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Coupling of ATPase activity, microtubule binding, and mechanics in the dynein motor domain.

Niekamp S, Coudray N, Zhang N, Vale RD, Bhabha G.

EMBO J. 2019 Jul 1;38(13):e101414. doi: 10.15252/embj.2018101414. Epub 2019 May 31.


A composition-dependent molecular clutch between T cell signaling condensates and actin.

Ditlev JA, Vega AR, Köster DV, Su X, Tani T, Lakoduk AM, Vale RD, Mayor S, Jaqaman K, Rosen MK.

Elife. 2019 Jul 3;8. pii: e42695. doi: 10.7554/eLife.42695.


Coupling of ATPase activity, microtubule binding, and mechanics in the dynein motor domain.

Niekamp S, Coudray N, Zhang N, Vale RD, Bhabha G.

EMBO J. 2019 May 31. pii: e101414. doi: 10.15252/embj.2018101414. [Epub ahead of print]


Keep Your Eyes on the Prize.

Vale RD.

Cell. 2019 Apr 18;177(3):506-509. doi: 10.1016/j.cell.2019.03.039. Epub 2019 Apr 2. No abstract available.


CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic.

Wang Y, Huynh W, Skokan TD, Lu W, Weiss A, Vale RD.

J Cell Biol. 2019 May 6;218(5):1619-1633. doi: 10.1083/jcb.201806097. Epub 2019 Feb 27.


Nanometer-accuracy distance measurements between fluorophores at the single-molecule level.

Niekamp S, Sung J, Huynh W, Bhabha G, Vale RD, Stuurman N.

Proc Natl Acad Sci U S A. 2019 Feb 15. pii: 201815826. doi: 10.1073/pnas.1815826116. [Epub ahead of print]


Publish peer reviews.

Polka JK, Kiley R, Konforti B, Stern B, Vale RD.

Nature. 2018 Aug;560(7720):545-547. doi: 10.1038/d41586-018-06032-w. No abstract available.


Spatial control of Draper receptor signaling initiates apoptotic cell engulfment.

Williamson AP, Vale RD.

J Cell Biol. 2018 Nov 5;217(11):3977-3992. doi: 10.1083/jcb.201711175. Epub 2018 Aug 23.


Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles.

Greenan GA, Keszthelyi B, Vale RD, Agard DA.

Elife. 2018 Aug 6;7. pii: e36851. doi: 10.7554/eLife.36851.


Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC.

Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017.


Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia.

McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD.

Elife. 2018 Jun 13;7. pii: e36739. doi: 10.7554/eLife.36739.


Chimeric antigen receptors that trigger phagocytosis.

Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale RD.

Elife. 2018 Jun 4;7. pii: e36688. doi: 10.7554/eLife.36688.


Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes.

Reck-Peterson SL, Redwine WB, Vale RD, Carter AP.

Nat Rev Mol Cell Biol. 2018 Jul;19(7):479. doi: 10.1038/s41580-018-0021-2.


The cytoplasmic dynein transport machinery and its many cargoes.

Reck-Peterson SL, Redwine WB, Vale RD, Carter AP.

Nat Rev Mol Cell Biol. 2018 Jun;19(6):382-398. doi: 10.1038/s41580-018-0004-3. Review. Erratum in: Nat Rev Mol Cell Biol. 2018 May 8;:.


In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.

Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9338-E9345. doi: 10.1073/pnas.1710358114. Epub 2017 Oct 17.


Disease-associated mutations in human BICD2 hyperactivate motility of dynein-dynactin.

Huynh W, Vale RD.

J Cell Biol. 2017 Oct 2;216(10):3051-3060. doi: 10.1083/jcb.201703201. Epub 2017 Sep 7.


RNA phase transitions in repeat expansion disorders.

Jain A, Vale RD.

Nature. 2017 Jun 8;546(7657):243-247. doi: 10.1038/nature22386. Epub 2017 May 31.


Ten simple rules to consider regarding preprint submission.

Bourne PE, Polka JK, Vale RD, Kiley R.

PLoS Comput Biol. 2017 May 4;13(5):e1005473. doi: 10.1371/journal.pcbi.1005473. eCollection 2017 May. No abstract available.


Architectures of Lipid Transport Systems for the Bacterial Outer Membrane.

Ekiert DC, Bhabha G, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, Vale RD.

Cell. 2017 Apr 6;169(2):273-285.e17. doi: 10.1016/j.cell.2017.03.019.


A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.

Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD.

Cell. 2017 Mar 23;169(1):108-119.e20. doi: 10.1016/j.cell.2017.03.006.


T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD.

Science. 2017 Mar 31;355(6332):1428-1433. doi: 10.1126/science.aaf1292. Epub 2017 Mar 9.


Reconstitution of TCR Signaling Using Supported Lipid Bilayers.

Su X, Ditlev JA, Rosen MK, Vale RD.

Methods Mol Biol. 2017;1584:65-76. doi: 10.1007/978-1-4939-6881-7_5.


An acquisition and analysis pipeline for scanning angle interference microscopy.

Carbone CB, Vale RD, Stuurman N.

Nat Methods. 2016 Oct 31;13(11):897-898. doi: 10.1038/nmeth.4030. No abstract available.


Impact of New Camera Technologies on Discoveries in Cell Biology.

Stuurman N, Vale RD.

Biol Bull. 2016 Aug;231(1):5-13.


Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.

Schroeder CM, Vale RD.

J Cell Biol. 2016 Aug 1;214(3):309-18. doi: 10.1083/jcb.201604002.


Priority of discovery in the life sciences.

Vale RD, Hyman AA.

Elife. 2016 Jun 16;5. pii: e16931. doi: 10.7554/eLife.16931.


SCIENTIFIC COMMUNITY. Preprints for the life sciences.

Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale RD, VijayRaghavan K, Wolberger C.

Science. 2016 May 20;352(6288):899-901. doi: 10.1126/science.aaf9133. No abstract available.


Dynamics of Translation of Single mRNA Molecules In Vivo.

Yan X, Hoek TA, Vale RD, Tanenbaum ME.

Cell. 2016 May 5;165(4):976-89. doi: 10.1016/j.cell.2016.04.034.


Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.

Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN.

Neuron. 2016 May 4;90(3):551-63. doi: 10.1016/j.neuron.2016.03.027. Epub 2016 Apr 21.


Phase separation of signaling molecules promotes T cell receptor signal transduction.

Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD.

Science. 2016 Apr 29;352(6285):595-9. doi: 10.1126/science.aad9964. Epub 2016 Apr 7.


Tyrosination of α-tubulin controls the initiation of processive dynein-dynactin motility.

McKenney RJ, Huynh W, Vale RD, Sirajuddin M.

EMBO J. 2016 Jun 1;35(11):1175-85. doi: 10.15252/embj.201593071. Epub 2016 Mar 11.


How Dynein Moves Along Microtubules.

Bhabha G, Johnson GT, Schroeder CM, Vale RD.

Trends Biochem Sci. 2016 Jan;41(1):94-105. doi: 10.1016/j.tibs.2015.11.004. Epub 2015 Dec 9. Review.


Accelerating scientific publication in biology.

Vale RD.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13439-46. doi: 10.1073/pnas.1511912112. Epub 2015 Oct 27.


iBioChina and iBiology: spreading scientific knowledge together.

Dell KR, Vale RD.

Sci China Life Sci. 2015 Nov;58(11):1180-2. doi: 10.1007/s11427-015-4938-9. Epub 2015 Oct 1. No abstract available.


Total Internal Reflection Fluorescence Microscopy.

Yildiz A, Vale RD.

Cold Spring Harb Protoc. 2015 Sep 1;2015(9):pdb.top086348. doi: 10.1101/pdb.top086348.


Tracking Movements of the Microtubule Motors Kinesin and Dynein Using Total Internal Reflection Fluorescence Microscopy.

Yildiz A, Vale RD.

Cold Spring Harb Protoc. 2015 Sep 1;2015(9):pdb.prot086355. doi: 10.1101/pdb.prot086355.


Clustering of a kinesin-14 motor enables processive retrograde microtubule-based transport in plants.

Jonsson E, Yamada M, Vale RD, Goshima G.

Nat Plants. 2015 Jul;1(7). pii: 15087.


Microtubule nucleation at the centrosome and beyond.

Petry S, Vale RD.

Nat Cell Biol. 2015 Sep;17(9):1089-93. doi: 10.1038/ncb3220. Review. No abstract available.


Regulation of mRNA translation during mitosis.

Tanenbaum ME, Stern-Ginossar N, Weissman JS, Vale RD.

Elife. 2015 Aug 25;4. doi: 10.7554/eLife.07957.


De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy.

Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale RD, Barkovich AJ, Sherr EH.

Ann Clin Transl Neurol. 2015 Jun;2(6):623-35. doi: 10.1002/acn3.198. Epub 2015 May 1.


HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.

Ham H, Huynh W, Schoon RA, Vale RD, Billadeau DD.

J Immunol. 2015 Apr 15;194(8):3984-96. doi: 10.4049/jimmunol.1402897. Epub 2015 Mar 11.


Advanced methods of microscope control using μManager software.

Edelstein AD, Tsuchida MA, Amodaj N, Pinkard H, Vale RD, Stuurman N.

J Biol Methods. 2014;1(2). pii: e10.


Allosteric communication in the dynein motor domain.

Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale RD.

Cell. 2014 Nov 6;159(4):857-68. doi: 10.1016/j.cell.2014.10.018.


A protein-tagging system for signal amplification in gene expression and fluorescence imaging.

Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD.

Cell. 2014 Oct 23;159(3):635-46. doi: 10.1016/j.cell.2014.09.039. Epub 2014 Oct 9.


Induction of focal adhesions and motility in Drosophila S2 cells.

Ribeiro SA, D'Ambrosio MV, Vale RD.

Mol Biol Cell. 2014 Dec 1;25(24):3861-9. doi: 10.1091/mbc.E14-04-0863. Epub 2014 Oct 1.


A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.

Schroeder CM, Ostrem JM, Hertz NT, Vale RD.

Elife. 2014 Oct 1;3:e03351. doi: 10.7554/eLife.03351.


Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.

McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD.

Science. 2014 Jul 18;345(6194):337-41. doi: 10.1126/science.1254198. Epub 2014 Jun 19.


Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin.

Hendershott MC, Vale RD.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5860-5. doi: 10.1073/pnas.1404133111. Epub 2014 Mar 26.


Regulation of microtubule motors by tubulin isotypes and post-translational modifications.

Sirajuddin M, Rice LM, Vale RD.

Nat Cell Biol. 2014 Apr;16(4):335-44. doi: 10.1038/ncb2920. Epub 2014 Mar 16.


Preface: the role of reconstitution in cytoskeleton research.

Vale RD.

Methods Enzymol. 2014;540:xix-xxiii. doi: 10.1016/B978-0-12-397924-7.09985-4. No abstract available.


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