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Items: 19

1.

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module.

Wang H, Lo WT, Vujičić Žagar A, Gulluni F, Lehmann M, Scapozza L, Haucke V, Vadas O.

Mol Cell. 2018 Jul 19;71(2):343-351.e4. doi: 10.1016/j.molcel.2018.06.042.

2.

A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch.

Lo WT, Vujičić Žagar A, Gerth F, Lehmann M, Puchkov D, Krylova O, Freund C, Scapozza L, Vadas O, Haucke V.

Dev Cell. 2017 Nov 20;43(4):522-529.e4. doi: 10.1016/j.devcel.2017.10.019.

3.

Design and purification of active truncated phosphoinositide 3-kinase gamma protein constructs for structural studies.

Vujičić Žagar A, Scapozza L, Vadas O.

Protein Expr Purif. 2017 Jul;135:1-7. doi: 10.1016/j.pep.2017.04.011. Epub 2017 Apr 22.

PMID:
28442430
4.

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.

Dornan GL, Siempelkamp BD, Jenkins ML, Vadas O, Lucas CL, Burke JE.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1982-1987. doi: 10.1073/pnas.1617244114. Epub 2017 Feb 6.

5.

Using Hydrogen-Deuterium Exchange Mass Spectrometry to Examine Protein-Membrane Interactions.

Vadas O, Jenkins ML, Dornan GL, Burke JE.

Methods Enzymol. 2017;583:143-172. doi: 10.1016/bs.mie.2016.09.008. Epub 2016 Oct 18. Review.

PMID:
28063489
6.

Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS).

Vadas O, Burke JE.

Biochem Soc Trans. 2015 Oct;43(5):773-86. doi: 10.1042/BST20150065. Review.

PMID:
26517882
7.

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B.

Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099.

8.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4.

9.

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S.

Science. 2013 Nov 15;342(6160):866-71. doi: 10.1126/science.1243292. Epub 2013 Oct 17.

10.

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

Dbouk HA, Vadas O, Williams RL, Backer JM.

Oncotarget. 2012 Dec;3(12):1485-6. No abstract available.

11.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.

12.

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Burke JE, Perisic O, Masson GR, Vadas O, Williams RL.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15259-64. Epub 2012 Sep 4.

13.

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases.

Vadas O, Burke JE, Zhang X, Berndt A, Williams RL.

Sci Signal. 2011 Oct 18;4(195):re2. doi: 10.1126/scisignal.2002165. Review.

PMID:
22009150
14.

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.

Burke JE, Vadas O, Berndt A, Finegan T, Perisic O, Williams RL.

Structure. 2011 Aug 10;19(8):1127-37. doi: 10.1016/j.str.2011.06.003.

15.

Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.

Zhang X, Vadas O, Perisic O, Anderson KE, Clark J, Hawkins PT, Stephens LR, Williams RL.

Mol Cell. 2011 Mar 4;41(5):567-78. doi: 10.1016/j.molcel.2011.01.026.

16.

Multimeric peptides as agonists of the erythropoietin receptor.

Vadas O, Rose K.

Adv Exp Med Biol. 2009;611:505-6. No abstract available.

PMID:
19400286
17.

PICarver: a software tool and strategy for peptides isoelectric focusing.

Vaezzadeh AR, Hernandez C, Vadas O, Deshusses JJ, Lescuyer P, Lisacek F, Hochstrasser DF.

J Proteome Res. 2008 Oct;7(10):4336-45. doi: 10.1021/pr8002672. Epub 2008 Sep 11.

PMID:
18783261
18.

Characterization of new multimeric erythropoietin receptor agonists.

Vadas O, Hartley O, Rose K.

Biopolymers. 2008;90(4):496-502. doi: 10.1002/bip.20959.

PMID:
18273892
19.

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