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The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies.

Huguet F, Flynn S, Vagnarelli P.

Cells. 2019 Jul 7;8(7). pii: E687. doi: 10.3390/cells8070687. Review.


PP1 Phosphatase Complexes: Undruggable No Longer.

Vagnarelli P, Alessi DR.

Cell. 2018 Aug 23;174(5):1049-1051. doi: 10.1016/j.cell.2018.08.007.


Ki-67: More Hidden behind a 'Classic Proliferation Marker'.

Sales Gil R, Vagnarelli P.

Trends Biochem Sci. 2018 Oct;43(10):747-748. doi: 10.1016/j.tibs.2018.08.004. Epub 2018 Aug 18.


Protein phosphatases in chromatin structure and function.

Gil RS, Vagnarelli P.

Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):90-101. doi: 10.1016/j.bbamcr.2018.07.016. Epub 2018 Jul 20. Review.


CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis.

de Castro IJ, Gil RS, Ligammari L, Di Giacinto ML, Vagnarelli P.

Oncotarget. 2017 Dec 23;9(8):7763-7773. doi: 10.18632/oncotarget.23666. eCollection 2018 Jan 30.


Protein phosphatases at the nuclear envelope.

Sales Gil R, de Castro IJ, Berihun J, Vagnarelli P.

Biochem Soc Trans. 2018 Feb 19;46(1):173-182. doi: 10.1042/BST20170139. Epub 2018 Feb 6. Review.


Network of phosphatases and HDAC complexes at repressed chromatin.

de Castro IJ, Amin HA, Vinciotti V, Vagnarelli P.

Cell Cycle. 2017;16(21):2011-2017. doi: 10.1080/15384101.2017.1371883. Epub 2017 Sep 14.


Mitotic post-translational modifications of histones promote chromatin compaction in vitro.

Zhiteneva A, Bonfiglio JJ, Makarov A, Colby T, Vagnarelli P, Schirmer EC, Matic I, Earnshaw WC.

Open Biol. 2017 Sep;7(9). pii: 170076. doi: 10.1098/rsob.170076.


Corrigendum: Mutations in genes encoding condensins cause microcephaly through decatenation failure at mitosis.

Martin CA, Murray JE, Carroll P, Leitch A, MacKenzie KJ, Halachev M, Fetit AE, Keith C, Bicknell LS, Fluteau A, Gautier P, Hall EA, Joss S, Soares G, Silva J, Bober MB, Duker A, Wise CA, Quigley AJ, Phadke SR; Deciphering Developmental Disorders Study,, Wood AJ, Vagnarelli P, Jackson AP.

Genes Dev. 2017 May 1;31(9):953. doi: 10.1101/gad.300871.117. No abstract available.


Repo-Man/PP1 regulates heterochromatin formation in interphase.

de Castro IJ, Budzak J, Di Giacinto ML, Ligammari L, Gokhan E, Spanos C, Moralli D, Richardson C, de Las Heras JI, Salatino S, Schirmer EC, Ullman KS, Bickmore WA, Green C, Rappsilber J, Lamble S, Goldberg MW, Vinciotti V, Vagnarelli P.

Nat Commun. 2017 Jan 16;8:14048. doi: 10.1038/ncomms14048.


Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer.

Corda G, Sala G, Lattanzio R, Iezzi M, Sallese M, Fragassi G, Lamolinara A, Mirza H, Barcaroli D, Ermler S, Silva E, Yasaei H, Newbold RF, Vagnarelli P, Mottolese M, Natali PG, Perracchio L, Quist J, Grigoriadis A, Marra P, Tutt AN, Piantelli M, Iacobelli S, De Laurenzi V, Sala A.

J Pathol. 2017 Feb;241(3):350-361. doi: 10.1002/path.4841. Epub 2016 Dec 29.


Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis.

Martin CA, Murray JE, Carroll P, Leitch A, Mackenzie KJ, Halachev M, Fetit AE, Keith C, Bicknell LS, Fluteau A, Gautier P, Hall EA, Joss S, Soares G, Silva J, Bober MB, Duker A, Wise CA, Quigley AJ, Phadke SR; Deciphering Developmental Disorders Study, Wood AJ, Vagnarelli P, Jackson AP.

Genes Dev. 2016 Oct 1;30(19):2158-2172. Epub 2016 Oct 13. Erratum in: Genes Dev. 2017 May 1;31(9):953.


The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.

Kumar GS, Gokhan E, De Munter S, Bollen M, Vagnarelli P, Peti W, Page R.

Elife. 2016 Aug 30;5. pii: e16539. doi: 10.7554/eLife.16539.


Resetting a functional G1 nucleus after mitosis.

de Castro IJ, Gokhan E, Vagnarelli P.

Chromosoma. 2016 Sep;125(4):607-19. doi: 10.1007/s00412-015-0561-6. Epub 2016 Jan 4. Review.


Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.

Booth DG, Takagi M, Sanchez-Pulido L, Petfalski E, Vargiu G, Samejima K, Imamoto N, Ponting CP, Tollervey D, Earnshaw WC, Vagnarelli P.

Elife. 2014 May 27;3:e01641. doi: 10.7554/eLife.01641.


DNA content of a functioning chicken kinetochore.

Ribeiro SA, Vagnarelli P, Earnshaw WC.

Chromosome Res. 2014 Apr;22(1):7-13. doi: 10.1007/s10577-014-9410-3.


Repo-man at the intersection of chromatin remodelling, DNA repair, nuclear envelope organization, and cancer progression.

Vagnarelli P.

Adv Exp Med Biol. 2014;773:401-14. doi: 10.1007/978-1-4899-8032-8_18. Review.


Meeting report: mitosis and nuclear structure.

Meadows JC, Graumann K, Platani M, Schweizer N, Shimi T, Vagnarelli P, Gatlin JC.

J Cell Sci. 2013 Nov 15;126(Pt 22):5087-90. doi: 10.1242/jcs.142950.


Chromatin reorganization through mitosis.

Vagnarelli P.

Adv Protein Chem Struct Biol. 2013;90:179-224. doi: 10.1016/B978-0-12-410523-2.00006-7.


Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα.

Samejima K, Samejima I, Vagnarelli P, Ogawa H, Vargiu G, Kelly DA, de Lima Alves F, Kerr A, Green LC, Hudson DF, Ohta S, Cooke CA, Farr CJ, Rappsilber J, Earnshaw WC.

J Cell Biol. 2012 Nov 26;199(5):755-70. doi: 10.1083/jcb.201202155. Epub 2012 Nov 19.


Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly.

Vagnarelli P, Earnshaw WC.

Nucleus. 2012 Mar 1;3(2):138-42. doi: 10.4161/nucl.19267. Epub 2012 Mar 1. Review.


Mitotic chromosome condensation in vertebrates.

Vagnarelli P.

Exp Cell Res. 2012 Jul 15;318(12):1435-41. doi: 10.1016/j.yexcr.2012.03.017. Epub 2012 Mar 27. Review.


Contrasting roles of condensin I and condensin II in mitotic chromosome formation.

Green LC, Kalitsis P, Chang TM, Cipetic M, Kim JH, Marshall O, Turnbull L, Whitchurch CB, Vagnarelli P, Samejima K, Earnshaw WC, Choo KH, Hudson DF.

J Cell Sci. 2012 Mar 15;125(Pt 6):1591-604. doi: 10.1242/jcs.097790. Epub 2012 Feb 17.


Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit.

Vagnarelli P, Ribeiro S, Sennels L, Sanchez-Pulido L, de Lima Alves F, Verheyen T, Kelly DA, Ponting CP, Rappsilber J, Earnshaw WC.

Dev Cell. 2011 Aug 16;21(2):328-42. doi: 10.1016/j.devcel.2011.06.020. Epub 2011 Aug 4.


Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.

Xu Z, Vagnarelli P, Ogawa H, Samejima K, Earnshaw WC.

J Biol Chem. 2010 Dec 17;285(51):40163-70. doi: 10.1074/jbc.M110.181545. Epub 2010 Oct 18.


A super-resolution map of the vertebrate kinetochore.

Ribeiro SA, Vagnarelli P, Dong Y, Hori T, McEwen BF, Fukagawa T, Flors C, Earnshaw WC.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10484-9. doi: 10.1073/pnas.1002325107. Epub 2010 May 18.


Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.

Mocciaro A, Berdougo E, Zeng K, Black E, Vagnarelli P, Earnshaw W, Gillespie D, Jallepalli P, Schiebel E.

J Cell Biol. 2010 May 17;189(4):631-9. doi: 10.1083/jcb.200910057.


INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization.

Xu Z, Ogawa H, Vagnarelli P, Bergmann JH, Hudson DF, Ruchaud S, Fukagawa T, Earnshaw WC, Samejima K.

J Cell Biol. 2009 Nov 30;187(5):637-53. doi: 10.1083/jcb.200906053. Erratum in: J Cell Biol. 2010 Feb 22;188(4):611.


Condensin regulates the stiffness of vertebrate centromeres.

Ribeiro SA, Gatlin JC, Dong Y, Joglekar A, Cameron L, Hudson DF, Farr CJ, McEwen BF, Salmon ED, Earnshaw WC, Vagnarelli P.

Mol Biol Cell. 2009 May;20(9):2371-80. doi: 10.1091/mbc.E08-11-1127. Epub 2009 Mar 4.


Centromeres: old tales and new tools.

Vagnarelli P, Ribeiro SA, Earnshaw WC.

FEBS Lett. 2008 Jun 18;582(14):1950-9. doi: 10.1016/j.febslet.2008.04.014. Epub 2008 Apr 22. Review.


Inactivation of a human kinetochore by specific targeting of chromatin modifiers.

Nakano M, Cardinale S, Noskov VN, Gassmann R, Vagnarelli P, Kandels-Lewis S, Larionov V, Earnshaw WC, Masumoto H.

Dev Cell. 2008 Apr;14(4):507-22. doi: 10.1016/j.devcel.2008.02.001.


A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes.

Samejima K, Ogawa H, Cooke CA, Hudson DF, Macisaac F, Ribeiro SA, Vagnarelli P, Cardinale S, Kerr A, Lai F, Ruchaud S, Yue Z, Earnshaw WC.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2457-62. doi: 10.1073/pnas.0712083105. Epub 2008 Feb 8. Erratum in: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5650. Hudson, Damien [Hudson, Damien F].


Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling.

Griffith E, Walker S, Martin CA, Vagnarelli P, Stiff T, Vernay B, Al Sanna N, Saggar A, Hamel B, Earnshaw WC, Jeggo PA, Jackson AP, O'Driscoll M.

Nat Genet. 2008 Feb;40(2):232-6. Epub 2007 Dec 23.


Chk1 is required for spindle checkpoint function.

Zachos G, Black EJ, Walker M, Scott MT, Vagnarelli P, Earnshaw WC, Gillespie DA.

Dev Cell. 2007 Feb;12(2):247-60.


Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis.

Vagnarelli P, Hudson DF, Ribeiro SA, Trinkle-Mulcahy L, Spence JM, Lai F, Farr CJ, Lamond AI, Earnshaw WC.

Nat Cell Biol. 2006 Oct;8(10):1133-42. Epub 2006 Sep 24.


CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1.

Régnier V, Vagnarelli P, Fukagawa T, Zerjal T, Burns E, Trouche D, Earnshaw W, Brown W.

Mol Cell Biol. 2005 May;25(10):3967-81.


Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

Dodson H, Bourke E, Jeffers LJ, Vagnarelli P, Sonoda E, Takeda S, Earnshaw WC, Merdes A, Morrison C.

EMBO J. 2004 Oct 1;23(19):3864-73. Epub 2004 Sep 9.


Chromosomal passengers: the four-dimensional regulation of mitotic events.

Vagnarelli P, Earnshaw WC.

Chromosoma. 2004 Nov;113(5):211-22. Epub 2004 Sep 4. Review.


Mitotic chromosome formation and the condensin paradox.

Gassmann R, Vagnarelli P, Hudson D, Earnshaw WC.

Exp Cell Res. 2004 May 15;296(1):35-42. Review.


Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores.

Vagnarelli P, Morrison C, Dodson H, Sonoda E, Takeda S, Earnshaw WC.

EMBO Rep. 2004 Feb;5(2):167-71. Epub 2004 Jan 23.


Characterization of chicken CENP-A and comparative sequence analysis of vertebrate centromere-specific histone H3-like proteins.

Régnier V, Novelli J, Fukagawa T, Vagnarelli P, Brown W.

Gene. 2003 Oct 16;316:39-46.


Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes.

Hudson DF, Vagnarelli P, Gassmann R, Earnshaw WC.

Dev Cell. 2003 Aug;5(2):323-36.


Sister chromatid cohesion and genome stability in vertebrate cells.

Morrison C, Vagnarelli P, Sonoda E, Takeda S, Earnshaw WC.

Biochem Soc Trans. 2003 Feb;31(Pt 1):263-5. Review.


Insertion of a loxP site in a size-reduced human accessory chromosome.

Moralli D, Vagnarelli P, Bensi M, De Carli L, Raimondi E.

Cytogenet Cell Genet. 2001;94(3-4):113-20.


Kinetochore localisation of the DNA damage response component 53BP1 during mitosis.

Jullien D, Vagnarelli P, Earnshaw WC, Adachi Y.

J Cell Sci. 2002 Jan 1;115(Pt 1):71-9.


Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells.

Sonoda E, Matsusaka T, Morrison C, Vagnarelli P, Hoshi O, Ushiki T, Nojima K, Fukagawa T, Waizenegger IC, Peters JM, Earnshaw WC, Takeda S.

Dev Cell. 2001 Dec;1(6):759-70.


INCENP loss from an inactive centromere correlates with the loss of sister chromatid cohesion.

Vagnarelli PB, Earnshaw WC.

Chromosoma. 2001 Nov;110(6):393-401. Epub 2001 Sep 14.


INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.

Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC.

Curr Biol. 2001 Jun 5;11(11):886-90.


Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.

Adams RR, Eckley DM, Vagnarelli P, Wheatley SP, Gerloff DL, Mackay AM, Svingen PA, Kaufmann SH, Earnshaw WC.

Chromosoma. 2001 May;110(2):65-74.


Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression.

Craig JM, Earnshaw WC, Vagnarelli P.

Exp Cell Res. 1999 Feb 1;246(2):249-62. Review.


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