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Items: 45


Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome.

Meydan S, Marks J, Klepacki D, Sharma V, Baranov PV, Firth AE, Margus T, Kefi A, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2019 May 2;74(3):481-493.e6. doi: 10.1016/j.molcel.2019.02.017. Epub 2019 Mar 20.


Assembly and functionality of the ribosome with tethered subunits.

Aleksashin NA, Leppik M, Hockenberry AJ, Klepacki D, Vázquez-Laslop N, Jewett MC, Remme J, Mankin AS.

Nat Commun. 2019 Feb 25;10(1):930. doi: 10.1038/s41467-019-08892-w.


How Macrolide Antibiotics Work.

Vázquez-Laslop N, Mankin AS.

Trends Biochem Sci. 2018 Sep;43(9):668-684. doi: 10.1016/j.tibs.2018.06.011. Epub 2018 Jul 24. Review.


Genes within Genes in Bacterial Genomes.

Meydan S, Vázquez-Laslop N, Mankin AS.

Microbiol Spectr. 2018 Jul;6(4). doi: 10.1128/microbiolspec.RWR-0020-2018. Review.


Context-Specific Action of Ribosomal Antibiotics.

Vázquez-Laslop N, Mankin AS.

Annu Rev Microbiol. 2018 Sep 8;72:185-207. doi: 10.1146/annurev-micro-090817-062329. Epub 2018 Jun 15. Review.


Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics.

Svetlov MS, Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13673-13678. doi: 10.1073/pnas.1717168115. Epub 2017 Dec 11.


Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.

Almutairi MM, Svetlov MS, Hansen DA, Khabibullina NF, Klepacki D, Kang HY, Sherman DH, Vázquez-Laslop N, Polikanov YS, Mankin AS.

Nucleic Acids Res. 2017 Sep 19;45(16):9573-9582. doi: 10.1093/nar/gkx673.


An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.

Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS.

Nat Struct Mol Biol. 2017 Sep;24(9):752-757. doi: 10.1038/nsmb.3439. Epub 2017 Jul 24.


Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene.

Meydan S, Klepacki D, Karthikeyan S, Margus T, Thomas P, Jones JE, Khan Y, Briggs J, Dinman JD, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2017 Jan 19;65(2):207-219. doi: 10.1016/j.molcel.2016.12.008.


Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center.

Marks J, Kannan K, Roncase EJ, Klepacki D, Kefi A, Orelle C, Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12150-12155. Epub 2016 Oct 10.


Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size.

Sothiselvam S, Neuner S, Rigger L, Klepacki D, Micura R, Vázquez-Laslop N, Mankin AS.

Cell Rep. 2016 Aug 16;16(7):1789-99. doi: 10.1016/j.celrep.2016.07.018. Epub 2016 Aug 4.


Nascent peptide assists the ribosome in recognizing chemically distinct small molecules.

Gupta P, Liu B, Klepacki D, Gupta V, Schulten K, Mankin AS, Vázquez-Laslop N.

Nat Chem Biol. 2016 Mar;12(3):153-8. doi: 10.1038/nchembio.1998. Epub 2016 Jan 4.


Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.

Almutairi MM, Park SR, Rose S, Hansen DA, Vázquez-Laslop N, Douthwaite S, Sherman DH, Mankin AS.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12956-61. doi: 10.1073/pnas.1512090112. Epub 2015 Oct 5.


Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.

Polikanov YS, Szal T, Jiang F, Gupta P, Matsuda R, Shiozuka M, Steitz TA, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2014 Nov 20;56(4):541-50. doi: 10.1016/j.molcel.2014.09.021. Epub 2014 Oct 9.


Drug sensing by the ribosome induces translational arrest via active site perturbation.

Arenz S, Meydan S, Starosta AL, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN.

Mol Cell. 2014 Nov 6;56(3):446-52. doi: 10.1016/j.molcel.2014.09.014. Epub 2014 Oct 8.


Macrolide antibiotics allosterically predispose the ribosome for translation arrest.

Sothiselvam S, Liu B, Han W, Ramu H, Klepacki D, Atkinson GC, Brauer A, Remm M, Tenson T, Schulten K, Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9804-9. doi: 10.1073/pnas.1403586111. Epub 2014 Jun 24.


Protein accounting in the cellular economy.

Vázquez-Laslop N, Mankin AS.

Cell. 2014 Apr 24;157(3):529-31. doi: 10.1016/j.cell.2014.04.002.


Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.

Arenz S, Ramu H, Gupta P, Berninghausen O, Beckmann R, Vázquez-Laslop N, Mankin AS, Wilson DN.

Nat Commun. 2014 Mar 24;5:3501. doi: 10.1038/ncomms4501.


Regulation of gene expression by macrolide-induced ribosomal frameshifting.

Gupta P, Kannan K, Mankin AS, Vázquez-Laslop N.

Mol Cell. 2013 Dec 12;52(5):629-42. doi: 10.1016/j.molcel.2013.10.013. Epub 2013 Nov 14.


Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.

Martínez AK, Gordon E, Sengupta A, Shirole N, Klepacki D, Martinez-Garriga B, Brown LM, Benedik MJ, Yanofsky C, Mankin AS, Vazquez-Laslop N, Sachs MS, Cruz-Vera LR.

Nucleic Acids Res. 2014 Jan;42(2):1245-56. doi: 10.1093/nar/gkt923. Epub 2013 Oct 16.


Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.

Orelle C, Szal T, Klepacki D, Shaw KJ, Vázquez-Laslop N, Mankin AS.

Nucleic Acids Res. 2013 Aug;41(14):e144. doi: 10.1093/nar/gkt526. Epub 2013 Jun 12.


Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible.

Gupta P, Sothiselvam S, Vázquez-Laslop N, Mankin AS.

Nat Commun. 2013;4:1984. doi: 10.1038/ncomms2984.


Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel.

Kannan K, Vázquez-Laslop N, Mankin AS.

Cell. 2012 Oct 26;151(3):508-20. doi: 10.1016/j.cell.2012.09.018.


Role of antibiotic ligand in nascent peptide-dependent ribosome stalling.

Vázquez-Laslop N, Klepacki D, Mulhearn DC, Ramu H, Krasnykh O, Franzblau S, Mankin AS.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10496-501. doi: 10.1073/pnas.1103474108. Epub 2011 Jun 13.


Picky nascent peptides do not talk to foreign ribosomes.

Vázquez-Laslop N, Mankin AS.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5931-2. doi: 10.1073/pnas.1103011108. Epub 2011 Apr 4. No abstract available.


Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center.

Ramu H, Vázquez-Laslop N, Klepacki D, Dai Q, Piccirilli J, Micura R, Mankin AS.

Mol Cell. 2011 Feb 4;41(3):321-30. doi: 10.1016/j.molcel.2010.12.031.


The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.

Vázquez-Laslop N, Ramu H, Klepacki D, Kannan K, Mankin AS.

EMBO J. 2010 Sep 15;29(18):3108-17. doi: 10.1038/emboj.2010.180. Epub 2010 Jul 30.


Programmed drug-dependent ribosome stalling.

Ramu H, Mankin A, Vazquez-Laslop N.

Mol Microbiol. 2009 Feb;71(4):811-24. doi: 10.1111/j.1365-2958.2008.06576.x. Epub 2008 Nov 30. Review.


Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion.

Newberry KJ, Huffman JL, Miller MC, Vazquez-Laslop N, Neyfakh AA, Brennan RG.

J Biol Chem. 2008 Sep 26;283(39):26795-804. doi: 10.1074/jbc.M804191200. Epub 2008 Jul 25.


Molecular mechanism of drug-dependent ribosome stalling.

Vazquez-Laslop N, Thum C, Mankin AS.

Mol Cell. 2008 Apr 25;30(2):190-202. doi: 10.1016/j.molcel.2008.02.026.


Isolation of antibiotic hypersusceptibility mutants of Acinetobacter spp. by selection for DNA release.

Lee H, Vázquez-Laslop N, Klyachko KA, Neyfakh AA.

Antimicrob Agents Chemother. 2003 Apr;47(4):1267-74.


Molecular sieve mechanism of selective release of cytoplasmic proteins by osmotically shocked Escherichia coli.

Vázquez-Laslop N, Lee H, Hu R, Neyfakh AA.

J Bacteriol. 2001 Apr;183(8):2399-404.


Recognition of multiple drugs by a single protein: a trivial solution of an old paradox.

Vazquez-Laslop N, Zheleznova EE, Markham PN, Brennan RG, Neyfakh AA.

Biochem Soc Trans. 2000;28(4):517-20. Review.


Efflux of the natural polyamine spermidine facilitated by the Bacillus subtilis multidrug transporter Blt.

Woolridge DP, Vazquez-Laslop N, Markham PN, Chevalier MS, Gerner EW, Neyfakh AA.

J Biol Chem. 1997 Apr 4;272(14):8864-6.


Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated.

Ahmed M, Lyass L, Markham PN, Taylor SS, Vázquez-Laslop N, Neyfakh AA.

J Bacteriol. 1995 Jul;177(14):3904-10.


The native F0F1-inhibitor protein complex from beef heart mitochondria and its reconstitution in liposomes.

Vázquez-Contreras E, Vázquez-Laslop N, Dreyfus G.

J Bioenerg Biomembr. 1995 Feb;27(1):109-16.


A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates.

Ahmed M, Borsch CM, Taylor SS, Vázquez-Laslop N, Neyfakh AA.

J Biol Chem. 1994 Nov 11;269(45):28506-13.


The vacuolar ATPase of Neurospora crassa.

Bowman BJ, Vázquez-Laslop N, Bowman EJ.

J Bioenerg Biomembr. 1992 Aug;24(4):361-70. Review.


Aurovertin fluorescence changes of the mitochondrial F1-ATPase during multi- and uni-site ATP hydrolysis.

Vázquez-Laslop N, Ramírez J, Dreyfus G.

J Biol Chem. 1989 Oct 15;264(29):17064-8.


Modulation of mitochondrial F0F1 catalysis by boundary and bulk phase phospholipids.

Dabbeni-Sala F, Vázquez-Laslop N, Fachinetti A, Devars S, Dreyfus G.

Biochem Biophys Res Commun. 1989 Feb 15;158(3):1013-20.


Mitochondrial H+-ATPase activation by an amine oxide detergent.

Vázquez-Laslop N, Dreyfus G.

J Biol Chem. 1986 Jun 15;261(17):7807-10.

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