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PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers.

Keung MYT, Wu Y, Vadgama JV.

J Clin Med. 2019 Mar 30;8(4). pii: E435. doi: 10.3390/jcm8040435. Review.


Utilization of NGS technologies to investigate transcriptomic and epigenomic mechanisms in trastuzumab resistance.

Nava M, Dutta P, Farias-Eisner R, Vadgama JV, Wu Y.

Sci Rep. 2019 Mar 26;9(1):5141. doi: 10.1038/s41598-019-41672-6.


AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer.

Cao W, Li J, Hao Q, Vadgama JV, Wu Y.

Breast Cancer Res. 2019 Feb 21;21(1):29. doi: 10.1186/s13058-019-1107-2. Review.


Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets.

Nava M, Dutta P, Zemke NR, Farias-Eisner R, Vadgama JV, Wu Y.

BMC Med Genomics. 2019 Feb 8;12(1):32. doi: 10.1186/s12920-019-0477-8.


Celecoxib in breast cancer prevention and therapy.

Li J, Hao Q, Cao W, Vadgama JV, Wu Y.

Cancer Manag Res. 2018 Oct 26;10:4653-4667. doi: 10.2147/CMAR.S178567. eCollection 2018. Review.


Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells.

Chung SS, Dutta P, Austin D, Wang P, Awad A, Vadgama JV.

Oncotarget. 2018 Aug 31;9(68):32943-32957. doi: 10.18632/oncotarget.25993. eCollection 2018 Aug 31.


Optimization Of Cancer Treatment Through Overcoming Drug Resistance.

Elshimali YI, Wu Y, Khaddour H, Wu Y, Gradinaru D, Sukhija H, Chung SS, Vadgama JV.

J Cancer Res Oncobiol. 2018;1(2). pii: 107. doi: 10.31021/jcro.20181107. Epub 2018 Feb 27.


Targeting of PP2Cδ By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo.

Wu K, Yu X, Huang Z, Zhu D, Yi X, Wu YL, Hao Q, Kemp KT 2nd, Elshimali Y, Iyer R, Nguyen KT, Zheng S, Chen G, Chen QH, Wang G, Vadgama JV, Wu Y.

Antioxid Redox Signal. 2019 Jun 10;30(17):1983-1998. doi: 10.1089/ars.2017.7486. Epub 2018 Jul 13.


MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis.

Dutta P, Sarkissyan M, Paico K, Wu Y, Vadgama JV.

Breast Cancer Res Treat. 2018 Aug;170(3):477-486. doi: 10.1007/s10549-018-4760-8. Epub 2018 Mar 28.


Time to Clinical Follow-up after Abnormal Mammogram among African American and Hispanic Women.

Petersen SS, Sarkissyan M, Wu Y, Clayton S, Vadgama JV.

J Health Care Poor Underserved. 2018;29(1):448-462. doi: 10.1353/hpu.2018.0030.


Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women.

Wu Y, Sarkissyan M, Clayton S, Chlebowski R, Vadgama JV.

Cancers (Basel). 2017 Oct 24;9(10). pii: E144. doi: 10.3390/cancers9100144.


Arctigenin inhibits prostate tumor cell growth in vitro and in vivo.

Wang P, Solorzano W, Diaz T, Magyar CE, Henning SM, Vadgama JV.

Clin Nutr Exp. 2017 Jun;13:1-11. doi: 10.1016/j.yclnex.2017.04.001. Epub 2017 Apr 8.


Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells.

Chung SS, Wu Y, Okobi Q, Adekoya D, Atefi M, Clarke O, Dutta P, Vadgama JV.

Mediators Inflamm. 2017;2017:5958429. doi: 10.1155/2017/5958429. Epub 2017 Jun 6.


GROα overexpression drives cell migration and invasion in triple negative breast cancer cells.

Bhat K, Sarkissyan M, Wu Y, Vadgama JV.

Oncol Rep. 2017 Jul;38(1):21-30. doi: 10.3892/or.2017.5668. Epub 2017 May 24.


Androgen Receptor as a Potential Target for Treatment of Breast Cancer.

Wu Y, Vadgama JV.

Int J Cancer Res Mol Mech. 2017 Apr;3(1). doi: 10.16966/2381-3318.129. Epub 2016 Oct 6.


A83-01 inhibits TGF-β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells.

Wu Y, Tran T, Dwabe S, Sarkissyan M, Kim J, Nava M, Clayton S, Pietras R, Farias-Eisner R, Vadgama JV.

Breast Cancer Res Treat. 2017 Jun;163(3):449-460. doi: 10.1007/s10549-017-4211-y. Epub 2017 Mar 23.


Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells.

Chung SS, Adekoya D, Enenmoh I, Clarke O, Wang P, Sarkyssian M, Wu Y, Vadgama JV.

Anticancer Res. 2017 Feb;37(2):445-453.


Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis.

Wu Y, Yu X, Yi X, Wu K, Dwabe S, Atefi M, Elshimali Y, Kemp KT 2nd, Bhat K, Haro J, Sarkissyan M, Vadgama JV.

Cancer Res. 2017 Mar 15;77(6):1383-1394. doi: 10.1158/0008-5472.CAN-16-2012. Epub 2017 Jan 23.


Lactate, a Neglected Factor for Diabetes and Cancer Interaction.

Wu Y, Dong Y, Atefi M, Liu Y, Elshimali Y, Vadgama JV.

Mediators Inflamm. 2016;2016:6456018. doi: 10.1155/2016/6456018. Epub 2016 Dec 18. Review.


Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features.

Gelfand R, Vernet D, Bruhn KW, Sarkissyan S, Heber D, Vadgama JV, Gonzalez-Cadavid NF.

Int J Oncol. 2017 Jan;50(1):49-65. doi: 10.3892/ijo.2016.3800. Epub 2016 Dec 9.


Combination treatment with flavonoid morin and telomerase inhibitor MST‑312 reduces cancer stem cell traits by targeting STAT3 and telomerase.

Chung SS, Oliva B, Dwabe S, Vadgama JV.

Int J Oncol. 2016 Aug;49(2):487-98. doi: 10.3892/ijo.2016.3546. Epub 2016 May 31.


Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy.

Wang P, Henning SM, Magyar CE, Elshimali Y, Heber D, Vadgama JV.

J Exp Clin Cancer Res. 2016 May 6;35:73. doi: 10.1186/s13046-016-0351-x.


Epithelial-Mesenchymal Transition and Breast Cancer.

Wu Y, Sarkissyan M, Vadgama JV.

J Clin Med. 2016 Jan 26;5(2). pii: E13. doi: 10.3390/jcm5020013. Review.


Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.

Chung S, Dwabe S, Elshimali Y, Sukhija H, Aroh C, Vadgama JV.

PLoS One. 2015 Aug 10;10(8):e0134948. doi: 10.1371/journal.pone.0134948. eCollection 2015.


Understanding Perceived Benefit of Early Cancer Detection: Community-Partnered Research with African American Women in South Los Angeles.

Bazargan M, Lucas-Wright A, Jones L, Vargas R, Vadgama JV, Evers-Manly S, Maxwell AE.

J Womens Health (Larchmt). 2015 Sep;24(9):755-61. doi: 10.1089/jwh.2014.5049. Epub 2015 Jul 1.


Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing.

Wu Y, Sarkissyan M, Mcghee E, Lee S, Vadgama JV.

Breast Cancer Res Treat. 2015 Jun;151(3):529-39. doi: 10.1007/s10549-015-3386-3. Epub 2015 May 15.


Sensitization to docetaxel in prostate cancer cells by green tea and quercetin.

Wang P, Henning SM, Heber D, Vadgama JV.

J Nutr Biochem. 2015 Apr;26(4):408-15. doi: 10.1016/j.jnutbio.2014.11.017. Epub 2015 Jan 15.


Slug contributes to cancer progression by direct regulation of ERα signaling pathway.

Li Y, Wu Y, Abbatiello TC, Wu WL, Kim JR, Sarkissyan M, Sarkissyan S, Chung SS, Elshimali Y, Vadgama JV.

Int J Oncol. 2015 Apr;46(4):1461-72. doi: 10.3892/ijo.2015.2878. Epub 2015 Feb 5.


Epigenetics in breast and prostate cancer.

Wu Y, Sarkissyan M, Vadgama JV.

Methods Mol Biol. 2015;1238:425-66. doi: 10.1007/978-1-4939-1804-1_23. Review.


Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells.

Wang P, Phan T, Gordon D, Chung S, Henning SM, Vadgama JV.

Mol Nutr Food Res. 2015 Feb;59(2):250-61. doi: 10.1002/mnfr.201400558. Epub 2014 Dec 5.


Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells.

Wang P, Wang B, Chung S, Wu Y, Henning SM, Vadgama JV.

RSC Adv. 2014 Aug 5;4(66):35242-35250.


IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion.

Sarkissyan S, Sarkissyan M, Wu Y, Cardenas J, Koeffler HP, Vadgama JV.

PLoS One. 2014 Jul 25;9(7):e103534. doi: 10.1371/journal.pone.0103534. eCollection 2014.


Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice.

Wu Y, Kim J, Elshimali Y, Sarkissyan M, Vadgama JV.

BMC Cancer. 2014 Apr 17;14:266. doi: 10.1186/1471-2407-14-266.


Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants.

Sarkissyan M, Wu Y, Chen Z, Mishra DK, Sarkissyan S, Giannikopoulos I, Vadgama JV.

Cancer. 2014 May 1;120(9):1387-93. doi: 10.1002/cncr.28565. Epub 2014 Feb 7.


Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells.

Chung SS, Aroh C, Vadgama JV.

PLoS One. 2013 Dec 30;8(12):e83971. doi: 10.1371/journal.pone.0083971. eCollection 2013.


Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea.

Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM.

J Nutr Biochem. 2014 Jan;25(1):73-80. doi: 10.1016/j.jnutbio.2013.09.005. Epub 2013 Oct 10.


STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits.

Chung SS, Giehl N, Wu Y, Vadgama JV.

Int J Oncol. 2014 Feb;44(2):403-11. doi: 10.3892/ijo.2013.2195. Epub 2013 Nov 29.


Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN.

Wu Y, Sarkissyan M, Elshimali Y, Vadgama JV.

PLoS One. 2013 Oct 22;8(10):e78259. doi: 10.1371/journal.pone.0078259. eCollection 2013.


The clinical utilization of circulating cell free DNA (CCFDNA) in blood of cancer patients.

Elshimali YI, Khaddour H, Sarkissyan M, Wu Y, Vadgama JV.

Int J Mol Sci. 2013 Sep 13;14(9):18925-58. doi: 10.3390/ijms140918925. Review.


Correlates of perceived risk of developing cancer among African-Americans in South Los Angeles.

Lucas-Wright A, Bazargan M, Jones L, Vadgama JV, Vargas R, Sarkissyan M, Smith J, Yazdanshenas H, Maxwell AE.

J Community Health. 2014 Feb;39(1):173-80. doi: 10.1007/s10900-013-9756-z.


Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women.

Mishra DK, Wu Y, Sarkissyan M, Sarkissyan S, Chen Z, Shang X, Ong M, Heber D, Koeffler HP, Vadgama JV.

PLoS One. 2013;8(3):e57967. doi: 10.1371/journal.pone.0057967. Epub 2013 Mar 12.


Comparing perceived and test-based knowledge of cancer risk and prevention among Hispanic and African Americans: an example of community participatory research.

Jones L, Bazargan M, Lucas-Wright A, Vadgama JV, Vargas R, Smith J, Otoukesh S, Maxwell AE.

Ethn Dis. 2013 Spring;23(2):210-6.


Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells.

Wu Y, Ginther C, Kim J, Mosher N, Chung S, Slamon D, Vadgama JV.

Mol Cancer Res. 2012 Dec;10(12):1597-606. doi: 10.1158/1541-7786.MCR-12-0155-T. Epub 2012 Oct 15.


Expression of FOXO1 is associated with GATA3 and Annexin-1 and predicts disease-free survival in breast cancer.

Wu Y, Elshimali Y, Sarkissyan M, Mohamed H, Clayton S, Vadgama JV.

Am J Cancer Res. 2012;2(1):104-15. Epub 2011 Nov 21.


IGF gene polymorphisms and breast cancer in African-American and Hispanic women.

Sarkissyan M, Mishra DK, Wu Y, Shang X, Sarkissyan S, Vadgama JV.

Int J Oncol. 2011 Jun;38(6):1663-73. doi: 10.3892/ijo.2011.990. Epub 2011 Mar 30.


Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles.

Sarkissyan M, Wu Y, Vadgama JV.

Cancer. 2011 Aug 15;117(16):3814-23. doi: 10.1002/cncr.25956. Epub 2011 Feb 8.


FOXO1A is a target for HER2-overexpressing breast tumors.

Wu Y, Shang X, Sarkissyan M, Slamon D, Vadgama JV.

Cancer Res. 2010 Jul 1;70(13):5475-85. doi: 10.1158/0008-5472.CAN-10-0176. Epub 2010 Jun 15.


Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.

Wu Y, Alvarez M, Slamon DJ, Koeffler P, Vadgama JV.

BMC Cancer. 2010 Feb 4;10:32. doi: 10.1186/1471-2407-10-32.


Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells.

Mishra DK, Chen Z, Wu Y, Sarkissyan M, Koeffler HP, Vadgama JV.

Mol Cancer Ther. 2010 Jan;9(1):33-45. doi: 10.1158/1535-7163.MCT-09-0486. Epub 2010 Jan 6.

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