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Items: 45


Inferring Transmission Histories of Rare Alleles in Population-Scale Genealogies.

Nelson D, Moreau C, de Vriendt M, Zeng Y, Preuss C, Vézina H, Milot E, Andelfinger G, Labuda D, Gravel S.

Am J Hum Genet. 2018 Dec 6;103(6):893-906. doi: 10.1016/j.ajhg.2018.10.017.


Relaxed Selection During a Recent Human Expansion.

Peischl S, Dupanloup I, Foucal A, Jomphe M, Bruat V, Grenier JC, Gouy A, Gilbert KJ, Gbeha E, Bosshard L, Hip-Ki E, Agbessi M, Hodgkinson A, Vézina H, Awadalla P, Excoffier L.

Genetics. 2018 Feb;208(2):763-777. doi: 10.1534/genetics.117.300551. Epub 2017 Nov 29.


Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future.

Vezina HE, Cotreau M, Han TH, Gupta M.

J Clin Pharmacol. 2017 Oct;57 Suppl 10:S11-S25. doi: 10.1002/jcph.981. Review.


QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models.

Cheng Y, Thalhauser CJ, Smithline S, Pagidala J, Miladinov M, Vezina HE, Gupta M, Leil TA, Schmidt BJ.

AAPS J. 2017 Jul;19(4):1002-1016. doi: 10.1208/s12248-017-0100-x. Epub 2017 May 24.


Assessment of nivolumab benefit-risk profile of a 240-mg flat dose relative to a 3-mg/kg dosing regimen in patients with advanced tumors.

Zhao X, Suryawanshi S, Hruska M, Feng Y, Wang X, Shen J, Vezina HE, McHenry MB, Waxman IM, Achanta A, Bello A, Roy A, Agrawal S.

Ann Oncol. 2017 Aug 1;28(8):2002-2008. doi: 10.1093/annonc/mdx235.


Socio-economic status and fertility decline: Insights from historical transitions in Europe and North America.

Dribe M, Breschi M, Gagnon A, Gauvreau D, Hanson HA, Maloney TN, Mazzoni S, Molitoris J, Pozzi L, Smith KR, Vézina H.

Popul Stud (Camb). 2017 Mar;71(1):3-21. doi: 10.1080/00324728.2016.1253857. Epub 2016 Nov 25.


Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays.

Wang J, Gu H, Liu A, Kozhich A, Rangan V, Myler H, Luo L, Wong R, Sun H, Wang B, Vezina HE, Deshpande S, Zhang Y, Yang Z, Olah TV, Aubry AF, Arnold ME, Pillutla R, DeSilva B.

Bioanalysis. 2016 Jul;8(13):1383-401. doi: 10.4155/bio-2016-0017. Epub 2016 Jun 9.


An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.

Myler H, Rangan VS, Wang J, Kozhich A, Cummings JA, Neely R, Dail D, Liu A, Wang B, Vezina HE, Freebern W, Sung MC, Passmore D, Deshpande S, Kempe T, Gu H, Saewert M, Manney A, Lute J, Zambito F, Wong RL, Piccoli SP, Aubry AF, Pillutla R, Arnold M, DeSilva B.

Bioanalysis. 2015;7(13):1569-82. doi: 10.4155/bio.15.80.


GENLIB: an R package for the analysis of genealogical data.

Gauvin H, Lefebvre JF, Moreau C, Lavoie EM, Labuda D, Vézina H, Roy-Gagnon MH.

BMC Bioinformatics. 2015 May 15;16:160. doi: 10.1186/s12859-015-0581-5.


Adjuvant therapies for HIV-associated neurocognitive disorders.

McGuire JL, Barrett JS, Vezina HE, Spitsin S, Douglas SD.

Ann Clin Transl Neurol. 2014 Nov;1(11):938-52. doi: 10.1002/acn3.131. Epub 2014 Oct 23. Review.


Population pharmacokinetics of unbound hydrocortisone in critically ill neonates and infants with vasopressor-resistant hypotension.

Vezina HE, Ng CM, Vazquez DM, Barks JD, Bhatt-Mehta V.

Pediatr Crit Care Med. 2014 Jul;15(6):546-53. doi: 10.1097/PCC.0000000000000152.


Population pharmacokinetics of valganciclovir prophylaxis in paediatric and adult solid organ transplant recipients.

Vezina HE, Brundage RC, Balfour HH Jr.

Br J Clin Pharmacol. 2014 Aug;78(2):343-52. doi: 10.1111/bcp.12343.


Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population.

Gauvin H, Moreau C, Lefebvre JF, Laprise C, Vézina H, Labuda D, Roy-Gagnon MH.

Eur J Hum Genet. 2014 Jun;22(6):814-21. doi: 10.1038/ejhg.2013.227. Epub 2013 Oct 16.


PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: are we asking the right questions?

Barrett JS, McGuire J, Vezina H, Spitsin S, Douglas SD.

J Clin Psychopharmacol. 2013 Dec;33(6):725-8. doi: 10.1097/JCP.0b013e3182a88654.


Native American admixture in the Quebec founder population.

Moreau C, Lefebvre JF, Jomphe M, Bhérer C, Ruiz-Linares A, Vézina H, Roy-Gagnon MH, Labuda D.

PLoS One. 2013 Jun 12;8(6):e65507. doi: 10.1371/journal.pone.0065507. Print 2013.


Feasibility, acceptability and preliminary efficacy of an online peer-to-peer social support ART adherence intervention.

Horvath KJ, Oakes JM, Rosser BR, Danilenko G, Vezina H, Amico KR, Williams ML, Simoni J.

AIDS Behav. 2013 Jul;17(6):2031-44. doi: 10.1007/s10461-013-0469-1.


Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students.

Balfour HH Jr, Odumade OA, Schmeling DO, Mullan BD, Ed JA, Knight JA, Vezina HE, Thomas W, Hogquist KA.

J Infect Dis. 2013 Jan 1;207(1):80-8. doi: 10.1093/infdis/jis646. Epub 2012 Oct 24. Erratum in: J Infect Dis. 2013 Jun 15;207(12):1940.


Deep human genealogies reveal a selective advantage to be on an expanding wave front.

Moreau C, Bhérer C, Vézina H, Jomphe M, Labuda D, Excoffier L.

Science. 2011 Nov 25;334(6059):1148-50. doi: 10.1126/science.1212880. Epub 2011 Nov 3.


Admixed ancestry and stratification of Quebec regional populations.

Bherer C, Labuda D, Roy-Gagnon MH, Houde L, Tremblay M, Vézina H.

Am J Phys Anthropol. 2011 Mar;144(3):432-41. doi: 10.1002/ajpa.21424. Epub 2010 Nov 10.


Genomic and genealogical investigation of the French Canadian founder population structure.

Roy-Gagnon MH, Moreau C, Bherer C, St-Onge P, Sinnett D, Laprise C, Vézina H, Labuda D.

Hum Genet. 2011 May;129(5):521-31. doi: 10.1007/s00439-010-0945-x. Epub 2011 Jan 15.


When genetics and genealogies tell different stories-maternal lineages in Gaspesia.

Moreau C, Vézina H, Jomphe M, Lavoie EM, Roy-Gagnon MH, Labuda D.

Ann Hum Genet. 2011 Mar;75(2):247-54. doi: 10.1111/j.1469-1809.2010.00617.x. Epub 2010 Nov 8.


Mutability of Y-chromosomal microsatellites: rates, characteristics, molecular bases, and forensic implications.

Ballantyne KN, Goedbloed M, Fang R, Schaap O, Lao O, Wollstein A, Choi Y, van Duijn K, Vermeulen M, Brauer S, Decorte R, Poetsch M, von Wurmb-Schwark N, de Knijff P, Labuda D, Vézina H, Knoblauch H, Lessig R, Roewer L, Ploski R, Dobosz T, Henke L, Henke J, Furtado MR, Kayser M.

Am J Hum Genet. 2010 Sep 10;87(3):341-53. doi: 10.1016/j.ajhg.2010.08.006.


Genealogical analysis of maternal and paternal lineages in the Quebec population.

Tremblay M, Vézina H.

Hum Biol. 2010 Apr;82(2):179-98. doi: 10.3378/027.082.0204.


The pharmacokinetics of valganciclovir prophylaxis in pediatric solid organ transplant patients at risk for Epstein-Barr virus disease.

Vezina HE, Brundage RC, Nevins TE, Balfour HH Jr.

Clin Pharmacol. 2010;2:1-7. doi: 10.2147/CPAA.S8341. Epub 2009 Dec 22.


Valacyclovir pharmacokinetics and exploratory pharmacodynamics in young adults with Epstein-Barr virus infectious mononucleosis.

Vezina HE, Balfour HH Jr, Weller DR, Anderson BJ, Brundage RC.

J Clin Pharmacol. 2010 Jul;50(7):734-42. doi: 10.1177/0091270009351884. Epub 2009 Nov 6.


Is there a trade-off between fertility and longevity? A comparative study of women from three large historical databases accounting for mortality selection.

Gagnon A, Smith KR, Tremblay M, Vézina H, Paré PP, Desjardins B.

Am J Hum Biol. 2009 Jul-Aug;21(4):533-40. doi: 10.1002/ajhb.20893.


Genetic heterogeneity in regional populations of Quebec--parental lineages in the Gaspe Peninsula.

Moreau C, Vézina H, Yotova V, Hamon R, de Knijff P, Sinnett D, Labuda D.

Am J Phys Anthropol. 2009 Aug;139(4):512-22. doi: 10.1002/ajpa.21012.


Intergenerational and Genealogical Approaches for the Study of Longevity in the Saguenay-Lac-St-Jean Population.

Houde L, Tremblay M, Vézina H.

Hum Nat. 2008 Mar;19(1):70-86. doi: 10.1007/s12110-008-9031-7.


Mucolipidosis II: a single causal mutation in the N-acetylglucosamine-1-phosphotransferase gene (GNPTAB) in a French Canadian founder population.

Plante M, Claveau S, Lepage P, Lavoie EM, Brunet S, Roquis D, Morin C, Vézina H, Laprise C.

Clin Genet. 2008 Mar;73(3):236-44. doi: 10.1111/j.1399-0004.2007.00954.x. Epub 2008 Jan 7.


[Founder effects and genetic variability in Quebec].

Moreau C, Vézina H, Labuda D.

Med Sci (Paris). 2007 Nov;23(11):1008-13. French.


Contribution of hierarchical clustering techniques to the modeling of the geographic distribution of genetic polymorphisms associated with chronic inflammatory diseases in the Québec population.

Madore AM, Houde L, Vézina H, Vohl MC, Pérusse L, Mior N, Connelly PW, Laberge C, Gaudet D, Laprise C.

Community Genet. 2007;10(4):218-26.


A virologic pilot study of valacyclovir in infectious mononucleosis.

Balfour HH Jr, Hokanson KM, Schacherer RM, Fietzer CM, Schmeling DO, Holman CJ, Vezina HE, Brundage RC.

J Clin Virol. 2007 May;39(1):16-21. Epub 2007 Mar 21.


An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma.

Weller DR, Brundage RC, Balfour HH Jr, Vezina HE.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Apr 1;848(2):369-73. Epub 2006 Nov 1.


Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multistep testing approach in French-Canadian families with high risk of breast and ovarian cancer.

Simard J, Dumont M, Moisan AM, Gaborieau V, Malouin H, Durocher F, Chiquette J, Plante M, Avard D, Bessette P, Brousseau C, Dorval M, Godard B, Houde L; INHERIT BRCAs, Joly Y, Lajoie MA, Leblanc G, Lépine J, Lespérance B, Vézina H, Parboosingh J, Pichette R, Provencher L, Rhéaume J, Sinnett D, Samson C, Simard JC, Tranchant M, Voyer P, Easton D, Tavtigian SV, Knoppers BM, Laframboise R, Bridge P, Goldgar D.

J Med Genet. 2007 Feb;44(2):107-21. Epub 2006 Aug 11. Erratum in: J Med Genet. 2007 Jul;44(7):471.


Partnering in oncogenetic research--the INHERIT BRCAs experience: opportunities and challenges.

Avard D, Bridge P, Bucci LM, Chiquette J, Dorval M, Durocher F, Easton D, Godard B, Goldgar D, Knoppers BM, Laframboise R, Lespérance B, Plante M, Tavtigian SV, Vézina H, Wilson B; INHERIT BRCAs, Simard J.

Fam Cancer. 2006;5(1):3-13. Review.


A randomized crossover study to determine bioequivalence of generic and brand name nevirapine, zidovudine, and lamivudine in HIV-negative women in India.

Vezina HE, Henry K, Ravindran GD, Kurpad AV, Raj TD, Fox K, Weller D, Brundage RC, Cavert W, Balfour HH Jr.

J Acquir Immune Defic Syndr. 2006 Feb 1;41(2):131-6.


Demogenetic study of three populations within a region with strong founder effects.

Lavoie EM, Tremblay M, Houde L, Vézina H.

Community Genet. 2005;8(3):152-60.


A "Fille du Roy" introduced the T14484C Leber hereditary optic neuropathy mutation in French Canadians.

Laberge AM, Jomphe M, Houde L, Vezina H, Tremblay M, Desjardins B, Labuda D, St-Hilaire M, Macmillan C, Shoubridge EA, Brais B.

Am J Hum Genet. 2005 Aug;77(2):313-7. Epub 2005 Jun 13.


Molecular and genealogical characterization of the R1443X BRCA1 mutation in high-risk French-Canadian breast/ovarian cancer families.

Vézina H, Durocher F, Dumont M, Houde L, Szabo C, Tranchant M, Chiquette J, Plante M, Laframboise R, Lépine J, Nevanlinna H, Stoppa-Lyonnet D, Goldgar D, Bridge P, Simard J.

Hum Genet. 2005 Jul;117(2-3):119-32. Epub 2005 May 10.


Anatomy of a founder effect: myotonic dystrophy in Northeastern Quebec.

Yotova V, Labuda D, Zietkiewicz E, Gehl D, Lovell A, Lefebvre JF, Bourgeois S, Lemieux-Blanchard E, Labuda M, Vézina H, Houde L, Tremblay M, Toupance B, Heyer E, Hudson TJ, Laberge C.

Hum Genet. 2005 Jul;117(2-3):177-87. Epub 2005 May 10.


A genealogical study of essential hypertension with and without obesity in French Canadians.

Pausova Z, Jomphe M, Houde L, Vezina H, Orlov SN, Gossard F, Gaudet D, Tremblay J, Kotchen TA, Cowley AW, Bouchard G, Hamet P.

Obes Res. 2002 Jun;10(6):463-70.


A genealogical study of Alzheimer disease in the Saguenay region of Quebec.

Vézina H, Heyer E, Fortier I, Ouellette G, Robitaille Y, Gauvreau D.

Genet Epidemiol. 1999;16(4):412-25.


Season of birth and Alzheimer's disease: a population-based study in Saguenay-Lac-St-Jean/Québec (IMAGE Project).

Vézina H, Houde L, Charbonneau H, Beaudry M, Cholette A, Daoud N, Mathieu J, Robitaille Y, Veilleux F, Gauvreau D.

Psychol Med. 1996 Jan;26(1):143-9.


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