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Items: 1 to 50 of 66

1.

Emergence of AnnexinVpos CD31neg CD42blow/neg extracellular vesicles in plasma of humans at extreme altitude.

Utermöhlen O, Jakobshagen K, Blissenbach B, Wiegmann K, Merz T, Hefti JP, Krönke M.

PLoS One. 2019 Aug 1;14(8):e0220133. doi: 10.1371/journal.pone.0220133. eCollection 2019.

2.

Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO.

Herb M, Gluschko A, Wiegmann K, Farid A, Wolf A, Utermöhlen O, Krut O, Krönke M, Schramm M.

Sci Signal. 2019 Feb 12;12(568). pii: eaar5926. doi: 10.1126/scisignal.aar5926.

PMID:
30755476
3.

TLR signals license CD8 T cells to destroy oligodendrocytes expressing an antigen shared with a Listeria pathogen.

Sánchez-Ruiz M, Polakos NK, Blau T, Utermöhlen O, Brunn A, Montesinos-Rongen M, Hünig T, Deckert M.

Eur J Immunol. 2019 Mar;49(3):413-427. doi: 10.1002/eji.201847834. Epub 2019 Feb 11.

PMID:
30666625
4.

Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor.

von Bargen K, Scraba M, Krämer I, Ketterer M, Nehls C, Krokowski S, Repnik U, Wittlich M, Maaser A, Zapka P, Bunge M, Schlesinger M, Huth G, Klees A, Hansen P, Jeschke A, Bendas G, Utermöhlen O, Griffiths G, Gutsmann T, Wohlmann J, Haas A.

Cell Microbiol. 2019 Jan;21(1):e12958. doi: 10.1111/cmi.12958. Epub 2018 Nov 9.

PMID:
30251327
5.

The β2 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes.

Gluschko A, Herb M, Wiegmann K, Krut O, Neiss WF, Utermöhlen O, Krönke M, Schramm M.

Cell Host Microbe. 2018 Mar 14;23(3):324-337.e5. doi: 10.1016/j.chom.2018.01.018.

6.

Using Antigen-Specific B Cells to Combine Antibody and T Cell-Based Cancer Immunotherapy.

Wennhold K, Thelen M, Schlößer HA, Haustein N, Reuter S, Garcia-Marquez M, Lechner A, Kobold S, Rataj F, Utermöhlen O, Chakupurakal G, Theurich S, Hallek M, Abken H, Shimabukuro-Vornhagen A, von Bergwelt-Baildon M.

Cancer Immunol Res. 2017 Sep;5(9):730-743. doi: 10.1158/2326-6066.CIR-16-0236. Epub 2017 Aug 4.

7.

Autophagy determines efficiency of liver-directed gene therapy with adeno-associated viral vectors.

Hösel M, Huber A, Bohlen S, Lucifora J, Ronzitti G, Puzzo F, Boisgerault F, Hacker UT, Kwanten WJ, Klöting N, Blüher M, Gluschko A, Schramm M, Utermöhlen O, Bloch W, Mingozzi F, Krut O, Büning H.

Hepatology. 2017 Jul;66(1):252-265. doi: 10.1002/hep.29176. Epub 2017 May 29.

8.

Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.

Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, Korhonen E, Smura T, Vapalahti O, Papantonis A, Schmidt-Chanasit J, Riparbelli M, Callaini G, Krönke M, Utermöhlen O, Gopalakrishnan J.

Cell Stem Cell. 2017 Mar 2;20(3):397-406.e5. doi: 10.1016/j.stem.2016.12.005. Epub 2017 Jan 26.

9.

Toll-Like Receptor 2, Toll-Like Receptor 4, Myeloid Differentiation Response Gene 88, and Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing Interferon-γ (TRIF) Selectively Regulate Susceptibility of P0106-125-Induced Murine Experimental Autoimmune Neuritis.

Brunn A, Mihelcic M, Carstov M, Feind L, Wieser EC, Schmidt J, Utermöhlen O, Deckert M.

Am J Pathol. 2017 Jan;187(1):42-54. doi: 10.1016/j.ajpath.2016.09.009. Epub 2016 Nov 11.

PMID:
27842213
10.

An inducible transgenic mouse breast cancer model for the analysis of tumor antigen specific CD8+ T-cell responses.

Bruns M, Wanger J, Utermöhlen O, Deppert W.

Oncotarget. 2015 Nov 17;6(36):38487-503. doi: 10.18632/oncotarget.5750.

11.

Endogenous Il10 alleviates the systemic antiviral cellular immune response and T cell-mediated immunopathology in select organs of acutely LCMV-infected mice.

Jakobshagen K, Ward B, Baschuk N, Huss S, Brunn A, Malecki M, Fiolka M, Rappl G, Corogeanu D, Karow U, Schiller P, Abken H, Heukamp LC, Deckert M, Krönke M, Utermöhlen O.

Am J Pathol. 2015 Nov;185(11):3025-38. doi: 10.1016/j.ajpath.2015.07.019.

PMID:
26506472
12.

Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function.

Dannhausen K, Karlstetter M, Caramoy A, Volz C, Jägle H, Liebisch G, Utermöhlen O, Langmann T.

Biochem Biophys Res Commun. 2015 Aug 21;464(2):434-40. doi: 10.1016/j.bbrc.2015.06.133. Epub 2015 Jun 27.

PMID:
26129774
13.

Host microbiota constantly control maturation and function of microglia in the CNS.

Erny D, Hrabě de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Utermöhlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A, Staeheli P, Stecher B, Amit I, Prinz M.

Nat Neurosci. 2015 Jul;18(7):965-77. doi: 10.1038/nn.4030. Epub 2015 Jun 1.

14.

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.

Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20.

15.

The N-terminal domain of NLRC5 confers transcriptional activity for MHC class I and II gene expression.

Neerincx A, Jakobshagen K, Utermöhlen O, Büning H, Steimle V, Kufer TA.

J Immunol. 2014 Sep 15;193(6):3090-100. doi: 10.4049/jimmunol.1401065. Epub 2014 Aug 15.

16.

IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis.

Brunn A, Mihelcic M, Carstov M, Hummel L, Geier F, Schmidt A, Saupe L, Utermöhlen O, Deckert M.

Am J Pathol. 2014 Oct;184(10):2627-40. doi: 10.1016/j.ajpath.2014.06.012. Epub 2014 Aug 7.

PMID:
25108223
17.

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H.

EMBO J. 2014 Oct 1;33(19):2171-87. doi: 10.15252/embj.201387244. Epub 2014 Jul 23.

18.

Costimulatory molecule CD40 is essential for myelin protein 0 peptide 106-125-induced experimental autoimmune neuritis in mice.

Brunn A, Utermöhlen O, Mihelcic M, Saupe L, Fiocco Z, Schmidt A, Carstov M, Montesinos-Rongen M, Deckert M.

J Neuropathol Exp Neurol. 2014 May;73(5):454-66. doi: 10.1097/NEN.0000000000000069.

PMID:
24709684
19.

Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes.

Schramm M, Wiegmann K, Schramm S, Gluschko A, Herb M, Utermöhlen O, Krönke M.

Eur J Immunol. 2014 Mar;44(3):728-41. doi: 10.1002/eji.201343940. Epub 2013 Dec 27.

20.

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.

Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B.

Nature. 2013 Sep 19;501(7467):416-20. doi: 10.1038/nature12452. Epub 2013 Aug 25.

21.

TNF-receptor-1 adaptor protein FAN mediates TNF-induced B16 melanoma motility and invasion.

Boecke A, Carstens AC, Neacsu CD, Baschuk N, Haubert D, Kashkar H, Utermöhlen O, Pongratz C, Krönke M.

Br J Cancer. 2013 Jul 23;109(2):422-32. doi: 10.1038/bjc.2013.242. Epub 2013 May 14.

22.

Differential effects of CXCR4-CXCL12- and CXCR7-CXCL12-mediated immune reactions on murine P0106-125 -induced experimental autoimmune neuritis.

Brunn A, Utermöhlen O, Mihelcic M, Sánchez-Ruiz M, Carstov M, Blau T, Ustinova I, Penfold M, Montesinos-Rongen M, Deckert M.

Neuropathol Appl Neurobiol. 2013 Dec;39(7):772-87. doi: 10.1111/nan.12039.

PMID:
23452257
23.

Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.

Sydor T, von Bargen K, Hsu FF, Huth G, Holst O, Wohlmann J, Becken U, Dykstra T, Söhl K, Lindner B, Prescott JF, Schaible UE, Utermöhlen O, Haas A.

Cell Microbiol. 2013 Mar;15(3):458-73. doi: 10.1111/cmi.12050. Epub 2012 Nov 13.

24.

Therapeutic concentrations of antibiotics inhibit Shiga toxin release from enterohemorrhagic E. coli O104:H4 from the 2011 German outbreak.

Corogeanu D, Willmes R, Wolke M, Plum G, Utermöhlen O, Krönke M.

BMC Microbiol. 2012 Aug 1;12:160. doi: 10.1186/1471-2180-12-160.

25.

Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death.

Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, Karow U, Herold MJ, Lühder F, Utermöhlen O, Reichardt HM.

J Immunol. 2011 Nov 1;187(9):4509-16. doi: 10.4049/jimmunol.1100911. Epub 2011 Sep 23.

26.

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

Liesenfeld O, Parvanova I, Zerrahn J, Han SJ, Heinrich F, Muñoz M, Kaiser F, Aebischer T, Buch T, Waisman A, Reichmann G, Utermöhlen O, von Stebut E, von Loewenich FD, Bogdan C, Specht S, Saeftel M, Hoerauf A, Mota MM, Könen-Waisman S, Kaufmann SH, Howard JC.

PLoS One. 2011;6(6):e20568. doi: 10.1371/journal.pone.0020568. Epub 2011 Jun 17.

27.

Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.

von Bargen K, Wohlmann J, Taylor GA, Utermöhlen O, Haas A.

Infect Immun. 2011 May;79(5):2098-111. doi: 10.1128/IAI.00983-10. Epub 2011 Mar 7.

28.

Antibody response to the extracellular adherence protein (Eap) of Staphylococcus aureus in healthy and infected individuals.

Joost I, Jacob S, Utermöhlen O, Schubert U, Patti JM, Ong MF, Gross J, Justinger C, Renno JH, Preissner KT, Bischoff M, Herrmann M.

FEMS Immunol Med Microbiol. 2011 Jun;62(1):23-31. doi: 10.1111/j.1574-695X.2011.00783.x. Epub 2011 Feb 14.

29.

Dual role of B cells with accelerated onset but reduced disease activity in P0₁₀₆₋₁₂₅-induced experimental autoimmune neuritis of IgH ⁰(/)⁰ mice.

Brunn A, Utermöhlen O, Sánchez-Ruiz M, Montesinos-Rongen M, Blau T, Schlüter D, Deckert M.

Acta Neuropathol. 2010 Nov;120(5):667-81. doi: 10.1007/s00401-010-0724-8. Epub 2010 Jul 18.

PMID:
20640902
30.

Immunologic hurdles of therapeutic stem cell transplantation.

Utermöhlen O, Baschuk N, Abdullah Z, Engelmann A, Siebolts U, Wickenhauser C, Stocking C, Krönke M.

Biol Chem. 2009 Oct;390(10):977-83. doi: 10.1515/BC.2009.114. Review.

PMID:
19642871
31.

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.

Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M.

Nature. 2009 Aug 27;460(7259):1159-63. doi: 10.1038/nature08206. Epub 2009 Jul 29.

PMID:
19641494
32.

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.

Herz J, Pardo J, Kashkar H, Schramm M, Kuzmenkina E, Bos E, Wiegmann K, Wallich R, Peters PJ, Herzig S, Schmelzer E, Krönke M, Simon MM, Utermöhlen O.

Nat Immunol. 2009 Jul;10(7):761-8. doi: 10.1038/ni.1757. Epub 2009 Jun 14.

PMID:
19525969
33.

Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes.

Frenzel LP, Abdullah Z, Kriegeskorte AK, Dieterich R, Lange N, Busch DH, Krönke M, Utermöhlen O, Hescheler J, Sarić T.

Stem Cells. 2009 Feb;27(2):307-16. doi: 10.1634/stemcells.2008-0528.

34.

Infection of myeloid dendritic cells with Listeria monocytogenes leads to the suppression of T cell function by multiple inhibitory mechanisms.

Popov A, Driesen J, Abdullah Z, Wickenhauser C, Beyer M, Debey-Pascher S, Saric T, Kummer S, Takikawa O, Domann E, Chakraborty T, Krönke M, Utermöhlen O, Schultze JL.

J Immunol. 2008 Oct 1;181(7):4976-88.

35.

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.

Ermolaeva MA, Michallet MC, Papadopoulou N, Utermöhlen O, Kranidioti K, Kollias G, Tschopp J, Pasparakis M.

Nat Immunol. 2008 Sep;9(9):1037-46. doi: 10.1038/ni.1638. Epub 2008 Jul 20.

PMID:
18641654
36.

CD4 T cells mediate axonal damage and spinal cord motor neuron apoptosis in murine p0106-125-induced experimental autoimmune neuritis.

Brunn A, Utermöhlen O, Carstov M, Ruiz MS, Miletic H, Schlüter D, Deckert M.

Am J Pathol. 2008 Jul;173(1):93-105. doi: 10.2353/ajpath.2008.071101. Epub 2008 Jun 5.

37.

Acid sphingomyelinase is required for efficient phago-lysosomal fusion.

Schramm M, Herz J, Haas A, Krönke M, Utermöhlen O.

Cell Microbiol. 2008 Sep;10(9):1839-53. doi: 10.1111/j.1462-5822.2008.01169.x. Epub 2008 May 13.

PMID:
18485117
38.

Fusogenicity of membranes: the impact of acid sphingomyelinase on innate immune responses.

Utermöhlen O, Herz J, Schramm M, Krönke M.

Immunobiology. 2008;213(3-4):307-14. doi: 10.1016/j.imbio.2007.10.016. Epub 2007 Dec 31. Review.

PMID:
18406376
39.

Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis.

Sakowicz-Burkiewicz M, Nishanth G, Helmuth U, Drögemüller K, Busch DH, Utermöhlen O, Naumann M, Deckert M, Schlüter D.

J Immunol. 2008 Apr 15;180(8):5601-12.

40.

Survival of priceless cells: active and passive protection of embryonic stem cells against immune destruction.

Utermöhlen O, Krönke M.

Arch Biochem Biophys. 2007 Jun 15;462(2):273-7. Epub 2007 Apr 10. Review.

PMID:
17459325
41.

Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice.

Baschuk N, Utermöhlen O, Gugel R, Warnecke G, Karow U, Paulsen D, Brombacher F, Krönke M, Deppert W.

Cancer Immunol Immunother. 2007 Oct;56(10):1625-36. Epub 2007 Apr 13.

PMID:
17431618
42.

Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTL.

Abdullah Z, Saric T, Kashkar H, Baschuk N, Yazdanpanah B, Fleischmann BK, Hescheler J, Krönke M, Utermöhlen O.

J Immunol. 2007 Mar 15;178(6):3390-9.

43.

Fast set-up of doxycycline-inducible protein expression in human cell lines with a single plasmid based on Epstein-Barr virus replication and the simple tetracycline repressor.

Bach M, Grigat S, Pawlik B, Fork C, Utermöhlen O, Pal S, Banczyk D, Lazar A, Schömig E, Gründemann D.

FEBS J. 2007 Feb;274(3):783-90.

44.

Accelerated wound closure in mice deficient for interleukin-10.

Eming SA, Werner S, Bugnon P, Wickenhauser C, Siewe L, Utermöhlen O, Davidson JM, Krieg T, Roers A.

Am J Pathol. 2007 Jan;170(1):188-202.

45.

Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection.

Popov A, Abdullah Z, Wickenhauser C, Saric T, Driesen J, Hanisch FG, Domann E, Raven EL, Dehus O, Hermann C, Eggle D, Debey S, Chakraborty T, Krönke M, Utermöhlen O, Schultze JL.

J Clin Invest. 2006 Dec;116(12):3160-70. Epub 2006 Nov 16.

46.

A-to-G hypermutation in the genome of lymphocytic choriomeningitis virus.

Zahn RC, Schelp I, Utermöhlen O, von Laer D.

J Virol. 2007 Jan;81(2):457-64. Epub 2006 Oct 4.

47.

XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack.

Kashkar H, Seeger JM, Hombach A, Deggerich A, Yazdanpanah B, Utermöhlen O, Heimlich G, Abken H, Krönke M.

Blood. 2006 Nov 15;108(10):3434-40. Epub 2006 Jul 25.

48.

Regulation of the inflammatory response to Staphylococcus aureus-induced brain abscess by interleukin-10.

Stenzel W, Dahm J, Sanchez-Ruiz M, Miletic H, Hermann M, Courts C, Schwindt H, Utermöhlen O, Schlüter D, Deckert M.

J Neuropathol Exp Neurol. 2005 Dec;64(12):1046-57.

PMID:
16319715
49.

Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient mice.

Knobeloch KP, Utermöhlen O, Kisser A, Prinz M, Horak I.

Mol Cell Biol. 2005 Dec;25(24):11030-4.

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