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Items: 46

1.

Importance of cynomolgus monkeys in development of monoclonal antibody drugs.

Iwasaki K, Uno Y, Utoh M, Yamazaki H.

Drug Metab Pharmacokinet. 2018 Mar 20. pii: S1347-4367(17)30074-5. doi: 10.1016/j.dmpk.2018.02.003. [Epub ahead of print] Review.

PMID:
29655914
2.

Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies.

Murayama N, Yajima K, Hikawa M, Shimura K, Ishii Y, Takada M, Uno Y, Utoh M, Iwasaki K, Yamazaki H.

Biopharm Drug Dispos. 2018 Feb;39(2):116-121. doi: 10.1002/bdd.2115. Epub 2017 Dec 21.

PMID:
29136681
3.

Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models.

Kusama T, Toda A, Shimizu M, Uehara S, Inoue T, Uno Y, Utoh M, Sasaki E, Yamazaki H.

Xenobiotica. 2018 Oct;48(10):1072-1077. doi: 10.1080/00498254.2017.1393121. Epub 2017 Nov 10.

PMID:
29034770
4.

Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.

Toda A, Uehara S, Inoue T, Utoh M, Kusama T, Shimizu M, Uno Y, Mogi M, Sasaki E, Yamazaki H.

Xenobiotica. 2018 Jul;48(7):720-726. doi: 10.1080/00498254.2017.1353716. Epub 2017 Jul 25.

PMID:
28686070
5.

Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models.

Utoh M, Miura T, Kusama T, Uehara S, Shimizu M, Uno Y, Yamazaki H.

Biopharm Drug Dispos. 2017 Oct;38(7):439-442. doi: 10.1002/bdd.2084. Epub 2017 Jul 19.

PMID:
28608515
6.

R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys.

Utoh M, Kusama T, Miura T, Mitsui M, Kawano M, Hirano T, Shimizu M, Uno Y, Yamazaki H.

Xenobiotica. 2018 Feb;48(2):206-210. doi: 10.1080/00498254.2017.1288945. Epub 2017 Feb 20.

PMID:
28136132
7.

Strong Induction of Cytochrome P450 1A/3A, But not P450 2B, in Cultured Hepatocytes from Common Marmosets and Cynomolgus Monkeys by Typical Human P450 Inducing Agents.

Uehara S, Uno Y, Suzuki T, Inoue T, Utoh M, Sasaki E, Yamazaki H.

Drug Metab Lett. 2017;10(4):244-253. doi: 10.2174/1872312810666161114144412.

PMID:
27842484
8.

Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.

Takahashi T, Ohtsuka T, Uno Y, Utoh M, Yamazaki H, Kume T.

Biopharm Drug Dispos. 2016 Nov;37(8):479-490. doi: 10.1002/bdd.2039. Epub 2016 Oct 14.

PMID:
27603548
9.

Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets.

Uehara S, Kawano M, Murayama N, Uno Y, Utoh M, Inoue T, Sasaki E, Yamazaki H.

Biochem Pharmacol. 2016 Nov 15;120:56-62. doi: 10.1016/j.bcp.2016.09.010. Epub 2016 Sep 21.

PMID:
27641812
10.

In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.

Iwasaki K, Kitsugi Y, Ikeda K, Yoshikawa T, Hosaka S, Uehara S, Uno Y, Utoh M, Yamazaki H.

Biopharm Drug Dispos. 2016 Sep;37(6):379-83. doi: 10.1002/bdd.2021.

PMID:
27417918
11.

Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers.

Uehara S, Uno Y, Inoue T, Kawano M, Shimizu M, Toda A, Utoh M, Sasaki E, Yamazaki H.

Drug Metab Dispos. 2016 Jul;44(7):911-5. doi: 10.1124/dmd.116.070383. Epub 2016 Apr 20.

PMID:
27098744
12.
13.

Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets.

Uehara S, Uno Y, Inoue T, Suzuki T, Utoh M, Sasaki E, Yamazaki H.

Xenobiotica. 2016 Jul;46(7):573-578. doi: 10.3109/00498254.2015.1096980. Epub 2015 Oct 27.

PMID:
26503341
14.

Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.

Uehara S, Uno Y, Inoue T, Kawano M, Shimizu M, Toda A, Utoh M, Sasaki E, Yamazaki H.

Drug Metab Dispos. 2015 Oct;43(10):1408-16. doi: 10.1124/dmd.115.066100. Epub 2015 Jul 30.

PMID:
26228688
15.

Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus).

Uehara S, Inoue T, Utoh M, Toda A, Shimizu M, Uno Y, Sasaki E, Yamazaki H.

Xenobiotica. 2016;46(2):163-8. doi: 10.3109/00498254.2015.1057270. Epub 2015 Jun 26.

PMID:
26114209
16.

Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.

Shida S, Utoh M, Murayama N, Shimizu M, Uno Y, Yamazaki H.

Xenobiotica. 2015;45(10):881-6. doi: 10.3109/00498254.2015.1028511. Epub 2015 Jun 15.

PMID:
26075833
17.

Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo.

Utoh M, Yoshikawa T, Hayashi Y, Shimizu M, Iwasaki K, Uno Y, Yamazaki H.

Biochem Pharmacol. 2015 May 15;95(2):110-4. doi: 10.1016/j.bcp.2015.03.008. Epub 2015 Mar 20.

PMID:
25801008
18.

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.

Koyanagi T, Nakanishi Y, Murayama N, Yamaura Y, Ikeda K, Yano K, Uehara S, Utoh M, Kim S, Uno Y, Yamazaki H.

Xenobiotica. 2015 Apr;45(4):312-21. doi: 10.3109/00498254.2014.979271. Epub 2014 Nov 3.

PMID:
25364857
19.

Polymorphisms of neonatal Fc receptor in cynomolgus and rhesus macaques.

Uno Y, Utoh M, Iwasaki K.

Drug Metab Pharmacokinet. 2014;29(5):427-30. Epub 2014 May 6.

20.

Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450.

Yajima K, Uno Y, Murayama N, Uehara S, Shimizu M, Nakamura C, Iwasaki K, Utoh M, Yamazaki H.

Drug Metab Dispos. 2014 May;42(5):867-71. doi: 10.1124/dmd.113.056804. Epub 2014 Feb 19.

PMID:
24553381
21.

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.

Murayama N, van Beuningen R, Suemizu H, Guillouzo CG, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H.

Chem Res Toxicol. 2014 Feb 17;27(2):304-308. doi: 10.1021/tx4004374. Epub 2014 Feb 5.

22.

Pitavastatin as an in vivo probe for studying hepatic organic anion transporting polypeptide-mediated drug-drug interactions in cynomolgus monkeys.

Takahashi T, Ohtsuka T, Yoshikawa T, Tatekawa I, Uno Y, Utoh M, Yamazaki H, Kume T.

Drug Metab Dispos. 2013 Oct;41(10):1875-82. doi: 10.1124/dmd.113.052753. Epub 2013 Aug 8.

PMID:
23929936
23.

Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline.

Utoh M, Murayama N, Uno Y, Onose Y, Hosaka S, Fujino H, Shimizu M, Iwasaki K, Yamazaki H.

Xenobiotica. 2013 Dec;43(12):1037-42. doi: 10.3109/00498254.2013.793874. Epub 2013 May 16.

PMID:
23679834
24.

Cytochrome P450 metabolic activities in the small intestine of cynomolgus macaques bred in Cambodia, China, and Indonesia.

Nakanishi Y, Yamashita H, Yoshikawa T, Tominaga T, Nojiri K, Sunaga Y, Muneoka A, Iwasaki K, Utoh M, Nakamura C, Yamazaki H, Uno Y.

Drug Metab Pharmacokinet. 2013;28(6):510-3. Epub 2013 May 7.

25.

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP.

Chem Res Toxicol. 2013 Mar 18;26(3):486-9. doi: 10.1021/tx400008g. Epub 2013 Mar 1.

26.

Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs.

Mogi M, Toda A, Iwasaki K, Kusumoto S, Takehara H, Shimizu M, Murayama N, Izumi H, Utoh M, Yamazaki H.

J Toxicol Sci. 2012;37(6):1157-64.

27.

Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation.

Hosoi Y, Uno Y, Murayama N, Fujino H, Shukuya M, Iwasaki K, Shimizu M, Utoh M, Yamazaki H.

Biochem Pharmacol. 2012 Dec 15;84(12):1691-5. doi: 10.1016/j.bcp.2012.09.026. Epub 2012 Oct 3.

PMID:
23041648
28.

Expression profile of hepatic genes in cynomolgus macaques bred in Cambodia, China, and Indonesia: implications for cytochrome P450 genes.

Ise R, Nakanishi Y, Kohara S, Yamashita H, Yoshikawa T, Iwasaki K, Nagata R, Fukuzaki K, Utoh M, Nakamura C, Yamazaki H, Uno Y.

Drug Metab Pharmacokinet. 2012;27(3):307-16. Epub 2011 Dec 13.

29.

Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey.

Uno Y, Uehara S, Kohara S, Iwasaki K, Nagata R, Fukuzaki K, Utoh M, Murayama N, Yamazaki H.

PLoS One. 2011 Feb 8;6(2):e16923. doi: 10.1371/journal.pone.0016923.

30.

Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.

Nakanishi Y, Matsushita A, Matsuno K, Iwasaki K, Utoh M, Nakamura C, Uno Y.

Drug Metab Pharmacokinet. 2011 Jun;26(3):288-94. doi: 10.2133/dmpk.DMPK-10-NT-101. Epub 2011 Jan 25.

31.

Cynomolgus macaque CYP4 isoforms are functional, metabolizing arachidonic acid.

Uno Y, Matsuno K, Nakamura C, Utoh M, Yamazaki H.

J Vet Med Sci. 2011 Apr;73(4):487-90. Epub 2010 Nov 19.

32.

Regional distribution of cytochrome p450 mRNA expression in the liver and small intestine of cynomolgus monkeys.

Nakanishi Y, Matsushita A, Matsuno K, Iwasaki K, Utoh M, Nakamura C, Uno Y.

Drug Metab Pharmacokinet. 2010;25(3):290-7.

33.

Alprazolam as an in vivo probe for studying induction of CYP3A in cynomolgus monkeys.

Ohtsuka T, Yoshikawa T, Kozakai K, Tsuneto Y, Uno Y, Utoh M, Yamazaki H, Kume T.

Drug Metab Dispos. 2010 Oct;38(10):1806-13. doi: 10.1124/dmd.110.032656. Epub 2010 Jun 28.

PMID:
20584745
34.

Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes.

Uno Y, Fujino H, Iwasaki K, Utoh M.

Curr Drug Metab. 2010 Feb;11(2):142-52. Review.

PMID:
20359284
35.

Identification and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis).

Uno Y, Matsuno K, Nakamura C, Utoh M, Yamazaki H.

J Vet Med Sci. 2009 Dec;71(12):1653-6.

36.

Cloning, expression, and characterization of CYP3A43 cDNA in cynomolgus macaque (Macaca fascicularis).

Uno Y, Matsuno K, Nakamura C, Utoh M, Yamazaki H.

Drug Metab Lett. 2009 Dec;3(4):228-33.

PMID:
20041831
37.

Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis).

Uno Y, Matsuno K, Nakamura C, Utoh M, Yamazaki H.

J Vet Med Sci. 2010 Feb;72(2):225-8. Epub 2009 Nov 25.

38.

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

Uno Y, Matsushita A, Osada N, Uehara S, Kohara S, Nagata R, Fukuzaki K, Utoh M, Murayama N, Yamazaki H.

Drug Metab Dispos. 2010 Feb;38(2):209-14. doi: 10.1124/dmd.109.029710. Epub 2009 Nov 12.

PMID:
19910514
39.

Effect of oral ketoconazole on oral and intravenous pharmacokinetics of simvastatin and its acid in cynomolgus monkeys.

Ogasawara A, Utoh M, Nii K, Ueda A, Yoshikawa T, Kume T, Fukuzaki K.

Drug Metab Dispos. 2009 Jan;37(1):122-8. doi: 10.1124/dmd.108.022574. Epub 2008 Oct 14.

PMID:
18854378
40.

Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients.

Schüller J, Cassidy J, Dumont E, Roos B, Durston S, Banken L, Utoh M, Mori K, Weidekamm E, Reigner B.

Cancer Chemother Pharmacol. 2000;45(4):291-7.

PMID:
10755317
41.

Effect of hepatic dysfunction due to liver metastases on the pharmacokinetics of capecitabine and its metabolites.

Twelves C, Glynne-Jones R, Cassidy J, Schüller J, Goggin T, Roos B, Banken L, Utoh M, Weidekamm E, Reigner B.

Clin Cancer Res. 1999 Jul;5(7):1696-702.

42.

Influence of the antacid Maalox on the pharmacokinetics of capecitabine in cancer patients.

Reigner B, Clive S, Cassidy J, Jodrell D, Schulz R, Goggin T, Banken L, Roos B, Utoh M, Mulligan T, Weidekamm E.

Cancer Chemother Pharmacol. 1999;43(4):309-15.

PMID:
10071982
43.

Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts.

Ishikawa T, Utoh M, Sawada N, Nishida M, Fukase Y, Sekiguchi F, Ishitsuka H.

Biochem Pharmacol. 1998 Apr 1;55(7):1091-7.

PMID:
9605432
44.

Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients.

Reigner B, Verweij J, Dirix L, Cassidy J, Twelves C, Allman D, Weidekamm E, Roos B, Banken L, Utoh M, Osterwalder B.

Clin Cancer Res. 1998 Apr;4(4):941-8.

45.

Determination of 5-fluorouracil in plasma and liver after oral administration of 5'-deoxy-5-fluorouridine using gas chromatography-mass spectrometry.

Odagiri H, Ichihara S, Semura E, Utoh M, Tateishi M, Kuruma I.

J Pharmacobiodyn. 1988 Apr;11(4):234-40.

PMID:
2970537

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