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Items: 42

1.

Monitoring Cell Type-Specific Gene Expression Using Ribosome Profiling In Vivo During Cardiac Hemodynamic Stress.

Doroudgar S, Hofmann C, Boileau E, Malone B, Riechert E, Gorska AA, Jakobi T, Sandmann C, Juergensen L, Kmietczyk V, Malovrh E, Burghaus J, Rettel M, Stein F, Younesi FS, Friedrich UA, Mauz V, Backs J, Kramer G, Katus HA, Dieterich C, Völkers M.

Circ Res. 2019 Jul 9. doi: 10.1161/CIRCRESAHA.119.314817. [Epub ahead of print]

PMID:
31284834
2.

m6A-mRNA methylation regulates cardiac gene expression and cellular growth.

Kmietczyk V, Riechert E, Kalinski L, Boileau E, Malovrh E, Malone B, Gorska A, Hofmann C, Varma E, Jürgensen L, Kamuf-Schenk V, Altmüller J, Tappu R, Busch M, Most P, Katus HA, Dieterich C, Völkers M.

Life Sci Alliance. 2019 Apr 9;2(2). pii: e201800233. doi: 10.26508/lsa.201800233. Print 2019 Apr.

3.

Crosstalk Between the Endoplasmic Reticulum and mTOR Signaling.

Malovrh E, Völkers M.

Circ Res. 2019 Jan 4;124(1):9-11. doi: 10.1161/CIRCRESAHA.118.314326. No abstract available.

PMID:
30605413
4.

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.

Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J.

Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11.

PMID:
29227474
5.

Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy.

Haas J, Mester S, Lai A, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Rausch T, Nietsch R, Boeckel JN, Carstensen A, Völkers M, Dietrich C, Pils D, Amr A, Holzer DB, Martins Bordalo D, Oehler D, Weis T, Mereles D, Buss S, Riechert E, Wirsz E, Wuerstle M, Korbel JO, Keller A, Katus HA, Posch AE, Meder B.

EMBO Mol Med. 2018 Jan;10(1):107-120. doi: 10.15252/emmm.201707838.

6.

Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.

Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C.

J Mol Cell Cardiol. 2017 Aug;109:48-56. doi: 10.1016/j.yjmcc.2017.06.015. Epub 2017 Jul 1.

PMID:
28676412
7.

S100A4 protects the myocardium against ischemic stress.

Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Völkers M.

J Mol Cell Cardiol. 2016 Nov;100:54-63. doi: 10.1016/j.yjmcc.2016.10.001. Epub 2016 Oct 6.

8.

Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.

Eden M, Meder B, Völkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M, Hrabě de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N.

Nat Commun. 2016 May 26;7:11835. doi: 10.1038/ncomms11835. No abstract available.

9.

Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.

Scherer D, Seyler C, Xynogalos P, Scholz EP, Thomas D, Backs J, Andrassy M, Völkers M, Karle CA, Katus HA, Zitron E.

PLoS One. 2016 May 23;11(5):e0156181. doi: 10.1371/journal.pone.0156181. eCollection 2016.

10.

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.

Eden M, Meder B, Völkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M; German Mouse Clinic Consortium, Hrabě de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N.

Nat Commun. 2016 Apr 28;7:11317. doi: 10.1315/11317. Erratum in: Nat Commun. 2016 May 26;7:11835.

11.

Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.

Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC.

Circ Res. 2015 Aug 28;117(6):536-46. doi: 10.1161/CIRCRESAHA.115.306993. Epub 2015 Jul 2.

12.

S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction.

Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RHA, Koch WJ, Katus HA, Most P.

Mol Ther. 2015 Aug;23(8):1320-1330. doi: 10.1038/mt.2015.93. Epub 2015 May 25.

13.

Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells.

Samse K, Emathinger J, Hariharan N, Quijada P, Ilves K, Völkers M, Ormachea L, De La Torre A, Orogo AM, Alvarez R, Din S, Mohsin S, Monsanto M, Fischer KM, Dembitsky WP, Gustafsson ÅB, Sussman MA.

J Biol Chem. 2015 May 29;290(22):13935-47. doi: 10.1074/jbc.M114.617431. Epub 2015 Apr 16.

14.

Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.

Din S, Konstandin MH, Johnson B, Emathinger J, Völkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA.

Circ Res. 2014 Jul 18;115(3):376-87. doi: 10.1161/CIRCRESAHA.115.304441. Epub 2014 Jun 10.

15.

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4.

Rohde D, Schön C, Boerries M, Didrihsone I, Ritterhoff J, Kubatzky KF, Völkers M, Herzog N, Mähler M, Tsoporis JN, Parker TG, Linke B, Giannitsis E, Gao E, Peppel K, Katus HA, Most P.

EMBO Mol Med. 2014 Jun;6(6):778-94. doi: 10.15252/emmm.201303498. Epub 2014 Apr 6.

16.

PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.

Völkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA.

EMBO Mol Med. 2014 Jan;6(1):57-65. doi: 10.1002/emmm.201303183.

17.

IL-1α reversibly inhibits skeletal muscle ryanodine receptor. a novel mechanism for critical illness myopathy?

Friedrich O, Yi B, Edwards JN, Reischl B, Wirth-Hücking A, Buttgereit A, Lang R, Weber C, Polyak F, Liu I, von Wegner F, Cully TR, Lee A, Most P, Völkers M.

Am J Respir Cell Mol Biol. 2014 Jun;50(6):1096-106. doi: 10.1165/rcmb.2013-0059OC.

18.

mTOR/PRAS40 interaction: hypertrophy or proliferation.

Völkers M, Sussman M.

Cell Cycle. 2013 Dec 1;12(23):3579-80. doi: 10.4161/cc.26822. Epub 2013 Oct 21. No abstract available.

19.

Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.

Völkers M, Konstandin MH, Doroudgar S, Toko H, Quijada P, Din S, Joyo A, Ornelas L, Samse K, Thuerauf DJ, Gude N, Glembotski CC, Sussman MA.

Circulation. 2013 Nov 5;128(19):2132-44. doi: 10.1161/CIRCULATIONAHA.113.003638. Epub 2013 Sep 5.

20.

Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth.

Konstandin MH, Völkers M, Collins B, Quijada P, Quintana M, De La Torre A, Ormachea L, Din S, Gude N, Toko H, Sussman MA.

Basic Res Cardiol. 2013 Sep;108(5):375. doi: 10.1007/s00395-013-0375-8. Epub 2013 Aug 4.

21.

Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.

Völkers M, Toko H, Doroudgar S, Din S, Quijada P, Joyo AY, Ornelas L, Joyo E, Thuerauf DJ, Konstandin MH, Gude N, Glembotski CC, Sussman MA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12661-6. doi: 10.1073/pnas.1301455110. Epub 2013 Jul 10.

22.

Fibronectin is essential for reparative cardiac progenitor cell response after myocardial infarction.

Konstandin MH, Toko H, Gastelum GM, Quijada P, De La Torre A, Quintana M, Collins B, Din S, Avitabile D, Völkers M, Gude N, Fässler R, Sussman MA.

Circ Res. 2013 Jul 5;113(2):115-25. doi: 10.1161/CIRCRESAHA.113.301152. Epub 2013 May 7.

23.

High-sensitive Troponin T increase after exercise in patients with pulmonary arterial hypertension.

Völkers M, Rohde D, Zelniker T, Weiss CS, Giannitsis E, Katus HA, Meyer FJ.

BMC Pulm Med. 2013 Apr 29;13:28. doi: 10.1186/1471-2466-13-28.

24.

Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation.

Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, Joyo AY, Quijada P, Erhardt P, Magnuson NS, Konstandin MH, Sussman MA.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5969-74. doi: 10.1073/pnas.1213294110. Epub 2013 Mar 25.

25.

Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.

Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, Uchida T, Sussman MA.

Circ Res. 2013 Apr 26;112(9):1244-52. doi: 10.1161/CIRCRESAHA.113.301084. Epub 2013 Mar 13.

26.

Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish.

Völkers M, Dolatabadi N, Gude N, Most P, Sussman MA, Hassel D.

J Cell Sci. 2012 Jan 15;125(Pt 2):287-94. doi: 10.1242/jcs.090464. Epub 2012 Feb 2.

27.

Central role of PKCα in isoenzyme-selective regulation of cardiac transient outward current Ito and Kv4.3 channels.

Scholz EP, Welke F, Joss N, Seyler C, Zhang W, Scherer D, Völkers M, Bloehs R, Thomas D, Katus HA, Karle CA, Zitron E.

J Mol Cell Cardiol. 2011 Nov;51(5):722-9. doi: 10.1016/j.yjmcc.2011.07.012. Epub 2011 Jul 22.

PMID:
21803046
28.

Myocardial AKT: the omnipresent nexus.

Sussman MA, Völkers M, Fischer K, Bailey B, Cottage CT, Din S, Gude N, Avitabile D, Alvarez R, Sundararaman B, Quijada P, Mason M, Konstandin MH, Malhowski A, Cheng Z, Khan M, McGregor M.

Physiol Rev. 2011 Jul;91(3):1023-70. doi: 10.1152/physrev.00024.2010. Review.

29.

Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin.

Avitabile D, Bailey B, Cottage CT, Sundararaman B, Joyo A, McGregor M, Gude N, Truffa S, Zarrabi A, Konstandin M, Khan M, Mohsin S, Völkers M, Toko H, Mason M, Cheng Z, Din S, Alvarez R Jr, Fischer K, Sussman MA.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6145-50. doi: 10.1073/pnas.1017935108. Epub 2011 Mar 28.

30.

Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling.

Fischer KM, Cottage CT, Konstandin MH, Völkers M, Khan M, Sussman MA.

J Mol Cell Cardiol. 2011 Oct;51(4):554-8. doi: 10.1016/j.yjmcc.2011.01.004. Epub 2011 Jan 19. Review.

31.

Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis.

Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA.

Eur Heart J. 2011 Sep;32(17):2179-88. doi: 10.1093/eurheartj/ehq496. Epub 2011 Jan 12.

32.

The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.

Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, Wegner FV, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P.

Circ Res. 2011 Jan 7;108(1):27-39. doi: 10.1161/CIRCRESAHA.110.225201. Epub 2010 Nov 24.

33.

S100A1: a regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function.

Völkers M, Rohde D, Goodman C, Most P.

J Biomed Biotechnol. 2010;2010:178614. doi: 10.1155/2010/178614. Epub 2010 Mar 28. Review.

34.

Pim-1 kinase protects mitochondrial integrity in cardiomyocytes.

Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA.

Circ Res. 2010 Apr 16;106(7):1265-74. doi: 10.1161/CIRCRESAHA.109.212035. Epub 2010 Mar 4.

35.

Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis.

Kaya Z, Göser S, Buss SJ, Leuschner F, Ottl R, Li J, Völkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA.

Circulation. 2008 Nov 11;118(20):2063-72. doi: 10.1161/CIRCULATIONAHA.108.788711. Epub 2008 Oct 27.

36.

Endothelial S100A1 modulates vascular function via nitric oxide.

Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Völkers M, Heierhorst J, Øie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P.

Circ Res. 2008 Apr 11;102(7):786-94. doi: 10.1161/CIRCRESAHA.108.172031. Epub 2008 Feb 21.

PMID:
18292599
37.

Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.

Most P, Seifert H, Gao E, Funakoshi H, Völkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR Jr, Eckhart AD, Feldman AM, Koch WJ.

Circulation. 2006 Sep 19;114(12):1258-68. Epub 2006 Sep 4.

PMID:
16952982
38.

S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes.

Völkers M, Loughrey CM, Macquaide N, Remppis A, DeGeorge BR Jr, Wegner FV, Friedrich O, Fink RH, Koch WJ, Smith GL, Most P.

Cell Calcium. 2007 Feb;41(2):135-43. Epub 2006 Aug 21.

PMID:
16919727
39.

S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.

Pleger ST, Remppis A, Heidt B, Völkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, Müller OJ, Eckhart AD, Katus HA, Koch WJ, Most P.

Mol Ther. 2005 Dec;12(6):1120-9. Epub 2005 Sep 15.

40.

Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes.

Most P, Boerries M, Eicher C, Schweda C, Völkers M, Wedel T, Söllner S, Katus HA, Remppis A, Aebi U, Koch WJ, Schoenenberger CA.

J Cell Sci. 2005 Jan 15;118(Pt 2):421-31.

41.

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.

Most P, Pleger ST, Völkers M, Heidt B, Boerries M, Weichenhan D, Löffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ.

J Clin Invest. 2004 Dec;114(11):1550-63.

42.

Hope for a broken heart?

Most P, Eicher C, Völkers M, Pleger ST, Katus HA.

Trends Biotechnol. 2004 Oct;22(10):487-9.

PMID:
15450736

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