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Items: 14


Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases.

Mukherjee B, Tessaro F, Vahokoski J, Kursula I, Marq JB, Scapozza L, Soldati-Favre D.

EMBO J. 2018 Apr 3;37(7). pii: e98047. doi: 10.15252/embj.201798047. Epub 2018 Mar 8.


A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress.

Pino P, Caldelari R, Mukherjee B, Vahokoski J, Klages N, Maco B, Collins CR, Blackman MJ, Kursula I, Heussler V, Brochet M, Soldati-Favre D.

Science. 2017 Oct 27;358(6362):522-528. doi: 10.1126/science.aaf8675.


Apicomplexan actin polymerization depends on nucleation.

Kumpula EP, Pires I, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J, Kursula I.

Sci Rep. 2017 Sep 22;7(1):12137. doi: 10.1038/s41598-017-11330-w.


Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability.

Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I, Raunser S.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10636-10641. doi: 10.1073/pnas.1707506114. Epub 2017 Sep 18.


Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.

Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R, Holder AA.

J Biol Chem. 2017 Oct 27;292(43):17857-17875. doi: 10.1074/jbc.M117.802769. Epub 2017 Sep 11.


Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites.

Simon B, Huart AS, Temmerman K, Vahokoski J, Mertens HD, Komadina D, Hoffmann JE, Yumerefendi H, Svergun DI, Kursula P, Schultz C, McCarthy AA, Hart DJ, Wilmanns M.

Structure. 2016 Jun 7;24(6):851-61. doi: 10.1016/j.str.2016.03.020. Epub 2016 Apr 28.


Two independently folding units of Plasmodium profilin suggest evolution via gene fusion.

Bhargav SP, Vahokoski J, Kallio JP, Torda AE, Kursula P, Kursula I.

Cell Mol Life Sci. 2015 Nov;72(21):4193-203. doi: 10.1007/s00018-015-1932-0. Epub 2015 May 27.


Structural differences explain diverse functions of Plasmodium actins.

Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Sidén-Kiamos I, Sachse C, Kursula I.

PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091. eCollection 2014 Apr.


Crystallization and preliminary structural characterization of the two actin isoforms of the malaria parasite.

Bhargav SP, Vahokoski J, Kumpula EP, Kursula I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct;69(Pt 10):1171-6. doi: 10.1107/S174430911302441X. Epub 2013 Sep 30.


A unique Oct4 interface is crucial for reprogramming to pluripotency.

Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Araúzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Schöler HR.

Nat Cell Biol. 2013 Mar;15(3):295-301. doi: 10.1038/ncb2680. Epub 2013 Feb 3.


Juxtanodin is an intrinsically disordered F-actin-binding protein.

Ruskamo S, Chukhlieb M, Vahokoski J, Bhargav SP, Liang F, Kursula I, Kursula P.

Sci Rep. 2012;2:899. doi: 10.1038/srep00899. Epub 2012 Nov 29.


The lasso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain.

Ignatev A, Bhargav SP, Vahokoski J, Kursula P, Kursula I.

PLoS One. 2012;7(3):e33586. doi: 10.1371/journal.pone.0033586. Epub 2012 Mar 13.


Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.

Sauer F, Vahokoski J, Song YH, Wilmanns M.

EMBO Rep. 2010 Jul;11(7):534-40. doi: 10.1038/embor.2010.65. Epub 2010 May 21.


Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples.

Bertini I, Kursula P, Luchinat C, Parigi G, Vahokoski J, Wilmanns M, Yuan J.

J Am Chem Soc. 2009 Apr 15;131(14):5134-44. doi: 10.1021/ja8080764.


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