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Items: 1 to 50 of 58

1.

Correction: Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor.

Hansen LH, Madsen TD, Goth CK, Clausen H, Chen Y, Dzoyashvili N, Iyer SR, Sangaralingham SJ, Burnett JC Jr, Rehfeld JF, Vakhrushev SY, Schjoldager KT, Goetze JP.

J Biol Chem. 2019 Nov 29;294(48):18516. doi: 10.1074/jbc.AAC119.011661. No abstract available.

2.

Glyco-DIA: a method for quantitative O-glycoproteomics with in silico-boosted glycopeptide libraries.

Ye Z, Mao Y, Clausen H, Vakhrushev SY.

Nat Methods. 2019 Sep;16(9):902-910. doi: 10.1038/s41592-019-0504-x. Epub 2019 Aug 5.

PMID:
31384044
3.

Different isolation approaches lead to diverse glycosylated extracellular vesicle populations.

Freitas D, Balmaña M, Poças J, Campos D, Osório H, Konstantinidi A, Vakhrushev SY, Magalhães A, Reis CA.

J Extracell Vesicles. 2019 Jun 3;8(1):1621131. doi: 10.1080/20013078.2019.1621131. eCollection 2019.

4.

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.

Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H.

Mol Cell. 2019 Jul 25;75(2):394-407.e5. doi: 10.1016/j.molcel.2019.05.017. Epub 2019 Jun 18.

PMID:
31227230
5.

Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor.

Hansen LH, Madsen TD, Goth CK, Clausen H, Chen Y, Dzhoyashvili N, Iyer SR, Sangaralingham SJ, Burnett JC Jr, Rehfeld JF, Vakhrushev SY, Schjoldager KT, Goetze JP.

J Biol Chem. 2019 Aug 23;294(34):12567-12578. doi: 10.1074/jbc.RA119.008102. Epub 2019 Jun 11. Erratum in: J Biol Chem. 2019 Nov 29;294(48):18516.

6.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2019 May 24;294(21):8349. doi: 10.1074/jbc.AAC119.009121. No abstract available.

7.

The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells.

Tian W, Ye Z, Wang S, Schulz MA, Van Coillie J, Sun L, Chen YH, Narimatsu Y, Hansen L, Kristensen C, Mandel U, Bennett EP, Jabbarzadeh-Tabrizi S, Schiffmann R, Shen JS, Vakhrushev SY, Clausen H, Yang Z.

Nat Commun. 2019 Apr 30;10(1):1785. doi: 10.1038/s41467-019-09809-3.

8.

Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics.

Narimatsu Y, Joshi HJ, Schjoldager KT, Hintze J, Halim A, Steentoft C, Nason R, Mandel U, Bennett EP, Clausen H, Vakhrushev SY.

Mol Cell Proteomics. 2019 Jul;18(7):1396-1409. doi: 10.1074/mcp.RA118.001121. Epub 2019 Apr 30.

PMID:
31040225
9.

A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion.

Valoskova K, Biebl J, Roblek M, Emtenani S, Gyoergy A, Misova M, Ratheesh A, Reis-Rodrigues P, Shkarina K, Larsen ISB, Vakhrushev SY, Clausen H, Siekhaus DE.

Elife. 2019 Mar 26;8. pii: e41801. doi: 10.7554/eLife.41801.

10.

A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody.

Steentoft C, Fuhrmann M, Battisti F, Van Coillie J, Madsen TD, Campos D, Halim A, Vakhrushev SY, Joshi HJ, Schreiber H, Mandel U, Narimatsu Y.

Glycobiology. 2019 Apr 1;29(4):307-319. doi: 10.1093/glycob/cwz004.

PMID:
30726901
11.

Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics.

Narimatsu H, Kaji H, Vakhrushev SY, Clausen H, Zhang H, Noro E, Togayachi A, Nagai-Okatani C, Kuno A, Zou X, Cheng L, Tao SC, Sun Y.

J Proteome Res. 2018 Dec 7;17(12):4097-4112. doi: 10.1021/acs.jproteome.8b00515. Epub 2018 Oct 25. Review.

PMID:
30359034
12.

Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines.

Hintze J, Ye Z, Narimatsu Y, Madsen TD, Joshi HJ, Goth CK, Linstedt A, Bachert C, Mandel U, Bennett EP, Vakhrushev SY, Schjoldager KT.

J Biol Chem. 2018 Dec 7;293(49):19064-19077. doi: 10.1074/jbc.RA118.004516. Epub 2018 Oct 16.

13.

Viral glycoproteomes: technologies for characterization and outlook for vaccine design.

Bagdonaite I, Vakhrushev SY, Joshi HJ, Wandall HH.

FEBS Lett. 2018 Dec;592(23):3898-3920. doi: 10.1002/1873-3468.13177. Epub 2018 Jul 12. Review.

14.

Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.

de Las Rivas M, Coelho H, Diniz A, Lira-Navarrete E, Compañón I, Jiménez-Barbero J, Schjoldager KT, Bennett EP, Vakhrushev SY, Clausen H, Corzana F, Marcelo F, Hurtado-Guerrero R.

Chemistry. 2018 Jun 12;24(33):8382-8392. doi: 10.1002/chem.201800701. Epub 2018 May 16.

PMID:
29601100
15.

Glycoengineering design options for IgG1 in CHO cells using precise gene editing.

Schulz MA, Tian W, Mao Y, Van Coillie J, Sun L, Larsen JS, Chen YH, Kristensen C, Vakhrushev SY, Clausen H, Yang Z.

Glycobiology. 2018 Jul 1;28(7):542-549. doi: 10.1093/glycob/cwy022.

PMID:
29596681
16.

TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation.

King SL, Goth CK, Eckhard U, Joshi HJ, Haue AD, Vakhrushev SY, Schjoldager KT, Overall CM, Wandall HH.

J Biol Chem. 2018 May 18;293(20):7629-7644. doi: 10.1074/jbc.RA118.001978. Epub 2018 Mar 28.

17.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2018 May 11;293(19):7408-7422. doi: 10.1074/jbc.M117.817981. Epub 2018 Mar 20. Erratum in: J Biol Chem. 2019 May 24;294(21):8349.

18.

Fine-Tuning Limited Proteolysis: A Major Role for Regulated Site-Specific O-Glycosylation.

Goth CK, Vakhrushev SY, Joshi HJ, Clausen H, Schjoldager KT.

Trends Biochem Sci. 2018 Apr;43(4):269-284. doi: 10.1016/j.tibs.2018.02.005. Epub 2018 Mar 2. Review.

PMID:
29506880
19.

Characterizing the O-glycosylation landscape of human plasma, platelets, and endothelial cells.

King SL, Joshi HJ, Schjoldager KT, Halim A, Madsen TD, Dziegiel MH, Woetmann A, Vakhrushev SY, Wandall HH.

Blood Adv. 2017 Feb 23;1(7):429-442. doi: 10.1182/bloodadvances.2016002121. eCollection 2017 Feb 28.

20.

GlycoDomainViewer: a bioinformatics tool for contextual exploration of glycoproteomes.

Joshi HJ, Jørgensen A, Schjoldager KT, Halim A, Dworkin LA, Steentoft C, Wandall HH, Clausen H, Vakhrushev SY.

Glycobiology. 2018 Mar 1;28(3):131-136. doi: 10.1093/glycob/cwx104.

PMID:
29267884
21.

De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.

Lavrsen K, Dabelsteen S, Vakhrushev SY, Levann AMR, Haue AD, Dylander A, Mandel U, Hansen L, Frödin M, Bennett EP, Wandall HH.

J Biol Chem. 2018 Jan 26;293(4):1298-1314. doi: 10.1074/jbc.M117.812826. Epub 2017 Nov 29.

22.

Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane.

Lackman JJ, Goth CK, Halim A, Vakhrushev SY, Clausen H, Petäjä-Repo UE.

Cell Signal. 2018 Jan;42:184-193. doi: 10.1016/j.cellsig.2017.10.016. Epub 2017 Oct 31.

PMID:
29097258
23.

Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins.

Larsen ISB, Narimatsu Y, Joshi HJ, Siukstaite L, Harrison OJ, Brasch J, Goodman KM, Hansen L, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11163-11168. doi: 10.1073/pnas.1708319114. Epub 2017 Oct 2.

24.

Chromogranin A in the mammalian heart: expression without secretion.

Hansen LH, Darkner S, Svendsen JH, Henningsen K, Pehrson S, Chen X, Vakhrushev SY, Schjoldager KT, Goetze JP.

Biomark Med. 2017 Jul;11(7):541-545. doi: 10.2217/bmm-2017-0052. Epub 2017 Jul 7.

PMID:
28685598
25.

Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.

Larsen ISB, Narimatsu Y, Joshi HJ, Yang Z, Harrison OJ, Brasch J, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A.

J Biol Chem. 2017 Jul 7;292(27):11586-11598. doi: 10.1074/jbc.M117.794487. Epub 2017 May 16.

26.

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ.

Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012.

27.

Global Mapping of O-Glycosylation of Varicella Zoster Virus, Human Cytomegalovirus, and Epstein-Barr Virus.

Bagdonaite I, Nordén R, Joshi HJ, King SL, Vakhrushev SY, Olofsson S, Wandall HH.

J Biol Chem. 2016 Jun 3;291(23):12014-28. doi: 10.1074/jbc.M116.721746. Epub 2016 Apr 15.

28.

Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Halim A, Larsen IS, Neubert P, Joshi HJ, Petersen BL, Vakhrushev SY, Strahl S, Clausen H.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15648-53. doi: 10.1073/pnas.1511743112. Epub 2015 Dec 7.

29.

An innate antiviral pathway acting before interferons at epithelial surfaces.

Iversen MB, Reinert LS, Thomsen MK, Bagdonaite I, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev SY, Krzyzowska M, Kratholm SK, Ruiz-Perez F, Petersen SV, Goriely S, Bibby BM, Eriksson K, Ruland J, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR.

Nat Immunol. 2016 Feb;17(2):150-8. doi: 10.1038/ni.3319. Epub 2015 Nov 30.

PMID:
26595890
30.

Deconstruction of O-glycosylation--GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.

Schjoldager KT, Joshi HJ, Kong Y, Goth CK, King SL, Wandall HH, Bennett EP, Vakhrushev SY, Clausen H.

EMBO Rep. 2015 Dec;16(12):1713-22. doi: 10.15252/embr.201540796. Epub 2015 Nov 13.

31.

A novel monoclonal antibody to a defined peptide epitope in MUC16.

Marcos-Silva L, Ricardo S, Chen K, Blixt O, Arigi E, Pereira D, Høgdall E, Mandel U, Bennett EP, Vakhrushev SY, David L, Clausen H.

Glycobiology. 2015 Nov;25(11):1172-82. doi: 10.1093/glycob/cwv056. Epub 2015 Jul 22.

PMID:
26201951
32.

Engineered CHO cells for production of diverse, homogeneous glycoproteins.

Yang Z, Wang S, Halim A, Schulz MA, Frodin M, Rahman SH, Vester-Christensen MB, Behrens C, Kristensen C, Vakhrushev SY, Bennett EP, Wandall HH, Clausen H.

Nat Biotechnol. 2015 Aug;33(8):842-4. doi: 10.1038/nbt.3280. Epub 2015 Jul 20.

PMID:
26192319
33.

A strategy for O-glycoproteomics of enveloped viruses--the O-glycoproteome of herpes simplex virus type 1.

Bagdonaite I, Nordén R, Joshi HJ, Dabelsteen S, Nyström K, Vakhrushev SY, Olofsson S, Wandall HH.

PLoS Pathog. 2015 Apr 1;11(4):e1004784. doi: 10.1371/journal.ppat.1004784. eCollection 2015 Apr.

34.

Probing the O-glycoproteome of gastric cancer cell lines for biomarker discovery.

Campos D, Freitas D, Gomes J, Magalhães A, Steentoft C, Gomes C, Vester-Christensen MB, Ferreira JA, Afonso LP, Santos LL, Pinto de Sousa J, Mandel U, Clausen H, Vakhrushev SY, Reis CA.

Mol Cell Proteomics. 2015 Jun;14(6):1616-29. doi: 10.1074/mcp.M114.046862. Epub 2015 Mar 26.

35.

Glycoproteomic analysis of seven major allergenic proteins reveals novel post-translational modifications.

Halim A, Carlsson MC, Madsen CB, Brand S, Møller SR, Olsen CE, Vakhrushev SY, Brimnes J, Wurtzen PA, Ipsen H, Petersen BL, Wandall HH.

Mol Cell Proteomics. 2015 Jan;14(1):191-204. doi: 10.1074/mcp.M114.042614. Epub 2014 Nov 11.

36.

Advances in mass spectrometry driven O-glycoproteomics.

Levery SB, Steentoft C, Halim A, Narimatsu Y, Clausen H, Vakhrushev SY.

Biochim Biophys Acta. 2015 Jan;1850(1):33-42. doi: 10.1016/j.bbagen.2014.09.026. Epub 2014 Oct 2. Review.

PMID:
25284204
37.

Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy.

Nalla A, Ringholm L, Søstrup B, Højrup P, Thim L, Levery SB, Vakhrushev SY, Billestrup N, Mathiesen ER, Damm P, Nielsen JH.

Acta Obstet Gynecol Scand. 2014 Nov;93(11):1181-9. doi: 10.1111/aogs.12505. Epub 2014 Oct 16.

PMID:
25223212
38.

Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis.

Kong Y, Joshi HJ, Schjoldager KT, Madsen TD, Gerken TA, Vester-Christensen MB, Wandall HH, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.

Glycobiology. 2015 Jan;25(1):55-65. doi: 10.1093/glycob/cwu089. Epub 2014 Aug 25.

39.

Immature truncated O-glycophenotype of cancer directly induces oncogenic features.

Radhakrishnan P, Dabelsteen S, Madsen FB, Francavilla C, Kopp KL, Steentoft C, Vakhrushev SY, Olsen JV, Hansen L, Bennett EP, Woetmann A, Yin G, Chen L, Song H, Bak M, Hlady RA, Peters SL, Opavsky R, Thode C, Qvortrup K, Schjoldager KT, Clausen H, Hollingsworth MA, Wandall HH.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4066-75. doi: 10.1073/pnas.1406619111. Epub 2014 Aug 12.

40.

The GalNAc-type O-Glycoproteome of CHO cells characterized by the SimpleCell strategy.

Yang Z, Halim A, Narimatsu Y, Jitendra Joshi H, Steentoft C, Schjoldager KT, Alder Schulz M, Sealover NR, Kayser KJ, Paul Bennett E, Levery SB, Vakhrushev SY, Clausen H.

Mol Cell Proteomics. 2014 Dec;13(12):3224-35. doi: 10.1074/mcp.M114.041541. Epub 2014 Aug 4.

41.

Precision genome editing: a small revolution for glycobiology.

Steentoft C, Bennett EP, Schjoldager KT, Vakhrushev SY, Wandall HH, Clausen H.

Glycobiology. 2014 Aug;24(8):663-80. doi: 10.1093/glycob/cwu046. Epub 2014 May 26. Review.

PMID:
24861053
42.

Characterization of binding epitopes of CA125 monoclonal antibodies.

Marcos-Silva L, Narimatsu Y, Halim A, Campos D, Yang Z, Tarp MA, Pereira PJ, Mandel U, Bennett EP, Vakhrushev SY, Levery SB, David L, Clausen H.

J Proteome Res. 2014 Jul 3;13(7):3349-59. doi: 10.1021/pr500215g. Epub 2014 Jun 4.

PMID:
24850311
43.

Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.

Vester-Christensen MB, Halim A, Joshi HJ, Steentoft C, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21018-23. doi: 10.1073/pnas.1313446110. Epub 2013 Oct 7.

44.

Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.

Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H.

EMBO J. 2013 May 15;32(10):1478-88. doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12.

45.

Enhanced mass spectrometric mapping of the human GalNAc-type O-glycoproteome with SimpleCells.

Vakhrushev SY, Steentoft C, Vester-Christensen MB, Bennett EP, Clausen H, Levery SB.

Mol Cell Proteomics. 2013 Apr;12(4):932-44. doi: 10.1074/mcp.O112.021972. Epub 2013 Feb 11.

46.

Proteoglycans from Boswellia serrata Roxb. and B. carteri Birdw. and identification of a proteolytic plant basic secretory protein.

Herrmann A, König S, Lechtenberg M, Sehlbach M, Vakhrushev SY, Peter-Katalinic J, Hensel A.

Glycobiology. 2012 Nov;22(11):1424-39. doi: 10.1093/glycob/cws107. Epub 2012 Jul 6.

PMID:
22773449
47.

Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.

Schjoldager KT, Vakhrushev SY, Kong Y, Steentoft C, Nudelman AS, Pedersen NB, Wandall HH, Mandel U, Bennett EP, Levery SB, Clausen H.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9893-8. doi: 10.1073/pnas.1203563109. Epub 2012 May 7.

48.

Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells.

Klimmeck D, Hansson J, Raffel S, Vakhrushev SY, Trumpp A, Krijgsveld J.

Mol Cell Proteomics. 2012 Aug;11(8):286-302. doi: 10.1074/mcp.M111.016790. Epub 2012 Mar 27.

49.

Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.

Steentoft C, Vakhrushev SY, Vester-Christensen MB, Schjoldager KT, Kong Y, Bennett EP, Mandel U, Wandall H, Levery SB, Clausen H.

Nat Methods. 2011 Oct 9;8(11):977-82. doi: 10.1038/nmeth.1731.

PMID:
21983924
50.

Software utilities for the interpretation of mass spectrometric data of glycoconjugates: application to glycosphingolipids of human serum.

Souady J, Dadimov D, Kirsch S, Bindila L, Peter-Katalinić J, Vakhrushev SY.

Rapid Commun Mass Spectrom. 2010 Apr 15;24(7):1039-48. doi: 10.1002/rcm.4479.

PMID:
20213680

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