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Items: 28


Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation.

Tsytlonok M, Sanabria H, Wang Y, Felekyan S, Hemmen K, Phillips AH, Yun MK, Waddell MB, Park CG, Vaithiyalingam S, Iconaru L, White SW, Tompa P, Seidel CAM, Kriwacki R.

Nat Commun. 2019 Apr 11;10(1):1676. doi: 10.1038/s41467-019-09446-w.


Is it feasible to carry out active case finding for tuberculosis in community-based settings?

Mani M, Riyaz M, Shaheena M, Vaithiyalingam S, Anand V, Selvaraj K, Purty AJ.

Lung India. 2019 Jan-Feb;36(1):28-31. doi: 10.4103/lungindia.lungindia_324_18.


Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.

Vanarotti M, Grace CR, Miller DJ, Actis ML, Inoue A, Evison BJ, Vaithiyalingam S, Singh AP, McDonald ET, Fujii N.

J Mol Biol. 2018 Aug 17;430(17):2857-2872. doi: 10.1016/j.jmb.2018.05.042. Epub 2018 Jun 2.


Structure and mechanism of the phage T4 recombination mediator protein UvsY.

Gajewski S, Waddell MB, Vaithiyalingam S, Nourse A, Li Z, Woetzel N, Alexander N, Meiler J, White SW.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3275-80. doi: 10.1073/pnas.1519154113. Epub 2016 Mar 7.


Advancing Product Quality: a Summary of the Second FDA/PQRI Conference.

Yu LX, Akseli I, Allen B, Amidon G, Bizjak TG, Boam A, Caulk M, Doleski D, Famulare J, Fisher AC, Furness S, Hasselbalch B, Havel H, Hoag SW, Iser R, Johnson BD, Ju R, Katz P, Lacana E, Lee SL, Lostritto R, McNally G, Mehta M, Mohan G, Nasr M, Nosal R, Oates M, O'Connor T, Polli J, Raju GK, Ramanadham M, Randazzo G, Rosencrance S, Schwendeman A, Selen A, Seo P, Shah V, Sood R, Thien MP, Tong T, Trout BL, Tyner K, Vaithiyalingam S, VanTrieste M, Walsh F, Wesdyk R, Woodcock J, Wu G, Wu L, Yu L, Zezza D.

AAPS J. 2016 Mar;18(2):528-43. doi: 10.1208/s12248-016-9874-5. Epub 2016 Feb 9. No abstract available.


Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.

Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P.

Mol Cell. 2015 Jul 16;59(2):176-87. doi: 10.1016/j.molcel.2015.05.032. Epub 2015 Jul 2.


Advancing Product Quality: a Summary of the Inaugural FDA/PQRI Conference.

Yu LX, Baker J, Berlam SC, Boam A, Brandreth EJ, Buhse L, Cosgrove T, Doleski D, Ensor L, Famulare J, Ganapathy M, Grampp G, Hussong D, Iser R, Johnston G, Kesisoglou F, Khan M, Kozlowski S, Lacana E, Lee SL, Miller S, Miksinski SP, Moore CM, Mullin T, Raju GK, Raw A, Rosencrance S, Rosolowsky M, Stinavage P, Thomas H, Wesdyk R, Windisch J, Vaithiyalingam S.

AAPS J. 2015 Jul;17(4):1011-8. doi: 10.1208/s12248-015-9754-4. Epub 2015 Apr 4.


Best practices for the development, scale-up, and post-approval change control of IR and MR dosage forms in the current quality-by-design paradigm.

Van Buskirk GA, Asotra S, Balducci C, Basu P, DiDonato G, Dorantes A, Eickhoff WM, Ghosh T, González MA, Henry T, Howard M, Kamm J, Laurenz S, MacKenzie R, Mannion R, Noonan PK, Ocheltree T, Pai U, Poska RP, Putnam ML, Raghavan RR, Ruegger C, Sánchez E, Shah VP, Shao ZJ, Somma R, Tammara V, Thombre AG, Thompson B, Timko RJ, Upadrashta S, Vaithiyalingam S; Manufacturing Technical Committee of the Product Quality Research Institute.

AAPS PharmSciTech. 2014 Jun;15(3):665-93. doi: 10.1208/s12249-014-0087-x. Epub 2014 Mar 1. Review.


Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase.

Vaithiyalingam S, Arnett DR, Aggarwal A, Eichman BF, Fanning E, Chazin WJ.

J Mol Biol. 2014 Feb 6;426(3):558-69. doi: 10.1016/j.jmb.2013.11.007. Epub 2013 Nov 13.


Binding to retinoblastoma pocket domain does not alter the inter-domain flexibility of the J domain of SV40 large T antigen.

Williams CK, Vaithiyalingam S, Hammel M, Pipas J, Chazin WJ.

Arch Biochem Biophys. 2012 Feb 15;518(2):111-8. doi: 10.1016/ Epub 2011 Dec 29.


Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress.

Guler GD, Liu H, Vaithiyalingam S, Arnett DR, Kremmer E, Chazin WJ, Fanning E.

J Biol Chem. 2012 Feb 24;287(9):6469-81. doi: 10.1074/jbc.M111.324582. Epub 2011 Dec 21.


BID binds to replication protein A and stimulates ATR function following replicative stress.

Liu Y, Vaithiyalingam S, Shi Q, Chazin WJ, Zinkel SS.

Mol Cell Biol. 2011 Nov;31(21):4298-309. doi: 10.1128/MCB.05737-11. Epub 2011 Aug 22.


Critical factors in manufacturing multi-layer tablets--assessing material attributes, in-process controls, manufacturing process and product performance.

Vaithiyalingam SR, Sayeed VA.

Int J Pharm. 2010 Oct 15;398(1-2):9-13. doi: 10.1016/j.ijpharm.2010.07.025. Epub 2010 Jul 23. Review.


Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.

Vaithiyalingam S, Warren EM, Eichman BF, Chazin WJ.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13684-9. doi: 10.1073/pnas.1002009107. Epub 2010 Jul 19.


Structural basis for DNA binding by replication initiator Mcm10.

Warren EM, Vaithiyalingam S, Haworth J, Greer B, Bielinsky AK, Chazin WJ, Eichman BF.

Structure. 2008 Dec 10;16(12):1892-901. doi: 10.1016/j.str.2008.10.005.


The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D.

Mol Cell Biol. 2008 Dec;28(24):7345-53. doi: 10.1128/MCB.01079-08. Epub 2008 Oct 20.


Cardiovascular effects of transdermally delivered bupranolol in rabbits: effect of chemical penetration enhancers.

Babu RJ, Dhanasekaran M, Vaithiyalingam SR, Singh PN, Pandit JK.

Life Sci. 2008 Jan 30;82(5-6):273-8. Epub 2007 Nov 23.


Formulation and stability evaluation of ketoprofen sustained-release tablets prepared by fluid bed granulation with Carbopol 971P solution.

Vaithiyalingam SR, Tuliani P, Wilber W, Reddy IK, Khan MA.

Drug Dev Ind Pharm. 2002 Nov;28(10):1231-40.


Preparation and characterization of a customized cellulose acetate butyrate dispersion for controlled drug delivery.

Vaithiyalingam S, Nutan M, Reddy I, Khan M.

J Pharm Sci. 2002 Jun;91(6):1512-22.


Design, in vitro stability, and ocular hypotensive activity of t-butalone chemical delivery systems.

Reddy IK, Vaithiyalingam SR, Khan MA, Bodor NS.

J Pharm Sci. 2001 Aug;90(8):1026-33.


Response surface methodology to obtain naproxen controlled release tablets from its microspheres with Eudragit L100-55.

Zaghloul AA, Vaithiyalingam SR, Faltinek J, Reddy IK, Khan MA.

J Microencapsul. 2001 Sep-Oct;18(5):651-62.


Naproxen-Eudragit microspheres: screening of process and formulation variables for the preparation of extended release tablets.

Zaghloul AA, Faltinek J, Vaithiyalingam SR, Reddy IK, Khan MA.

Pharmazie. 2001 Apr;56(4):321-4.


Intraocular pressure-lowering activity and in vivo disposition of dipivalyl terbutalone in rabbits.

Reddy IK, Vaithiyalingam SR, Khan MA, Bodor NS.

Drug Dev Ind Pharm. 2001 Feb;27(2):137-41.


Long-term stability characterization of a controlled release gastrointestinal therapeutic system coated with a cellulose acetate pseudolatex.

Vaithiyalingam SR, Sastry SV, Dehon RH, Reddy IK, Khan MA.

Pharmazie. 2001 Jan;56(1):66-9.


Stability characterization of controlled release coprecipitates and solid dispersions.

Khan MA, Karnachi AA, Agarwal V, Vaithiyalingam SR, Nazzal S, Reddy IK.

J Control Release. 2000 Jan 3;63(1-2):1-6.


Captopril gastrointestinal therapeutic system coated with cellulose acetate pseudolatex: evaluation of main effects of several formulation variables.

Khan MA, Sastry SV, Vaithiyalingam SR, Agarwal V, Nazzal S, Reddy IK.

Int J Pharm. 2000 Jan 5;193(2):147-56.


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