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Items: 1 to 50 of 80

1.

The crystal structures of CDD-1, the intrinsic class D β-lactamase from the pathogenic Gram-positive bacterium Clostridioides difficile, and its complex with cefotaxime.

Stewart NK, Smith CA, Toth M, Stasyuk A, Vakulenko SB.

J Struct Biol. 2019 Sep 21. pii: S1047-8477(19)30202-3. doi: 10.1016/j.jsb.2019.09.008. [Epub ahead of print]

PMID:
31550535
2.

Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 β-Lactamase.

Smith CA, Stewart NK, Toth M, Vakulenko SB.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e01202-19. doi: 10.1128/AAC.01202-19. Print 2019 Oct.

PMID:
31358584
3.

Intrinsic Class D β-Lactamases of Clostridium difficile.

Toth M, Stewart NK, Smith C, Vakulenko SB.

MBio. 2018 Dec 18;9(6). pii: e01803-18. doi: 10.1128/mBio.01803-18.

4.

Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D β-Lactamases.

Stewart NK, Smith CA, Antunes NT, Toth M, Vakulenko SB.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e02191-18. doi: 10.1128/AAC.02191-18. Print 2019 Feb.

5.

A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria To Commit Suicide with a Gram-Positive Antibiotic.

Liu R, Miller PA, Vakulenko SB, Stewart NK, Boggess WC, Miller MJ.

J Med Chem. 2018 May 10;61(9):3845-3854. doi: 10.1021/acs.jmedchem.8b00218. Epub 2018 Mar 23.

PMID:
29554424
6.

Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6')-Im.

Smith CA, Bhattacharya M, Toth M, Stewart NK, Vakulenko SB.

Microb Cell. 2017 Nov 9;4(12):402-410. doi: 10.15698/mic2017.12.602.

7.

The role of conserved surface hydrophobic residues in the carbapenemase activity of the class D β-lactamases.

Toth M, Smith CA, Antunes NT, Stewart NK, Maltz L, Vakulenko SB.

Acta Crystallogr D Struct Biol. 2017 Aug 1;73(Pt 8):692-701. doi: 10.1107/S2059798317008671. Epub 2017 Jul 28.

8.

Role of the Conserved Disulfide Bridge in Class A Carbapenemases.

Smith CA, Nossoni Z, Toth M, Stewart NK, Frase H, Vakulenko SB.

J Biol Chem. 2016 Oct 14;291(42):22196-22206. Epub 2016 Sep 2.

9.

Class D β-lactamases do exist in Gram-positive bacteria.

Toth M, Antunes NT, Stewart NK, Frase H, Bhattacharya M, Smith CA, Vakulenko SB.

Nat Chem Biol. 2016 Jan;12(1):9-14. doi: 10.1038/nchembio.1950. Epub 2015 Nov 9.

10.

Kinetic and structural requirements for carbapenemase activity in GES-type β-lactamases.

Stewart NK, Smith CA, Frase H, Black DJ, Vakulenko SB.

Biochemistry. 2015 Jan 20;54(2):588-97. doi: 10.1021/bi501052t. Epub 2014 Dec 22.

11.

Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis.

Smith CA, Toth M, Weiss TM, Frase H, Vakulenko SB.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2754-64. doi: 10.1107/S1399004714017635. Epub 2014 Sep 27.

12.

Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia.

Smith CA, Toth M, Bhattacharya M, Frase H, Vakulenko SB.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1561-71. doi: 10.1107/S1399004714005331. Epub 2014 May 23.

13.

Structure of the extended-spectrum class C β-lactamase ADC-1 from Acinetobacter baumannii.

Bhattacharya M, Toth M, Antunes NT, Smith CA, Vakulenko SB.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):760-71. doi: 10.1107/S1399004713033014. Epub 2014 Feb 22.

14.

Class D β-lactamases: are they all carbapenemases?

Antunes NT, Lamoureaux TL, Toth M, Stewart NK, Frase H, Vakulenko SB.

Antimicrob Agents Chemother. 2014;58(4):2119-25. doi: 10.1128/AAC.02522-13. Epub 2014 Jan 27.

15.

Crystal structure of carbapenemase OXA-58 from Acinetobacter baumannii.

Smith CA, Antunes NT, Toth M, Vakulenko SB.

Antimicrob Agents Chemother. 2014;58(4):2135-43. doi: 10.1128/AAC.01983-13. Epub 2014 Jan 27.

16.

Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii.

Smith CA, Antunes NT, Stewart NK, Toth M, Kumarasiri M, Chang M, Mobashery S, Vakulenko SB.

Chem Biol. 2013 Sep 19;20(9):1107-15. doi: 10.1016/j.chembiol.2013.07.015. Epub 2013 Sep 5.

17.

Bulky "gatekeeper" residue changes the cosubstrate specificity of aminoglycoside 2''-phosphotransferase IIa.

Bhattacharya M, Toth M, Smith CA, Vakulenko SB.

Antimicrob Agents Chemother. 2013 Aug;57(8):3763-6. doi: 10.1128/AAC.00381-13. Epub 2013 May 28.

18.

A novel extended-spectrum β-lactamase, SGM-1, from an environmental isolate of Sphingobium sp.

Lamoureaux TL, Vakulenko V, Toth M, Frase H, Vakulenko SB.

Antimicrob Agents Chemother. 2013 Aug;57(8):3783-8. doi: 10.1128/AAC.00808-13. Epub 2013 May 28.

19.

Structural basis for progression toward the carbapenemase activity in the GES family of β-lactamases.

Smith CA, Frase H, Toth M, Kumarasiri M, Wiafe K, Munoz J, Mobashery S, Vakulenko SB.

J Am Chem Soc. 2012 Dec 5;134(48):19512-5. doi: 10.1021/ja308197j. Epub 2012 Nov 16.

20.

Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen.

Toth M, Frase H, Antunes NT, Vakulenko SB.

Antimicrob Agents Chemother. 2013 Jan;57(1):452-7. doi: 10.1128/AAC.02049-12. Epub 2012 Nov 5.

21.
22.

Antibiotic resistance and substrate profiles of the class A carbapenemase KPC-6.

Lamoureaux TL, Frase H, Antunes NT, Vakulenko SB.

Antimicrob Agents Chemother. 2012 Nov;56(11):6006-8. doi: 10.1128/AAC.01338-12. Epub 2012 Aug 20.

23.

Purification, crystallization and preliminary X-ray analysis of the aminoglycoside-6'-acetyltransferase AAC(6')-Im.

Toth M, Vakulenko SB, Smith CA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):472-5. doi: 10.1107/S1744309112007117. Epub 2012 Mar 28.

24.

Class A carbapenemase FPH-1 from Francisella philomiragia.

Toth M, Vakulenko V, Antunes NT, Frase H, Vakulenko SB.

Antimicrob Agents Chemother. 2012 Jun;56(6):2852-7. doi: 10.1128/AAC.00223-12. Epub 2012 Mar 26.

25.

Aminoglycoside 2''-phosphotransferase IIIa (APH(2'')-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2'' kinases.

Smith CA, Toth M, Frase H, Byrnes LJ, Vakulenko SB.

J Biol Chem. 2012 Apr 13;287(16):12893-903. doi: 10.1074/jbc.M112.341206. Epub 2012 Feb 24.

26.

The class A β-lactamase FTU-1 is native to Francisella tularensis.

Antunes NT, Frase H, Toth M, Vakulenko SB.

Antimicrob Agents Chemother. 2012 Feb;56(2):666-71. doi: 10.1128/AAC.05305-11. Epub 2011 Nov 14.

27.

Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism.

Antunes NT, Frase H, Toth M, Mobashery S, Vakulenko SB.

Biochemistry. 2011 Jul 26;50(29):6387-95. doi: 10.1021/bi200403e. Epub 2011 Jun 29.

PMID:
21696166
28.

Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry.

Frase H, Smith CA, Toth M, Champion MM, Mobashery S, Vakulenko SB.

J Biol Chem. 2011 Apr 22;286(16):14396-409. doi: 10.1074/jbc.M110.208744. Epub 2011 Feb 22.

29.

Importance of position 170 in the inhibition of GES-type β-lactamases by clavulanic acid.

Frase H, Toth M, Champion MM, Antunes NT, Vakulenko SB.

Antimicrob Agents Chemother. 2011 Apr;55(4):1556-62. doi: 10.1128/AAC.01292-10. Epub 2011 Jan 10.

30.

Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2''-IVa.

Toth M, Frase H, Antunes NT, Smith CA, Vakulenko SB.

Protein Sci. 2010 Aug;19(8):1565-76. doi: 10.1002/pro.437.

31.

Mutant APH(2'')-IIa enzymes with increased activity against amikacin and isepamicin.

Toth M, Frase H, Chow JW, Smith C, Vakulenko SB.

Antimicrob Agents Chemother. 2010 Apr;54(4):1590-5. doi: 10.1128/AAC.01444-09. Epub 2010 Feb 9.

32.

Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases.

Frase H, Shi Q, Testero SA, Mobashery S, Vakulenko SB.

J Biol Chem. 2009 Oct 23;284(43):29509-13. doi: 10.1074/jbc.M109.011262. Epub 2009 Aug 5.

33.

Purification, crystallization and preliminary X-ray analysis of the beta-lactamase Oih-1 from Oceanobacillus iheyensis.

Toth M, Vakulenko SB, Smith CA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):582-5. doi: 10.1107/S1744309109015759. Epub 2009 May 22.

34.

The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.

Young PG, Walanj R, Lakshmi V, Byrnes LJ, Metcalf P, Baker EN, Vakulenko SB, Smith CA.

J Bacteriol. 2009 Jul;191(13):4133-43. doi: 10.1128/JB.00149-09. Epub 2009 May 8.

35.

Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases.

Toth M, Chow JW, Mobashery S, Vakulenko SB.

J Biol Chem. 2009 Mar 13;284(11):6690-6. doi: 10.1074/jbc.M808148200. Epub 2009 Jan 21.

36.

Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics.

Villegas-Estrada A, Lee M, Hesek D, Vakulenko SB, Mobashery S.

J Am Chem Soc. 2008 Jul 23;130(29):9212-3. doi: 10.1021/ja8029448. Epub 2008 Jun 27.

37.

Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum.

Byrnes LJ, Badarau A, Vakulenko SB, Smith CA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Feb 1;64(Pt 2):126-9. doi: 10.1107/S1744309108001450. Epub 2008 Jan 31.

38.

Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli.

Zhang W, Shi Q, Meroueh SO, Vakulenko SB, Mobashery S.

Biochemistry. 2007 Sep 4;46(35):10113-21. Epub 2007 Aug 9.

PMID:
17685588
39.
40.

Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance.

Suvorov M, Vakulenko SB, Mobashery S.

Antimicrob Agents Chemother. 2007 Aug;51(8):2937-42. Epub 2007 May 14.

41.

Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens.

Kim C, Hesek D, Zajícek J, Vakulenko SB, Mobashery S.

Biochemistry. 2006 Jul 11;45(27):8368-77.

PMID:
16819836
42.

Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus.

Fuda C, Hesek D, Lee M, Heilmayer W, Novak R, Vakulenko SB, Mobashery S.

J Biol Chem. 2006 Apr 14;281(15):10035-41. Epub 2006 Feb 3.

43.

Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme.

Kim C, Cha JY, Yan H, Vakulenko SB, Mobashery S.

J Biol Chem. 2006 Mar 17;281(11):6964-9. Epub 2006 Jan 3.

44.

Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.

Thomas VL, Golemi-Kotra D, Kim C, Vakulenko SB, Mobashery S, Shoichet BK.

Biochemistry. 2005 Jul 5;44(26):9330-8.

45.

The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

Fuda C, Suvorov M, Vakulenko SB, Mobashery S.

J Biol Chem. 2004 Sep 24;279(39):40802-6. Epub 2004 Jun 28.

46.

The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins.

Golemi-Kotra D, Meroueh SO, Kim C, Vakulenko SB, Bulychev A, Stemmler AJ, Stemmler TL, Mobashery S.

J Biol Chem. 2004 Aug 13;279(33):34665-73. Epub 2004 May 19.

47.

Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria.

Kim C, Haddad J, Vakulenko SB, Meroueh SO, Wu Y, Yan H, Mobashery S.

Biochemistry. 2004 Mar 9;43(9):2373-83.

PMID:
14992574
48.

Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria.

Hesek D, Suvorov M, Morio K, Lee M, Brown S, Vakulenko SB, Mobashery S.

J Org Chem. 2004 Feb 6;69(3):778-84.

PMID:
14750804
49.

Versatility of aminoglycosides and prospects for their future.

Vakulenko SB, Mobashery S.

Clin Microbiol Rev. 2003 Jul;16(3):430-50. Review.

50.

Multiplex PCR for detection of aminoglycoside resistance genes in enterococci.

Vakulenko SB, Donabedian SM, Voskresenskiy AM, Zervos MJ, Lerner SA, Chow JW.

Antimicrob Agents Chemother. 2003 Apr;47(4):1423-6.

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