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Items: 1 to 50 of 335

1.

Placental passage of eculizumab and complement blockade in a newborn.

Duineveld C, Wijnsma KL, Volokhina EB, van den Heuvel LPB, van de Kar NCAJ, Wetzels JFM.

Kidney Int. 2019 Apr;95(4):996. doi: 10.1016/j.kint.2019.01.012. No abstract available.

PMID:
30904074
2.

Nephrotic syndrome in a dish: recent developments in modeling in vitro.

Veissi S, Smeets B, van den Heuvel LP, Schreuder MF, Jansen J.

Pediatr Nephrol. 2019 Feb 28. doi: 10.1007/s00467-019-4203-8. [Epub ahead of print] Review.

PMID:
30820702
3.

Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera.

Pouw RB, Brouwer MC, de Gast M, van Beek AE, van den Heuvel LP, Schmidt CQ, van der Ende A, Sánchez-Corral P, Kuijpers TW, Wouters D.

Blood Adv. 2019 Feb 26;3(4):621-632. doi: 10.1182/bloodadvances.2018025692.

4.

Diagnosis and treatment of C3 glomerulopathy in a center of expertise.

Koopman JJE, Teng YKO, Boon CJF, van den Heuvel LP, Rabelink TJ, van Kooten C, de Vries APJ.

Neth J Med. 2019 Jan;77(1):10-18.

5.

Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab.

Wijnsma KL, Ter Heine R, Moes DJAR, Langemeijer S, Schols SEM, Volokhina EB, van den Heuvel LP, Wetzels JFM, van de Kar NCAJ, Brüggemann RJ.

Clin Pharmacokinet. 2019 Jul;58(7):859-874. doi: 10.1007/s40262-019-00742-8. Review.

PMID:
30758736
6.

Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs.

Ter Meer M, Dillion R, Nielsen SM, Walther R, Meyer RL, Daamen WF, van den Heuvel LP, van der Vliet JA, Lomme RMLM, Hoogeveen YL, Schultze Kool LJ, Schaffer JE, Zelikin AN.

Chem Commun (Camb). 2019 Jan 3;55(4):443-446. doi: 10.1039/c8cc08737g.

PMID:
30489589
7.

Mutated SUCLG1 causes mislocalization of SUCLG2 protein, morphological alterations of mitochondria and an early-onset severe neurometabolic disorder.

Chinopoulos C, Batzios S, van den Heuvel LP, Rodenburg R, Smeets R, Waterham HR, Turkenburg M, Ruiter JP, Wanders RJA, Doczi J, Horvath G, Dobolyi A, Vargiami E, Wevers RA, Zafeiriou D.

Mol Genet Metab. 2019 Jan;126(1):43-52. doi: 10.1016/j.ymgme.2018.11.009. Epub 2018 Nov 16.

PMID:
30470562
8.

Glyco-iELISA: a highly sensitive and unambiguous serological method to diagnose STEC-HUS caused by serotype O157.

Wijnsma KL, Veissi ST, van Bommel SAM, Heuver R, Volokhina EB, Comerci DJ, Ugalde JE, van de Kar NCAJ, van den Heuvel LPWJ.

Pediatr Nephrol. 2019 Apr;34(4):631-639. doi: 10.1007/s00467-018-4118-9. Epub 2018 Oct 26.

9.

Genetic Renal Diseases: The Emerging Role of Zebrafish Models.

Elmonem MA, Berlingerio SP, van den Heuvel LP, de Witte PA, Lowe M, Levtchenko EN.

Cells. 2018 Sep 1;7(9). pii: E130. doi: 10.3390/cells7090130. Review.

10.

The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Michels MAHM, Volokhina EB, van de Kar NCAJ, van den Heuvel LPWJ.

Pediatr Nephrol. 2019 Aug;34(8):1349-1367. doi: 10.1007/s00467-018-4042-z. Epub 2018 Aug 23.

PMID:
30141176
11.

Allogeneic HSCT transfers wild-type cystinosin to nonhematological epithelial cells in cystinosis: First human report.

Elmonem MA, Veys K, Oliveira Arcolino F, Van Dyck M, Benedetti MC, Diomedi-Camassei F, De Hertogh G, van den Heuvel LP, Renard M, Levtchenko E.

Am J Transplant. 2018 Nov;18(11):2823-2828. doi: 10.1111/ajt.15029. Epub 2018 Aug 21.

PMID:
30030899
12.

Genotype-phenotype correlations of low-frequency variants in the complement system in renal disease and age-related macular degeneration.

Geerlings MJ, Volokhina EB, de Jong EK, van de Kar N, Pauper M, Hoyng CB, van den Heuvel LP, den Hollander AI.

Clin Genet. 2018 Oct;94(3-4):330-338. doi: 10.1111/cge.13392. Epub 2018 Jul 10.

13.

Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation.

Ashikov A, Abu Bakar N, Wen XY, Niemeijer M, Rodrigues Pinto Osorio G, Brand-Arzamendi K, Hasadsri L, Hansikova H, Raymond K, Vicogne D, Ondruskova N, Simon MEH, Pfundt R, Timal S, Beumers R, Biot C, Smeets R, Kersten M, Huijben K; CDG group, Linders PTA, van den Bogaart G, van Hijum SAFT, Rodenburg R, van den Heuvel LP, van Spronsen F, Honzik T, Foulquier F, van Scherpenzeel M, Lefeber DJ; CDG group, Mirjam W, Han B, Helen M, Helen M, Peter VH, Jiddeke VK, Diego M, Lars M, Katja BH, Jozef H, Majid A, Kevin C, Johann TWN.

Hum Mol Genet. 2018 Sep 1;27(17):3029-3045. doi: 10.1093/hmg/ddy213.

PMID:
29878199
14.

Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.

Michels MAHM, van de Kar NCAJ, Okrój M, Blom AM, van Kraaij SAW, Volokhina EB, van den Heuvel LPWJ.

Front Immunol. 2018 Apr 4;9:612. doi: 10.3389/fimmu.2018.00612. eCollection 2018.

15.

Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

Osborne AJ, Breno M, Borsa NG, Bu F, Frémeaux-Bacchi V, Gale DP, van den Heuvel LP, Kavanagh D, Noris M, Pinto S, Rallapalli PM, Remuzzi G, Rodríguez de Cordoba S, Ruiz A, Smith RJH, Vieira-Martins P, Volokhina E, Wilson V, Goodship THJ, Perkins SJ.

J Immunol. 2018 Apr 1;200(7):2464-2478. doi: 10.4049/jimmunol.1701695. Epub 2018 Mar 2.

16.

A Novel Choroidal Endothelial Cell Line Has a Decreased Affinity for the Age-Related Macular Degeneration-Associated Complement Factor H Variant 402H.

Loeven MA, van Gemst JJ, Schophuizen CMS, Tilakaratna V, van den Heuvel LP, Day AJ, Klevering BJ, van der Vlag J.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):722-730. doi: 10.1167/iovs.IOVS-17-22893.

PMID:
29392318
17.

The genetics of atypical hemolytic uremic syndrome.

Feitz WJC, van de Kar NCAJ, Orth-Höller D, van den Heuvel LPJW, Licht C.

Med Genet. 2018;30(4):400-409. doi: 10.1007/s11825-018-0216-0. Epub 2018 Dec 21. Review.

18.

Safety and effectiveness of restrictive eculizumab treatment in atypical haemolytic uremic syndrome.

Wijnsma KL, Duineveld C, Volokhina EB, van den Heuvel LP, van de Kar NCAJ, Wetzels JFM.

Nephrol Dial Transplant. 2018 Apr 1;33(4):635-645. doi: 10.1093/ndt/gfx196.

PMID:
29106598
19.

REducing STEroids in Relapsing Nephrotic syndrome: the RESTERN study- protocol of a national, double-blind, randomised, placebo-controlled, non-inferiority intervention study.

Schijvens AM, Dorresteijn EM, Roeleveld N, Ter Heine R, van Wijk JAE, Bouts AHM, Keijzer-Veen MG, van de Kar NCAJ, van den Heuvel LPWJ, Schreuder MF.

BMJ Open. 2017 Sep 27;7(9):e018148. doi: 10.1136/bmjopen-2017-018148.

20.

Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model.

Schirris TJJ, Jansen J, Mihajlovic M, van den Heuvel LP, Masereeuw R, Russel FGM.

Sci Rep. 2017 Sep 6;7(1):10623. doi: 10.1038/s41598-017-10483-y.

21.

Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application.

Mihajlovic M, van den Heuvel LP, Hoenderop JG, Jansen J, Wilmer MJ, Westheim AJF, Allebes WA, Stamatialis D, Hilbrands LB, Masereeuw R.

Sci Rep. 2017 Aug 2;7(1):7103. doi: 10.1038/s41598-017-07582-1.

22.

Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome.

Eneman B, Elmonem MA, van den Heuvel LP, Khodaparast L, Khodaparast L, van Geet C, Freson K, Levtchenko E.

PLoS One. 2017 Jul 31;12(7):e0182100. doi: 10.1371/journal.pone.0182100. eCollection 2017.

23.

Early postnatal gentamicin and ceftazidime treatment in normal and food restricted neonatal wistar rats: Implications for kidney development.

Bueters RRG, Jeronimus-Klaasen A, Brüggemann RJM, van den Heuvel LP, Schreuder MF.

Birth Defects Res. 2017 Sep 1;109(15):1228-1235. doi: 10.1002/bdr2.1071. Epub 2017 Jul 11.

PMID:
28696058
24.

Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses.

Nilsson PH, Thomas AM, Bergseth G, Gustavsen A, Volokhina EB, van den Heuvel LP, Barratt-Due A, Mollnes TE.

Mol Immunol. 2017 Sep;89:111-114. doi: 10.1016/j.molimm.2017.05.021. Epub 2017 Jun 10.

25.

ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.

Desai R, Frazier AE, Durigon R, Patel H, Jones AW, Dalla Rosa I, Lake NJ, Compton AG, Mountford HS, Tucker EJ, Mitchell ALR, Jackson D, Sesay A, Di Re M, van den Heuvel LP, Burke D, Francis D, Lunke S, McGillivray G, Mandelstam S, Mochel F, Keren B, Jardel C, Turner AM, Ian Andrews P, Smeitink J, Spelbrink JN, Heales SJ, Kohda M, Ohtake A, Murayama K, Okazaki Y, Lombès A, Holt IJ, Thorburn DR, Spinazzola A.

Brain. 2017 Jun 1;140(6):1595-1610. doi: 10.1093/brain/awx094.

26.

Continuously Grooved Stent Struts for Enhanced Endothelial Cell Seeding.

Ter Meer M, Daamen WF, Hoogeveen YL, van Son GJF, Schaffer JE, van der Vliet JA, Kool LJS, van den Heuvel LP.

Cardiovasc Intervent Radiol. 2017 Aug;40(8):1237-1245. doi: 10.1007/s00270-017-1659-4. Epub 2017 May 3.

27.

First Successful Conception Induced by a Male Cystinosis Patient.

Veys KR, D'Hauwers KW, van Dongen AJCM, Janssen MC, Besouw MTP, Goossens E, van den Heuvel LP, Wetzels AAMM, Levtchenko EN.

JIMD Rep. 2018;38:1-6. doi: 10.1007/8904_2017_19. Epub 2017 Apr 13.

28.

Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction.

Elmonem MA, Khalil R, Khodaparast L, Khodaparast L, Arcolino FO, Morgan J, Pastore A, Tylzanowski P, Ny A, Lowe M, de Witte PA, Baelde HJ, van den Heuvel LP, Levtchenko E.

Sci Rep. 2017 Feb 15;7:42583. doi: 10.1038/srep42583.

29.

Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation.

Knops N, Herman J, van Dyck M, Ramazani Y, Debbaut E, van Damme-Lombaerts R, Levtchenko E, van den Heuvel LP, Fieuws S, Kuypers D.

Br J Clin Pharmacol. 2017 Apr;83(4):863-874. doi: 10.1111/bcp.13174. Epub 2016 Dec 13.

30.

Intranuclear Aggregates Precede Clinical Onset in Oculopharyngeal Muscular Dystrophy.

van der Sluijs BM, Raz V, Lammens M, van den Heuvel LP, Voermans NC, van Engelen BG.

J Neuromuscul Dis. 2016 Mar 3;3(1):101-109.

PMID:
27854203
31.

Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome.

Westra D, Volokhina EB, van der Molen RG, van der Velden TJ, Jeronimus-Klaasen A, Goertz J, Gracchi V, Dorresteijn EM, Bouts AH, Keijzer-Veen MG, van Wijk JA, Bakker JA, Roos A, van den Heuvel LP, van de Kar NC.

Pediatr Nephrol. 2017 Feb;32(2):297-309. doi: 10.1007/s00467-016-3496-0. Epub 2016 Oct 7.

32.

Ca(2+) signalling in human proximal tubular epithelial cells deficient for cystinosin.

Ivanova EA, Elmonem MA, Bongaerts I, Luyten T, Missiaen L, van den Heuvel LP, Levtchenko EN, Bultynck G.

Cell Calcium. 2016 Oct;60(4):282-7. doi: 10.1016/j.ceca.2016.07.001. Epub 2016 Jul 5.

PMID:
27451386
33.

Bioengineered kidney tubules efficiently excrete uremic toxins.

Jansen J, Fedecostante M, Wilmer MJ, Peters JG, Kreuser UM, van den Broek PH, Mensink RA, Boltje TJ, Stamatialis D, Wetzels JF, van den Heuvel LP, Hoenderop JG, Masereeuw R.

Sci Rep. 2016 May 31;6:26715. doi: 10.1038/srep26715.

34.

Fecal diagnostics in combination with serology: best test to establish STEC-HUS.

Wijnsma KL, van Bommel SA, van der Velden T, Volokhina E, Schreuder MF, van den Heuvel LP, van de Kar NC.

Pediatr Nephrol. 2016 Nov;31(11):2163-70. doi: 10.1007/s00467-016-3420-7. Epub 2016 May 30.

35.

Cystinosis: a review.

Elmonem MA, Veys KR, Soliman NA, van Dyck M, van den Heuvel LP, Levtchenko E.

Orphanet J Rare Dis. 2016 Apr 22;11:47. doi: 10.1186/s13023-016-0426-y. Review.

36.

Cystinosin deficiency causes podocyte damage and loss associated with increased cell motility.

Ivanova EA, Arcolino FO, Elmonem MA, Rastaldi MP, Giardino L, Cornelissen EM, van den Heuvel LP, Levtchenko EN.

Kidney Int. 2016 May;89(5):1037-1048. doi: 10.1016/j.kint.2016.01.013. Epub 2016 Mar 11.

PMID:
27083281
37.

Whole Exome Sequencing in Patients with the Cuticular Drusen Subtype of Age-Related Macular Degeneration.

Duvvari MR, van de Ven JP, Geerlings MJ, Saksens NT, Bakker B, Henkes A, Neveling K, del Rosario M, Westra D, van den Heuvel LP, Schick T, Fauser S, Boon CJ, Hoyng CB, de Jong EK, den Hollander AI.

PLoS One. 2016 Mar 23;11(3):e0152047. doi: 10.1371/journal.pone.0152047. eCollection 2016.

38.

Altered mTOR signalling in nephropathic cystinosis.

Ivanova EA, van den Heuvel LP, Elmonem MA, De Smedt H, Missiaen L, Pastore A, Mekahli D, Bultynck G, Levtchenko EN.

J Inherit Metab Dis. 2016 May;39(3):457-464. doi: 10.1007/s10545-016-9919-z. Epub 2016 Feb 24.

PMID:
26909499
39.

Immunomodulatory Effects of Chitotriosidase Enzyme.

Elmonem MA, van den Heuvel LP, Levtchenko EN.

Enzyme Res. 2016;2016:2682680. doi: 10.1155/2016/2682680. Epub 2016 Jan 3. Review.

40.

CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation.

Jansen JC, Cirak S, van Scherpenzeel M, Timal S, Reunert J, Rust S, Pérez B, Vicogne D, Krawitz P, Wada Y, Ashikov A, Pérez-Cerdá C, Medrano C, Arnoldy A, Hoischen A, Huijben K, Steenbergen G, Quelhas D, Diogo L, Rymen D, Jaeken J, Guffon N, Cheillan D, van den Heuvel LP, Maeda Y, Kaiser O, Schara U, Gerner P, van den Boogert MA, Holleboom AG, Nassogne MC, Sokal E, Salomon J, van den Bogaart G, Drenth JP, Huynen MA, Veltman JA, Wevers RA, Morava E, Matthijs G, Foulquier F, Marquardt T, Lefeber DJ.

Am J Hum Genet. 2016 Feb 4;98(2):310-21. doi: 10.1016/j.ajhg.2015.12.010. Epub 2016 Jan 28.

41.

The Effects of Early Postnatal Diuretics Treatment on Kidney Development and Long-Term Kidney Function in Wistar Rats.

Bueters RR, Jeronimus-Klaasen A, Maicas N, Florquin S, van den Heuvel LP, Schreuder MF.

Nephron. 2016;132(2):110-8. doi: 10.1159/000442674. Epub 2016 Jan 26.

42.

Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.

van der Maten E, Westra D, van Selm S, Langereis JD, Bootsma HJ, van Opzeeland FJ, de Groot R, Ruseva MM, Pickering MC, van den Heuvel LP, van de Kar NC, de Jonge MI, van der Flier M.

J Infect Dis. 2016 Jun 1;213(11):1820-7. doi: 10.1093/infdis/jiw029. Epub 2016 Jan 21.

43.

Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations.

Jansen J, De Napoli IE, Fedecostante M, Schophuizen CM, Chevtchik NV, Wilmer MJ, van Asbeck AH, Croes HJ, Pertijs JC, Wetzels JF, Hilbrands LB, van den Heuvel LP, Hoenderop JG, Stamatialis D, Masereeuw R.

Sci Rep. 2015 Nov 16;5:16702. doi: 10.1038/srep16702.

44.

Regularized MANOVA (rMANOVA) in untargeted metabolomics.

Engel J, Blanchet L, Bloemen B, van den Heuvel LP, Engelke UH, Wevers RA, Buydens LM.

Anal Chim Acta. 2015 Oct 29;899:1-12. doi: 10.1016/j.aca.2015.06.042. Epub 2015 Aug 7.

PMID:
26547490
45.

Impact of Early Postnatal NSAID Treatment on Nephrogenesis in Wistar Rats.

Bueters RR, Klaasen A, Maicas N, Florquin S, van den Heuvel LP, Schreuder MF.

Birth Defects Res B Dev Reprod Toxicol. 2015 Oct;104(5):218-26. doi: 10.1002/bdrb.21161. Epub 2015 Sep 16.

PMID:
26375421
46.

Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology.

Lensen JF, van der Vlag J, Versteeg EM, Wetzels JF, van den Heuvel LP, Berden JH, van Kuppevelt TH, Rops AL.

PLoS One. 2015 Aug 31;10(9):e0134946. doi: 10.1371/journal.pone.0134946. eCollection 2015.

47.

Eculizumab in Pediatric Dense Deposit Disease.

Oosterveld MJ, Garrelfs MR, Hoppe B, Florquin S, Roelofs JJ, van den Heuvel LP, Amann K, Davin JC, Bouts AH, Schriemer PJ, Groothoff JW.

Clin J Am Soc Nephrol. 2015 Oct 7;10(10):1773-82. doi: 10.2215/CJN.01360215. Epub 2015 Aug 27.

48.

Adult-onset congenital thrombotic thrombocytopenic purpura caused by a novel compound heterozygous mutation of the ADAMTS13 gene.

Krabbe JG, Kemna EW, Strunk AL, Jobse PA, Kramer PA, Dikkeschei LD, van den Heuvel LP, Fijnheer R, Verdonck LF.

Int J Hematol. 2015 Oct;102(4):477-81. doi: 10.1007/s12185-015-1849-2. Epub 2015 Aug 13.

PMID:
26267233
49.

Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology.

Mutsaers HA, Caetano-Pinto P, Seegers AE, Dankers AC, van den Broek PH, Wetzels JF, van den Brand JA, van den Heuvel LP, Hoenderop JG, Wilmer MJ, Masereeuw R.

Toxicol In Vitro. 2015 Oct;29(7):1868-77. doi: 10.1016/j.tiv.2015.07.020. Epub 2015 Jul 26.

PMID:
26216510
50.

Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo.

Volokhina EB, Bergseth G, van de Kar NC, van den Heuvel LP, Mollnes TE.

Blood. 2015 Jul 9;126(2):278-9. doi: 10.1182/blood-2015-03-637645. No abstract available.

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