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The ATC/TTC haplotype in the Interleukin 8 gene in response to Gram-negative bacteria: A pilot study.

Pigossi SC, Anovazzi G, Finoti LS, de Medeiros MC, de Souza-Moreira TM, Mayer MPA, Zanelli CF, Valentini SR, Rossa Junior C, Scarel-Caminaga RM.

Arch Oral Biol. 2019 Nov;107:104508. doi: 10.1016/j.archoralbio.2019.104508. Epub 2019 Jul 24.


Improving the cost effectiveness of enhanced green fluorescent protein production using recombinant Escherichia coli BL21 (DE3): Decreasing the expression inducer concentration.

Lopes C, Dos Santos NV, Dupont J, Pedrolli DB, Valentini SR, de Carvalho Santos-Ebinuma V, Pereira JFB.

Biotechnol Appl Biochem. 2019 Jul;66(4):527-536. doi: 10.1002/bab.1749. Epub 2019 Apr 16.


Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non-reproductive periods.

Luz JS, Caneguim BH, Baggio A, Santoni MM, Helbing CC, Valentini SR, Sasso-Cerri E, Oliveira CC.

BMC Res Notes. 2019 Jan 21;12(1):46. doi: 10.1186/s13104-019-4077-7.


The polyproline-motif of S6K2: eIF5A translational dependence and importance for protein-protein interactions.

Meneguello L, Barbosa NM, Pereira KD, Proença ARG, Tamborlin L, Simabuco FM, Iwai LK, Zanelli CF, Valentini SR, Luchessi AD.

J Cell Biochem. 2019 Apr;120(4):6015-6025. doi: 10.1002/jcb.27888. Epub 2018 Oct 15.


Screening of 2A peptides for polycistronic gene expression in yeast.

Souza-Moreira TM, Navarrete C, Chen X, Zanelli CF, Valentini SR, Furlan M, Nielsen J, Krivoruchko A.

FEMS Yeast Res. 2018 Aug 1;18(5). doi: 10.1093/femsyr/foy036.


Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms.

Alves TB, Souza-Moreira TM, Valentini SR, Zanelli CF, Furlan M.

Molecules. 2018 Mar 20;23(3). pii: E700. doi: 10.3390/molecules23030700.


Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis.

Celiberto LS, Bedani R, Dejani NN, Ivo de Medeiros A, Sampaio Zuanon JA, Spolidorio LC, Tallarico Adorno MA, Amâncio Varesche MB, Carrilho Galvão F, Valentini SR, Font de Valdez G, Rossi EA, Cavallini DCU.

PLoS One. 2017 Apr 24;12(4):e0175935. doi: 10.1371/journal.pone.0175935. eCollection 2017.


Functionality and opposite roles of two interleukin 4 haplotypes in immune cells.

Anovazzi G, Medeiros MC, Pigossi SC, Finoti LS, Souza Moreira TM, Mayer MP, Zanelli CF, Valentini SR, Rossa-Junior C, Scarel-Caminaga RM.

Genes Immun. 2017 Jan;18(1):33-41. doi: 10.1038/gene.2016.47. Epub 2017 Jan 5.


Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene.

Souza-Moreira TM, Alves TB, Pinheiro KA, Felippe LG, De Lima GM, Watanabe TF, Barbosa CC, Santos VA, Lopes NP, Valentini SR, Guido RV, Furlan M, Zanelli CF.

Sci Rep. 2016 Nov 22;6:36858. doi: 10.1038/srep36858.


Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis.

Barbosa NM, Boldrin PE, Rossi D, Yamamoto PA, Watanabe TF, Serrão VH, Hershey JW, Fraser CS, Valentini SR, Zanelli CF.

Amino Acids. 2016 Oct;48(10):2363-74. doi: 10.1007/s00726-016-2279-z. Epub 2016 Jul 7.


Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome.

Rossi D, Barbosa NM, Galvão FC, Boldrin PE, Hershey JW, Zanelli CF, Fraser CS, Valentini SR.

PLoS One. 2016 Apr 26;11(4):e0154205. doi: 10.1371/journal.pone.0154205. eCollection 2016.


Probiotic Soy Product Supplemented with Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: A Randomized Controlled Trial.

Cavallini DC, Manzoni MS, Bedani R, Roselino MN, Celiberto LS, Vendramini RC, de Valdez G, Abdalla DS, Pinto RA, Rosetto D, Valentini SR, Rossi EA.

Nutrients. 2016 Jan 19;8(1). pii: E52. doi: 10.3390/nu8010052.


Functional analysis of Paracoccidioides brasiliensis 14-3-3 adhesin expressed in Saccharomyces cerevisiae.

Assato PA, da Silva Jde F, de Oliveira HC, Marcos CM, Rossi D, Valentini SR, Mendes-Giannini MJ, Zanelli CF, Fusco-Almeida AM.

BMC Microbiol. 2015 Nov 4;15:256. doi: 10.1186/s12866-015-0586-2.


Insulin complexation with hydroxypropyl-beta-cyclodextrin: Spectroscopic evaluation of molecular inclusion and use of the complex in gel for healing of pressure ulcers.

Valentini SR, Nogueira AC, Fenelon VC, Sato F, Medina AN, Santana RG, Baesso ML, Matioli G.

Int J Pharm. 2015 Jul 25;490(1-2):229-39. doi: 10.1016/j.ijpharm.2015.05.037. Epub 2015 May 15.


MxA interacts with and is modified by the SUMOylation machinery.

Brantis-de-Carvalho CE, Maarifi G, Gonçalves Boldrin PE, Zanelli CF, Nisole S, Chelbi-Alix MK, Valentini SR.

Exp Cell Res. 2015 Jan 1;330(1):151-63. doi: 10.1016/j.yexcr.2014.10.020. Epub 2014 Oct 31.


eIF5A and EF-P: two unique translation factors are now traveling the same road.

Rossi D, Kuroshu R, Zanelli CF, Valentini SR.

Wiley Interdiscip Rev RNA. 2014 Mar-Apr;5(2):209-22. doi: 10.1002/wrna.1211. Epub 2014 Jan 8. Review.


eIF5A has a function in the cotranslational translocation of proteins into the ER.

Rossi D, Galvão FC, Bellato HM, Boldrin PE, Andrews BJ, Valentini SR, Zanelli CF.

Amino Acids. 2014 Mar;46(3):645-53. doi: 10.1007/s00726-013-1618-6. Epub 2013 Dec 5.


The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.

Morais ATs, Terzian AC, Duarte DV, Bronzoni RV, Madrid MC, Gavioli AF, Gil LH, Oliveira AG, Zanelli CF, Valentini SR, Rahal P, Nogueira ML.

Virol J. 2013 Jun 22;10:205. doi: 10.1186/1743-422X-10-205.


Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: understanding the action of the inhibitor GC7 on a murine macrophage cell line.

de Almeida OP Jr, Toledo TR, Rossi D, Rossetto Dde B, Watanabe TF, Galvão FC, Medeiros AI, Zanelli CF, Valentini SR.

Curr Pharm Des. 2014;20(2):284-92. Review.


The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.

Galvão FC, Rossi D, Silveira Wda S, Valentini SR, Zanelli CF.

PLoS One. 2013;8(4):e60140. doi: 10.1371/journal.pone.0060140. Epub 2013 Apr 1.


Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is accompanied by changes in BDNF in the nucleus accumbens of rats.

Leão RM, Cruz FC, Carneiro-de-Oliveira PE, Rossetto DB, Valentini SR, Zanelli CF, Planeta CS.

Pharmacol Biochem Behav. 2013 Mar;104:169-76. doi: 10.1016/j.pbb.2013.01.007. Epub 2013 Jan 17.


Immunoexpression of aromatase and estrogen receptors β in stem spermatogonia of bullfrogs indicates a role of estrogen in the seasonal spermatogonial mitotic activity.

Caneguim BH, da Luz JS, Valentini SR, Cerri PS, Sasso-Cerri E.

Gen Comp Endocrinol. 2013 Feb 1;182:65-72. doi: 10.1016/j.ygcen.2012.12.002. Epub 2012 Dec 13.


Expression of interferon-γ, interferon-α and related genes in individuals with Down syndrome and periodontitis.

Tanaka MH, Giro EM, Cavalcante LB, Pires JR, Apponi LH, Valentini SR, Spolidório DM, Capela MV, Rossa C Jr, Scarel-Caminaga RM.

Cytokine. 2012 Dec;60(3):875-81. doi: 10.1016/j.cyto.2012.08.020. Epub 2012 Sep 18.


Primordial germ cells (spermatogonial stem cells) of bullfrogs express sex hormone-binding globulin and steroid receptors during seasonal spermatogenesis.

Caneguim BH, Beltrame FL, da Luz JS, Valentini SR, Cerri PS, Sasso-Cerri E.

Cells Tissues Organs. 2013;197(2):136-44. doi: 10.1159/000341517. Epub 2012 Sep 11.


eIF5A dimerizes not only in vitro but also in vivo and its molecular envelope is similar to the EF-P monomer.

Dias CA, Garcia W, Zanelli CF, Valentini SR.

Amino Acids. 2013 Feb;44(2):631-44. doi: 10.1007/s00726-012-1387-7. Epub 2012 Sep 4.


Expression of the interleukin-10 signaling pathway genes in individuals with Down syndrome and periodontitis.

Cavalcante LB, Tanaka MH, Pires JR, Apponi LH, Aparecida Giro EM, Valentini SR, Palomari Spolidório DM, Capela MV, Rossa C Jr, Scarel-Caminaga RM.

J Periodontol. 2012 Jul;83(7):926-35. doi: 10.1902/jop.2011.110056. Epub 2011 Nov 3.


Effect of a calcium hydroxide/chlorhexidine paste as intracanal dressing in human primary teeth with necrotic pulp against Porphyromonas gingivalis and Enterococcus faecalis.

Gondim JO, Avaca-Crusca JS, Valentini SR, Zanelli CF, Spolidorio DM, Giro EM.

Int J Paediatr Dent. 2012 Mar;22(2):116-24. doi: 10.1111/j.1365-263X.2011.01174.x. Epub 2011 Aug 24.


eIF5A interacts functionally with eEF2.

Dias CA, Gregio AP, Rossi D, Galvão FC, Watanabe TF, Park MH, Valentini SR, Zanelli CF.

Amino Acids. 2012 Feb;42(2-3):697-702. doi: 10.1007/s00726-011-0985-0. Epub 2011 Aug 6.


Effect of ingestion of soy yogurt on intestinal parameters of rats fed on a beef-based animal diet.

Bedani R, Pauly-Silveira ND, Cano VS, Valentini SR, de Rossi GF, Valdez EA.

Braz J Microbiol. 2011 Jul;42(3):1238-47. doi: 10.1590/S1517-838220110003000050. Epub 2011 Sep 1.


New insights into trypanosomatid U5 small nuclear ribonucleoproteins.

Silva MT, Ambrósio DL, Trevelin CC, Watanabe TF, Laure HJ, Greene LJ, Rosa JC, Valentini SR, Cicarelli RM.

Mem Inst Oswaldo Cruz. 2011 Mar;106(2):130-8.


Studies on the effects of phosphine on Salmonella enterica serotype Enteritidis in culture medium and in black pepper (Piper nigrum).

Castro MF, Rezende AC, Benato EA, Valentini SR, Furlani RP, Tfouni SA.

J Food Prot. 2011 Apr;74(4):665-71. doi: 10.4315/0362-028X.JFP-10-205.


The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus.

Bronzoni RV, Madrid MC, Duarte DV, Pellegrini VO, Pacca CC, Carmo AC, Zanelli CF, Valentini SR, Santacruz-Pérez C, Barbosa JA, Lutz CS, Rahal P, Nogueira ML.

Arch Virol. 2011 Jun;156(6):931-8. doi: 10.1007/s00705-011-0927-x. Epub 2011 Feb 6.


Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.

Park JH, Dias CA, Lee SB, Valentini SR, Sokabe M, Fraser CS, Park MH.

Protein Eng Des Sel. 2011 Mar;24(3):301-9. doi: 10.1093/protein/gzq110. Epub 2010 Dec 2.


Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis.

Apponi LH, Leung SW, Williams KR, Valentini SR, Corbett AH, Pavlath GK.

Hum Mol Genet. 2010 Mar 15;19(6):1058-65. doi: 10.1093/hmg/ddp569. Epub 2009 Dec 24.


Epigenetic silencing of CRABP2 and MX1 in head and neck tumors.

Calmon MF, Rodrigues RV, Kaneto CM, Moura RP, Silva SD, Mota LD, Pinheiro DG, Torres C, de Carvalho AF, Cury PM, Nunes FD, Nishimoto IN, Soares FA, da Silva AM, Kowalski LP, Brentani H, Zanelli CF, Silva WA Jr, Rahal P, Tajara EH, Carraro DM, Camargo AA, Valentini SR.

Neoplasia. 2009 Dec;11(12):1329-39.


Functional significance of eIF5A and its hypusine modification in eukaryotes.

Park MH, Nishimura K, Zanelli CF, Valentini SR.

Amino Acids. 2010 Feb;38(2):491-500. doi: 10.1007/s00726-009-0408-7. Epub 2009 Dec 8. Review.


Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site.

Cano VS, Medrano FJ, Park MH, Valentini SR.

Amino Acids. 2010 Feb;38(2):479-90. doi: 10.1007/s00726-009-0407-8. Epub 2009 Dec 3.


eIF5A has a function in the elongation step of translation in yeast.

Gregio AP, Cano VP, Avaca JS, Valentini SR, Zanelli CF.

Biochem Biophys Res Commun. 2009 Mar 20;380(4):785-90. doi: 10.1016/j.bbrc.2009.01.148. Epub 2009 Jan 29.


Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein.

Leung SW, Apponi LH, Cornejo OE, Kitchen CM, Valentini SR, Pavlath GK, Dunham CM, Corbett AH.

Gene. 2009 Jun 15;439(1-2):71-8. doi: 10.1016/j.gene.2009.02.022. Epub 2009 Mar 18.


Expression and purification of human respiratory syncytial virus recombinant fusion protein.

Arcuri HA, Apponi LH, Valentini SR, Durigon EL, de Azevedo WF Jr, Fossey MA, Rahal P, de Souza FP.

Protein Expr Purif. 2008 Dec;62(2):146-52. doi: 10.1016/j.pep.2008.08.005. Epub 2008 Aug 26.


Synthetic lethality between eIF5A and Ypt1 reveals a connection between translation and the secretory pathway in yeast.

Frigieri MC, João Luiz MV, Apponi LH, Zanelli CF, Valentini SR.

Mol Genet Genomics. 2008 Sep;280(3):211-21. doi: 10.1007/s00438-008-0357-y. Epub 2008 Jun 21.


Structural modeling and mutational analysis of yeast eukaryotic translation initiation factor 5A reveal new critical residues and reinforce its involvement in protein synthesis.

Dias CA, Cano VS, Rangel SM, Apponi LH, Frigieri MC, Muniz JR, Garcia W, Park MH, Garratt RC, Zanelli CF, Valentini SR.

FEBS J. 2008 Apr;275(8):1874-88. doi: 10.1111/j.1742-4658.2008.06345.x. Epub 2008 Mar 13.


Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification.

Cano VS, Jeon GA, Johansson HE, Henderson CA, Park JH, Valentini SR, Hershey JW, Park MH.

FEBS J. 2008 Jan;275(1):44-58. Epub 2007 Dec 6.


A novel PCR-RFLP assay for the detection of the single nucleotide polymorphism at position +1440 in the human CXCR2 gene.

Viana AC, Kim YJ, Cirelli JA, Orrico SR, Curtis KC, Cano VS, Valentini SR, Scarel-Caminaga RM.

Biochem Genet. 2007 Oct;45(9-10):737-41. Epub 2007 Oct 16.


Opposite effects of bFGF and TGF-beta on collagen metabolism by human periodontal ligament fibroblasts.

Silverio-Ruiz KG, Martinez AE, Garlet GP, Barbosa CF, Silva JS, Cicarelli RM, Valentini SR, Abi-Rached RS, Junior CR.

Cytokine. 2007 Aug;39(2):130-7. Epub 2007 Aug 28.


An interaction between two RNA binding proteins, Nab2 and Pub1, links mRNA processing/export and mRNA stability.

Apponi LH, Kelly SM, Harreman MT, Lehner AN, Corbett AH, Valentini SR.

Mol Cell Biol. 2007 Sep;27(18):6569-79. Epub 2007 Jul 16.


Is there a role for eIF5A in translation?

Zanelli CF, Valentini SR.

Amino Acids. 2007 Aug;33(2):351-8. Epub 2007 Jun 20. Review.


Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae.

Frigieri MC, Thompson GM, Pandolfi JR, Zanelli CF, Valentini SR.

Genet Mol Res. 2007 Mar 28;6(1):152-65.


Actively transcribed GAL genes can be physically linked to the nuclear pore by the SAGA chromatin modifying complex.

Luthra R, Kerr SC, Harreman MT, Apponi LH, Fasken MB, Ramineni S, Chaurasia S, Valentini SR, Corbett AH.

J Biol Chem. 2007 Feb 2;282(5):3042-9. Epub 2006 Dec 6.


eIF5A binds to translational machinery components and affects translation in yeast.

Zanelli CF, Maragno AL, Gregio AP, Komili S, Pandolfi JR, Mestriner CA, Lustri WR, Valentini SR.

Biochem Biophys Res Commun. 2006 Oct 6;348(4):1358-66. Epub 2006 Aug 7.


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