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Items: 1 to 50 of 64

1.

Positive allosteric modulation of native and recombinant GABAA receptors by hops prenylflavonoids.

Benkherouf AY, Soini SL, Stompor M, Uusi-Oukari M.

Eur J Pharmacol. 2019 Jun 5;852:34-41. doi: 10.1016/j.ejphar.2019.02.034. Epub 2019 Feb 21.

PMID:
30797788
2.

Extrasynaptic δ-GABAA receptors are high-affinity muscimol receptors.

Benkherouf AY, Taina KR, Meera P, Aalto AJ, Li XG, Soini SL, Wallner M, Uusi-Oukari M.

J Neurochem. 2019 Apr;149(1):41-53. doi: 10.1111/jnc.14646. Epub 2019 Mar 6.

PMID:
30565258
3.

Modifications of diflunisal and meclofenamate carboxyl groups affect their allosteric effects on GABAA receptor ligand binding.

Uusi-Oukari M, Vähätalo L, Liljeblad A.

Neurochem Res. 2014 Jul;39(7):1183-91. doi: 10.1007/s11064-014-1351-x. Epub 2014 Jun 13. Erratum in: Neurochem Res. 2014 Jul;39(7):1192.

PMID:
24925262
4.

Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons.

Vashchinkina E, Manner AK, Vekovischeva O, den Hollander B, Uusi-Oukari M, Aitta-Aho T, Korpi ER.

Neuropsychopharmacology. 2014 Feb;39(3):727-37. doi: 10.1038/npp.2013.258. Epub 2013 Sep 27.

5.

Long-term cognitive and neurochemical effects of "bath salt" designer drugs methylone and mephedrone.

den Hollander B, Rozov S, Linden AM, Uusi-Oukari M, Ojanperä I, Korpi ER.

Pharmacol Biochem Behav. 2013 Jan;103(3):501-9. doi: 10.1016/j.pbb.2012.10.006. Epub 2012 Oct 22.

PMID:
23099177
6.

Enhancement of GABAergic activity: neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology.

Saari TI, Uusi-Oukari M, Ahonen J, Olkkola KT.

Pharmacol Rev. 2011 Mar;63(1):243-67. doi: 10.1124/pr.110.002717. Epub 2011 Jan 18. Review.

PMID:
21245208
7.

The cerebellar GABAAR α6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats.

Kontturi LS, Aalto AJ, Wallner M, Uusi-Oukari M.

Alcohol. 2011 Nov;45(7):653-61. doi: 10.1016/j.alcohol.2010.11.003. Epub 2010 Dec 15.

8.

AMPAR signaling mediating GABA(A)R delta subunit up-regulation in cultured mouse cerebellar granule cells.

Uusi-Oukari M, Kontturi LS, Coffey ET, Kallinen SA.

Neurochem Int. 2010 Sep;57(2):136-42. doi: 10.1016/j.neuint.2010.05.005. Epub 2010 May 12.

PMID:
20470842
9.

Human locus coeruleus neurons express the GABA(A) receptor gamma2 subunit gene and produce benzodiazepine binding.

Hellsten KS, Sinkkonen ST, Hyde TM, Kleinman JE, Särkioja T, Maksimow A, Uusi-Oukari M, Korpi ER.

Neurosci Lett. 2010 Jun 21;477(2):77-81. doi: 10.1016/j.neulet.2010.04.035. Epub 2010 Apr 22.

10.

AMPA receptors serum-dependently mediate GABAA receptor alpha1 and alpha6 subunit down-regulation in cultured mouse cerebellar granule cells.

Uusi-Oukari M, Kontturi LS, Kallinen SA, Salonen V.

Neurochem Int. 2010 Apr;56(5):720-6. doi: 10.1016/j.neuint.2010.02.009. Epub 2010 Feb 16.

PMID:
20170697
11.

Regulation of GABA(A) receptor subunit expression by pharmacological agents.

Uusi-Oukari M, Korpi ER.

Pharmacol Rev. 2010 Mar;62(1):97-135. doi: 10.1124/pr.109.002063. Epub 2010 Feb 1. Review.

PMID:
20123953
12.

Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic alpha6beta GABA(A) receptors.

Saarelainen KS, Ranna M, Rabe H, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Linden AM, Lüddens H, Korpi ER.

J Neurochem. 2008 Apr;105(2):338-50. Epub 2007 Nov 16.

13.

Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain.

Laurén HB, Lopez-Picon FR, Kukko-Lukjanov TK, Uusi-Oukari M, Holopainen IE.

Neuroscience. 2007 May 11;146(2):802-11. Epub 2007 Mar 13.

PMID:
17360122
14.

Allosteric modulation of [3H]EBOB binding to GABAA receptors by diflunisal analogues.

Uusi-Oukari M, Maksay G.

Neurochem Int. 2006 Dec;49(7):676-82. Epub 2006 Aug 1.

PMID:
16884828
15.

AMPA/kainate receptor-mediated up-regulation of GABAA receptor delta subunit mRNA expression in cultured rat cerebellar granule cells is dependent on NMDA receptor activation.

Salonen V, Kallinen S, Lopez-Picon FR, Korpi ER, Holopainen IE, Uusi-Oukari M.

Brain Res. 2006 May 4;1087(1):33-40. Epub 2006 Apr 13.

PMID:
16626639
16.

Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.

Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER.

BMC Pharmacol. 2006 Jan 13;6:1.

17.

Brain regional heterogeneity of pH effects on GABA(A) receptor-associated [35s]TBPS binding.

Uusi-Oukari M, Kosonen P, Homanics GE, Korpi ER.

Neurochem Res. 2004 Apr;29(4):771-80.

PMID:
15098940
18.

Kainate down-regulates a subset of GABAA receptor subunits expressed in cultured mouse cerebellar granule cells.

Martikainen IK, Lauk K, Möykkynen T, Holopainen IE, Korpi ER, Uusi-Oukari M.

Cerebellum. 2004;3(1):27-38.

PMID:
15072265
20.

Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug.

Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER.

Mol Pharmacol. 2003 Sep;64(3):753-63.

PMID:
12920213
21.

Tolerance to diazepam-induced motor impairment: a study with GABAA receptor alpha6 subunit knockout mice.

Vekovischeva O, Uusi-Oukari M, Korpi ER.

Neurochem Res. 2003 May;28(5):757-64.

PMID:
12716027
22.

Cation modulation of GABA(A) receptors in brain sections of AT and ANT rats.

Uusi-Oukari M, Mäkelä R, Soini S, Korpi ER.

Alcohol. 2001 Oct;25(2):69-75.

PMID:
11747975
23.

Morphine withdrawal increases expression of GABA(A) receptor epsilon subunit mRNA in locus coeruleus neurons.

Heikkilä AT, Echenko O, Uusi-Oukari M, Sinkkonen ST, Korpi ER.

Neuroreport. 2001 Sep 17;12(13):2981-5.

PMID:
11588615
24.

Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice.

Suppola S, Heikkinen S, Parkkinen JJ, Uusi-Oukari M, Korhonen VP, Keinänen T, Alhonen L, Jänne J.

Biochem J. 2001 Sep 1;358(Pt 2):343-8.

25.

Magnesium potentiation of the function of native and recombinant GABA(A) receptors.

Möykkynen T, Uusi-Oukari M, Heikkilä J, Lovinger DM, Lüddens H, Korpi ER.

Neuroreport. 2001 Jul 20;12(10):2175-9.

PMID:
11447329
26.

Increased behavioral neurosteroid sensitivity in a rat line selectively bred for high alcohol sensitivity.

Korpi ER, Mäkelä R, Romeo E, Guidotti A, Uusi-Oukari M, Furnari C, di Michele F, Sarviharju M, Xu M, Rosenberg PH.

Eur J Pharmacol. 2001 Jun 1;421(1):31-8.

PMID:
11408046
27.

Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits.

Vekovischeva OY, Zamanillo D, Echenko O, Seppälä T, Uusi-Oukari M, Honkanen A, Seeburg PH, Sprengel R, Korpi ER.

J Neurosci. 2001 Jun 15;21(12):4451-9.

28.

Ethanol: Novel Actions on Nerve Cell Physiology Explain Impaired Functions.

Korpi ER, Mäkelä R, Uusi-Oukari M.

News Physiol Sci. 1998 Aug;13:164-170.

PMID:
11390783
29.

Characterization of gamma-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions.

Sinkkonen ST, Uusi-Oukari M, Tupala E, Särkioja T, Tiihonen J, Panula P, Lüddens H, Korpi ER.

Brain Res Mol Brain Res. 2001 Jan 31;86(1-2):168-78.

PMID:
11165383
30.

Coupling between agonist and chloride ionophore sites of the GABA(A) receptor: agonist/antagonist efficacy of 4-PIOL.

Rabe H, Picard R, Uusi-Oukari M, Hevers W, Lüddens H, Korpi ER.

Eur J Pharmacol. 2000 Dec 15;409(3):233-42.

PMID:
11108817
31.

Chronic ethanol treatment and GABA(A) receptor α6 subunit gene expression: a study using α6 subunit-deficient mice.

Vekovischeva OY, Uusi-Oukari M, Korpi ER.

Addict Biol. 2000 Oct 1;5(4):463-7. doi: 10.1111/j.1369-1600.2000.tb00216.x.

PMID:
20575865
32.

Stereospecific modulation of GABA(A) receptor function by urocanic acid isomers.

Uusi-Oukari M, Soini SL, Heikkilä J, Koivisto A, Neuvonen K, Pasanen P, Sinkkonen ST, Laihia JK, Jansén CT, Korpi ER.

Eur J Pharmacol. 2000 Jul 14;400(1):11-7.

PMID:
10913580
33.

Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster.

Uusi-Oukari M, Heikkilä J, Sinkkonen ST, Mäkelä R, Hauer B, Homanics GE, Sieghart W, Wisden W, Korpi ER.

Mol Cell Neurosci. 2000 Jul;16(1):34-41.

PMID:
10882481
34.

Quantification of GABA(A) receptor subunit mRNAs by non-radioisotopic competitive RT-PCR utilizing plate-based EIA methodology.

Uusi-Oukari M, Kleinz R, Mäkelä R, Lüddens H, Korpi ER.

J Neurosci Methods. 2000 Jan 31;95(1):65-73.

PMID:
10776816
35.

Furosemide action on cerebellar GABA(A) receptors in alcohol-sensitive ANT rats.

Mäkelä R, Uusi-Oukari M, Oja SS, Alho H, Anghelescu I, Klawe C, Lüddens H, Korpi ER.

Alcohol. 1999 Nov;19(3):197-205.

PMID:
10580508
36.

Cerebellar granule-cell-specific GABAA receptors attenuate benzodiazepine-induced ataxia: evidence from alpha 6-subunit-deficient mice.

Korpi ER, Koikkalainen P, Vekovischeva OY, Mäkelä R, Kleinz R, Uusi-Oukari M, Wisden W.

Eur J Neurosci. 1999 Jan;11(1):233-40.

PMID:
9987027
37.

Bimodal action of furosemide on convulsant [3H]EBOB binding to cerebellar and cortical GABA(A) receptors.

Maksay G, Korpi ER, Uusi-Oukari M.

Neurochem Int. 1998 Oct;33(4):353-8.

PMID:
9840226
38.

Flavodoxin-dependent pyruvate oxidation, acetate production and metronidazole reduction by Helicobacter pylori.

Kaihovaara P, Höök-Nikanne J, Uusi-Oukari M, Kosunen TU, Salaspuro M.

J Antimicrob Chemother. 1998 Feb;41(2):171-7.

PMID:
9533458
39.

Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.

Alhonen L, Karppinen A, Uusi-Oukari M, Vujcic S, Korhonen VP, Halmekytö M, Kramer DL, Hines R, Jänne J, Porter CW.

J Biol Chem. 1998 Jan 23;273(4):1964-9.

40.

Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.

Mäkelä R, Uusi-Oukari M, Homanics GE, Quinlan JJ, Firestone LL, Wisden W, Korpi ER.

Mol Pharmacol. 1997 Sep;52(3):380-8.

PMID:
9281599
41.

Structure, organization and expression of the mouse ornithine decarboxylase antizyme gene.

Kankare K, Uusi-Oukari M, Jänne OA.

Biochem J. 1997 Jun 15;324 ( Pt 3):807-13.

42.

Expression of bovine beta-lactoglobulin/human erythropoietin fusion protein in the milk of transgenic mice and rabbits.

Korhonen VP, Tolvanen M, Hyttinen JM, Uusi-Oukari M, Sinervirta R, Alhonen L, Jauhiainen M, Jänne OA, Jänne J.

Eur J Biochem. 1997 Apr 15;245(2):482-9.

43.

Heterozygous hepatic lipase deficiency, due to two missense mutations R186H and L334F, in the HL gene.

Knudsen P, Antikainen M, Uusi-Oukari M, Ehnholm S, Lahdenperä S, Bensadoun A, Funke H, Wiebusch H, Assmann G, Taskinen MR, Ehnholm C.

Atherosclerosis. 1997 Feb 10;128(2):165-74.

PMID:
9050773
44.

Bovine alpha s1-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice.

Uusi-Oukari M, Hyttinen JM, Korhonen VP, Västi A, Alhonen L, Jänne OA, Jänne J.

Transgenic Res. 1997 Jan;6(1):75-84.

PMID:
9032980
45.
46.

A compound heterozygote for hepatic lipase gene mutations Leu334-->Phe and Thr383-->Met: correlation between hepatic lipase activity and phenotypic expression.

Knudsen P, Antikainen M, Ehnholm S, Uusi-Oukari M, Tenkanen H, Lahdenperä S, Kahri J, Tilly-Kiesi M, Bensadoun A, Taskinen MR, Ehnholm C.

J Lipid Res. 1996 Apr;37(4):825-34.

47.
48.

Characterization of novel ligands for wild-type and natural mutant diazepam-insensitive benzodiazepine receptors.

Wong G, Uusi-Oukari M, Hansen HC, Suzdak PD, Korpi ER.

Eur J Pharmacol. 1995 Apr 28;289(2):335-42.

PMID:
7621907
49.

Quantitative PCR for hepatitis B virus with colorimetric detection.

Lehtovaara P, Uusi-Oukari M, Buchert P, Laaksonen M, Bengtström M, Ranki M.

PCR Methods Appl. 1993 Dec;3(3):169-75.

50.

Postnatal development of diazepam-insensitive [3H]Ro 15-4513 binding sites.

Korpi ER, Uusi-Oukari M, Kaivola J.

Neuroscience. 1993 Mar;53(2):483-8.

PMID:
8388087

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