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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

Meroni M, Dongiovanni P, Longo M, Carli F, Baselli G, Rametta R, Pelusi S, Badiali S, Maggioni M, Gaggini M, Fracanzani AL, Romeo S, Gatti S, Davidson NO, Gastaldelli A, Valenti L.

EBioMedicine. 2020 Feb;52:102658. doi: 10.1016/j.ebiom.2020.102658. Epub 2020 Feb 12.


Virtual genetic diagnosis for familial hypercholesterolemia powered by machine learning.

Pina A, Helgadottir S, Mancina RM, Pavanello C, Pirazzi C, Montalcini T, Henriques R, Calabresi L, Wiklund O, Macedo MP, Valenti L, Volpe G, Romeo S.

Eur J Prev Cardiol. 2020 Feb 4:2047487319898951. doi: 10.1177/2047487319898951. [Epub ahead of print]


Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker.

Baselli GA, Dongiovanni P, Rametta R, Meroni M, Pelusi S, Maggioni M, Badiali S, Pingitore P, Maurotti S, Montalcini T, Taliento AE, Prati D, Rossi G, Fracanzani AL, Mancina RM, Romeo S, Valenti L.

Gut. 2020 Jan 30. pii: gutjnl-2019-319226. doi: 10.1136/gutjnl-2019-319226. [Epub ahead of print]


Comparison of three therapeutic regimens for genotype-3 hepatitis C virus infection in a large real-life multicentre cohort.

Soria A, Fava M, Bernasconi DP, Lapadula G, Colella E, Valsecchi MG, Migliorino GM, D'Ambrosio R, Landonio S, Schiavini M, Spinetti A, Carriero C, Degasperi E, Cologni G, Gatti F, Viganò P, Hasson H, Uberti-Foppa C, Pasulo L, Baiguera C, Rossotti R, Vinci M, Puoti M, Giorgini A, Menzaghi B, Lombardi A, Pan A, Aghemo A, Grossi PA, Boldizzoni R, Colombo S, Viganò M, Rumi MG, Del Poggio P, Valenti L, Giglio O, De Bona A, d'Arminio Monforte A, Colombo A, Spinelli O, Pigozzi MG, Molteni C, Bonfanti P, Terreni N, Perini P, Capretti A, Bella D, Liani C, Polo S, Aimo G, Pagnucco L, Bhoori S, Centenaro R, Graffeo M, Ciaccio A, Dionigi E, Lazzaroni S, Carderi I, Di Marco M, Rizzardini G, Noventa F, Lampertico P, Fagiuoli S.

Liver Int. 2020 Jan 22. doi: 10.1111/liv.14386. [Epub ahead of print]



Cespiati A, Youngson NA, Tourna A, Valenti L.

Curr Pharm Des. 2020 Jan 22. doi: 10.2174/1381612826666200122151251. [Epub ahead of print]


Uncovering the genetics of cirrhosis: New plots for the usual suspects.

Valenti L.

Liver Int. 2020 Feb;40(2):281-282. doi: 10.1111/liv.14333. No abstract available.


Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease.

Romeo S, Sanyal A, Valenti L.

Cell Metab. 2020 Jan 7;31(1):35-45. doi: 10.1016/j.cmet.2019.12.002. Review.


AISF update on the diagnosis and management of adult-onset lysosomal storage diseases with hepatic involvement.

Nascimbeni F, Dionisi Vici C, Vespasiani Gentilucci U, Angelico F, Nobili V, Petta S, Valenti L; AISF Rare Diseases Committee.

Dig Liver Dis. 2020 Jan 2. pii: S1590-8658(19)30952-1. doi: 10.1016/j.dld.2019.12.005. [Epub ahead of print] Review.


Uncovering occult hepatitis B in blood donations: a tale of two worlds.

Prati D, Valenti L.

Blood Transfus. 2019 Nov;17(6):399-400. doi: 10.2450/2019.0302-19. Epub 2019 Dec 11. No abstract available.


Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis.

Cai B, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I.

Cell Metab. 2020 Feb 4;31(2):406-421.e7. doi: 10.1016/j.cmet.2019.11.013. Epub 2019 Dec 12.


Impact of natural neuromedin-B receptor variants on iron metabolism.

Rametta R, Dongiovanni P, Baselli GA, Pelusi S, Meroni M, Fracanzani AL, Busti F, Castagna A, Scarlini S, Corradini E, Pietrangelo A, Girelli D, Fargion S, Valenti L.

Am J Hematol. 2020 Feb;95(2):167-177. doi: 10.1002/ajh.25679. Epub 2019 Dec 16.


Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study.

Colussi G, Donnini D, Brizzi RF, Maier S, Valenti L, Catena C, Cavarape A, Sechi LA, Soardo G.

World J Gastroenterol. 2019 Oct 28;25(40):6094-6106. doi: 10.3748/wjg.v25.i40.6094.


mir-101-3p Downregulation Promotes Fibrogenesis by Facilitating Hepatic Stellate Cell Transdifferentiation During Insulin Resistance.

Meroni M, Longo M, Erconi V, Valenti L, Gatti S, Fracanzani AL, Dongiovanni P.

Nutrients. 2019 Oct 29;11(11). pii: E2597. doi: 10.3390/nu11112597.


β-Klotho gene variation is associated with liver damage in children with NAFLD.

Dongiovanni P, Crudele A, Panera N, Romito I, Meroni M, De Stefanis C, Palma A, Comparcola D, Fracanzani AL, Miele L, Valenti L, Nobili V, Alisi A.

J Hepatol. 2020 Mar;72(3):411-419. doi: 10.1016/j.jhep.2019.10.011. Epub 2019 Oct 23.


Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers.

Stickel F, Lutz P, Buch S, Nischalke HD, Silva I, Rausch V, Fischer J, Weiss KH, Gotthardt D, Rosendahl J, Marot A, Elamly M, Krawczyk M, Casper M, Lammert F, Buckley TW, McQuillin A, Spengler U, Eyer F, Vogel A, Marhenke S, von Felden J, Wege H, Sharma R, Atkinson S, Franke A, Nehring S, Moser V, Schafmayer C, Spahr L, Lackner C, Stauber RE, Canbay A, Link A, Valenti L, Grove JI, Aithal GP, Marquardt JU, Fateen W, Zopf S, Dufour JF, Trebicka J, Datz C, Deltenre P, Mueller S, Berg T, Hampe J, Morgan MY.

Hepatology. 2019 Oct 19. doi: 10.1002/hep.30996. [Epub ahead of print]


Dietary supplements, drugs and doping in the sport society.

Savino G, Valenti L, D'Alisera R, Pinelli M, Persi Y, Trenti T; WDPP, Working Group Doping Prevention Project.

Ann Ig. 2019 Nov-Dec;31(6):548-555. doi: 10.7416/ai.2019.2315.


Liver International: Anticipating the future of hepatology worldwide.

Valenti L, Aghemo A, Forner A.

Liver Int. 2019 Oct;39(10):1796-1797. doi: 10.1111/liv.14240. No abstract available.


A Patient with Graves' Disease Scheduled for Thyroidectomy with High Risk for Thyroid Storm Caused by Severe Medication Nonadherence: Anaesthetic and Surgical Considerations.

Reber A, Valenti L, Müller S.

Case Rep Anesthesiol. 2019 Jul 22;2019:4781902. doi: 10.1155/2019/4781902. eCollection 2019.


A simple surface biofunctionalization strategy to inhibit the biofilm formation by Staphylococcus aureus on solid substrates.

Martín ML, Dassie SA, Valenti LE, Giacomelli CE.

Colloids Surf B Biointerfaces. 2019 Nov 1;183:110432. doi: 10.1016/j.colsurfb.2019.110432. Epub 2019 Aug 7.


The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids.

Prill S, Caddeo A, Baselli G, Jamialahmadi O, Dongiovanni P, Rametta R, Kanebratt KP, Pujia A, Pingitore P, Mancina RM, Lindén D, Whatling C, Janefeldt A, Kozyra M, Ingelman-Sundberg M, Valenti L, Andersson TB, Romeo S.

Sci Rep. 2019 Aug 12;9(1):11585. doi: 10.1038/s41598-019-47737-w.


Preliminary Evidences of Safety and Efficacy of Flavonoids- and Omega 3-Based Compound for Muscular Dystrophies Treatment: A Randomized Double-Blind Placebo Controlled Pilot Clinical Trial.

Sitzia C, Meregalli M, Belicchi M, Farini A, Arosio M, Bestetti D, Villa C, Valenti L, Brambilla P, Torrente Y.

Front Neurol. 2019 Jul 23;10:755. doi: 10.3389/fneur.2019.00755. eCollection 2019.


Novel Insights into the Genetic Landscape of Nonalcoholic Fatty Liver Disease.

Taliento AE, Dallio M, Federico A, Prati D, Valenti L.

Int J Environ Res Public Health. 2019 Aug 1;16(15). pii: E2755. doi: 10.3390/ijerph16152755. Review.


Whole exome sequencing for personalized hepatology: Expanding applications in adults and challenges.

Valenti L, Pelusi S, Baselli G.

J Hepatol. 2019 Oct;71(4):849-850. doi: 10.1016/j.jhep.2019.06.008. Epub 2019 Jul 27. No abstract available.


NAFLD in children: new genes, new diagnostic modalities and new drugs.

Nobili V, Alisi A, Valenti L, Miele L, Feldstein AE, Alkhouri N.

Nat Rev Gastroenterol Hepatol. 2019 Sep;16(9):517-530. doi: 10.1038/s41575-019-0169-z. Epub 2019 Jul 5. Review.


Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents.

Zusi C, Mantovani A, Olivieri F, Morandi A, Corradi M, Miraglia Del Giudice E, Dauriz M, Valenti L, Byrne CD, Targher G, Maffeis C.

Dig Liver Dis. 2019 Nov;51(11):1586-1592. doi: 10.1016/j.dld.2019.05.029. Epub 2019 Jun 27.


Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity.

Di Mauro S, Scamporrino A, Petta S, Urbano F, Filippello A, Ragusa M, Di Martino MT, Scionti F, Grimaudo S, Pipitone RM, Privitera G, Di Pino A, Scicali R, Valenti L, Dongiovanni P, Fracanzani A, Rabuazzo AM, Craxì A, Purrello M, Purrello F, Piro S.

Liver Int. 2019 Sep;39(9):1742-1754. doi: 10.1111/liv.14167. Epub 2019 Jun 26.


Building mass to prevent non-alcoholic fatty liver disease?

Pelusi S, Valenti L.

Hepatobiliary Surg Nutr. 2019 Apr;8(2):173-176. doi: 10.21037/hbsn.2018.12.07. No abstract available.


Association between Helicobacter pylori infection and risk of nonalcoholic fatty liver disease: An updated meta-analysis.

Mantovani A, Turino T, Altomari A, Lonardo A, Zoppini G, Valenti L, Tilg H, Byrne CD, Targher G.

Metabolism. 2019 Jul;96:56-65. doi: 10.1016/j.metabol.2019.04.012. Epub 2019 Apr 29.


Accuracy of imaging methods for steatohepatitis diagnosis in non-alcoholic fatty liver disease patients: A systematic review.

Besutti G, Valenti L, Ligabue G, Bassi MC, Pattacini P, Guaraldi G, Giorgi Rossi P.

Liver Int. 2019 Aug;39(8):1521-1534. doi: 10.1111/liv.14118. Epub 2019 May 8.


PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.

Dongiovanni P, Meroni M, Baselli G, Mancina RM, Ruscica M, Longo M, Rametta R, Cespiati A, Pelusi S, Ferri N, Ranzani V, Nobili V, Pihlajamaki J, Fracanzani AL, Badiali S, Petta S, Fargion S, Romeo S, Kozlitina J, Valenti L.

J Lipid Res. 2019 Jun;60(6):1144-1153. doi: 10.1194/jlr.P090449. Epub 2019 Mar 27.


Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.

Pelusi S, Baselli G, Pietrelli A, Dongiovanni P, Donati B, McCain MV, Meroni M, Fracanzani AL, Romagnoli R, Petta S, Grieco A, Miele L, Soardo G, Bugianesi E, Fargion S, Aghemo A, D'Ambrosio R, Xing C, Romeo S, De Francesco R, Reeves HL, Valenti LVC.

Sci Rep. 2019 Mar 6;9(1):3682. doi: 10.1038/s41598-019-39998-2.


Post-transplant metabolic syndrome in children: Know better to cure better.

Nobili V, Pietrobattista A, Valenti L, Spada M.

Pediatr Transplant. 2019 May;23(3):e13367. doi: 10.1111/petr.13367. Epub 2019 Feb 21. No abstract available.


Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.

Lindén D, Ahnmark A, Pingitore P, Ciociola E, Ahlstedt I, Andréasson AC, Sasidharan K, Madeyski-Bengtson K, Zurek M, Mancina RM, Lindblom A, Bjursell M, Böttcher G, Ståhlman M, Bohlooly-Y M, Haynes WG, Carlsson B, Graham M, Lee R, Murray S, Valenti L, Bhanot S, Åkerblad P, Romeo S.

Mol Metab. 2019 Apr;22:49-61. doi: 10.1016/j.molmet.2019.01.013. Epub 2019 Feb 5.


Association between PNPLA3rs738409 polymorphism decreased kidney function in postmenopausal type 2 diabetic women with or without non-alcoholic fatty liver disease.

Mantovani A, Zusi C, Sani E, Colecchia A, Lippi G, Zaza GL, Valenti L, Byrne CD, Maffeis C, Bonora E, Targher G.

Diabetes Metab. 2019 Oct;45(5):480-487. doi: 10.1016/j.diabet.2019.01.011. Epub 2019 Feb 11.


Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps.

Santos RD, Valenti L, Romeo S.

Atherosclerosis. 2019 Mar;282:110-120. doi: 10.1016/j.atherosclerosis.2019.01.029. Epub 2019 Jan 30. Review.


Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis.

Pelusi S, Cespiati A, Rametta R, Pennisi G, Mannisto V, Rosso C, Baselli G, Dongiovanni P, Fracanzani AL, Badiali S, Maggioni M, Craxi A, Fargion S, Prati D, Nobili V, Bugianesi E, Romeo S, Pihlajamaki J, Petta S, Valenti L.

Clin Gastroenterol Hepatol. 2019 Oct;17(11):2310-2319.e6. doi: 10.1016/j.cgh.2019.01.027. Epub 2019 Jan 29.


Genetics of Nonalcoholic Fatty Liver Disease: A 2018 Update.

Valenti LVC, Baselli GA.

Curr Pharm Des. 2018;24(38):4566-4573. doi: 10.2174/1381612825666190119113836. Review.


NGM282: a step forward in the nonalcoholic steatohepatitis treatment landscape?

Valenti L, Nobili V.

Hepatobiliary Surg Nutr. 2018 Dec;7(6):484-486. doi: 10.21037/hbsn.2018.10.03. No abstract available.


FibroScan Identifies Patients With Nonalcoholic Fatty Liver Disease and Cardiovascular Damage.

Lombardi R, Petta S, Pisano G, Dongiovanni P, Rinaldi L, Adinolfi LE, Acierno C, Valenti L, Boemi R, Spatola F, Craxì A, Fargion S, Fracanzani AL.

Clin Gastroenterol Hepatol. 2020 Feb;18(2):517-519. doi: 10.1016/j.cgh.2018.11.011. Epub 2018 Dec 8.


Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.

Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaat0344. doi: 10.1126/scitranslmed.aat0344.


A bioassay-based protocol for chemical neutralization of human faecal wastes treated by physico-chemical disinfection processes: A case study on benzalkonium chloride.

Sozzi E, Baloch M, Strasser J, Fisher MB, Leifels M, Camacho J, Mishal N, Elmes SF, Allen G, Gadai G, Valenti L, Sobsey MD.

Int J Hyg Environ Health. 2019 Mar;222(2):155-167. doi: 10.1016/j.ijheh.2018.07.002. Epub 2018 Nov 10.


Beyond fat accumulation, NAFLD genetics converges on lipid droplet biology.

Baselli G, Valenti L.

J Lipid Res. 2019 Jan;60(1):7-8. doi: 10.1194/jlr.C091116. Epub 2018 Nov 12. No abstract available.


Hepatic fat as clinical outcome and therapeutic target for nonalcoholic fatty liver disease.

Pelusi S, Valenti L.

Liver Int. 2019 Feb;39(2):250-256. doi: 10.1111/liv.13972. Epub 2018 Oct 17. Review.


FGF23 and Fetuin-A Interaction in the Liver and in the Circulation.

Mattinzoli D, Ikehata M, Tsugawa K, Alfieri CM, Dongiovanni P, Trombetta E, Valenti L, Puliti A, Lazzari L, Messa P.

Int J Biol Sci. 2018 Apr 25;14(6):586-598. doi: 10.7150/ijbs.23256. eCollection 2018.


Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease.

Dongiovanni P, Meroni M, Mancina RM, Baselli G, Rametta R, Pelusi S, Männistö V, Fracanzani AL, Badiali S, Miele L, Grimaudo S, Petta S, Bugianesi E, Soardo G, Fargion S, Pihlajamäki J, Romeo S, Valenti L.

Hepatol Commun. 2018 Apr 25;2(6):666-675. doi: 10.1002/hep4.1192. eCollection 2018 Jun.


Effect of Sexual Intercourse on Lower Extremity Muscle Force in Strength-Trained Men.

Valenti LM, Suchil C, Beltran G, Rogers RC, Massey EA, Astorino TA.

J Sex Med. 2018 Jun;15(6):888-893. doi: 10.1016/j.jsxm.2018.04.636. Epub 2018 May 9.


Albumin biofunctionalization to minimize the Staphylococcus aureus adhesion on solid substrates.

Martín ML, Pfaffen V, Valenti LE, Giacomelli CE.

Colloids Surf B Biointerfaces. 2018 Jul 1;167:156-164. doi: 10.1016/j.colsurfb.2018.04.006. Epub 2018 Apr 3.


Digital liver biopsy: Bio-imaging of fatty liver for translational and clinical research.

Mancini M, Summers P, Faita F, Brunetto MR, Callea F, De Nicola A, Di Lascio N, Farinati F, Gastaldelli A, Gridelli B, Mirabelli P, Neri E, Salvadori PA, Rebelos E, Tiribelli C, Valenti L, Salvatore M, Bonino F.

World J Hepatol. 2018 Feb 27;10(2):231-245. doi: 10.4254/wjh.v10.i2.231. Review.


Hepatitis C virus eradication by direct-acting antiviral agents improves carotid atherosclerosis in patients with severe liver fibrosis.

Petta S, Adinolfi LE, Fracanzani AL, Rini F, Caldarella R, Calvaruso V, Cammà C, Ciaccio M, Di Marco V, Grimaudo S, Licata A, Marrone A, Nevola R, Pipitone RM, Pinto A, Rinaldi L, Torres D, Tuttolomondo A, Valenti L, Fargion S, Craxì A.

J Hepatol. 2018 Jul;69(1):18-24. doi: 10.1016/j.jhep.2018.02.015. Epub 2018 Mar 2.


Nonalcoholic Fatty Liver Disease in Children.

Mann JP, Valenti L, Scorletti E, Byrne CD, Nobili V.

Semin Liver Dis. 2018 Feb;38(1):1-13. doi: 10.1055/s-0038-1627456. Epub 2018 Feb 22. Review.

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