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Items: 1 to 50 of 89


Sequential adjustment of cytotoxic T lymphocyte densities improves efficacy in controlling tumor growth.

Khazen R, Müller S, Lafouresse F, Valitutti S, Cussat-Blanc S.

Sci Rep. 2019 Aug 23;9(1):12308. doi: 10.1038/s41598-019-48711-2.


Theophylline induces differentiation and modulates cytoskeleton dynamics and cytokines secretion in human melanoma-initiating cells.

Cordella M, Tabolacci C, Senatore C, Rossi S, Mueller S, Lintas C, Eramo A, D'Arcangelo D, Valitutti S, Facchiano A, Facchiano F.

Life Sci. 2019 Aug 1;230:121-131. doi: 10.1016/j.lfs.2019.05.050. Epub 2019 May 21.


Multiparametric analysis of CD8+ T cell compartment phenotype in chronic lymphocytic leukemia reveals a signature associated with progression toward therapy.

Gonnord P, Costa M, Abreu A, Peres M, Ysebaert L, Gadat S, Valitutti S.

Oncoimmunology. 2019 Feb 7;8(4):e1570774. doi: 10.1080/2162402X.2019.1570774. eCollection 2019.


Hydroxychloroquine as a novel therapeutic approach in mast cell activation diseases.

Espinosa E, Valitutti S, Laroche M, Laurent C, Apoil PA, Hermine O, Lavit M, Paul C, Bulai Livideanu C.

Clin Immunol. 2018 Sep;194:75-79. doi: 10.1016/j.clim.2018.07.004. Epub 2018 Jul 10.


The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse.

Houmadi R, Guipouy D, Rey-Barroso J, Vasconcelos Z, Cornet J, Manghi M, Destainville N, Valitutti S, Allart S, Dupré L.

Cell Rep. 2018 Jan 23;22(4):979-991. doi: 10.1016/j.celrep.2017.12.088. Epub 2018 Jan 28.


New roles and controls of mast cells.

Espinosa E, Valitutti S.

Curr Opin Immunol. 2018 Feb;50:39-47. doi: 10.1016/j.coi.2017.10.012. Epub 2017 Nov 13. Review.


Direct monitoring of basophil degranulation by using avidin-based probes.

Joulia R, Mailhol C, Valitutti S, Didier A, Espinosa E.

J Allergy Clin Immunol. 2017 Oct;140(4):1159-1162.e6. doi: 10.1016/j.jaci.2017.03.030. Epub 2017 Apr 20. No abstract available.


The Mast Cell Antibody-Dependent Degranulatory Synapse.

Valitutti S, Joulia R, Espinosa E.

Methods Mol Biol. 2017;1584:487-495. doi: 10.1007/978-1-4939-6881-7_30.


Impaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement.

Gravelle P, Do C, Franchet C, Mueller S, Oberic L, Ysebaert L, Larocca LM, Hohaus S, Calmels MN, Frenois FX, Kridel R, Gascoyne RD, Laurent G, Brousset P, Valitutti S, Laurent C.

Oncoimmunology. 2016 Aug 24;5(10):e1224044. eCollection 2016.


IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level.

Joulia R, L'Faqihi FE, Valitutti S, Espinosa E.

J Allergy Clin Immunol. 2017 Aug;140(2):497-509.e10. doi: 10.1016/j.jaci.2016.09.049. Epub 2016 Nov 19.


Different activation signals induce distinct mast cell degranulation strategies.

Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ.

J Clin Invest. 2016 Oct 3;126(10):3981-3998. doi: 10.1172/JCI85538. Epub 2016 Sep 19.


A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion.

Petit AE, Demotte N, Scheid B, Wildmann C, Bigirimana R, Gordon-Alonso M, Carrasco J, Valitutti S, Godelaine D, van der Bruggen P.

Nat Commun. 2016 Jul 22;7:12242. doi: 10.1038/ncomms12242.


The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells.

Chiaruttini G, Piperno GM, Jouve M, De Nardi F, Larghi P, Peden AA, Baj G, Müller S, Valitutti S, Galli T, Benvenuti F.

Cell Rep. 2016 Mar 22;14(11):2624-36. doi: 10.1016/j.celrep.2016.02.055. Epub 2016 Mar 10.


Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse.

Khazen R, Müller S, Gaudenzio N, Espinosa E, Puissegur MP, Valitutti S.

Nat Commun. 2016 Mar 4;7:10823. doi: 10.1038/ncomms10823.


Individual Human Cytotoxic T Lymphocytes Exhibit Intraclonal Heterogeneity during Sustained Killing.

Vasconcelos Z, Müller S, Guipouy D, Yu W, Christophe C, Gadat S, Valitutti S, Dupré L.

Cell Rep. 2015 Jun 9;11(9):1474-85. doi: 10.1016/j.celrep.2015.05.002. Epub 2015 May 28.


Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes.

Yu W, Jiang N, Ebert PJ, Kidd BA, Müller S, Lund PJ, Juang J, Adachi K, Tse T, Birnbaum ME, Newell EW, Wilson DM, Grotenbreg GM, Valitutti S, Quake SR, Davis MM.

Immunity. 2015 May 19;42(5):929-41. doi: 10.1016/j.immuni.2015.05.001.


A biased competition theory of cytotoxic T lymphocyte interaction with tumor nodules.

Christophe C, Müller S, Rodrigues M, Petit AE, Cattiaux P, Dupré L, Gadat S, Valitutti S.

PLoS One. 2015 Mar 27;10(3):e0120053. doi: 10.1371/journal.pone.0120053. eCollection 2015.


Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence.

Joulia R, Gaudenzio N, Rodrigues M, Lopez J, Blanchard N, Valitutti S, Espinosa E.

Nat Commun. 2015 Jan 28;6:6174. doi: 10.1038/ncomms7174.


Reply: To PMID 23518141.

Gaudenzio N, Laurent C, Valitutti S, Espinosa E.

J Allergy Clin Immunol. 2013 Dec;132(6):1458-9. doi: 10.1016/j.jaci.2013.09.025. Epub 2013 Nov 1. No abstract available.


A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.

Huang J, Brameshuber M, Zeng X, Xie J, Li QJ, Chien YH, Valitutti S, Davis MM.

Immunity. 2013 Nov 14;39(5):846-57. doi: 10.1016/j.immuni.2013.08.036. Epub 2013 Oct 10.


An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse.

Bertrand F, Müller S, Roh KH, Laurent C, Dupré L, Valitutti S.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6073-8. doi: 10.1073/pnas.1218640110. Epub 2013 Mar 27.


Lymphatic endothelium forms integrin-engaging 3D structures during DC transit across inflamed lymphatic vessels.

Teijeira A, Garasa S, Peláez R, Azpilikueta A, Ochoa C, Marré D, Rodrigues M, Alfaro C, Aubá C, Valitutti S, Melero I, Rouzaut A.

J Invest Dermatol. 2013 Sep;133(9):2276-85. doi: 10.1038/jid.2013.152. Epub 2013 Mar 25.


Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype.

Gaudenzio N, Laurent C, Valitutti S, Espinosa E.

J Allergy Clin Immunol. 2013 May;131(5):1400-7.e11. doi: 10.1016/j.jaci.2013.01.029. Epub 2013 Mar 19.


The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy.

Valitutti S.

Front Immunol. 2012 Aug 28;3:272. doi: 10.3389/fimmu.2012.00272. eCollection 2012.


Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1.

Lafouresse F, Cotta-de-Almeida V, Malet-Engra G, Galy A, Valitutti S, Dupré L.

Immunology. 2012 Oct;137(2):183-96. doi: 10.1111/j.1365-2567.2012.03620.x.


Stepwise maturation of lytic granules during differentiation and activation of human CD8+ T lymphocytes.

Sanchez-Ruiz Y, Valitutti S, Dupre L.

PLoS One. 2011;6(11):e27057. doi: 10.1371/journal.pone.0027057. Epub 2011 Nov 4.


Reciprocal polarization of T and B cells at the immunological synapse.

Duchez S, Rodrigues M, Bertrand F, Valitutti S.

J Immunol. 2011 Nov 1;187(9):4571-80. doi: 10.4049/jimmunol.1100600. Epub 2011 Sep 19.


Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study.

Laurent C, Müller S, Do C, Al-Saati T, Allart S, Larocca LM, Hohaus S, Duchez S, Quillet-Mary A, Laurent G, Brousset P, Valitutti S.

Blood. 2011 Nov 17;118(20):5371-9. doi: 10.1182/blood-2011-04-345777. Epub 2011 Aug 19.


The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling.

Calvez R, Lafouresse F, De Meester J, Galy A, Valitutti S, Dupré L.

Haematologica. 2011 Oct;96(10):1415-23. doi: 10.3324/haematol.2011.040204. Epub 2011 Jun 9.


Cognate interactions between mast cells and helper T lymphocytes.

Valitutti S, Espinosa E.

Self Nonself. 2010 Apr;1(2):114-122. Epub 2010 Mar 17.


The space and time frames of T cell activation at the immunological synapse.

Valitutti S, Coombs D, Dupré L.

FEBS Lett. 2010 Dec 15;584(24):4851-7. doi: 10.1016/j.febslet.2010.10.010. Epub 2010 Oct 14.


The Wiskott-Aldrich syndrome protein regulates CTL cytotoxicity and is required for efficient killing of B cell lymphoma targets.

De Meester J, Calvez R, Valitutti S, Dupré L.

J Leukoc Biol. 2010 Nov;88(5):1031-40. doi: 10.1189/jlb.0410197. Epub 2010 Aug 5.


Activation of the ancestral polarity regulator protein kinase C zeta at the immunological synapse drives polarization of Th cell secretory machinery toward APCs.

Bertrand F, Esquerré M, Petit AE, Rodrigues M, Duchez S, Delon J, Valitutti S.

J Immunol. 2010 Sep 1;185(5):2887-94. doi: 10.4049/jimmunol.1000739. Epub 2010 Aug 2.


T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC.

Carreño LJ, Riquelme EM, González PA, Espagnolle N, Riedel CA, Valitutti S, Kalergis AM.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):210-5. doi: 10.1073/pnas.0911258107. Epub 2009 Dec 14.


Plasticity of immunological synapses.

Valitutti S, Dupré L.

Curr Top Microbiol Immunol. 2010;340:209-28. doi: 10.1007/978-3-642-03858-7_11. Review.


Cell-cell cooperation at the T helper cell/mast cell immunological synapse.

Gaudenzio N, Espagnolle N, Mars LT, Liblau R, Valitutti S, Espinosa E.

Blood. 2009 Dec 3;114(24):4979-88. doi: 10.1182/blood-2009-02-202648. Epub 2009 Oct 5.


Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery.

Dushek O, Mueller S, Soubies S, Depoil D, Caramalho I, Coombs D, Valitutti S.

PLoS One. 2008;3(12):e3913. doi: 10.1371/journal.pone.0003913. Epub 2008 Dec 11.


Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation.

Caramalho I, Faroudi M, Padovan E, Müller S, Valitutti S.

J Cell Mol Med. 2009 Sep;13(9B):3834-46. doi: 10.1111/j.1582-4934.2008.00586.x. Epub 2008 Oct 6.


Immunological synapse: center of attention again.

Valitutti S.

Immunity. 2008 Sep 19;29(3):384-6. doi: 10.1016/j.immuni.2008.08.002.


Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism.

Esquerré M, Tauzin B, Guiraud M, Müller S, Saoudi A, Valitutti S.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2550-5. doi: 10.1073/pnas.0708350105. Epub 2008 Feb 11.


CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment.

Rabot M, El Costa H, Polgar B, Marie-Cardine A, Aguerre-Girr M, Barakonyi A, Valitutti S, Bensussan A, Le Bouteiller P.

Int Immunol. 2007 Apr;19(4):401-9. Epub 2007 Feb 16.


CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse.

Espagnolle N, Depoil D, Zaru R, Demeur C, Champagne E, Guiraud M, Valitutti S.

Int Immunol. 2007 Mar;19(3):239-48. Epub 2007 Jan 12.


Analysis of peptide/MHC-induced TCR downregulation: deciphering the triggering kinetics.

Utzny C, Coombs D, Müller S, Valitutti S.

Cell Biochem Biophys. 2006;46(2):101-11.


Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses.

Wiedemann A, Depoil D, Faroudi M, Valitutti S.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10985-90. Epub 2006 Jul 10.


CD4+ T cells downregulate Bcl-2 in germinal centers.

Schenka AA, Müller S, Fournié JJ, Capila F, Vassallo J, Delsol G, Valitutti S, Brousset P.

J Clin Immunol. 2005 May;25(3):224-9.


T-cell activation is accompanied by an ubiquitination process occurring at the immunological synapse.

Wiedemann A, Müller S, Favier B, Penna D, Guiraud M, Delmas C, Champagne E, Valitutti S.

Immunol Lett. 2005 Apr 15;98(1):57-61. Epub 2004 Nov 20.


Immunological synapses are versatile structures enabling selective T cell polarization.

Depoil D, Zaru R, Guiraud M, Chauveau A, Harriague J, Bismuth G, Utzny C, Müller S, Valitutti S.

Immunity. 2005 Feb;22(2):185-94.


Frequency encoding of T-cell receptor engagement dynamics in calcium time series.

Utzny C, Faroudi M, Valitutti S.

Biophys J. 2005 Jan;88(1):1-14. Epub 2004 Oct 22.


Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold.

Faroudi M, Utzny C, Salio M, Cerundolo V, Guiraud M, Müller S, Valitutti S.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14145-50. Epub 2003 Nov 10.


Uncoupling between immunological synapse formation and functional outcome in human gamma delta T lymphocytes.

Favier B, Espinosa E, Tabiasco J, Dos Santos C, Bonneville M, Valitutti S, Fournié JJ.

J Immunol. 2003 Nov 15;171(10):5027-33.

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