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Items: 30

1.

The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.

Li X, Zhao Q, Wei W, Lin Q, Magnan C, Emami MR, Wearick-Silva LE, Viola TW, Marshall PR, Yin J, Madugalle SU, Wang Z, Nainar S, Vågbø CB, Leighton LJ, Zajaczkowski EL, Ke K, Grassi-Oliveira R, Bjørås M, Baldi PF, Spitale RC, Bredy TW.

Nat Neurosci. 2019 Feb 18. doi: 10.1038/s41593-019-0339-x. [Epub ahead of print]

PMID:
30778148
2.

A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.

Brickner JR, Soll JM, Lombardi PM, Vågbø CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gécz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N.

Nature. 2017 Nov 16;551(7680):389-393. doi: 10.1038/nature24484. Epub 2017 Nov 8.

PMID:
29144457
3.

m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.

Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vågbø CB, Geula S, Hanna JH, Black DL, Darnell JE Jr, Darnell RB.

Genes Dev. 2017 May 15;31(10):990-1006. doi: 10.1101/gad.301036.117.

4.

Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A.

Cell Discov. 2017 May 9;3:17013. doi: 10.1038/celldisc.2017.13. eCollection 2017.

5.

Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia.

Zatula A, Dikic A, Mulder C, Sharma A, Vågbø CB, Sousa MML, Waage A, Slupphaug G.

Oncotarget. 2017 Mar 21;8(12):19427-19442. doi: 10.18632/oncotarget.14294.

6.

Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.

Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J.

Epigenetics Chromatin. 2016 May 31;9:21. doi: 10.1186/s13072-016-0070-8. eCollection 2016.

7.

Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.

Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P.

Nat Commun. 2016 Mar 2;7:10806. doi: 10.1038/ncomms10806.

8.

DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.

Rasmussen EMK, Vågbø CB, Münch D, Krokan HE, Klungland A, Amdam GV, Dahl JA.

Biochem Biophys Rep. 2016 Feb 22;6:9-15. doi: 10.1016/j.bbrep.2016.02.011. eCollection 2016 Jul.

9.

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.

Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M.

Cell Rep. 2015 Dec 29;13(12):2671-8. doi: 10.1016/j.celrep.2015.12.001. Epub 2015 Dec 17.

10.

A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.

Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE Jr, Darnell RB.

Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.

11.

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.

Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ.

PLoS One. 2014 Jun 10;9(6):e98729. doi: 10.1371/journal.pone.0098729. eCollection 2014.

12.

A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.

Galashevskaya A, Sarno A, Vågbø CB, Aas PA, Hagen L, Slupphaug G, Krokan HE.

DNA Repair (Amst). 2013 Sep;12(9):699-706. doi: 10.1016/j.dnarep.2013.05.002. Epub 2013 Jun 3.

13.

Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.

Vågbø CB, Svaasand EK, Aas PA, Krokan HE.

DNA Repair (Amst). 2013 Mar 1;12(3):188-95. doi: 10.1016/j.dnarep.2012.11.010. Epub 2012 Dec 29.

PMID:
23276627
14.

The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.

Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H.

Mol Cell. 2013 Jan 24;49(2):339-45. doi: 10.1016/j.molcel.2012.11.010. Epub 2012 Dec 13.

15.

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C.

Mol Cell. 2013 Jan 10;49(1):18-29. doi: 10.1016/j.molcel.2012.10.015. Epub 2012 Nov 21.

16.

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.

Meza TJ, Moen MN, Vågbø CB, Krokan HE, Klungland A, Grini PE, Falnes PØ.

Nucleic Acids Res. 2012 Aug;40(14):6620-31. doi: 10.1093/nar/gks327. Epub 2012 Apr 24.

17.

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.

Pettersen HS, Visnes T, Vågbø CB, Svaasand EK, Doseth B, Slupphaug G, Kavli B, Krokan HE.

Nucleic Acids Res. 2011 Oct;39(19):8430-44. doi: 10.1093/nar/gkr563. Epub 2011 Jul 10.

18.

Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.

Leihne V, Kirpekar F, Vågbø CB, van den Born E, Krokan HE, Grini PE, Meza TJ, Falnes PØ.

Nucleic Acids Res. 2011 Sep 1;39(17):7688-701. doi: 10.1093/nar/gkr406. Epub 2011 Jun 7.

19.

A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.

Robertson AB, Dahl JA, Vågbø CB, Tripathi P, Krokan HE, Klungland A.

Nucleic Acids Res. 2011 Apr;39(8):e55. doi: 10.1093/nar/gkr051. Epub 2011 Feb 7.

20.

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.

van den Born E, Vågbø CB, Songe-Møller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PØ.

Nat Commun. 2011 Feb 1;2:172. doi: 10.1038/ncomms1173.

PMID:
21285950
21.

Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.

Songe-Møller L, van den Born E, Leihne V, Vågbø CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PØ, Klungland A.

Mol Cell Biol. 2010 Apr;30(7):1814-27. doi: 10.1128/MCB.01602-09. Epub 2010 Feb 1.

22.

Identification of a novel, widespread, and functionally important PCNA-binding motif.

Gilljam KM, Feyzi E, Aas PA, Sousa MM, Müller R, Vågbø CB, Catterall TC, Liabakk NB, Slupphaug G, Drabløs F, Krokan HE, Otterlei M.

J Cell Biol. 2009 Sep 7;186(5):645-54. doi: 10.1083/jcb.200903138.

23.

AlkB demethylases flip out in different ways.

Sundheim O, Talstad VA, Vågbø CB, Slupphaug G, Krokan HE.

DNA Repair (Amst). 2008 Nov 1;7(11):1916-23. doi: 10.1016/j.dnarep.2008.07.015. Epub 2008 Sep 6. Review.

PMID:
18723127
24.

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.

Westbye MP, Feyzi E, Aas PA, Vågbø CB, Talstad VA, Kavli B, Hagen L, Sundheim O, Akbari M, Liabakk NB, Slupphaug G, Otterlei M, Krokan HE.

J Biol Chem. 2008 Sep 5;283(36):25046-56. doi: 10.1074/jbc.M803776200. Epub 2008 Jul 3.

25.

RNA base damage and repair.

Feyzi E, Sundheim O, Westbye MP, Aas PA, Vågbø CB, Otterlei M, Slupphaug G, Krokan HE.

Curr Pharm Biotechnol. 2007 Dec;8(6):326-31. Review.

PMID:
18289040
26.

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.

Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G.

EMBO J. 2006 Jul 26;25(14):3389-97. Epub 2006 Jul 6.

27.

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.

Ringvoll J, Nordstrand LM, Vågbø CB, Talstad V, Reite K, Aas PA, Lauritzen KH, Liabakk NB, Bjørk A, Doughty RW, Falnes PØ, Krokan HE, Klungland A.

EMBO J. 2006 May 17;25(10):2189-98. Epub 2006 Apr 27.

28.

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.

Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, Krokan HE.

Nature. 2003 Feb 20;421(6925):859-63.

PMID:
12594517
30.

Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6.

Hadidi H, Irshaid Y, Vågbø CB, Brunsvik A, Cholerton S, Zahlsen K, Idle JR.

Eur J Clin Pharmacol. 1998 Jul;54(5):437-41.

PMID:
9754990

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