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Items: 1 to 50 of 101

1.

Quantitative monitoring of His and Asp phosphorylation in a bacterial signaling system by using Phos-tag Magenta/Cyan fluorescent dyes.

Kinoshita-Kikuta E, Kusamoto H, Ono S, Akayama K, Eguchi Y, Igarashi M, Okajima T, Utsumi R, Kinoshita E, Koike T.

Electrophoresis. 2019 Nov;40(22):3005-3013. doi: 10.1002/elps.201900261. Epub 2019 Sep 16.

PMID:
31495938
2.

Identification of an internal cavity in the PhoQ sensor domain for PhoQ activity and SafA-mediated control.

Yoshitani K, Ishii E, Taniguchi K, Sugimoto H, Shiro Y, Akiyama Y, Kato A, Utsumi R, Eguchi Y.

Biosci Biotechnol Biochem. 2019 Apr;83(4):684-694. doi: 10.1080/09168451.2018.1562879. Epub 2019 Jan 11.

PMID:
30632929
3.

Essentiality of WalRK for growth in Bacillus subtilis and its role during heat stress.

Takada H, Shiwa Y, Takino Y, Osaka N, Ueda S, Watanabe S, Chibazakura T, Su'etsugu M, Utsumi R, Yoshikawa H.

Microbiology. 2018 Apr;164(4):670-684. doi: 10.1099/mic.0.000625. Epub 2018 Feb 20.

PMID:
29465029
4.

Bacterial signal transduction networks via connectors and development of the inhibitors as alternative antibiotics.

Utsumi R.

Biosci Biotechnol Biochem. 2017 Sep;81(9):1663-1669. doi: 10.1080/09168451.2017.1350565. Epub 2017 Jul 26. Review.

PMID:
28743208
5.

Characterization of H-box region mutants of WalK inert to the action of waldiomycin in Bacillus subtilis.

Kato A, Ueda S, Oshima T, Inukai Y, Okajima T, Igarashi M, Eguchi Y, Utsumi R.

J Gen Appl Microbiol. 2017 Sep 5;63(4):212-221. doi: 10.2323/jgam.2016.10.007. Epub 2017 Jul 1.

6.

Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases.

Eguchi Y, Okajima T, Tochio N, Inukai Y, Shimizu R, Ueda S, Shinya S, Kigawa T, Fukamizo T, Igarashi M, Utsumi R.

J Antibiot (Tokyo). 2017 Mar;70(3):251-258. doi: 10.1038/ja.2016.151. Epub 2016 Dec 21.

PMID:
27999439
7.

Fe3+-dependent epistasis between the CpxR-activated loci and the PmrA-activated LPS modification loci in Salmonella enterica.

Kato A, Higashino N, Utsumi R.

J Gen Appl Microbiol. 2017 Jan 25;62(6):286-296. doi: 10.2323/jgam.2016.05.005. Epub 2016 Nov 8.

8.

Identification of the Three Genes Involved in Controlling Production of a Phytotoxin Tropolone in Burkholderia plantarii.

Miwa S, Kihira E, Yoshioka A, Nakasone K, Okamoto S, Hatano M, Igarashi M, Eguchi Y, Kato A, Ichikawa N, Sekine M, Fujita N, Kanesaki Y, Yoshikawa H, Utsumi R.

J Bacteriol. 2016 May 13;198(11):1604-1609. doi: 10.1128/JB.01028-15. Print 2016 Jun 1.

9.

Study on in vivo effects of bacterial histidine kinase inhibitor, Waldiomycin, in Bacillus subtilis and Staphylococcus aureus.

Fakhruzzaman M, Inukai Y, Yanagida Y, Kino H, Igarashi M, Eguchi Y, Utsumi R.

J Gen Appl Microbiol. 2015;61(5):177-84. doi: 10.2323/jgam.61.177.

10.

Functional Characterization of the Receiver Domain for Phosphorelay Control in Hybrid Sensor Kinases.

Kinoshita-Kikuta E, Kinoshita E, Eguchi Y, Yanagihara S, Edahiro K, Inoue Y, Taniguchi M, Yoshida M, Yamamoto K, Takahashi H, Sawasaki T, Utsumi R, Koike T.

PLoS One. 2015 Jul 7;10(7):e0132598. doi: 10.1371/journal.pone.0132598. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0136022.

11.

Alkali metals in addition to acidic pH activate the EvgS histidine kinase sensor in Escherichia coli.

Eguchi Y, Utsumi R.

J Bacteriol. 2014 Sep;196(17):3140-9. doi: 10.1128/JB.01742-14. Epub 2014 Jun 23.

12.

Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10.

Igarashi M, Watanabe T, Hashida T, Umekita M, Hatano M, Yanagida Y, Kino H, Kimura T, Kinoshita N, Inoue K, Sawa R, Nishimura Y, Utsumi R, Nomoto A.

J Antibiot (Tokyo). 2013 Aug;66(8):459-64. doi: 10.1038/ja.2013.33. Epub 2013 May 1.

PMID:
23632918
13.
14.

A connecter-like factor, CacA, links RssB/RpoS and the CpxR/CpxA two-component system in Salmonella.

Kato A, Hayashi H, Nomura W, Emori H, Hagihara K, Utsumi R.

BMC Microbiol. 2012 Oct 2;12:224. doi: 10.1186/1471-2180-12-224.

15.

The connector SafA interacts with the multi-sensing domain of PhoQ in Escherichia coli.

Eguchi Y, Ishii E, Yamane M, Utsumi R.

Mol Microbiol. 2012 Jul;85(2):299-313. doi: 10.1111/j.1365-2958.2012.08114.x. Epub 2012 Jun 11.

16.

Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK.

Watanabe T, Igarashi M, Okajima T, Ishii E, Kino H, Hatano M, Sawa R, Umekita M, Kimura T, Okamoto S, Eguchi Y, Akamatsu Y, Utsumi R.

Antimicrob Agents Chemother. 2012 Jul;56(7):3657-63. doi: 10.1128/AAC.06467-11. Epub 2012 Apr 23.

17.

[Two-component signal transduction as attractive drug targets in pathogenic bacteria].

Utsumi R, Igarashi M.

Yakugaku Zasshi. 2012;132(1):51-8. Review. Japanese.

18.

A short-chain dehydrogenase involved in terpene metabolism from Zingiber zerumbet.

Okamoto S, Yu F, Harada H, Okajima T, Hattan J, Misawa N, Utsumi R.

FEBS J. 2011 Aug;278(16):2892-900. doi: 10.1111/j.1742-4658.2011.08211.x. Epub 2011 Jul 5.

19.

Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C.

Eguchi Y, Kubo N, Matsunaga H, Igarashi M, Utsumi R.

Antimicrob Agents Chemother. 2011 Apr;55(4):1475-84. doi: 10.1128/AAC.01646-10. Epub 2011 Jan 31.

20.

Efficient functional analysis system for cyanobacterial or plant cytochromes P450 involved in sesquiterpene biosynthesis.

Harada H, Shindo K, Iki K, Teraoka A, Okamoto S, Yu F, Hattan J, Utsumi R, Misawa N.

Appl Microbiol Biotechnol. 2011 Apr;90(2):467-76. doi: 10.1007/s00253-010-3062-9. Epub 2011 Jan 13.

PMID:
21229242
21.

Regulation of acid resistance by connectors of two-component signal transduction systems in Escherichia coli.

Eguchi Y, Ishii E, Hata K, Utsumi R.

J Bacteriol. 2011 Mar;193(5):1222-8. doi: 10.1128/JB.01124-10. Epub 2010 Dec 30.

22.

PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine.

Sugiura T, Otake T, Shimizu T, Wakayama T, Silver DL, Utsumi R, Nishimura T, Iseki S, Nakamichi N, Kubo Y, Tsuji A, Kato Y.

Drug Metab Pharmacokinet. 2010;25(6):588-98. Epub 2010 Nov 12.

23.
24.

Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis.

Yu F, Okamoto S, Harada H, Yamasaki K, Misawa N, Utsumi R.

Cell Mol Life Sci. 2011 Mar;68(6):1033-40. doi: 10.1007/s00018-010-0506-4. Epub 2010 Aug 22.

PMID:
20730551
25.

Two-component signal transduction as potential drug targets in pathogenic bacteria.

Gotoh Y, Eguchi Y, Watanabe T, Okamoto S, Doi A, Utsumi R.

Curr Opin Microbiol. 2010 Apr;13(2):232-9. doi: 10.1016/j.mib.2010.01.008. Epub 2010 Feb 4. Review.

PMID:
20138000
26.

Novel antibacterial compounds specifically targeting the essential WalR response regulator.

Gotoh Y, Doi A, Furuta E, Dubrac S, Ishizaki Y, Okada M, Igarashi M, Misawa N, Yoshikawa H, Okajima T, Msadek T, Utsumi R.

J Antibiot (Tokyo). 2010 Mar;63(3):127-34. doi: 10.1038/ja.2010.4. Epub 2010 Jan 29.

PMID:
20111065
27.

Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.

Okada A, Igarashi M, Okajima T, Kinoshita N, Umekita M, Sawa R, Inoue K, Watanabe T, Doi A, Martin A, Quinn J, Nishimura Y, Utsumi R.

J Antibiot (Tokyo). 2010 Feb;63(2):89-94. doi: 10.1038/ja.2009.128. Epub 2010 Jan 8.

PMID:
20057515
28.

Diversity, regulation, and genetic manipulation of plant mono- and sesquiterpenoid biosynthesis.

Yu F, Utsumi R.

Cell Mol Life Sci. 2009 Sep;66(18):3043-52. doi: 10.1007/s00018-009-0066-7. Epub 2009 Jun 23. Review.

PMID:
19547916
29.

Molecular mechanism of transcriptional cascade initiated by the EvgS/EvgA system in Escherichia coli K-12.

Itou J, Eguchi Y, Utsumi R.

Biosci Biotechnol Biochem. 2009 Apr 23;73(4):870-8. Epub 2009 Apr 7.

30.

Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli.

Harada H, Yu F, Okamoto S, Kuzuyama T, Utsumi R, Misawa N.

Appl Microbiol Biotechnol. 2009 Jan;81(5):915-25. doi: 10.1007/s00253-008-1724-7. Epub 2008 Oct 3.

PMID:
18836713
31.

Inhibitors targeting two-component signal transduction.

Watanabe T, Okada A, Gotoh Y, Utsumi R.

Adv Exp Med Biol. 2008;631:229-36. doi: 10.1007/978-0-387-78885-2_16. Review.

PMID:
18792693
32.

Introduction to bacterial signal transduction networks.

Eguchi Y, Utsumi R.

Adv Exp Med Biol. 2008;631:1-6. doi: 10.1007/978-0-387-78885-2_1. Review.

PMID:
18792678
33.

Bacterial signal transduction: networks and drug targets. Preface.

Utsumi R.

Adv Exp Med Biol. 2008;631:v. No abstract available.

PMID:
18792677
34.

Response regulator YycF essential for bacterial growth: X-ray crystal structure of the DNA-binding domain and its PhoB-like DNA recognition motif.

Okajima T, Doi A, Okada A, Gotoh Y, Tanizawa K, Utsumi R.

FEBS Lett. 2008 Oct 15;582(23-24):3434-8. doi: 10.1016/j.febslet.2008.09.007. Epub 2008 Sep 26.

35.

Ascochytatin, a novel bioactive spirodioxynaphthalene metabolite produced by the marine-derived fungus, Ascochyta sp. NGB4.

Kanoh K, Okada A, Adachi K, Imagawa H, Nishizawa M, Matsuda S, Shizuri Y, Utsumi R.

J Antibiot (Tokyo). 2008 Mar;61(3):142-8. doi: 10.1038/ja.2008.123.

PMID:
18503192
36.

Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter.

Mitsuoka K, Miyoshi S, Kato Y, Murakami Y, Utsumi R, Kubo Y, Noda A, Nakamura Y, Nishimura S, Tsuji A.

J Nucl Med. 2008 Apr;49(4):615-22. doi: 10.2967/jnumed.107.048231. Epub 2008 Mar 14.

37.

Molecular cloning and functional characterization of alpha-humulene synthase, a possible key enzyme of zerumbone biosynthesis in shampoo ginger (Zingiber zerumbet Smith).

Yu F, Okamto S, Nakasone K, Adachi K, Matsuda S, Harada H, Misawa N, Utsumi R.

Planta. 2008 May;227(6):1291-9. doi: 10.1007/s00425-008-0700-x. Epub 2008 Feb 14.

PMID:
18273640
38.

Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith.

Yu F, Harada H, Yamasaki K, Okamoto S, Hirase S, Tanaka Y, Misawa N, Utsumi R.

FEBS Lett. 2008 Mar 5;582(5):565-72. doi: 10.1016/j.febslet.2008.01.020. Epub 2008 Jan 31.

39.

B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli.

Eguchi Y, Itou J, Yamane M, Demizu R, Yamato F, Okada A, Mori H, Kato A, Utsumi R.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18712-7. Epub 2007 Nov 12.

40.

Targeting two-component signal transduction: a novel drug discovery system.

Okada A, Gotoh Y, Watanabe T, Furuta E, Yamamoto K, Utsumi R.

Methods Enzymol. 2007;422:386-95.

PMID:
17628150
41.

A time- and cost-saving method of producing rat polyclonal antibodies.

Wakayama T, Kato Y, Utsumi R, Tsuji A, Iseki S.

Acta Histochem Cytochem. 2006 Jul 1;39(3):79-87. Epub 2006 Apr 19.

42.

Synthesis of a novel inhibitor against MRSA and VRE: preparation from zerumbone ring opening material showing histidine-kinase inhibition.

Kitayama T, Iwabuchi R, Minagawa S, Sawada S, Okumura R, Hoshino K, Cappiello J, Utsumi R.

Bioorg Med Chem Lett. 2007 Feb 15;17(4):1098-101. Epub 2006 Nov 10.

PMID:
17157007
43.

Negative regulation of DNA repair gene (uvrA) expression by ArcA/ArcB two-component system in Escherichia coli.

Ogasawara H, Teramoto J, Yamamoto S, Hirao K, Yamamoto K, Ishihama A, Utsumi R.

FEMS Microbiol Lett. 2005 Oct 15;251(2):243-9.

44.

Isolation and molecular characterization of the locked-on mutant of Mg2+ sensor PhoQ in Escherichia coli.

Minagawa S, Okura R, Tsuchitani H, Hirao K, Yamamoto K, Utsumi R.

Biosci Biotechnol Biochem. 2005 Jul;69(7):1281-7.

45.

Targeting protein homodimerization: a novel drug discovery system.

Furuta E, Yamamoto K, Tatebe D, Watabe K, Kitayama T, Utsumi R.

FEBS Lett. 2005 Apr 11;579(10):2065-70.

46.

A novel mechanism for connecting bacterial two-component signal-transduction systems.

Eguchi Y, Utsumi R.

Trends Biochem Sci. 2005 Feb;30(2):70-2.

PMID:
15691651
47.
48.

Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.

Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.

J Biol Chem. 2005 Jan 14;280(2):1448-56. Epub 2004 Nov 2.

49.

Unprecedented olefin-dependent histidine-kinase inhibitory of zerumbone ring-opening material.

Kitayama T, Iwabuchi R, Minagawa S, Shiomi F, Cappiello J, Sawada S, Utsumi R, Okamoto T.

Bioorg Med Chem Lett. 2004 Dec 6;14(23):5943-6.

PMID:
15501073
50.

P-glycoprotein mediates resistance to histidine kinase inhibitors.

Arora S, Yang JM, Utsumi R, Okamoto T, Kitayama T, Hait WN.

Mol Pharmacol. 2004 Sep;66(3):460-7.

PMID:
15322237

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