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ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis.

Lay AJ, Coleman PR, Formaz-Preston A, Ting KK, Roediger B, Weninger W, Schwartz MA, Vadas MA, Gamble JR.

J Am Heart Assoc. 2019 Jan 22;8(2):e010057. doi: 10.1161/JAHA.118.010057.


Therapeutic regulation of VE-cadherin with a novel oligonucleotide drug for diabetic eye complications using retinopathy mouse models.

Ting KK, Zhao Y, Shen W, Coleman P, Yam M, Chan-Ling T, Li J, Moller T, Gillies M, Vadas MA, Gamble JR.

Diabetologia. 2019 Feb;62(2):322-334. doi: 10.1007/s00125-018-4770-4. Epub 2018 Nov 15.


Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.

Chen J, Qi Y, Zhao Y, Kaczorowski D, Couttas TA, Coleman PR, Don AS, Bertolino P, Gamble JR, Vadas MA, Xia P, McCaughan GW.

Oncotarget. 2018 Feb 26;9(21):15635-15649. doi: 10.18632/oncotarget.24583. eCollection 2018 Mar 20.


ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype.

Liu R, Lo L, Lay AJ, Zhao Y, Ting KK, Robertson EN, Sherrah AG, Jarrah S, Li H, Zhou Z, Hambly BD, Richmond DR, Jeremy RW, Bannon PG, Vadas MA, Gamble JR.

Circ Res. 2017 Aug 18;121(5):512-524. doi: 10.1161/CIRCRESAHA.117.310692. Epub 2017 Jul 12.


Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell-Mediated Immunotherapy.

Zhao Y, Ting KK, Li J, Cogger VC, Chen J, Johansson-Percival A, Ngiow SF, Holst J, Grau G, Goel S, Muller T, Dejana E, McCaughan G, Smyth MJ, Ganss R, Vadas MA, Gamble JR.

Cancer Res. 2017 Aug 15;77(16):4434-4447. doi: 10.1158/0008-5472.CAN-16-3129. Epub 2017 Jun 27. Erratum in: Cancer Res. 2018 Oct 1;78(19):5718.


The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.

Lovelace MD, Powter EE, Coleman PR, Zhao Y, Parker A, Chang GH, Lay AJ, Hunter J, McGrath AP, Jormakka M, Bertolino P, McCaughan G, Kavallaris M, Vadas MA, Gamble JR.

Mol Biol Cell. 2017 Apr 15;28(8):1066-1078. doi: 10.1091/mbc.E16-05-0285. Epub 2017 Mar 1.


The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b.

Li J, Zhao Y, Lu Y, Ritchie W, Grau G, Vadas MA, Gamble JR.

Mol Ther Nucleic Acids. 2016 Aug 23;5(8):e354. doi: 10.1038/mtna.2016.62.


Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.

Chen J, Wang W, Qi Y, Kaczorowski D, McCaughan GW, Gamble JR, Don AS, Gao X, Vadas MA, Xia P.

Biochim Biophys Acta. 2016 Feb;1861(2):138-147. doi: 10.1016/j.bbalip.2015.11.006. Epub 2015 Nov 23.


ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.

Chang GH, Lay AJ, Ting KK, Zhao Y, Coleman PR, Powter EE, Formaz-Preston A, Jolly CJ, Bower NI, Hogan BM, Rinkwitz S, Becker TS, Vadas MA, Gamble JR.

Small GTPases. 2014;5(3):1-15. doi: 10.4161/21541248.2014.975002.


Caveolae control the anti-inflammatory phenotype of senescent endothelial cells.

Powter EE, Coleman PR, Tran MH, Lay AJ, Bertolino P, Parton RG, Vadas MA, Gamble JR.

Aging Cell. 2015 Feb;14(1):102-11. doi: 10.1111/acel.12270. Epub 2014 Nov 19.


miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer.

Brockhausen J, Tay SS, Grzelak CA, Bertolino P, Bowen DG, d'Avigdor WM, Teoh N, Pok S, Shackel N, Gamble JR, Vadas M, McCaughan GW.

Liver Int. 2015 Jan;35(1):240-53. doi: 10.1111/liv.12517. Epub 2014 Apr 30.


Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells.

Coleman PR, Chang G, Hutas G, Grimshaw M, Vadas MA, Gamble JR.

Aging (Albany NY). 2013 Dec;5(12):913-24.


Beyond liver fibrosis: hepatic stellate cell senescence links obesity to liver cancer by way of the microbiome.

Shackel NA, Vadas MA, Gamble JR, McCaughan GW.

Hepatology. 2014 Jun;59(6):2413-5. doi: 10.1002/hep.26932. Epub 2014 Apr 9. No abstract available.


Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27.

Young JA, Ting KK, Li J, Moller T, Dunn L, Lu Y, Moses J, Prado-Lourenço L, Khachigian LM, Ng M, Gregory PA, Goodall GJ, Tsykin A, Lichtenstein I, Hahn CN, Tran N, Shackel N, Kench JG, McCaughan G, Vadas MA, Gamble JR.

Blood. 2013 Oct 17;122(16):2911-9. doi: 10.1182/blood-2012-12-473017. Epub 2013 Sep 5. Erratum in: Blood. 2014 Nov 6;124(19):3034.


Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice.

Qi Y, Chen J, Lay A, Don A, Vadas M, Xia P.

FASEB J. 2013 Oct;27(10):4294-304. doi: 10.1096/fj.13-230052. Epub 2013 Jul 9.


Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies.

Lichtenstein I, Charleston MA, Caetano TS, Gamble JR, Vadas MA.

BMC Bioinformatics. 2013 Feb 21;14:59. doi: 10.1186/1471-2105-14-59.


Sinusoidal endothelium is essential for liver regeneration.

Gamble J, Vadas M, McCaughan G.

Hepatology. 2011 Aug;54(2):731-3. doi: 10.1002/hep.24455. No abstract available.


A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration.

Williams SL, Milne IR, Bagley CJ, Gamble JR, Vadas MA, Pitson SM, Khew-Goodall Y.

J Immunol. 2010 Sep 1;185(5):3057-63. doi: 10.4049/jimmunol.1000119. Epub 2010 Aug 2.


Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.

Coleman PR, Hahn CN, Grimshaw M, Lu Y, Li X, Brautigan PJ, Beck K, Stocker R, Vadas MA, Gamble JR.

Blood. 2010 Nov 11;116(19):4016-24. doi: 10.1182/blood-2009-11-252700. Epub 2010 Jul 27.


Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival.

Gamble JR, Sun WY, Li X, Hahn CN, Pitson SM, Vadas MA, Bonder CS.

Am J Pathol. 2009 Nov;175(5):2217-25. doi: 10.2353/ajpath.2009.090076. Epub 2009 Oct 8.


Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway.

Sukocheva O, Wang L, Verrier E, Vadas MA, Xia P.

Endocrinology. 2009 Oct;150(10):4484-92. doi: 10.1210/en.2009-0391. Epub 2009 Aug 25.


JAM-C induces endothelial cell permeability through its association and regulation of {beta}3 integrins.

Li X, Stankovic M, Lee BP, Aurrand-Lions M, Hahn CN, Lu Y, Imhof BA, Vadas MA, Gamble JR.

Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1200-6. doi: 10.1161/ATVBAHA.109.189217. Epub 2009 May 21.


The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells.

Limaye V, Vadas MA, Pitson SM, Gamble JR.

Cell Mol Biol Lett. 2009;14(3):411-23. doi: 10.2478/s11658-009-0008-2. Epub 2009 Feb 23.


Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells.

Limaye V, Xia P, Hahn C, Smith M, Vadas MA, Pitson SM, Gamble JR.

Cell Mol Biol Lett. 2009;14(3):424-41. doi: 10.2478/s11658-009-0009-1. Epub 2009 Feb 23.


Insights into defibrotide as therapy for veno-occlusive disease.

Gamble JR, Vadas MA.

Hepatology. 2009 Feb;49(2):689-90. doi: 10.1002/hep.22770. No abstract available.


Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation.

Bonder CS, Sun WY, Matthews T, Cassano C, Li X, Ramshaw HS, Pitson SM, Lopez AF, Coates PT, Proia RL, Vadas MA, Gamble JR.

Blood. 2009 Feb 26;113(9):2108-17. doi: 10.1182/blood-2008-07-166942. Epub 2008 Dec 24.


The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.

Zebol JR, Hewitt NM, Moretti PA, Lynn HE, Lake JA, Li P, Vadas MA, Wattenberg BW, Pitson SM.

Int J Biochem Cell Biol. 2009 Apr;41(4):822-7. doi: 10.1016/j.biocel.2008.08.012. Epub 2008 Aug 14.


The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?

Vadas M, Xia P, McCaughan G, Gamble J.

Biochim Biophys Acta. 2008 Sep;1781(9):442-7. doi: 10.1016/j.bbalip.2008.06.007. Epub 2008 Jun 27. Review.


The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.

Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ.

Nat Cell Biol. 2008 May;10(5):593-601. doi: 10.1038/ncb1722. Epub 2008 Mar 30.


Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.

Leclercq TM, Moretti PA, Vadas MA, Pitson SM.

J Biol Chem. 2008 Apr 11;283(15):9606-14. doi: 10.1074/jbc.M708782200. Epub 2008 Feb 8.


Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1.

Li X, Stankovic M, Bonder CS, Hahn CN, Parsons M, Pitson SM, Xia P, Proia RL, Vadas MA, Gamble JR.

Blood. 2008 Apr 1;111(7):3489-97. doi: 10.1182/blood-2007-05-092148. Epub 2008 Jan 16.


Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway.

Soldi R, Mandinova A, Venkataraman K, Hla T, Vadas M, Pitson S, Duarte M, Graziani I, Kolev V, Kacer D, Kirov A, Maciag T, Prudovsky I.

Exp Cell Res. 2007 Sep 10;313(15):3308-18. Epub 2007 Jul 6.


Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures.

Hissaria P, Smith W, Wormald PJ, Taylor J, Vadas M, Gillis D, Kette F.

J Allergy Clin Immunol. 2006 Jul;118(1):128-33. Epub 2006 May 19.


Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.

Sukocheva O, Wadham C, Holmes A, Albanese N, Verrier E, Feng F, Bernal A, Derian CK, Ullrich A, Vadas MA, Xia P.

J Cell Biol. 2006 Apr 24;173(2):301-10.


Assessing IRES activity in the HIF-1alpha and other cellular 5' UTRs.

Bert AG, Grépin R, Vadas MA, Goodall GJ.

RNA. 2006 Jun;12(6):1074-83. Epub 2006 Apr 6.


The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities.

Autelitano DJ, Rajic A, Smith AI, Berndt MC, Ilag LL, Vadas M.

Drug Discov Today. 2006 Apr;11(7-8):306-14. Review.


The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane.

Sutherland CM, Moretti PA, Hewitt NM, Bagley CJ, Vadas MA, Pitson SM.

J Biol Chem. 2006 Apr 28;281(17):11693-701. Epub 2006 Mar 6.


Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects.

Gamble JR, Xia P, Hahn CN, Drew JJ, Drogemuller CJ, Brown D, Vadas MA.

Int J Cancer. 2006 May 15;118(10):2412-20.


Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3beta and repression of the human VEGF promoter.

Coles LS, Lambrusco L, Burrows J, Hunter J, Diamond P, Bert AG, Vadas MA, Goodall GJ.

FEBS Lett. 2005 Oct 10;579(24):5372-8. Epub 2005 Sep 20.


Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells.

Wang L, Xing XP, Holmes A, Wadham C, Gamble JR, Vadas MA, Xia P.

Circ Res. 2005 Oct 28;97(9):891-9. Epub 2005 Sep 22.


Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis.

Hahn CN, Su ZJ, Drogemuller CJ, Tsykin A, Waterman SR, Brautigan PJ, Yu S, Kremmidiotis G, Gardner A, Solomon PJ, Goodall GJ, Vadas MA, Gamble JR.

Physiol Genomics. 2005 Jun 16;22(1):57-69. Epub 2005 Apr 19.


Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members.

Limaye V, Li X, Hahn C, Xia P, Berndt MC, Vadas MA, Gamble JR.

Blood. 2005 Apr 15;105(8):3169-77. Epub 2005 Jan 4.


Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling.

Pitson SM, Xia P, Leclercq TM, Moretti PA, Zebol JR, Lynn HE, Wattenberg BW, Vadas MA.

J Exp Med. 2005 Jan 3;201(1):49-54. Epub 2004 Dec 28.


A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis.

Su ZJ, Hahn CN, Goodall GJ, Reck NM, Leske AF, Davy A, Kremmidiotis G, Vadas MA, Gamble JR.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12212-7. Epub 2004 Aug 9.


An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes.

Roberts JL, Moretti PA, Darrow AL, Derian CK, Vadas MA, Pitson SM.

Anal Biochem. 2004 Aug 1;331(1):122-9.


Regulation of haematopoiesis by growth factors - emerging insights and therapies.

Thomas D, Vadas M, Lopez A.

Expert Opin Biol Ther. 2004 Jun;4(6):869-79. Review.


Role of protein kinase Czeta in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1.

Li X, Hahn CN, Parsons M, Drew J, Vadas MA, Gamble JR.

Blood. 2004 Sep 15;104(6):1716-24. Epub 2004 Jun 1.


PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase.

Verrier E, Wang L, Wadham C, Albanese N, Hahn C, Gamble JR, Chatterjee VK, Vadas MA, Xia P.

Circ Res. 2004 Jun 11;94(11):1515-22. Epub 2004 Apr 29.


High-density lipoproteins neutralize C-reactive protein proinflammatory activity.

Wadham C, Albanese N, Roberts J, Wang L, Bagley CJ, Gamble JR, Rye KA, Barter PJ, Vadas MA, Xia P.

Circulation. 2004 May 4;109(17):2116-22. Epub 2004 Apr 12.


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