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Items: 47

1.

BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells.

Hollingsworth J, Lau A, Tone A, Kollara A, Allen L, Colgan TJ, Dube V, Rosen B, Murphy KJ, Greenblatt EM, Feigenberg T, Virtanen C, Brown TJ.

Neoplasia. 2018 Jul;20(7):697-709. doi: 10.1016/j.neo.2018.05.005. Epub 2018 May 28.

2.

Gene expression signatures prognostic for relapse in stage I testicular germ cell tumours.

Lewin J, Soltan Ghoraie L, Bedard PL, Hamilton RJ, Chung P, Moore M, Jewett MAS, Anson-Cartwright L, Virtanen C, Winegarden N, Tsao J, Warde P, Sweet J, Haibe-Kains B, Hansen AR.

BJU Int. 2018 Nov;122(5):814-822. doi: 10.1111/bju.14372. Epub 2018 May 31.

PMID:
29726090
3.

A Genomically Characterized Collection of High-Grade Serous Ovarian Cancer Xenografts for Preclinical Testing.

Cybulska P, Stewart JM, Sayad A, Virtanen C, Shaw PA, Clarke B, Stickle N, Bernardini MQ, Neel BG.

Am J Pathol. 2018 May;188(5):1120-1131. doi: 10.1016/j.ajpath.2018.01.019. Epub 2018 Feb 16.

PMID:
29458007
4.

Exome-Wide Association Study of Pancreatic Cancer Risk.

Grant RC, Denroche RE, Borgida A, Virtanen C, Cook N, Smith AL, Connor AA, Wilson JM, Peterson G, Roberts NJ, Klein AP, Grimmond SM, Biankin A, Cleary S, Moore M, Lemire M, Zogopoulos G, Stein L, Gallinger S.

Gastroenterology. 2018 Feb;154(3):719-722.e3. doi: 10.1053/j.gastro.2017.10.015. Epub 2017 Oct 24.

PMID:
29074453
5.

SHP2 is required for BCR-ABL1-induced hematologic neoplasia.

Gu S, Sayad A, Chan G, Yang W, Lu Z, Virtanen C, Van Etten RA, Neel BG.

Leukemia. 2018 Jan;32(1):203-213. doi: 10.1038/leu.2017.250. Epub 2017 Aug 14.

6.

SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.

Kim BR, Van de Laar E, Cabanero M, Tarumi S, Hasenoeder S, Wang D, Virtanen C, Suzuki T, Bandarchi B, Sakashita S, Pham NA, Lee S, Keshavjee S, Waddell TK, Tsao MS, Moghal N.

PLoS Biol. 2016 Nov 23;14(11):e1002581. doi: 10.1371/journal.pbio.1002581. eCollection 2016 Nov.

7.

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.

Stockley TL, Oza AM, Berman HK, Leighl NB, Knox JJ, Shepherd FA, Chen EX, Krzyzanowska MK, Dhani N, Joshua AM, Tsao MS, Serra S, Clarke B, Roehrl MH, Zhang T, Sukhai MA, Califaretti N, Trinkaus M, Shaw P, van der Kwast T, Wang L, Virtanen C, Kim RH, Razak AR, Hansen AR, Yu C, Pugh TJ, Kamel-Reid S, Siu LL, Bedard PL.

Genome Med. 2016 Oct 25;8(1):109.

8.

Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer.

Greenaway JB, Virtanen C, Osz K, Revay T, Hardy D, Shepherd T, DiMattia G, Petrik J.

Oncotarget. 2016 Jul 26;7(30):47343-47365. doi: 10.18632/oncotarget.10121.

9.

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.

Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.

Nat Cell Biol. 2016 Jul;18(7):803-813. doi: 10.1038/ncb3376. Epub 2016 Jun 20.

10.

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.

Gu S, Chan WW, Mohi G, Rosenbaum J, Sayad A, Lu Z, Virtanen C, Li S, Neel BG, Van Etten RA.

Blood. 2016 Apr 7;127(14):1803-13. doi: 10.1182/blood-2015-06-653006. Epub 2016 Jan 15.

11.

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.

Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Reimand J, Haider M, Virtanen C, Bradner JE, Bader GD, Mills GB, Pe'er D, Moffat J, Neel BG.

Cell. 2016 Jan 14;164(1-2):293-309. doi: 10.1016/j.cell.2015.11.062.

12.

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.

Cordeddu V, Yin JC, Gunnarsson C, Virtanen C, Drunat S, Lepri F, De Luca A, Rossi C, Ciolfi A, Pugh TJ, Bruselles A, Priest JR, Pennacchio LA, Lu Z, Danesh A, Quevedo R, Hamid A, Martinelli S, Pantaleoni F, Gnazzo M, Daniele P, Lissewski C, Bocchinfuso G, Stella L, Odent S, Philip N, Faivre L, Vlckova M, Seemanova E, Digilio C, Zenker M, Zampino G, Verloes A, Dallapiccola B, Roberts AE, Cavé H, Gelb BD, Neel BG, Tartaglia M.

Hum Mutat. 2015 Nov;36(11):1080-7. doi: 10.1002/humu.22834. Epub 2015 Aug 3.

13.

Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling.

Shathasivam P, Kollara A, Ringuette MJ, Virtanen C, Wrana JL, Brown TJ.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3000-9. doi: 10.1073/pnas.1504671112. Epub 2015 May 26.

14.

ABC: a tool to identify SNVs causing allele-specific transcription factor binding from ChIP-Seq experiments.

Bailey SD, Virtanen C, Haibe-Kains B, Lupien M.

Bioinformatics. 2015 Sep 15;31(18):3057-9. doi: 10.1093/bioinformatics/btv321. Epub 2015 May 20.

15.

Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG-island amplification coupled with CpG-island microarray.

Huntriss J, Hemmings K, Baskaran P, Hazelwood L, Elder K, Virtanen C, Miller D, Picton HM.

Fertil Steril. 2015 Jun;103(6):1566-71.e1-4. doi: 10.1016/j.fertnstert.2015.03.020. Epub 2015 Apr 22.

16.

Gene expression differences between psoriasis patients with and without inflammatory arthritis.

Pollock RA, Abji F, Liang K, Chandran V, Pellett FJ, Virtanen C, Gladman DD.

J Invest Dermatol. 2015 Feb;135(2):620-623. doi: 10.1038/jid.2014.414. Epub 2014 Sep 22. No abstract available.

17.

Molecular profiling and clinical outcome of high-grade serous ovarian cancer presenting with low- versus high-volume ascites.

Feigenberg T, Clarke B, Virtanen C, Plotkin A, Letarte M, Rosen B, Bernardini MQ, Kollara A, Brown TJ, Murphy KJ.

Biomed Res Int. 2014;2014:367103. doi: 10.1155/2014/367103. Epub 2014 May 25.

18.

Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis.

Lau A, Kollara A, St John E, Tone AA, Virtanen C, Greenblatt EM, King WA, Brown TJ.

Exp Biol Med (Maywood). 2014 Jan;239(1):24-32. doi: 10.1177/1535370213508216. Epub 2013 Nov 1.

PMID:
24186266
19.

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Kaanta AS, Virtanen C, Selfors LM, Brugge JS, Neel BG.

Breast Cancer Res. 2013;15(4):R65.

20.

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes.

Ogawa S, Surapisitchat J, Virtanen C, Ogawa M, Niapour M, Sugamori KS, Wang S, Tamblyn L, Guillemette C, Hoffmann E, Zhao B, Strom S, Laposa RR, Tyndale RF, Grant DM, Keller G.

Development. 2013 Aug;140(15):3285-96. doi: 10.1242/dev.090266.

21.

Discovery of biomarkers of endometrial receptivity through a minimally invasive approach: a validation study with implications for assisted reproduction.

Chan C, Virtanen C, Winegarden NA, Colgan TJ, Brown TJ, Greenblatt EM.

Fertil Steril. 2013 Sep;100(3):810-7. doi: 10.1016/j.fertnstert.2013.04.047. Epub 2013 May 30.

PMID:
23725802
22.

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.

Brüstle A, Brenner D, Knobbe CB, Lang PA, Virtanen C, Hershenfield BM, Reardon C, Lacher SM, Ruland J, Ohashi PS, Mak TW.

J Clin Invest. 2012 Dec;122(12):4698-709. doi: 10.1172/JCI63528. Epub 2012 Nov 1.

23.

MicroRNA expression profiling of esophageal cancer before and after induction chemoradiotherapy.

Ko MA, Zehong G, Virtanen C, Guindi M, Waddell TK, Keshavjee S, Darling GE.

Ann Thorac Surg. 2012 Oct;94(4):1094-102; discussion 1102-3. doi: 10.1016/j.athoracsur.2012.04.145. Epub 2012 Aug 29.

PMID:
22939244
24.

In vivo optical imaging of tumor and microvascular response to ionizing radiation.

Maeda A, Leung MK, Conroy L, Chen Y, Bu J, Lindsay PE, Mintzberg S, Virtanen C, Tsao J, Winegarden NA, Wang Y, Morikawa L, Vitkin IA, Jaffray DA, Hill RP, DaCosta RS.

PLoS One. 2012;7(8):e42133. doi: 10.1371/journal.pone.0042133. Epub 2012 Aug 22.

25.

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.

Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW.

Nature. 2012 Aug 30;488(7413):656-9. doi: 10.1038/nature11323.

26.

Prolonged postovulatory proinflammatory signaling in the fallopian tube epithelium may be mediated through a BRCA1/DAB2 axis.

Tone AA, Virtanen C, Shaw P, Brown TJ.

Clin Cancer Res. 2012 Aug 15;18(16):4334-44. doi: 10.1158/1078-0432.CCR-12-0199. Epub 2012 Jul 2.

27.

Gene array analysis of embryonic- versus adult-derived hypothalamic NPY-expressing cell lines.

Dhillon SS, Gingerich S, Virtanen C, Belsham DD.

Mol Cell Endocrinol. 2012 Jul 6;358(1):116-26. doi: 10.1016/j.mce.2012.03.012. Epub 2012 Mar 28.

PMID:
22476083
28.
29.

Effect of topical interferon-γ gene therapy using gemini nanoparticles on pathophysiological markers of cutaneous scleroderma in Tsk/+ mice.

Badea I, Virtanen C, Verrall RE, Rosenberg A, Foldvari M.

Gene Ther. 2012 Oct;19(10):978-87. doi: 10.1038/gt.2011.159. Epub 2011 Nov 10.

PMID:
22071972
30.

Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".

Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Östman A, Moran MF, Neel BG.

Cell. 2011 Sep 2;146(5):826-40. doi: 10.1016/j.cell.2011.07.020.

31.

Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammation.

Gandhi R, Takahashi M, Virtanen C, Syed K, Davey JR, Mahomed NN.

J Rheumatol. 2011 Sep;38(9):1966-72. doi: 10.3899/jrheum.101302. Epub 2011 Jul 15.

PMID:
21765106
32.

Identification of abrogated pathways in fallopian tube epithelium from BRCA1 mutation carriers.

George SH, Greenaway J, Milea A, Clary V, Shaw S, Sharma M, Virtanen C, Shaw PA.

J Pathol. 2011 Sep;225(1):106-17. doi: 10.1002/path.2927. Epub 2011 Jul 8.

PMID:
21744340
33.

Decreased progesterone receptor isoform expression in luteal phase fallopian tube epithelium and high-grade serous carcinoma.

Tone AA, Virtanen C, Shaw PA, Brown TJ.

Endocr Relat Cancer. 2011 Feb 23;18(2):221-34. doi: 10.1530/ERC-10-0235. Print 2011 Apr.

34.

Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer.

Shimizu M, Cohen B, Goldvasser P, Berman H, Virtanen C, Reedijk M.

Cancer Res. 2011 Jan 1;71(1):277-86. doi: 10.1158/0008-5472.CAN-10-2523.

35.

Identification of a novel antigen-presenting cell population modulating antiinfluenza type 2 immunity.

Yoo JK, Galligan CL, Virtanen C, Fish EN.

J Exp Med. 2010 Jul 5;207(7):1435-51. doi: 10.1084/jem.20091373. Epub 2010 Jun 14.

36.

Low malignant potential tumors with micropapillary features are molecularly similar to low-grade serous carcinoma of the ovary.

May T, Virtanen C, Sharma M, Milea A, Begley H, Rosen B, Murphy KJ, Brown TJ, Shaw PA.

Gynecol Oncol. 2010 Apr;117(1):9-17. doi: 10.1016/j.ygyno.2010.01.006. Epub 2010 Feb 1.

PMID:
20117829
37.

DNA methylation profiles in monozygotic and dizygotic twins.

Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GH, Wong AH, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C, McRae AF, Visscher PM, Montgomery GW, Gottesman II, Martin NG, Petronis A.

Nat Genet. 2009 Feb;41(2):240-5. doi: 10.1038/ng.286. Epub 2009 Jan 18.

PMID:
19151718
38.

Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.

Virtanen C, Paris J, Takahashi M.

J Biol Chem. 2009 Jan 16;284(3):1636-43. doi: 10.1074/jbc.M807000200. Epub 2008 Nov 20.

39.

Clinical uses of microarrays in cancer research.

Virtanen C, Woodgett J.

Methods Mol Med. 2008;141:87-113. Review.

40.

Muscling in on microarrays.

Virtanen C, Takahashi M.

Appl Physiol Nutr Metab. 2008 Feb;33(1):124-9. doi: 10.1139/H07-150. Review.

PMID:
18347662
41.

Intra- and interindividual epigenetic variation in human germ cells.

Flanagan JM, Popendikyte V, Pozdniakovaite N, Sobolev M, Assadzadeh A, Schumacher A, Zangeneh M, Lau L, Virtanen C, Wang SC, Petronis A.

Am J Hum Genet. 2006 Jul;79(1):67-84. Epub 2006 May 25.

42.

Microarray-based DNA methylation profiling: technology and applications.

Schumacher A, Kapranov P, Kaminsky Z, Flanagan J, Assadzadeh A, Yau P, Virtanen C, Winegarden N, Cheng J, Gingeras T, Petronis A.

Nucleic Acids Res. 2006 Jan 20;34(2):528-42. Print 2006.

43.

Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization.

Inamura K, Fujiwara T, Hoshida Y, Isagawa T, Jones MH, Virtanen C, Shimane M, Satoh Y, Okumura S, Nakagawa K, Tsuchiya E, Ishikawa S, Aburatani H, Nomura H, Ishikawa Y.

Oncogene. 2005 Oct 27;24(47):7105-13.

PMID:
16007138
44.

Identification of MEF2-regulated genes during muscle differentiation.

Paris J, Virtanen C, Lu Z, Takahashi M.

Physiol Genomics. 2004 Dec 15;20(1):143-51. Epub 2004 Oct 26.

PMID:
15507520
45.

Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.

Jones MH, Virtanen C, Honjoh D, Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Nomura H, Ishikawa Y.

Lancet. 2004 Mar 6;363(9411):775-81.

PMID:
15016488
46.

Integrated classification of lung tumors and cell lines by expression profiling.

Virtanen C, Ishikawa Y, Honjoh D, Kimura M, Shimane M, Miyoshi T, Nomura H, Jones MH.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12357-62. Epub 2002 Sep 6.

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