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.

Matulef K, Annen AW, Nix JC, Valiyaveetil FI.

Structure. 2016 May 3;24(5):750-761. doi: 10.1016/j.str.2016.02.021. Epub 2016 Apr 14.


Ion-binding properties of a K+ channel selectivity filter in different conformations.

Liu S, Focke PJ, Matulef K, Bian X, Moënne-Loccoz P, Valiyaveetil FI, Lockless SW.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15096-100. doi: 10.1073/pnas.1510526112. Epub 2015 Nov 23.


Engineering the glutamate transporter homologue GltPh using protein semisynthesis.

Focke PJ, Annen AW, Valiyaveetil FI.

Biochemistry. 2015 Mar 3;54(8):1694-702. doi: 10.1021/bi501477y. Epub 2015 Feb 17.


Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels.

Matulef K, Komarov AG, Costantino CA, Valiyaveetil FI.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17886-91. doi: 10.1073/pnas.1314356110. Epub 2013 Oct 15.


Semisynthetic K+ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated state.

Devaraneni PK, Komarov AG, Costantino CA, Devereaux JJ, Matulef K, Valiyaveetil FI.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15698-703. doi: 10.1073/pnas.1308699110. Epub 2013 Sep 9.


Engineering K+ channels using semisynthesis.

Komarov AG, Costantino CA, Valiyaveetil FI.

Methods Mol Biol. 2013;995:3-17. doi: 10.1007/978-1-62703-345-9_1.


In vitro folding of KvAP, a voltage-gated K+ channel.

Devaraneni PK, Devereaux JJ, Valiyaveetil FI.

Biochemistry. 2011 Dec 6;50(48):10442-50. doi: 10.1021/bi2012965. Epub 2011 Nov 10.


Studies of ion channels using expressed protein ligation.

Focke PJ, Valiyaveetil FI.

Curr Opin Chem Biol. 2010 Dec;14(6):797-802. doi: 10.1016/j.cbpa.2010.09.014. Epub 2010 Oct 19. Review.


Semisynthesis of NaK, a Na(+) and K(+) conducting ion channel.

Linn KM, Derebe MG, Jiang Y, Valiyaveetil FI.

Biochemistry. 2010 Jun 1;49(21):4450-6. doi: 10.1021/bi100413z.


Modular strategy for the semisynthesis of a K+ channel: investigating interactions of the pore helix.

Komarov AG, Linn KM, Devereaux JJ, Valiyaveetil FI.

ACS Chem Biol. 2009 Dec 18;4(12):1029-38. doi: 10.1021/cb900210r.


Semisynthesis of K+ channels.

Komarov AG, Linn KM, Devereaux JJ, Valiyaveetil FI.

Methods Enzymol. 2009;462:135-50. doi: 10.1016/S0076-6879(09)62007-3.


Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation.

Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R.

Science. 2006 Nov 10;314(5801):1004-7.


Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel.

Valiyaveetil FI, Sekedat M, MacKinnon R, Muir TW.

J Am Chem Soc. 2006 Sep 6;128(35):11591-9.


Glycine as a D-amino acid surrogate in the K(+)-selectivity filter.

Valiyaveetil FI, Sekedat M, Mackinnon R, Muir TW.

Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17045-9. Epub 2004 Nov 24.


Semisynthesis of a functional K+ channel.

Valiyaveetil FI, Sekedat M, Muir TW, MacKinnon R.

Angew Chem Int Ed Engl. 2004 May 3;43(19):2504-7. No abstract available.


Lipids in the structure, folding, and function of the KcsA K+ channel.

Valiyaveetil FI, Zhou Y, MacKinnon R.

Biochemistry. 2002 Sep 3;41(35):10771-7.


Semisynthesis and folding of the potassium channel KcsA.

Valiyaveetil FI, MacKinnon R, Muir TW.

J Am Chem Soc. 2002 Aug 7;124(31):9113-20.


Subunit organization and structure in the F0 sector of Escherichia coli F1F0 ATP synthase.

Fillingame RH, Jones PC, Jiang W, Valiyaveetil FI, Dmitriev OY.

Biochim Biophys Acta. 1998 Jun 10;1365(1-2):135-42. Review.


Transmembrane topography of subunit a in the Escherichia coli F1F0 ATP synthase.

Valiyaveetil FI, Fillingame RH.

J Biol Chem. 1998 Jun 26;273(26):16241-7.


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