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Items: 47

1.

Bacterial outer membrane vesicles engineered with lipidated antigens as a platform for Staphylococcus aureus vaccine.

Irene C, Fantappiè L, Caproni E, Zerbini F, Anesi A, Tomasi M, Zanella I, Stupia S, Prete S, Valensin S, König E, Frattini L, Gagliardi A, Isaac SJ, Grandi A, Guella G, Grandi G.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201905112. doi: 10.1073/pnas.1905112116. [Epub ahead of print]

2.

Vaccination With a FAT1-Derived B Cell Epitope Combined With Tumor-Specific B and T Cell Epitopes Elicits Additive Protection in Cancer Mouse Models.

Grandi A, Fantappiè L, Irene C, Valensin S, Tomasi M, Stupia S, Corbellari R, Caproni E, Zanella I, Isaac SJ, Ganfini L, Frattini L, König E, Gagliardi A, Tavarini S, Sammicheli C, Parri M, Grandi G.

Front Oncol. 2018 Oct 26;8:481. doi: 10.3389/fonc.2018.00481. eCollection 2018.

3.

Multimodal molecular imaging system for pathway-specific reporter gene expression.

Rossi M, Massai L, Diamanti D, Fiengo P, De Rosa A, Magrini R, Magnoni L, Chellini S, Coniglio S, Diodato E, Pilli E, Caradonna NP, Sardone G, Monti M, Roggeri R, Lionetti V, Recchia F, Tunici P, Valensin S, Scali C, Pollio G, Porcari V.

Eur J Pharm Sci. 2016 Apr 30;86:136-42. doi: 10.1016/j.ejps.2016.03.006. Epub 2016 Mar 14.

PMID:
26987608
4.

Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway.

Nencini A, Pratelli C, Quinn JM, Salerno M, Tunici P, De Robertis A, Valensin S, Mennillo F, Rossi M, Bakker A, Benicchi T, Cappelli F, Turlizzi E, Nibbio M, Caradonna NP, Zanelli U, Andreini M, Magnani M, Varrone M.

Eur J Med Chem. 2015 May 5;95:526-45. doi: 10.1016/j.ejmech.2015.03.055. Epub 2015 Mar 25.

PMID:
25847770
5.

Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization.

De Robertis A, Mennillo F, Rossi M, Valensin S, Tunici P, Mori E, Caradonna N, Varrone M, Salerno M.

PLoS One. 2014 May 19;9(5):e97847. doi: 10.1371/journal.pone.0097847. eCollection 2014.

6.

CXCR4 Antagonists: A Screening Strategy for Identification of Functionally Selective Ligands.

Castaldo C, Benicchi T, Otrocka M, Mori E, Pilli E, Ferruzzi P, Valensin S, Diamanti D, Fecke W, Varrone M, Porcari V.

J Biomol Screen. 2014 Jul;19(6):859-69. doi: 10.1177/1087057114526283. Epub 2014 Mar 14.

PMID:
24632660
7.

Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.

De Robertis A, Valensin S, Rossi M, Tunici P, Verani M, De Rosa A, Giordano C, Varrone M, Nencini A, Pratelli C, Benicchi T, Bakker A, Hill J, Sangthongpitag K, Pendharkar V, Liu B, Ng FM, Then SW, Jing Tai S, Cheong SM, He X, Caricasole A, Salerno M.

Mol Cancer Ther. 2013 Jul;12(7):1180-9. doi: 10.1158/1535-7163.MCT-12-1176-T. Epub 2013 Apr 25.

8.

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.

Beekman M, Blanché H, Perola M, Hervonen A, Bezrukov V, Sikora E, Flachsbart F, Christiansen L, De Craen AJ, Kirkwood TB, Rea IM, Poulain M, Robine JM, Valensin S, Stazi MA, Passarino G, Deiana L, Gonos ES, Paternoster L, Sørensen TI, Tan Q, Helmer Q, van den Akker EB, Deelen J, Martella F, Cordell HJ, Ayers KL, Vaupel JW, Törnwall O, Johnson TE, Schreiber S, Lathrop M, Skytthe A, Westendorp RG, Christensen K, Gampe J, Nebel A, Houwing-Duistermaat JJ, Slagboom PE, Franceschi C; GEHA consortium.

Aging Cell. 2013 Apr;12(2):184-93. doi: 10.1111/acel.12039. Epub 2013 Feb 6.

9.

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project.

Skytthe A, Valensin S, Jeune B, Cevenini E, Balard F, Beekman M, Bezrukov V, Blanche H, Bolund L, Broczek K, Carru C, Christensen K, Christiansen L, Collerton JC, Cotichini R, de Craen AJ, Dato S, Davies K, De Benedictis G, Deiana L, Flachsbart F, Gampe J, Gilbault C, Gonos ES, Haimes E, Hervonen A, Hurme MA, Janiszewska D, Jylhä M, Kirkwood TB, Kristensen P, Laiho P, Leon A, Marchisio A, Masciulli R, Nebel A, Passarino G, Pelicci G, Peltonen L, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Scurti M, Sevini F, Sikora E, Skouteri A, Slagboom PE, Spazzafumo L, Stazi MA, Toccaceli V, Toussaint O, Törnwall O, Vaupel JW, Voutetakis K, Franceschi C; GEHA consortium.

Exp Gerontol. 2011 Nov;46(11):934-45. doi: 10.1016/j.exger.2011.08.005. Epub 2011 Aug 16.

10.

Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells.

Gaviraghi M, Tunici P, Valensin S, Rossi M, Giordano C, Magnoni L, Dandrea M, Montagna L, Ritelli R, Scarpa A, Bakker A.

Biosci Rep. 2011 Feb;31(1):45-55. doi: 10.1042/BSR20100018.

11.

Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies.

Cevenini E, Bellavista E, Tieri P, Castellani G, Lescai F, Francesconi M, Mishto M, Santoro A, Valensin S, Salvioli S, Capri M, Zaikin A, Monti D, de Magalhães JP, Franceschi C.

Curr Pharm Des. 2010;16(7):802-13. Review.

PMID:
20388091
12.

KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?

Valensin S, Ghiron C, Lamanna C, Kremer A, Rossi M, Ferruzzi P, Nievo M, Bakker A.

BMC Cancer. 2009 Jun 22;9:196. doi: 10.1186/1471-2407-9-196.

13.

Genes, ageing and longevity in humans: problems, advantages and perspectives.

Salvioli S, Olivieri F, Marchegiani F, Cardelli M, Santoro A, Bellavista E, Mishto M, Invidia L, Capri M, Valensin S, Sevini F, Cevenini E, Celani L, Lescai F, Gonos E, Caruso C, Paolisso G, De Benedictis G, Monti D, Franceschi C.

Free Radic Res. 2006 Dec;40(12):1303-23. Review.

PMID:
17090420
14.

Complexity of anti-immunosenescence strategies in humans.

Capri M, Monti D, Salvioli S, Lescai F, Pierini M, Altilia S, Sevini F, Valensin S, Ostan R, Bucci L, Franceschi C.

Artif Organs. 2006 Oct;30(10):730-42. Review.

PMID:
17026572
15.

Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.

Semeraro T, Lossani A, Botta M, Ghiron C, Alvarez R, Manetti F, Mugnaini C, Valensin S, Focher F, Corelli F.

J Med Chem. 2006 Oct 5;49(20):6037-45.

PMID:
17004717
16.

Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology.

Salvioli S, Capri M, Valensin S, Tieri P, Monti D, Ottaviani E, Franceschi C.

Curr Pharm Des. 2006;12(24):3161-71. Review.

PMID:
16918441
17.

Mitochondrial DNA involvement in human longevity.

Santoro A, Salvioli S, Raule N, Capri M, Sevini F, Valensin S, Monti D, Bellizzi D, Passarino G, Rose G, De Benedictis G, Franceschi C.

Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1388-99. Epub 2006 Jun 7. Review.

18.

The genetics of human longevity.

Capri M, Salvioli S, Sevini F, Valensin S, Celani L, Monti D, Pawelec G, De Benedictis G, Gonos ES, Franceschi C.

Ann N Y Acad Sci. 2006 May;1067:252-63. Review.

PMID:
16803995
19.

Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects.

Paccani SR, Boncristiano M, Patrussi L, Ulivieri C, Wack A, Valensin S, Hirst TR, Amedei A, Del Prete G, Telford JL, D'Elios MM, Baldari CT.

Blood. 2005 Jul 15;106(2):626-34. Epub 2005 Apr 7.

PMID:
15817684
20.

Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.

Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Capri M, Salvioli S, Valensin S, De Benedictis G, Di Iorio A, Caruso C, Paolisso G, Monti D.

Mech Ageing Dev. 2005 Feb;126(2):351-61. Review.

PMID:
15621218
21.

Quantifying the relevance of different mediators in the human immune cell network.

Tieri P, Valensin S, Latora V, Castellani GC, Marchiori M, Remondini D, Franceschi C.

Bioinformatics. 2005 Apr 15;21(8):1639-43. Epub 2004 Dec 21.

PMID:
15613387
22.

Normal B-1 cell development but defective BCR signaling in Lck-/- mice.

Ulivieri C, Valensin S, Majolini MB, Matthews RJ, Baldari CT.

Eur J Immunol. 2003 Feb;33(2):441-5.

23.

What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians.

Bonafè M, Barbi C, Storci G, Salvioli S, Capri M, Olivieri F, Valensin S, Monti D, Gonos ES, De Benedictis G, Franceschi C.

Exp Gerontol. 2002 Oct-Nov;37(10-11):1263-71. Review.

PMID:
12470840
24.

Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering.

Bini L, Pacini S, Liberatori S, Valensin S, Pellegrini M, Raggiaschi R, Pallini V, Baldari CT.

Biochem J. 2003 Jan 15;369(Pt 2):301-9.

25.

F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts.

Valensin S, Paccani SR, Ulivieri C, Mercati D, Pacini S, Patrussi L, Hirst T, Lupetti P, Baldari CT.

Eur J Immunol. 2002 Feb;32(2):435-46.

26.

A stochastic model for CD8(+)T cell dynamics in human immunosenescence: implications for survival and longevity.

Luciani F, Valensin S, Vescovini R, Sansoni P, Fagnoni F, Franceschi C, Bonafè M, Turchetti G.

J Theor Biol. 2001 Dec 21;213(4):587-97.

PMID:
11742527
27.

Measuring the genetic influence in modulating the human life span: gene-environment interaction and the sex-specific genetic effect.

Tan Q, De Benedictis G, Yashi AI, Bonafe M, DeLuca M, Valensin S, Vaupel JW, Franceschi C.

Biogerontology. 2001;2(3):141-53.

PMID:
11708716
28.

A mathematical model for the immunosenescence.

Luciani F, Turchetti G, Franceschi C, Valensin S.

Riv Biol. 2001 May-Aug;94(2):305-18.

PMID:
11702654
29.

The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old.

Bonafè M, Valensin S, Gianni W, Marigliano V, Franceschi C.

Crit Rev Oncol Hematol. 2001 Sep;39(3):227-33. Review.

PMID:
11500264
30.

Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype.

Franceschi C, Valensin S, Lescai F, Olivieri F, Licastro F, Grimaldi LM, Monti D, De Benedictis G, Bonafè M.

Aging (Milano). 2001 Jun;13(3):163-70. Review.

PMID:
11442299
31.

Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data.

Caruso C, Candore G, Romano GC, Lio D, Bonafè M, Valensin S, Franceschi C.

Mech Ageing Dev. 2001 Apr 30;122(5):445-62. Review.

PMID:
11292511
32.

Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians.

Monti D, Salvioli S, Capri M, Malorni W, Straface E, Cossarizza A, Botti B, Piacentini M, Baggio G, Barbi C, Valensin S, Bonafè M, Franceschi C.

Mech Ageing Dev. 2000 Dec 20;121(1-3):239-50.

PMID:
11164477
33.

The network and the remodeling theories of aging: historical background and new perspectives.

Franceschi C, Valensin S, Bonafè M, Paolisso G, Yashin AI, Monti D, De Benedictis G.

Exp Gerontol. 2000 Sep;35(6-7):879-96. Review.

PMID:
11053678
34.

HLA, aging, and longevity: a critical reappraisal.

Caruso C, Candore G, Colonna Romano G, Lio D, Bonafè M, Valensin S, Franceschi C.

Hum Immunol. 2000 Sep;61(9):942-9. Review.

PMID:
11053639
35.

Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects.

Boncristiano M, Majolini MB, D'Elios MM, Pacini S, Valensin S, Ulivieri C, Amedei A, Falini B, Del Prete G, Telford JL, Baldari CT.

Eur J Immunol. 2000 Sep;30(9):2632-8.

36.

Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR.

Pacini S, Valensin S, Telford JL, Ladbury J, Baldari CT.

Eur J Immunol. 2000 Sep;30(9):2620-31.

37.

A theoretical model for "in machina" experiments on immunosenescence.

Valensin S, di Caro G.

Ann N Y Acad Sci. 2000 Jun;908:344-7. No abstract available.

PMID:
10911982
38.

Inflamm-aging. An evolutionary perspective on immunosenescence.

Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G.

Ann N Y Acad Sci. 2000 Jun;908:244-54. Review.

PMID:
10911963
39.

Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE).

Franceschi C, Motta L, Valensin S, Rapisarda R, Franzone A, Berardelli M, Motta M, Monti D, Bonafè M, Ferrucci L, Deiana L, Pes GM, Carru C, Desole MS, Barbi C, Sartoni G, Gemelli C, Lescai F, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Gueresi P, Cossarizza A, Troiano L, Pini G, Sansoni P, Passeri G, Lisa R, Spazzafumo L, Amadio L, Giunta S, Stecconi R, Morresi R, Viticchi C, Mattace R, De Benedictis G, Baggio G.

Aging (Milano). 2000 Apr;12(2):77-84. Review.

PMID:
10902049
40.

Genes and longevity: lessons from studies of centenarians.

Yashin AI, De Benedictis G, Vaupel JW, Tan Q, Andreev KF, Iachine IA, Bonafe M, Valensin S, De Luca M, Carotenuto L, Franceschi C.

J Gerontol A Biol Sci Med Sci. 2000 Jul;55(7):B319-28.

PMID:
10898245
41.
42.

Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load.

Franceschi C, Valensin S, Fagnoni F, Barbi C, Bonafè M.

Exp Gerontol. 1999 Dec;34(8):911-21. Review.

PMID:
10673145
43.

P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia.

Bonafè M, Olivieri F, Mari D, Baggio G, Mattace R, Berardelli M, Sansoni P, De Benedictis G, De Luca M, Marchegiani F, Cavallone L, Cardelli M, Giovagnetti S, Ferrucci L, Amadio L, Lisa R, Tucci MG, Troiano L, Pini G, Gueresi P, Morellini M, Sorbi S, Passeri G, Barbi C, Valensin S, Monti D, Deiana L, Pes GM, Carru C, Franceschi C.

Am J Hum Genet. 1999 Dec;65(6):1782-5. No abstract available.

44.

Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity.

Yashin AI, De Benedictis G, Vaupel JW, Tan Q, Andreev KF, Iachine IA, Bonafe M, DeLuca M, Valensin S, Carotenuto L, Franceschi C.

Am J Hum Genet. 1999 Oct;65(4):1178-93.

45.

Obligatory cross-talk with the tyrosine kinases assembled with the TCR/CD3 complex in CD4 signal transduction.

Ulivieri C, Pacini S, Bartalini S, Valensin S, Telford JL, Baldari CT.

Eur J Immunol. 1999 Aug;29(8):2625-35.

46.

Long telomeres and well preserved proliferative vigor in cells from centenarians: a contribution to longevity?

Franceschi C, Mondello C, Bonafè M, Valensin S, Sansoni P, Sorbi S.

Aging (Milano). 1999 Apr;11(2):69-72. No abstract available.

PMID:
10386165
47.

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