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Items: 1 to 50 of 145

1.

Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire.

Pollastro S, Klarenbeek PL, Doorenspleet ME, van Schaik BDC, Esveldt REE, Thurlings RM, Boumans MJH, Gerlag DM, Tak PP, Vos K, Baas F, van Kampen AHC, de Vries N.

Ann Rheum Dis. 2019 Jun 19. pii: annrheumdis-2018-214898. doi: 10.1136/annrheumdis-2018-214898. [Epub ahead of print]

2.

Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability.

Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, Gossye H, De Vos K, De Coster W, Strazisar M, De Baets G, Schymkowitz J, Rousseau F, Geerts N, De Pooter T, Peeters K, Sieben A, Martin JJ, Engelborghs S, Salmon E, Santens P, Vandenberghe R, Cras P, P De Deyn P, C van Swieten J, M van Duijn C, van der Zee J, Sleegers K, Van Broeckhoven C; BELNEU Consortium.

Acta Neuropathol. 2019 Jun;137(6):901-918. doi: 10.1007/s00401-019-01976-3. Epub 2019 Mar 14.

3.

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.

Allen SP, Hall B, Castelli LM, Francis L, Woof R, Siskos AP, Kouloura E, Gray E, Thompson AG, Talbot K, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Hemingway J, Bauer CS, Webster CP, De Vos KJ, Turner MR, Keun HC, Hautbergue GM, Ferraiuolo L, Shaw PJ.

Brain. 2019 Mar 1;142(3):586-605. doi: 10.1093/brain/awy353.

4.

Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas.

Reis H, van der Vos KE, Niedworok C, Herold T, Módos O, Szendrői A, Hager T, Ingenwerth M, Vis DJ, Behrendt MA, de Jong J, van der Heijden MS, Peyronnet B, Mathieu R, Wiesweg M, Ablat J, Okon K, Tolkach Y, Keresztes D, Nagy N, Bremmer F, Gaisa NT, Chlosta P, Kriegsmann J, Kovalszky I, Timar J, Kristiansen G, Radzun HJ, Knüchel R, Schuler M, Black PC, Rübben H, Hadaschik BA, Schmid KW, van Rhijn BWG, Nyirády P, Szarvas T.

Int J Cancer. 2018 Apr 19. doi: 10.1002/ijc.31547. [Epub ahead of print]

5.

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.

Reátegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL.

Nat Commun. 2018 Jan 12;9(1):175. doi: 10.1038/s41467-017-02261-1.

6.

Exploring B π π , π K decays at the high-precision frontier.

Fleischer R, Jaarsma R, Malami E, Vos KK.

Eur Phys J C Part Fields. 2018;78(11):943. doi: 10.1140/epjc/s10052-018-6397-5. Epub 2018 Nov 16.

7.

Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.

Moller A, Bauer CS, Cohen RN, Webster CP, De Vos KJ.

Hum Mol Genet. 2017 Dec 1;26(23):4668-4679. doi: 10.1093/hmg/ddx348.

8.

Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer.

Patel KM, van der Vos KE, Smith CG, Mouliere F, Tsui D, Morris J, Chandrananda D, Marass F, van den Broek D, Neal DE, Gnanapragasam VJ, Forshew T, van Rhijn BW, Massie CE, Rosenfeld N, van der Heijden MS.

Sci Rep. 2017 Jul 17;7(1):5554. doi: 10.1038/s41598-017-05623-3.

9.

C9orf72 expansion disrupts ATM-mediated chromosomal break repair.

Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Elsayed W, Lukashchuk V, Chiang SC, Ray S, Mulcahy PJ, Jurga M, Tsagakis I, Iannitti T, Chandran J, Coldicott I, De Vos KJ, Hassan MK, Higginbottom A, Shaw PJ, Hautbergue GM, Azzouz M, El-Khamisy SF.

Nat Neurosci. 2017 Sep;20(9):1225-1235. doi: 10.1038/nn.4604. Epub 2017 Jul 17.

10.

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

Hautbergue GM, Castelli LM, Ferraiuolo L, Sanchez-Martinez A, Cooper-Knock J, Higginbottom A, Lin YH, Bauer CS, Dodd JE, Myszczynska MA, Alam SM, Garneret P, Chandran JS, Karyka E, Stopford MJ, Smith EF, Kirby J, Meyer K, Kaspar BK, Isaacs AM, El-Khamisy SF, De Vos KJ, Ning K, Azzouz M, Whitworth AJ, Shaw PJ.

Nat Commun. 2017 Jul 5;8:16063. doi: 10.1038/ncomms16063.

11.

The role of mitochondria in amyotrophic lateral sclerosis.

Smith EF, Shaw PJ, De Vos KJ.

Neurosci Lett. 2017 Jun 30. pii: S0304-3940(17)30544-X. doi: 10.1016/j.neulet.2017.06.052. [Epub ahead of print] Review.

12.

MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy.

Vos K, Sciuto CL, Piedade R, Ashton M, Björkman A, Ngasala B, Mårtensson A, Gil JP.

Pharmacogenomics. 2017 Jul;18(10):981-985. doi: 10.2217/pgs-2017-0032. Epub 2017 Jun 22.

PMID:
28639487
13.

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

Webster CP, Smith EF, Shaw PJ, De Vos KJ.

Front Mol Neurosci. 2017 May 2;10:123. doi: 10.3389/fnmol.2017.00123. eCollection 2017. Review.

14.

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

De Vos KJ, Hafezparast M.

Neurobiol Dis. 2017 Sep;105:283-299. doi: 10.1016/j.nbd.2017.02.004. Epub 2017 Feb 22. Review.

15.

C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.

Stopford MJ, Higginbottom A, Hautbergue GM, Cooper-Knock J, Mulcahy PJ, De Vos KJ, Renton AE, Pliner H, Calvo A, Chio A, Traynor BJ, Azzouz M, Heath PR; ITALSGEN Consortium, NeuroX Consortium, Kirby J, Shaw PJ.

Hum Mol Genet. 2017 Mar 15;26(6):1133-1145. doi: 10.1093/hmg/ddx022.

16.

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy.

Webster CP, Smith EF, Grierson AJ, De Vos KJ.

Small GTPases. 2018 Sep 3;9(5):399-408. doi: 10.1080/21541248.2016.1240495. Epub 2016 Oct 21. Review.

17.

Toward a Self-Updating Platform for Estimating Rates of Speciation and Migration, Ages, and Relationships of Taxa.

Antonelli A, Hettling H, Condamine FL, Vos K, Nilsson RH, Sanderson MJ, Sauquet H, Scharn R, Silvestro D, Töpel M, Bacon CD, Oxelman B, Vos RA.

Syst Biol. 2017 Mar 1;66(2):152-166. doi: 10.1093/sysbio/syw066.

18.

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

Stoica R, Paillusson S, Gomez-Suaga P, Mitchell JC, Lau DH, Gray EH, Sancho RM, Vizcay-Barrena G, De Vos KJ, Shaw CE, Hanger DP, Noble W, Miller CC.

EMBO Rep. 2016 Sep;17(9):1326-42. doi: 10.15252/embr.201541726. Epub 2016 Jul 14.

19.

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.

Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ.

EMBO J. 2016 Aug 1;35(15):1656-76. doi: 10.15252/embj.201694401. Epub 2016 Jun 22.

20.

Toward Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving.

Pauli GF, Niemitz M, Bisson J, Lodewyk MW, Soldi C, Shaw JT, Tantillo DJ, Saya JM, Vos K, Kleinnijenhuis RA, Hiemstra H, Chen SN, McAlpine JB, Lankin DC, Friesen JB.

J Org Chem. 2016 Feb 5;81(3):878-89. doi: 10.1021/acs.joc.5b02456. Epub 2016 Jan 26.

21.

Distinction between coordination and phosphine ligand oxidation: interactions of di- and triphosphines with Pn(3+) (Pn = P, As, Sb, Bi).

Chitnis SS, Vos KA, Burford N, McDonald R, Ferguson MJ.

Chem Commun (Camb). 2016 Jan 14;52(4):685-8. doi: 10.1039/c5cc08086j.

PMID:
26569099
22.

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.

Rodríguez-Martín T, Pooler AM, Lau DHW, Mórotz GM, De Vos KJ, Gilley J, Coleman MP, Hanger DP.

Neurobiol Dis. 2016 Jan;85:1-10. doi: 10.1016/j.nbd.2015.10.007. Epub 2015 Oct 11.

23.

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.

van der Vos KE, Abels ER, Zhang X, Lai C, Carrizosa E, Oakley D, Prabhakar S, Mardini O, Crommentuijn MH, Skog J, Krichevsky AM, Stemmer-Rachamimov A, Mempel TR, El Khoury J, Hickman SE, Breakefield XO.

Neuro Oncol. 2016 Jan;18(1):58-69. doi: 10.1093/neuonc/nov244. Epub 2015 Oct 3.

24.

Intra-articular etanercept treatment in inflammatory arthritis: A randomized double-blind placebo-controlled proof of mechanism clinical trial validating TNF as a potential therapeutic target for local treatment.

Aalbers C, Gerlag D, Vos K, Vervoordeldonk M, Landewé R, Tak PP.

Joint Bone Spine. 2015 Oct;82(5):338-44. doi: 10.1016/j.jbspin.2015.03.002. Epub 2015 Jul 15.

PMID:
26188879
25.

Total Synthesis of Aquatolide.

Saya JM, Vos K, Kleinnijenhuis RA, van Maarseveen JH, Ingemann S, Hiemstra H.

Org Lett. 2015 Aug 7;17(15):3892-4. doi: 10.1021/acs.orglett.5b01888. Epub 2015 Jul 17.

PMID:
26186274
26.

Emerging roles of extracellular vesicles in the nervous system.

Rajendran L, Bali J, Barr MM, Court FA, Krämer-Albers EM, Picou F, Raposo G, van der Vos KE, van Niel G, Wang J, Breakefield XO.

J Neurosci. 2014 Nov 12;34(46):15482-9. doi: 10.1523/JNEUROSCI.3258-14.2014. Review.

27.

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.

Godena VK, Brookes-Hocking N, Moller A, Shaw G, Oswald M, Sancho RM, Miller CC, Whitworth AJ, De Vos KJ.

Nat Commun. 2014 Oct 15;5:5245. doi: 10.1038/ncomms6245.

28.

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J, Dickson DW, Petrucelli L, Mitchell JC, Shaw CE, Miller CC.

Nat Commun. 2014 Jun 3;5:3996. doi: 10.1038/ncomms4996.

29.

Extracellular RNA mediates and marks cancer progression.

Redzic JS, Balaj L, van der Vos KE, Breakefield XO.

Semin Cancer Biol. 2014 Oct;28:14-23. doi: 10.1016/j.semcancer.2014.04.010. Epub 2014 Apr 28. Review.

30.

The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.

Coomans de Brachène A, Bollaert E, Eijkelenboom A, de Rocca Serra A, van der Vos KE, Burgering BM, Coffer PJ, Essaghir A, Demoulin JB.

Biochem J. 2014 May 15;460(1):25-34. doi: 10.1042/BJ20131467.

PMID:
24762137
31.

Bilateral tension pneumothorax following equipment improvisation.

Zambricki C, Schmidt C, Vos K.

AANA J. 2014 Feb;82(1):20-4.

PMID:
24654348
32.

Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.

Chapman AL, Bennett EJ, Ramesh TM, De Vos KJ, Grierson AJ.

PLoS One. 2013 Jun 26;8(6):e67276. doi: 10.1371/journal.pone.0067276. Print 2013.

33.

FOXP1 acts through a negative feedback loop to suppress FOXO-induced apoptosis.

van Boxtel R, Gomez-Puerto C, Mokry M, Eijkelenboom A, van der Vos KE, Nieuwenhuis EE, Burgering BM, Lam EW, Coffer PJ.

Cell Death Differ. 2013 Sep;20(9):1219-29. doi: 10.1038/cdd.2013.81. Epub 2013 Jul 5.

34.

Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis.

Strang AC, Bisoendial RJ, Kootte RS, Schulte DM, Dallinga-Thie GM, Levels JH, Kok M, Vos K, Tas SW, Tietge UJ, Müller N, Laudes M, Gerlag DM, Stroes ES, Tak PP.

Atherosclerosis. 2013 Jul;229(1):174-81. doi: 10.1016/j.atherosclerosis.2013.04.031. Epub 2013 May 11.

PMID:
23746537
35.

Progression of structural damage is not related to rituximab serum levels in rheumatoid arthritis patients.

Boumans M, Teng O, Thurlings R, Bijlsma J, Gerlag D, Huizinga T, Vos K, Stapel S, Wolbink G, Tekstra J, van Laar J, Tak PP.

Rheumatology (Oxford). 2013 Aug;52(8):1462-6. doi: 10.1093/rheumatology/ket137. Epub 2013 Apr 24.

PMID:
23620560
36.

Efficacy and safety of adalimumab for the treatment of peripheral arthritis in spondyloarthritis patients without ankylosing spondylitis or psoriatic arthritis.

Paramarta JE, De Rycke L, Heijda TF, Ambarus CA, Vos K, Dinant HJ, Tak PP, Baeten DL.

Ann Rheum Dis. 2013 Nov;72(11):1793-9. doi: 10.1136/annrheumdis-2012-202245. Epub 2012 Nov 8.

PMID:
23139265
37.

Glutamine metabolism links growth factor signaling to the regulation of autophagy.

van der Vos KE, Coffer PJ.

Autophagy. 2012 Dec;8(12):1862-4. doi: 10.4161/auto.22152. Epub 2012 Sep 20.

38.

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, Verhagen LP, Groot Koerkamp MJ, Braat AK, Dansen TB, Holstege FC, Gebhardt R, Burgering BM, Coffer PJ.

Nat Cell Biol. 2012 Aug;14(8):829-37. doi: 10.1038/ncb2536. Epub 2012 Jul 22.

PMID:
22820375
39.

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.

Mórotz GM, De Vos KJ, Vagnoni A, Ackerley S, Shaw CE, Miller CC.

Hum Mol Genet. 2012 May 1;21(9):1979-88. doi: 10.1093/hmg/dds011. Epub 2012 Jan 17.

40.

Esomeprazole relieves upper gastrointestinal symptoms in high-risk and average-risk NSAID users in daily clinical practice: results from an open-label study.

Tielemans MM, van Oijen MG, Mulder CJ, Vos KJ, Lems WF.

Eur J Gastroenterol Hepatol. 2012 Mar;24(3):281-7. doi: 10.1097/MEG.0b013e32834f4d19.

PMID:
22246328
41.

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.

De Vos KJ, Mórotz GM, Stoica R, Tudor EL, Lau KF, Ackerley S, Warley A, Shaw CE, Miller CC.

Hum Mol Genet. 2012 Mar 15;21(6):1299-311. doi: 10.1093/hmg/ddr559. Epub 2011 Nov 30.

42.

Regulation of autophagy by Forkhead box (FOX) O transcription factors.

van der Vos KE, Gomez-Puerto C, Coffer PJ.

Adv Biol Regul. 2012 Jan;52(1):122-36. Review. No abstract available.

PMID:
22115564
43.

Rituximab abrogates joint destruction in rheumatoid arthritis by inhibiting osteoclastogenesis.

Boumans MJ, Thurlings RM, Yeo L, Scheel-Toellner D, Vos K, Gerlag DM, Tak PP.

Ann Rheum Dis. 2012 Jan;71(1):108-13. doi: 10.1136/annrheumdis-2011-200198. Epub 2011 Nov 8.

PMID:
22072013
44.

Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.

Manser C, Guillot F, Vagnoni A, Davies J, Lau KF, McLoughlin DM, De Vos KJ, Miller CC.

Oncogene. 2012 May 31;31(22):2773-82. doi: 10.1038/onc.2011.437. Epub 2011 Sep 26.

45.

A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function.

Sargsyan SA, Blackburn DJ, Barber SC, Grosskreutz J, De Vos KJ, Monk PN, Shaw PJ.

BMC Neurosci. 2011 Sep 23;12:91. doi: 10.1186/1471-2202-12-91.

46.

Biological treatment of rheumatoid arthritis: towards a more cost-effective re-treatment regimen using rituximab?

Boumans MJ, Vos K, Gerlag DM, Tak PP.

Ann Rheum Dis. 2012 Mar;71(3):472-3. doi: 10.1136/annrheumdis-2011-200370. Epub 2011 Sep 8. No abstract available.

PMID:
21908451
47.

Response to rituximab in patients with rheumatoid arthritis in different compartments of the immune system.

Boumans MJ, Thurlings RM, Gerlag DM, Vos K, Tak PP.

Arthritis Rheum. 2011 Nov;63(11):3187-94. doi: 10.1002/art.30567. Review. No abstract available.

48.

A model of competing saturable kinetic processes with application to the pharmacokinetics of the anticancer drug paclitaxel.

Marsh RE, Tuszyński JA, Sawyer M, Vos KJ.

Math Biosci Eng. 2011 Apr;8(2):325-54. doi: 10.3934/mbe.2011.8.325.

49.

Brain tumor microvesicles: insights into intercellular communication in the nervous system.

van der Vos KE, Balaj L, Skog J, Breakefield XO.

Cell Mol Neurobiol. 2011 Aug;31(6):949-59. doi: 10.1007/s10571-011-9697-y. Epub 2011 May 8. Review.

50.

Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.

Vagnoni A, Rodriguez L, Manser C, De Vos KJ, Miller CC.

J Cell Sci. 2011 Apr 1;124(Pt 7):1032-42. doi: 10.1242/jcs.075168. Epub 2011 Mar 8.

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