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Items: 1 to 50 of 85

1.

MicroRNAs 1915-3p, 2861, and 4532 Are Associated with Long-Term Renal Function Decline in Type 1 Diabetes.

Monteiro MB, Santos-Bezerra DP, Pelaes TS, Vaidya VS, Corrêa-Giannella ML.

Clin Chem. 2019 Nov;65(11):1458-1459. doi: 10.1373/clinchem.2019.307686. Epub 2019 Aug 19. No abstract available.

PMID:
31427290
2.

Multi omics analysis of fibrotic kidneys in two mouse models.

Pavkovic M, Pantano L, Gerlach CV, Brutus S, Boswell SA, Everley RA, Shah JV, Sui SH, Vaidya VS.

Sci Data. 2019 Jun 14;6(1):92. doi: 10.1038/s41597-019-0095-5.

3.

Kidney Cortical Transporter Expression across Species Using Quantitative Proteomics.

Basit A, Radi Z, Vaidya VS, Karasu M, Prasad B.

Drug Metab Dispos. 2019 Aug;47(8):802-808. doi: 10.1124/dmd.119.086579. Epub 2019 May 23.

PMID:
31123036
4.

Introduction: Kidney Safety Science.

Vaidya VS.

Semin Nephrol. 2019 Mar;39(2):117-119. doi: 10.1016/j.semnephrol.2018.12.001. No abstract available.

PMID:
30827334
5.

A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro.

Ramm S, Todorov P, Chandrasekaran V, Dohlman A, Monteiro MB, Pavkovic M, Muhlich J, Shankaran H, Chen WW, Mettetal JT, Vaidya VS.

Toxicol Sci. 2019 May 1;169(1):54-69. doi: 10.1093/toxsci/kfz021.

PMID:
30649541
6.

A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation.

Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS.

J Am Soc Nephrol. 2018 Dec;29(12):2820-2833. doi: 10.1681/ASN.2018040392. Epub 2018 Oct 25.

7.

Industry Perspective on Biomarker Development and Qualification.

Gerlach CV, Derzi M, Ramaiah SK, Vaidya VS.

Clin Pharmacol Ther. 2018 Jan;103(1):27-31. doi: 10.1002/cpt.919. Epub 2017 Nov 16.

PMID:
29143971
8.

Targeting Phospholipase D4 Attenuates Kidney Fibrosis.

Trivedi P, Kumar RK, Iyer A, Boswell S, Gerarduzzi C, Dadhania VP, Herbert Z, Joshi N, Luyendyk JP, Humphreys BD, Vaidya VS.

J Am Soc Nephrol. 2017 Dec;28(12):3579-3589. doi: 10.1681/ASN.2016111222. Epub 2017 Aug 16.

9.

Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy.

Cardenas-Gonzalez M, Srivastava A, Pavkovic M, Bijol V, Rennke HG, Stillman IE, Zhang X, Parikh S, Rovin BH, Afkarian M, de Boer IH, Himmelfarb J, Waikar SS, Vaidya VS.

Clin Chem. 2017 Sep;63(9):1515-1526. doi: 10.1373/clinchem.2017.274175. Epub 2017 Jun 30.

10.

MicroRNAs in injury and repair.

Gerlach CV, Vaidya VS.

Arch Toxicol. 2017 Aug;91(8):2781-2797. doi: 10.1007/s00204-017-1974-1. Epub 2017 May 13. Review.

11.

Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation.

Gerarduzzi C, Kumar RK, Trivedi P, Ajay AK, Iyer A, Boswell S, Hutchinson JN, Waikar SS, Vaidya VS.

JCI Insight. 2017 Apr 20;2(8). pii: 90299. doi: 10.1172/jci.insight.90299. eCollection 2017 Apr 20.

12.

A High-Throughput Screening Assay to Identify Kidney Toxic Compounds.

Ramm S, Adler M, Vaidya VS.

Curr Protoc Toxicol. 2016 Aug 1;69:9.10.1-9.10.26. doi: 10.1002/cptx.12.

13.

Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1.

Cárdenas-González M, Osorio-Yáñez C, Gaspar-Ramírez O, Pavković M, Ochoa-Martínez A, López-Ventura D, Medeiros M, Barbier OC, Pérez-Maldonado IN, Sabbisetti VS, Bonventre JV, Vaidya VS.

Environ Res. 2016 Oct;150:653-662. doi: 10.1016/j.envres.2016.06.032. Epub 2016 Jul 15.

14.

RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA.

Jadhav S, Ajay AK, Trivedi P, Seematti J, Pellegrini K, Craciun F, Vaidya VS.

J Biol Chem. 2016 Jul 1;291(27):14085-94. doi: 10.1074/jbc.M115.713289. Epub 2016 Apr 28.

15.

MicroRNAs and drug-induced kidney injury.

Pavkovic M, Vaidya VS.

Pharmacol Ther. 2016 Jul;163:48-57. doi: 10.1016/j.pharmthera.2016.03.016. Epub 2016 Apr 25. Review.

16.

Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423.

Pavkovic M, Robinson-Cohen C, Chua AS, Nicoara O, Cárdenas-González M, Bijol V, Ramachandran K, Hampson L, Pirmohamed M, Antoine DJ, Frendl G, Himmelfarb J, Waikar SS, Vaidya VS.

Toxicol Sci. 2016 Jul;152(1):205-13. doi: 10.1093/toxsci/kfw077. Epub 2016 Apr 27.

17.

Evaluation of cystatin C as an early biomarker of cadmium nephrotoxicity in the rat.

Prozialeck WC, VanDreel A, Ackerman CD, Stock I, Papaeliou A, Yasmine C, Wilson K, Lamar PC, Sears VL, Gasiorowski JZ, DiNovo KM, Vaidya VS, Edwards JR.

Biometals. 2016 Feb;29(1):131-46. doi: 10.1007/s10534-015-9903-3. Epub 2015 Dec 29.

18.

Application of small RNA sequencing to identify microRNAs in acute kidney injury and fibrosis.

Pellegrini KL, Gerlach CV, Craciun FL, Ramachandran K, Bijol V, Kissick HT, Vaidya VS.

Toxicol Appl Pharmacol. 2016 Dec 1;312:42-52. doi: 10.1016/j.taap.2015.12.002. Epub 2015 Dec 17.

19.

RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis.

Craciun FL, Bijol V, Ajay AK, Rao P, Kumar RK, Hutchinson J, Hofmann O, Joshi N, Luyendyk JP, Kusebauch U, Moss CL, Srivastava A, Himmelfarb J, Waikar SS, Moritz RL, Vaidya VS.

J Am Soc Nephrol. 2016 Jun;27(6):1702-13. doi: 10.1681/ASN.2015020225. Epub 2015 Oct 8.

20.

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro.

Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS.

J Am Soc Nephrol. 2016 Apr;27(4):1015-28. doi: 10.1681/ASN.2015010060. Epub 2015 Aug 10.

21.

Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury.

Chung HJ, Pellegrini KL, Chung J, Wanigasuriya K, Jayawardene I, Lee K, Lee H, Vaidya VS, Weissleder R.

PLoS One. 2015 Jul 17;10(7):e0133417. doi: 10.1371/journal.pone.0133417. eCollection 2015.

22.

MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis.

Murugaiyan G, da Cunha AP, Ajay AK, Joller N, Garo LP, Kumaradevan S, Yosef N, Vaidya VS, Weiner HL.

J Clin Invest. 2015 Mar 2;125(3):1069-80. doi: 10.1172/JCI74347. Epub 2015 Feb 2.

23.

Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study.

Legrand M, De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Sambhare R, Di Somma S, Mebazaa A, Vaidya VS, Januzzi JL Jr; Global Research on Acute Conditions Team (GREAT).

PLoS One. 2014 Nov 11;9(11):e112313. doi: 10.1371/journal.pone.0112313. eCollection 2014.

24.

MicroRNA-155 deficient mice experience heightened kidney toxicity when dosed with cisplatin.

Pellegrini KL, Han T, Bijol V, Saikumar J, Craciun FL, Chen WW, Fuscoe JC, Vaidya VS.

Toxicol Sci. 2014 Oct;141(2):484-92. doi: 10.1093/toxsci/kfu143. Epub 2014 Jul 11.

25.

Pharmacological and genetic depletion of fibrinogen protects from kidney fibrosis.

Craciun FL, Ajay AK, Hoffmann D, Saikumar J, Fabian SL, Bijol V, Humphreys BD, Vaidya VS.

Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F471-84. doi: 10.1152/ajprenal.00189.2014. Epub 2014 Jul 9.

26.

Noninvasive micromarkers.

Saikumar J, Ramachandran K, Vaidya VS.

Clin Chem. 2014 Sep;60(9):1158-73. doi: 10.1373/clinchem.2013.216044. Epub 2014 Jan 9. Review.

27.

Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats.

Zhang Q, Davis KJ, Hoffmann D, Vaidya VS, Brown RP, Goering PL.

Biomark Med. 2014;8(1):85-94. doi: 10.2217/bmm.13.106.

28.

Impaired renal function and development in Belgrade rats.

Veuthey T, Hoffmann D, Vaidya VS, Wessling-Resnick M.

Am J Physiol Renal Physiol. 2014 Feb 1;306(3):F333-43. doi: 10.1152/ajprenal.00285.2013. Epub 2013 Nov 13.

29.

A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury.

Ajay AK, Kim TM, Ramirez-Gonzalez V, Park PJ, Frank DA, Vaidya VS.

J Am Soc Nephrol. 2014 Jan;25(1):105-18. doi: 10.1681/ASN.2013020161. Epub 2013 Oct 24.

30.

Human miRNome profiling identifies microRNAs differentially present in the urine after kidney injury.

Ramachandran K, Saikumar J, Bijol V, Koyner JL, Qian J, Betensky RA, Waikar SS, Vaidya VS.

Clin Chem. 2013 Dec;59(12):1742-52. doi: 10.1373/clinchem.2013.210245. Epub 2013 Oct 23.

31.

The current status of biomarkers for predicting toxicity.

Campion S, Aubrecht J, Boekelheide K, Brewster DW, Vaidya VS, Anderson L, Burt D, Dere E, Hwang K, Pacheco S, Saikumar J, Schomaker S, Sigman M, Goodsaid F.

Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1391-408. doi: 10.1517/17425255.2013.827170. Epub 2013 Aug 21. Review.

32.

Heterozygosity for fibrinogen results in efficient resolution of kidney ischemia reperfusion injury.

Ajay AK, Saikumar J, Bijol V, Vaidya VS.

PLoS One. 2012;7(9):e45628. doi: 10.1371/journal.pone.0045628. Epub 2012 Sep 19.

33.

Fibrinogen excretion in the urine and immunoreactivity in the kidney serves as a translational biomarker for acute kidney injury.

Hoffmann D, Bijol V, Krishnamoorthy A, Gonzalez VR, Frendl G, Zhang Q, Goering PL, Brown RP, Waikar SS, Vaidya VS.

Am J Pathol. 2012 Sep;181(3):818-28. doi: 10.1016/j.ajpath.2012.06.004. Epub 2012 Jul 20.

34.

Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury.

Saikumar J, Hoffmann D, Kim TM, Gonzalez VR, Zhang Q, Goering PL, Brown RP, Bijol V, Park PJ, Waikar SS, Vaidya VS.

Toxicol Sci. 2012 Oct;129(2):256-67. doi: 10.1093/toxsci/kfs210. Epub 2012 Jun 15.

35.

Gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney.

Kim TM, Ramírez V, Barrera-Chimal J, Bobadilla NA, Park PJ, Vaidya VS.

PLoS One. 2011;6(9):e25679. doi: 10.1371/journal.pone.0025679. Epub 2011 Sep 28.

36.

Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.

Krishnamoorthy A, Ajay AK, Hoffmann D, Kim TM, Ramirez V, Campanholle G, Bobadilla NA, Waikar SS, Vaidya VS.

Blood. 2011 Aug 18;118(7):1934-42. doi: 10.1182/blood-2011-02-338061. Epub 2011 Jun 17.

37.

Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function.

Endre ZH, Pickering JW, Walker RJ, Devarajan P, Edelstein CL, Bonventre JV, Frampton CM, Bennett MR, Ma Q, Sabbisetti VS, Vaidya VS, Walcher AM, Shaw GM, Henderson SJ, Nejat M, Schollum JB, George PM.

Kidney Int. 2011 May;79(10):1119-30. doi: 10.1038/ki.2010.555. Epub 2011 Feb 9.

38.

Ischemic kidney injury and mechanisms of tissue repair.

El Sabbahy M, Vaidya VS.

Wiley Interdiscip Rev Syst Biol Med. 2011 Sep-Oct;3(5):606-18. doi: 10.1002/wsbm.133. Epub 2010 Dec 31. Review.

39.

Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase.

Vaidya VS, Niewczas MA, Ficociello LH, Johnson AC, Collings FB, Warram JH, Krolewski AS, Bonventre JV.

Kidney Int. 2011 Feb;79(4):464-70. doi: 10.1038/ki.2010.404. Epub 2010 Oct 27.

40.

Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury.

Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E, Akhter SA, Raman J, Jeevanandam V, O'Connor MF, Devarajan P, Bonventre JV, Murray PT.

Clin J Am Soc Nephrol. 2010 Dec;5(12):2154-65. doi: 10.2215/CJN.00740110. Epub 2010 Aug 26.

41.

TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity.

Krishnamoorthy A, Clement ME, O'Leary E, Bonventre JV, Vaidya VS.

Toxicol Sci. 2010 Nov;118(1):298-306. doi: 10.1093/toxsci/kfq240. Epub 2010 Aug 11.

42.

Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate.

Damman K, Van Veldhuisen DJ, Navis G, Vaidya VS, Smilde TD, Westenbrink BD, Bonventre JV, Voors AA, Hillege HL.

Heart. 2010 Aug;96(16):1297-302. doi: 10.1136/hrt.2010.194878.

43.

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.

Vaidya VS, Ozer JS, Dieterle F, Collings FB, Ramirez V, Troth S, Muniappa N, Thudium D, Gerhold D, Holder DJ, Bobadilla NA, Marrer E, Perentes E, Cordier A, Vonderscher J, Maurer G, Goering PL, Sistare FD, Bonventre JV.

Nat Biotechnol. 2010 May;28(5):478-85. doi: 10.1038/nbt.1623.

44.

Next-generation biomarkers for detecting kidney toxicity.

Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F.

Nat Biotechnol. 2010 May;28(5):436-40. doi: 10.1038/nbt0510-436. No abstract available.

45.

Performance of novel kidney biomarkers in preclinical toxicity studies.

Hoffmann D, Adler M, Vaidya VS, Rached E, Mulrane L, Gallagher WM, Callanan JJ, Gautier JC, Matheis K, Staedtler F, Dieterle F, Brandenburg A, Sposny A, Hewitt P, Ellinger-Ziegelbauer H, Bonventre JV, Dekant W, Mally A.

Toxicol Sci. 2010 Jul;116(1):8-22. doi: 10.1093/toxsci/kfq029. Epub 2010 Jan 29.

46.

Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury.

Ferguson MA, Vaidya VS, Waikar SS, Collings FB, Sunderland KE, Gioules CJ, Bonventre JV.

Kidney Int. 2010 Apr;77(8):708-14. doi: 10.1038/ki.2009.422. Epub 2009 Nov 25.

47.

Age-related differences in susceptibility to cisplatin-induced renal toxicity.

Espandiari P, Rosenzweig B, Zhang J, Zhou Y, Schnackenberg L, Vaidya VS, Goering PL, Brown RP, Bonventre JV, Mahjoob K, Holland RD, Beger RD, Thompson K, Hanig J, Sadrieh N.

J Appl Toxicol. 2010 Mar;30(2):172-82. doi: 10.1002/jat.1484.

48.

Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine.

Zhang J, Goering PL, Espandiari P, Shaw M, Bonventre JV, Vaidya VS, Brown RP, Keenan J, Kilty CG, Sadrieh N, Hanig JP.

Toxicol Pathol. 2009 Aug;37(5):629-43. doi: 10.1177/0192623309339605. Epub 2009 Jun 17.

49.

Kidney injury molecule-1 is an early noninvasive indicator for donor brain death-induced injury prior to kidney transplantation.

Nijboer WN, Schuurs TA, Damman J, van Goor H, Vaidya VS, van der Heide JJ, Leuvenink HG, Bonventre JV, Ploeg RJ.

Am J Transplant. 2009 Aug;9(8):1752-9. doi: 10.1111/j.1600-6143.2009.02713.x. Epub 2009 Jun 12.

50.

A rapid urine test for early detection of kidney injury.

Vaidya VS, Ford GM, Waikar SS, Wang Y, Clement MB, Ramirez V, Glaab WE, Troth SP, Sistare FD, Prozialeck WC, Edwards JR, Bobadilla NA, Mefferd SC, Bonventre JV.

Kidney Int. 2009 Jul;76(1):108-14. doi: 10.1038/ki.2009.96. Epub 2009 Apr 22.

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