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Items: 16

1.

Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development.

Harbeson SL, Morgan AJ, Liu JF, Aslanian AM, Nguyen S, Bridson GW, Brummel CL, Wu L, Tung RD, Pilja L, Braman V, Uttamsingh V.

J Pharmacol Exp Ther. 2017 Aug;362(2):359-367. doi: 10.1124/jpet.117.241497. Epub 2017 Jun 13.

PMID:
28611092
2.

Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib.

Towles JK, Clark RN, Wahlin MD, Uttamsingh V, Rettie AE, Jackson KD.

Drug Metab Dispos. 2016 Oct;44(10):1584-97. doi: 10.1124/dmd.116.070839. Epub 2016 Jul 22.

3.

Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine.

Uttamsingh V, Gallegos R, Liu JF, Harbeson SL, Bridson GW, Cheng C, Wells DS, Graham PB, Zelle R, Tung R.

J Pharmacol Exp Ther. 2015 Jul;354(1):43-54. doi: 10.1124/jpet.115.223768. Epub 2015 May 5.

PMID:
25943764
4.

Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury.

Lu XC, Shear DA, Graham PB, Bridson GW, Uttamsingh V, Chen Z, Leung LY, Tortella FC.

J Neurotrauma. 2015 Oct 15;32(20):1621-32. doi: 10.1089/neu.2014.3766. Epub 2015 Jun 11.

5.

Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.

Shultz MD, Cao X, Chen CH, Cho YS, Davis NR, Eckman J, Fan J, Fekete A, Firestone B, Flynn J, Green J, Growney JD, Holmqvist M, Hsu M, Jansson D, Jiang L, Kwon P, Liu G, Lombardo F, Lu Q, Majumdar D, Meta C, Perez L, Pu M, Ramsey T, Remiszewski S, Skolnik S, Traebert M, Urban L, Uttamsingh V, Wang P, Whitebread S, Whitehead L, Yan-Neale Y, Yao YM, Zhou L, Atadja P.

J Med Chem. 2011 Jul 14;54(13):4752-72. doi: 10.1021/jm200388e. Epub 2011 Jun 17.

PMID:
21650221
6.

In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.

Mahajan MK, Uttamsingh V, Daniels JS, Gan LS, LeDuc BW, Williams DA.

Drug Metab Dispos. 2011 Apr;39(4):693-702. doi: 10.1124/dmd.110.036004. Epub 2010 Dec 21.

PMID:
21177487
7.

Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9.

Mahajan MK, Uttamsingh V, Gan LS, Leduc B, Williams DA.

J Pharm Sci. 2011 Feb;100(2):784-93. doi: 10.1002/jps.22303.

PMID:
20669329
8.

Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.

Lu C, Li P, Gallegos R, Uttamsingh V, Xia CQ, Miwa GT, Balani SK, Gan LS.

Drug Metab Dispos. 2006 Sep;34(9):1600-5. Epub 2006 Jun 21.

PMID:
16790553
9.

Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).

Ghosh S, Elder A, Guo J, Mani U, Patane M, Carson K, Ye Q, Bennett R, Chi S, Jenkins T, Guan B, Kolbeck R, Smith S, Zhang C, LaRosa G, Jaffee B, Yang H, Eddy P, Lu C, Uttamsingh V, Horlick R, Harriman G, Flynn D.

J Med Chem. 2006 May 4;49(9):2669-72.

PMID:
16640325
10.

Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes.

Lu C, Gallegos R, Li P, Xia CQ, Pusalkar S, Uttamsingh V, Nix D, Miwa GT, Gan LS.

Drug Metab Dispos. 2006 Apr;34(4):702-8. Epub 2006 Jan 27.

PMID:
16443666
11.
12.

Immunohistochemical localization of the acylases that catalyze the deacetylation of N-acetyl-L-cysteine and haloalkene-derived mercapturates.

Uttamsingh V, Baggs RB, Krenitsky DM, Anders MW.

Drug Metab Dispos. 2000 Jun;28(6):625-32.

PMID:
10820133
13.
14.

Acylase-catalyzed deacetylation of haloalkene-derived mercapturates.

Uttamsingh V, Anders MW.

Chem Res Toxicol. 1999 Oct;12(10):937-42.

PMID:
10525269
15.
16.

Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines.

Uttamsingh V, Keller DA, Anders MW.

Chem Res Toxicol. 1998 Jul;11(7):800-9.

PMID:
9671543

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