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Items: 1 to 50 of 217

1.

Neuromedin U is a gut peptide that alters oral glucose tolerance by delaying gastric emptying via direct contraction of the pylorus and vagal-dependent mechanisms.

Jarry AC, Merah N, Cisse F, Cayetanot F, Fiamma MN, Willemetz A, Gueddouri D, Barka B, Valet P, Guilmeau S, Bado A, Le Beyec J, Bodineau L, Le Gall M.

FASEB J. 2019 Apr;33(4):5377-5388. doi: 10.1096/fj.201801718R. Epub 2019 Feb 12.

PMID:
30753087
2.

Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP).

Lehuédé C, Li X, Dauvillier S, Vaysse C, Franchet C, Clement E, Esteve D, Longué M, Chaltiel L, Le Gonidec S, Lazar I, Geneste A, Dumontet C, Valet P, Nieto L, Fallone F, Muller C.

Breast Cancer Res. 2019 Jan 17;21(1):7. doi: 10.1186/s13058-018-1088-6.

3.

Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress.

Laurent V, Toulet A, Attané C, Milhas D, Dauvillier S, Zaidi F, Clement E, Cinato M, Le Gonidec S, Guérard A, Lehuédé C, Garandeau D, Nieto L, Renaud-Gabardos E, Prats AC, Valet P, Malavaud B, Muller C.

Mol Cancer Res. 2019 Mar;17(3):821-835. doi: 10.1158/1541-7786.MCR-18-0748. Epub 2019 Jan 3.

PMID:
30606769
4.

The apelin/APJ system as a therapeutic target in metabolic diseases.

Castan-Laurell I, Masri B, Valet P.

Expert Opin Ther Targets. 2019 Mar;23(3):215-225. doi: 10.1080/14728222.2019.1561871. Epub 2019 Jan 10.

PMID:
30570369
5.

Diet-induced obesity and associated disorders are prevented by natural bioactive type 1 fish collagen peptides (Naticol®) treatment.

Astre G, Deleruyelle S, Dortignac A, Bonnet C, Valet P, Dray C.

J Physiol Biochem. 2018 Nov;74(4):647-654. doi: 10.1007/s13105-018-0650-0. Epub 2018 Sep 19.

PMID:
30232707
6.

The exerkine apelin reverses age-associated sarcopenia.

Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradère JP, Le Gonidec S, Dortignac A, Geoffre N, Pereira O, Karaz S, Lee U, Camus M, Chaoui K, Mouisel E, Bigot A, Mouly V, Vigneau M, Pagano AF, Chopard A, Pillard F, Guyonnet S, Cesari M, Burlet-Schiltz O, Pahor M, Feige JN, Vellas B, Valet P, Dray C.

Nat Med. 2018 Sep;24(9):1360-1371. doi: 10.1038/s41591-018-0131-6. Epub 2018 Jul 30.

PMID:
30061698
7.

Isoprostanes as markers for muscle aging in older athletes.

Vinel C, Pereira O, Dupuy A, Bertrand-Michel J, Laoudj-Chenivesse D, Rolland Y, Rivière D, Valet P, Dray C, Pillard F.

Biochim Open. 2017 Dec 15;6:1-8. doi: 10.1016/j.biopen.2017.12.001. eCollection 2018 Jun.

8.

Esophageal cancer cells resistant to T-DM1 display alterations in cell adhesion and the prostaglandin pathway.

Sauveur J, Matera EL, Chettab K, Valet P, Guitton J, Savina A, Dumontet C.

Oncotarget. 2018 Apr 20;9(30):21141-21155. doi: 10.18632/oncotarget.24975. eCollection 2018 Apr 20.

9.

Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth.

Tajan M, Pernin-Grandjean J, Beton N, Gennero I, Capilla F, Neel BG, Araki T, Valet P, Tauber M, Salles JP, Yart A, Edouard T.

Hum Mol Genet. 2018 Jul 1;27(13):2276-2289. doi: 10.1093/hmg/ddy133.

10.

Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons.

Abot A, Lucas A, Bautzova T, Bessac A, Fournel A, Le-Gonidec S, Valet P, Moro C, Cani PD, Knauf C.

Mol Metab. 2018 Apr;10:100-108. doi: 10.1016/j.molmet.2018.01.020. Epub 2018 Jan 31.

11.

Chronic apelin treatment improves hepatic lipid metabolism in obese and insulin-resistant mice by an indirect mechanism.

Bertrand C, Pradère JP, Geoffre N, Deleruyelle S, Masri B, Personnaz J, Le Gonidec S, Batut A, Louche K, Moro C, Valet P, Castan-Laurell I.

Endocrine. 2018 Apr;60(1):112-121. doi: 10.1007/s12020-018-1536-1. Epub 2018 Feb 1.

PMID:
29392617
12.

Therapeutic Benefit and Gene Network Regulation by Combined Gene Transfer of Apelin, FGF2, and SERCA2a into Ischemic Heart.

Renaud-Gabardos E, Tatin F, Hantelys F, Lebas B, Calise D, Kunduzova O, Masri B, Pujol F, Sicard P, Valet P, Roncalli J, Chaufour X, Garmy-Susini B, Parini A, Prats AC.

Mol Ther. 2018 Mar 7;26(3):902-916. doi: 10.1016/j.ymthe.2017.11.007. Epub 2017 Nov 16.

13.

Pharmacological targeting of apelin impairs glioblastoma growth.

Harford-Wright E, Andre-Gregoire G, Jacobs KA, Treps L, Le Gonidec S, Leclair HM, Gonzalez-Diest S, Roux Q, Guillonneau F, Loussouarn D, Oliver L, Vallette FM, Foufelle F, Valet P, Davenport AP, Glen RC, Bidere N, Gavard J.

Brain. 2017 Nov 1;140(11):2939-2954. doi: 10.1093/brain/awx253.

14.

Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic-euglycaemic clamp.

Gourdy P, Cazals L, Thalamas C, Sommet A, Calvas F, Galitzky M, Vinel C, Dray C, Hanaire H, Castan-Laurell I, Valet P.

Diabetes Obes Metab. 2018 Jan;20(1):157-164. doi: 10.1111/dom.13055. Epub 2017 Aug 10.

PMID:
28681996
15.

Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction.

Tatin F, Renaud-Gabardos E, Godet AC, Hantelys F, Pujol F, Morfoisse F, Calise D, Viars F, Valet P, Masri B, Prats AC, Garmy-Susini B.

JCI Insight. 2017 Jun 15;2(12). pii: 93887. doi: 10.1172/jci.insight.93887. eCollection 2017 Jun 15.

16.

A biomimetic hydrogel functionalized with adipose ECM components as a microenvironment for the 3D culture of human and murine adipocytes.

Louis F, Pannetier P, Souguir Z, Le Cerf D, Valet P, Vannier JP, Vidal G, Demange E.

Biotechnol Bioeng. 2017 Aug;114(8):1813-1824. doi: 10.1002/bit.26306. Epub 2017 May 8.

PMID:
28398656
17.

Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice.

Tronchere H, Cinato M, Timotin A, Guitou L, Villedieu C, Thibault H, Baetz D, Payrastre B, Valet P, Parini A, Kunduzova O, Boal F.

EMBO Mol Med. 2017 Jun;9(6):770-785. doi: 10.15252/emmm.201607096.

18.

Improvement of cardiometabolic markers after fish oil intervention in young Mexican adults and the role of PPARα L162V and PPARγ2 P12A.

Binia A, Vargas-Martínez C, Ancira-Moreno M, Gosoniu LM, Montoliu I, Gámez-Valdez E, Soria-Contreras DC, Angeles-Quezada A, Gonzalez-Alberto R, Fernández S, Martínez-Conde D, Hernández-Morán B, Ramírez-Solano M, Pérez-Ortega C, Rodríguez-Carmona Y, Castan I, Rubio-Aliaga I, Vadillo-Ortega F, Márquez-Velasco R, Bojalil R, López-Alvarenga JC, Valet P, Kussmann M, Silva-Zolezzi I, Tejero ME.

J Nutr Biochem. 2017 May;43:98-106. doi: 10.1016/j.jnutbio.2017.02.002. Epub 2017 Feb 10.

19.

Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.

Le Gonidec S, Chaves-Almagro C, Bai Y, Kang HJ, Smith A, Wanecq E, Huang XP, Prats H, Knibiehler B, Roth BL, Barak LS, Caron MG, Valet P, Audigier Y, Masri B.

FASEB J. 2017 Jun;31(6):2507-2519. doi: 10.1096/fj.201601074R. Epub 2017 Feb 27.

20.

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

Wang YY, Attané C, Milhas D, Dirat B, Dauvillier S, Guerard A, Gilhodes J, Lazar I, Alet N, Laurent V, Le Gonidec S, Biard D, Hervé C, Bost F, Ren GS, Bono F, Escourrou G, Prentki M, Nieto L, Valet P, Muller C.

JCI Insight. 2017 Feb 23;2(4):e87489. doi: 10.1172/jci.insight.87489.

21.

The use of urinary proteomics in the assessment of suitability of mouse models for ageing.

Nkuipou-Kenfack E, Schanstra JP, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands JL, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber TB, Rudolph KL, Pich A, Mischak H, Zürbig P.

PLoS One. 2017 Feb 15;12(2):e0166875. doi: 10.1371/journal.pone.0166875. eCollection 2017.

22.

Cognitive deficit in hippocampal-dependent tasks in Werner syndrome mouse model.

Rekik K, Francés B, Valet P, Dray C, Florian C.

Behav Brain Res. 2017 Apr 14;323:68-77. doi: 10.1016/j.bbr.2017.01.034. Epub 2017 Jan 21.

PMID:
28119126
23.

Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice.

Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, Duparc T, Louche K, Batut A, Lucas A, Le-Gonidec S, Lesage J, Fioramonti X, Moro C, Valet P, Cani PD, Knauf C.

Sci Rep. 2016 Aug 23;6:31849. doi: 10.1038/srep31849.

24.

[Dissemination of prostate cancer: a way paved of fat].

Laurent V, Guérard A, Toulet A, Valet P, Malavaud B, Muller C.

Med Sci (Paris). 2016 Jun-Jul;32(6-7):563-5. doi: 10.1051/medsci/20163206012. Epub 2016 Jul 12. French. No abstract available.

25.

Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia.

Pomié C, Blasco-Baque V, Klopp P, Nicolas S, Waget A, Loubières P, Azalbert V, Puel A, Lopez F, Dray C, Valet P, Lelouvier B, Servant F, Courtney M, Amar J, Burcelin R, Garidou L.

Mol Metab. 2016 Mar 28;5(6):392-403. doi: 10.1016/j.molmet.2016.03.004. eCollection 2016 Jun.

26.

Corrigendum: Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch.

Dali-Youcef N, Hnia K, Blaise S, Messaddeq N, Blanc S, Postic C, Valet P, Tomasetto C, Rio MC.

Sci Rep. 2016 May 31;6:26916. doi: 10.1038/srep26916. No abstract available.

27.

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer.

Lazar I, Clement E, Dauvillier S, Milhas D, Ducoux-Petit M, LeGonidec S, Moro C, Soldan V, Dalle S, Balor S, Golzio M, Burlet-Schiltz O, Valet P, Muller C, Nieto L.

Cancer Res. 2016 Jul 15;76(14):4051-7. doi: 10.1158/0008-5472.CAN-16-0651. Epub 2016 May 23.

28.

Simultaneous quantitative profiling of 20 isoprostanoids from omega-3 and omega-6 polyunsaturated fatty acids by LC-MS/MS in various biological samples.

Dupuy A, Le Faouder P, Vigor C, Oger C, Galano JM, Dray C, Lee JC, Valet P, Gladine C, Durand T, Bertrand-Michel J.

Anal Chim Acta. 2016 May 19;921:46-58. doi: 10.1016/j.aca.2016.03.024. Epub 2016 Mar 19.

29.

Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch.

Dali-Youcef N, Hnia K, Blaise S, Messaddeq N, Blanc S, Postic C, Valet P, Tomasetto C, Rio MC.

Sci Rep. 2016 Apr 29;6:25140. doi: 10.1038/srep25140. Erratum in: Sci Rep. 2016 May 31;6:26916.

30.

Apelin-13 administration protects against ischaemia/reperfusion-mediated apoptosis through the FoxO1 pathway in high-fat diet-induced obesity.

Boal F, Timotin A, Roumegoux J, Alfarano C, Calise D, Anesia R, Parini A, Valet P, Tronchere H, Kunduzova O.

Br J Pharmacol. 2016 Jun;173(11):1850-63. doi: 10.1111/bph.13485. Epub 2016 Apr 20.

31.

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.

Laurent V, Guérard A, Mazerolles C, Le Gonidec S, Toulet A, Nieto L, Zaidi F, Majed B, Garandeau D, Socrier Y, Golzio M, Cadoudal T, Chaoui K, Dray C, Monsarrat B, Schiltz O, Wang YY, Couderc B, Valet P, Malavaud B, Muller C.

Nat Commun. 2016 Jan 12;7:10230. doi: 10.1038/ncomms10230.

32.

Apelin: an antithrombotic factor that inhibits platelet function.

Adam F, Khatib AM, Lopez JJ, Vatier C, Turpin S, Muscat A, Soulet F, Aries A, Jardin I, Bobe R, Stepanian A, de Prost D, Dray C, Rosado JA, Valet P, Feve B, Siegfried G.

Blood. 2016 Feb 18;127(7):908-20. doi: 10.1182/blood-2014-05-578781. Epub 2015 Dec 3.

33.

Apelin targets gut contraction to control glucose metabolism via the brain.

Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.

Gut. 2017 Feb;66(2):258-269. doi: 10.1136/gutjnl-2015-310230. Epub 2015 Nov 12.

34.

Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity.

Boal F, Roumegoux J, Alfarano C, Timotin A, Calise D, Anesia R, Drougard A, Knauf C, Lagente C, Roncalli J, Desmoulin F, Tronchere H, Valet P, Parini A, Kunduzova O.

Sci Rep. 2015 Nov 6;5:16104. doi: 10.1038/srep16104.

35.

SHP2 sails from physiology to pathology.

Tajan M, de Rocca Serra A, Valet P, Edouard T, Yart A.

Eur J Med Genet. 2015 Oct;58(10):509-25. doi: 10.1016/j.ejmg.2015.08.005. Epub 2015 Sep 2. Review.

PMID:
26341048
36.

Regulation of SREBPs by Sphingomyelin in Adipocytes via a Caveolin and Ras-ERK-MAPK-CREB Signaling Pathway.

Makdissy N, Haddad K, Mouawad C, Popa I, Younsi M, Valet P, Brunaud L, Ziegler O, Quilliot D.

PLoS One. 2015 Jul 31;10(7):e0133181. doi: 10.1371/journal.pone.0133181. eCollection 2015.

37.

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease.

Garidou L, Pomié C, Klopp P, Waget A, Charpentier J, Aloulou M, Giry A, Serino M, Stenman L, Lahtinen S, Dray C, Iacovoni JS, Courtney M, Collet X, Amar J, Servant F, Lelouvier B, Valet P, Eberl G, Fazilleau N, Douin-Echinard V, Heymes C, Burcelin R.

Cell Metab. 2015 Jul 7;22(1):100-12. doi: 10.1016/j.cmet.2015.06.001.

38.

Apelin receptors: From signaling to antidiabetic strategy.

Chaves-Almagro C, Castan-Laurell I, Dray C, Knauf C, Valet P, Masri B.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):149-59. doi: 10.1016/j.ejphar.2015.05.017. Epub 2015 May 22. Review.

PMID:
26007641
39.

Apelin and energy metabolism.

Bertrand C, Valet P, Castan-Laurell I.

Front Physiol. 2015 Apr 10;6:115. doi: 10.3389/fphys.2015.00115. eCollection 2015. Review.

40.

[The APJ receptor: a new therapeutic approach in diabetic treatment].

Masri B, Dray C, Knauf C, Valet P, Castan-Laurell I.

Med Sci (Paris). 2015 Mar;31(3):275-81. doi: 10.1051/medsci/20153103013. Epub 2015 Apr 8. Review. French.

41.

Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake.

Drougard A, Fournel A, Valet P, Knauf C.

Front Neurosci. 2015 Feb 24;9:56. doi: 10.3389/fnins.2015.00056. eCollection 2015. Review.

42.

Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.

Regazzetti C, Dumas K, Lacas-Gervais S, Pastor F, Peraldi P, Bonnafous S, Dugail I, Le Lay S, Valet P, Le Marchand-Brustel Y, Tran A, Gual P, Tanti JF, Cormont M, Giorgetti-Peraldi S.

Endocrinology. 2015 Mar;156(3):789-801. doi: 10.1210/en.2014-1656. Epub 2014 Dec 18.

PMID:
25521582
43.

Structural apelin analogues: mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury.

Pisarenko O, Shulzhenko V, Studneva I, Pelogeykina Y, Timoshin A, Anesia R, Valet P, Parini A, Kunduzova O.

Br J Pharmacol. 2015 Jun;172(12):2933-45. doi: 10.1111/bph.13038. Epub 2015 Apr 23.

44.

LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.

Tajan M, Batut A, Cadoudal T, Deleruyelle S, Le Gonidec S, Saint Laurent C, Vomscheid M, Wanecq E, Tréguer K, De Rocca Serra-Nédélec A, Vinel C, Marques MA, Pozzo J, Kunduzova O, Salles JP, Tauber M, Raynal P, Cavé H, Edouard T, Valet P, Yart A.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4494-503. doi: 10.1073/pnas.1406107111. Epub 2014 Oct 6.

45.

Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.

Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, Maynard D, Lehuédé C, Muller C, Valet P, Gespach CP, Bracke M, Cocquyt V, Denys H, De Wever O.

Cancer Res. 2014 Dec 1;74(23):6806-19. doi: 10.1158/0008-5472.CAN-14-0160. Epub 2014 Sep 24.

46.

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation.

Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF.

EMBO Mol Med. 2014 Oct;6(10):1328-46. doi: 10.15252/emmm.201404112.

47.

The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.

Labialle S, Marty V, Bortolin-Cavaillé ML, Hoareau-Osman M, Pradère JP, Valet P, Martin PG, Cavaillé J.

EMBO J. 2014 Oct 1;33(19):2216-30. doi: 10.15252/embj.201387038. Epub 2014 Aug 14.

48.

Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin.

Alfarano C, Foussal C, Lairez O, Calise D, Attané C, Anesia R, Daviaud D, Wanecq E, Parini A, Valet P, Kunduzova O.

Int J Obes (Lond). 2015 Feb;39(2):312-20. doi: 10.1038/ijo.2014.122. Epub 2014 Jul 16.

49.

Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications.

Pinnick KE, Nicholson G, Manolopoulos KN, McQuaid SE, Valet P, Frayn KN, Denton N, Min JL, Zondervan KT, Fleckner J; MolPAGE Consortium, McCarthy MI, Holmes CC, Karpe F.

Diabetes. 2014 Nov;63(11):3785-97. doi: 10.2337/db14-0385. Epub 2014 Jun 19.

50.

[Adipose tissue and cancer: a high risk tandem].

Laurent V, Nieto L, Valet P, Muller C.

Med Sci (Paris). 2014 Apr;30(4):398-404. doi: 10.1051/medsci/20143004013. Epub 2014 May 5. Review. French.

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