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Items: 1 to 50 of 146

1.

Mining the proteome associated with rheumatic and autoimmune diseases.

Ruiz-Romero C, Lam MP, Nilsson P, Önnerfjord P, Utz PJ, Van Eyk JE, Venkatraman V, Fert-Bober J, Watt FE, Blanco FJ.

J Proteome Res. 2019 Oct 10. doi: 10.1021/acs.jproteome.9b00360. [Epub ahead of print]

PMID:
31599600
2.

Unique Sjögren's syndrome patient subsets defined by molecular features.

James JA, Guthridge JM, Chen H, Lu R, Bourn RL, Bean K, Munroe ME, Smith M, Chakravarty E, Baer AN, Noaiseh G, Parke A, Boyle K, Keyes-Elstein L, Coca A, Utset T, Genovese MC, Pascual V, Utz PJ, Holers VM, Deane KD, Sivils KL, Aberle T, Wallace DJ, McNamara J, Franchimont N, St Clair EW.

Rheumatology (Oxford). 2019 Sep 8. pii: kez335. doi: 10.1093/rheumatology/kez335. [Epub ahead of print]

PMID:
31497844
3.

Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity.

Steinman L, Ho PP, Robinson WH, Utz PJ, Villoslada P.

Curr Opin Immunol. 2019 Aug 30;61:46-53. doi: 10.1016/j.coi.2019.07.011. [Epub ahead of print] Review.

PMID:
31476445
4.

Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs.

Jain MK, Cheung VG, Utz PJ, Kobilka BK, Yamada T, Lefkowitz R.

N Engl J Med. 2019 Aug 1;381(5):399-402. doi: 10.1056/NEJMp1904482. No abstract available.

PMID:
31365796
5.

Single-cell technologies - studying rheumatic diseases one cell at a time.

Cheung P, Khatri P, Utz PJ, Kuo AJ.

Nat Rev Rheumatol. 2019 Jun;15(6):340-354. doi: 10.1038/s41584-019-0220-z. Review.

PMID:
31065108
6.

AIRE expression controls the peripheral selection of autoreactive B cells.

Sng J, Ayoglu B, Chen JW, Schickel JN, Ferre EMN, Glauzy S, Romberg N, Hoenig M, Cunningham-Rundles C, Utz PJ, Lionakis MS, Meffre E.

Sci Immunol. 2019 Apr 12;4(34). pii: eaav6778. doi: 10.1126/sciimmunol.aav6778.

PMID:
30979797
7.

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions.

Christophersen A, Lund EG, Snir O, Solà E, Kanduri C, Dahal-Koirala S, Zühlke S, Molberg Ø, Utz PJ, Rohani-Pichavant M, Simard JF, Dekker CL, Lundin KEA, Sollid LM, Davis MM.

Nat Med. 2019 May;25(5):734-737. doi: 10.1038/s41591-019-0403-9. Epub 2019 Mar 25.

8.

Mycophenolate mofetil reduces STAT3 phosphorylation in systemic lupus erythematosus patients.

Slight-Webb S, Guthridge JM, Chakravarty EF, Chen H, Lu R, Macwana S, Bean K, Maecker HT, Utz PJ, James JA.

JCI Insight. 2019 Jan 24;4(2). pii: 124575. doi: 10.1172/jci.insight.124575. [Epub ahead of print]

9.

Quantification of cDNA on GMR biosensor array towards point-of-care gene expression analysis.

Ravi N, Rizzi G, Chang SE, Cheung P, Utz PJ, Wang SX.

Biosens Bioelectron. 2019 Apr 1;130:338-343. doi: 10.1016/j.bios.2018.09.050. Epub 2018 Sep 13.

PMID:
30269961
10.

Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.

11.

Single-cell epigenetics - Chromatin modification atlas unveiled by mass cytometry.

Cheung P, Vallania F, Dvorak M, Chang SE, Schaffert S, Donato M, Rao AM, Mao R, Utz PJ, Khatri P, Kuo AJ.

Clin Immunol. 2018 Nov;196:40-48. doi: 10.1016/j.clim.2018.06.009. Epub 2018 Jun 28. Review.

12.

KLRD1-expressing natural killer cells predict influenza susceptibility.

Bongen E, Vallania F, Utz PJ, Khatri P.

Genome Med. 2018 Jun 14;10(1):45. doi: 10.1186/s13073-018-0554-1.

13.

Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging.

Cheung P, Vallania F, Warsinske HC, Donato M, Schaffert S, Chang SE, Dvorak M, Dekker CL, Davis MM, Utz PJ, Khatri P, Kuo AJ.

Cell. 2018 May 31;173(6):1385-1397.e14. doi: 10.1016/j.cell.2018.03.079. Epub 2018 Apr 26.

14.

Neutralizing Anti-Cytokine Autoantibodies Against Interferon-α in Immunodysregulation Polyendocrinopathy Enteropathy X-Linked.

Rosenberg JM, Maccari ME, Barzaghi F, Allenspach EJ, Pignata C, Weber G, Torgerson TR, Utz PJ, Bacchetta R.

Front Immunol. 2018 Mar 29;9:544. doi: 10.3389/fimmu.2018.00544. eCollection 2018.

15.

Severe Toxoplasma gondii infection in a member of a NFKB2-deficient family with T and B cell dysfunction.

Maccari ME, Scarselli A, Di Cesare S, Floris M, Angius A, Deodati A, Chiriaco M, Cambiaso P, Corrente S, Colafati GS, Utz PJ, Angelini F, Fierabracci A, Aiuti A, Carsetti R, Rosenberg JM, Cappa M, Rossi P, Bacchetta R, Cancrini C.

Clin Immunol. 2017 Oct;183:273-277. doi: 10.1016/j.clim.2017.09.011. Epub 2017 Sep 14. No abstract available.

PMID:
28919517
16.

Clonal Evolution of Autoreactive Germinal Centers.

Degn SE, van der Poel CE, Firl DJ, Ayoglu B, Al Qureshah FA, Bajic G, Mesin L, Reynaud CA, Weill JC, Utz PJ, Victora GD, Carroll MC.

Cell. 2017 Aug 24;170(5):913-926.e19. doi: 10.1016/j.cell.2017.07.026.

17.

Proteomic Analysis of Sera from Individuals with Diffuse Cutaneous Systemic Sclerosis Reveals a Multianalyte Signature Associated with Clinical Improvement during Imatinib Mesylate Treatment.

Haddon DJ, Wand HE, Jarrell JA, Spiera RF, Utz PJ, Gordon JK, Chung LS.

J Rheumatol. 2017 May;44(5):631-638. doi: 10.3899/jrheum.160833. Epub 2017 Mar 15.

18.

Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies.

Perkins T, Rosenberg JM, Le Coz C, Alaimo JT, Trofa M, Mullegama SV, Antaya RJ, Jyonouchi S, Elsea SH, Utz PJ, Meffre E, Romberg N.

J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1344-1350.e3. doi: 10.1016/j.jaip.2017.01.028. Epub 2017 Mar 9.

19.

Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity.

Lofgren S, Hinchcliff M, Carns M, Wood T, Aren K, Arroyo E, Cheung P, Kuo A, Valenzuela A, Haemel A, Wolters PJ, Gordon J, Spiera R, Assassi S, Boin F, Chung L, Fiorentino D, Utz PJ, Whitfield ML, Khatri P.

JCI Insight. 2016 Dec 22;1(21):e89073. doi: 10.1172/jci.insight.89073.

20.

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD.

J Clin Invest. 2016 Nov 1;126(11):4389. doi: 10.1172/JCI91162. Epub 2016 Nov 1. No abstract available.

21.

High-Resolution Analysis of Antibodies to Post-Translational Modifications Using Peptide Nanosensor Microarrays.

Lee JR, Haddon DJ, Gupta N, Price JV, Credo GM, Diep VK, Kim K, Hall DA, Baechler EC, Petri M, Varma M, Utz PJ, Wang SX.

ACS Nano. 2016 Dec 27;10(12):10652-10660. doi: 10.1021/acsnano.6b03786. Epub 2016 Sep 20.

22.

Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance.

Revelo XS, Ghazarian M, Chng MH, Luck H, Kim JH, Zeng K, Shi SY, Tsai S, Lei H, Kenkel J, Liu CL, Tangsombatvisit S, Tsui H, Sima C, Xiao C, Shen L, Li X, Jin T, Lewis GF, Woo M, Utz PJ, Glogauer M, Engleman E, Winer S, Winer DA.

Cell Rep. 2016 Jul 19;16(3):717-30. doi: 10.1016/j.celrep.2016.06.024. Epub 2016 Jun 30.

23.

Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus.

Lee JR, Haddon DJ, Wand HE, Price JV, Diep VK, Hall DA, Petri M, Baechler EC, Balboni IM, Utz PJ, Wang SX.

Sci Rep. 2016 Jun 9;6:27623. doi: 10.1038/srep27623.

24.

Portable, one-step, and rapid GMR biosensor platform with smartphone interface.

Choi J, Gani AW, Bechstein DJB, Lee JR, Utz PJ, Wang SX.

Biosens Bioelectron. 2016 Nov 15;85:1-7. doi: 10.1016/j.bios.2016.04.046. Epub 2016 Apr 19.

PMID:
27148826
25.

Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.

Yu C, Burns JC, Robinson WH, Utz PJ, Ho PP, Steinman L, Frey AB.

J Diabetes Res. 2016;2016:9083103. doi: 10.1155/2016/9083103. Epub 2016 Mar 16.

26.

Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity.

Slight-Webb S, Lu R, Ritterhouse LL, Munroe ME, Maecker HT, Fathman CG, Utz PJ, Merrill JT, Guthridge JM, James JA.

Arthritis Rheumatol. 2016 Oct;68(10):2492-502. doi: 10.1002/art.39706.

27.

Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes.

Kim JH, Furrow E, Ritt MG, Utz PJ, Robinson WH, Yu L, Eckert A, Stuebner K, O'Brien TD, Steinman L, Modiano JF.

PLoS One. 2016 Mar 31;11(3):e0152397. doi: 10.1371/journal.pone.0152397. eCollection 2016.

28.

Development of Th17-Associated Interstitial Kidney Inflammation in Lupus-Prone Mice Lacking the Gene Encoding STAT-1.

Yiu G, Rasmussen TK, Ajami B, Haddon DJ, Chu AD, Tangsombatvisit S, Haynes WA, Diep V, Steinman L, Faix J, Utz PJ.

Arthritis Rheumatol. 2016 May;68(5):1233-44. doi: 10.1002/art.39535.

29.

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD.

J Clin Invest. 2015 Nov 2;125(11):4135-48. doi: 10.1172/JCI80477. Epub 2015 Oct 12. Erratum in: J Clin Invest. 2016 Nov 1;126(11):4389.

30.

Protein microarrays identify disease-specific anti-cytokine autoantibody profiles in the landscape of immunodeficiency.

Rosenberg JM, Price JV, Barcenas-Morales G, Ceron-Gutierrez L, Davies S, Kumararatne DS, Döffinger R, Utz PJ.

J Allergy Clin Immunol. 2016 Jan;137(1):204-213.e3. doi: 10.1016/j.jaci.2015.07.032. Epub 2015 Sep 11. Erratum in: J Allergy Clin Immunol. 2016 Jun;137(6):1917.

31.

Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution.

Haddon DJ, Jarrell JA, Diep VK, Wand HE, Price JV, Tangsombatvisit S, Credo GM, Mackey S, Dekker CL, Baechler EC, Liu CL, Varma M, Utz PJ.

Autoimmunity. 2015;48(8):513-23. doi: 10.3109/08916934.2015.1077233. Epub 2015 Aug 31.

32.

Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus.

Haddon DJ, Diep VK, Price JV, Limb C, Utz PJ, Balboni I.

Arthritis Res Ther. 2015 Jun 17;17:162. doi: 10.1186/s13075-015-0682-6.

33.

Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis.

Chakravarty EF, Martyanov V, Fiorentino D, Wood TA, Haddon DJ, Jarrell JA, Utz PJ, Genovese MC, Whitfield ML, Chung L.

Arthritis Res Ther. 2015 Jun 13;17:159. doi: 10.1186/s13075-015-0669-3.

34.

Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus.

Rasmussen TK, Andersen T, Bak RO, Yiu G, Sørensen CM, Stengaard-Pedersen K, Mikkelsen JG, Utz PJ, Holm CK, Deleuran B.

Arthritis Res Ther. 2015 Jun 9;17:154. doi: 10.1186/s13075-015-0660-z.

35.

Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus.

O'Gorman WE, Hsieh EW, Savig ES, Gherardini PF, Hernandez JD, Hansmann L, Balboni IM, Utz PJ, Bendall SC, Fantl WJ, Lewis DB, Nolan GP, Davis MM.

J Allergy Clin Immunol. 2015 Nov;136(5):1326-36. doi: 10.1016/j.jaci.2015.04.008. Epub 2015 May 30.

36.

Protein microarrays: a new tool for the study of autoantibodies in immunodeficiency.

Rosenberg JM, Utz PJ.

Front Immunol. 2015 Apr 7;6:138. doi: 10.3389/fimmu.2015.00138. eCollection 2015. Review.

37.

Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease.

Kattah NH, Newell EW, Jarrell JA, Chu AD, Xie J, Kattah MG, Goldberger O, Ye J, Chakravarty EF, Davis MM, Utz PJ.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3044-9. doi: 10.1073/pnas.1424796112. Epub 2015 Feb 23.

38.

Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1.

Nguyen le XT, Lee Y, Urbani L, Utz PJ, Hamburger AW, Sunwoo JB, Mitchell BS.

Blood. 2015 Apr 16;125(16):2519-29. doi: 10.1182/blood-2014-12-616433. Epub 2015 Feb 17.

39.

Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT).

Haddon DJ, Jarrell JA, Hughes MR, Snyder K, McNagny KM, Kattah MG, Utz PJ.

Methods Mol Biol. 2015;1220:381-400. doi: 10.1007/978-1-4939-1568-2_24.

PMID:
25388264
40.

Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis.

Kinloch AJ, Chang A, Ko K, Henry Dunand CJ, Henderson S, Maienschein-Cline M, Kaverina N, Rovin BH, Salgado Ferrer M, Wolfgeher D, Liarski V, Haddon DJ, Utz PJ, Wilson PC, Clark MR.

Arthritis Rheumatol. 2014 Dec;66(12):3359-70. doi: 10.1002/art.38888.

41.

Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.

Tang X, Zhang B, Jarrell JA, Price JV, Dai H, Utz PJ, Strober S.

J Autoimmun. 2014 May;50:87-98. doi: 10.1016/j.jaut.2014.01.002. Epub 2014 Feb 7.

42.

Broad-scale phosphoprotein profiling of beta adrenergic receptor (β-AR) signaling reveals novel phosphorylation and dephosphorylation events.

Chruscinski AJ, Singh H, Chan SM, Utz PJ.

PLoS One. 2013 Dec 5;8(12):e82164. doi: 10.1371/journal.pone.0082164. eCollection 2013.

43.

Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus.

Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum AK, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, Utz PJ.

J Clin Invest. 2013 Dec;123(12):5135-45. doi: 10.1172/JCI70231. Epub 2013 Nov 25.

44.

Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform.

Gottlieb P, Utz PJ, Robinson W, Steinman L.

Clin Immunol. 2013 Dec;149(3):297-306. doi: 10.1016/j.clim.2013.08.010. Epub 2013 Sep 1. Review.

45.

An integrated peptide-antigen microarray on plasmonic gold films for sensitive human antibody profiling.

Zhang B, Jarrell JA, Price JV, Tabakman SM, Li Y, Gong M, Hong G, Feng J, Utz PJ, Dai H.

PLoS One. 2013 Jul 29;8(7):e71043. doi: 10.1371/journal.pone.0071043. Print 2013.

46.

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.

Roep BO, Solvason N, Gottlieb PA, Abreu JRF, Harrison LC, Eisenbarth GS, Yu L, Leviten M, Hagopian WA, Buse JB, von Herrath M, Quan J, King RS, Robinson WH, Utz PJ, Garren H; BHT-3021 Investigators, Steinman L.

Sci Transl Med. 2013 Jun 26;5(191):191ra82. doi: 10.1126/scitranslmed.3006103.

47.

Interferon-α induction and detection of anti-ro, anti-la, anti-sm, and anti-rnp autoantibodies by autoantigen microarray analysis in juvenile dermatomyositis.

Balboni I, Niewold TB, Morgan G, Limb C, Eloranta ML, Rönnblom L, Utz PJ, Pachman LM.

Arthritis Rheum. 2013 Sep;65(9):2424-9. doi: 10.1002/art.38038.

48.

Characterization of influenza vaccine immunogenicity using influenza antigen microarrays.

Price JV, Jarrell JA, Furman D, Kattah NH, Newell E, Dekker CL, Davis MM, Utz PJ.

PLoS One. 2013 May 29;8(5):e64555. doi: 10.1371/journal.pone.0064555. Print 2013.

49.

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness.

Furman D, Jojic V, Kidd B, Shen-Orr S, Price J, Jarrell J, Tse T, Huang H, Lund P, Maecker HT, Utz PJ, Dekker CL, Koller D, Davis MM.

Mol Syst Biol. 2013 Apr 16;9:659. doi: 10.1038/msb.2013.15. Erratum in: Mol Syst Biol. 2013;9:680. Mol Syst Biol. 2014;10:750.

50.

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC.

Nat Chem Biol. 2012 Dec;8(12):990-8. doi: 10.1038/nchembio.1096. Epub 2012 Oct 28.

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