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Items: 1 to 50 of 60

1.

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.

Saleme B, Gurtu V, Zhang Y, Kinnaird A, Boukouris AE, Gopal K, Ussher JR, Sutendra G.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau8866. doi: 10.1126/scitranslmed.aau8866.

PMID:
30728290
2.

The antianginal ranolazine mitigates obesity-induced nonalcoholic fatty liver disease and increases hepatic pyruvate dehydrogenase activity.

Al Batran R, Gopal K, Aburasayn H, Eshreif A, Almutairi M, Greenwell AA, Campbell SA, Saleme B, Court EA, Eaton F, Light PE, Sutendra G, Ussher JR.

JCI Insight. 2019 Jan 10;4(1). pii: 124643. doi: 10.1172/jci.insight.124643. [Epub ahead of print]

3.

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction.

Karwi QG, Zhang L, Wagg CS, Wang W, Ghandi M, Thai D, Yan H, Ussher JR, Oudit GY, Lopaschuk GD.

Cardiovasc Diabetol. 2019 Jan 9;18(1):1. doi: 10.1186/s12933-019-0806-4.

4.

Glucagon-like peptide-1 receptor action in the vasculature.

Almutairi M, Al Batran R, Ussher JR.

Peptides. 2019 Jan;111:26-32. doi: 10.1016/j.peptides.2018.09.002. Epub 2018 Sep 15. Review.

PMID:
30227157
5.

Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet.

Al Batran R, Gopal K, Martin MD, Ho KL, Almutairi M, Aburasayn H, Eaton F, Campbell JE, Ussher JR.

Diabetologia. 2018 Aug;61(8):1849-1855. doi: 10.1007/s00125-018-4643-x. Epub 2018 Jun 1.

PMID:
29858650
6.

Cardiac-Specific Deletion of Pyruvate Dehydrogenase Impairs Glucose Oxidation Rates and Induces Diastolic Dysfunction.

Gopal K, Almutairi M, Al Batran R, Eaton F, Gandhi M, Ussher JR.

Front Cardiovasc Med. 2018 Mar 6;5:17. doi: 10.3389/fcvm.2018.00017. eCollection 2018.

7.

Glucagon-like peptide-1 receptor mediated control of cardiac energy metabolism.

Al Batran R, Almutairi M, Ussher JR.

Peptides. 2018 Feb;100:94-100. doi: 10.1016/j.peptides.2017.12.005. Review.

PMID:
29412838
8.

Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.

Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, McLean BA, Gopal K, Capozzi M, Yusta B, Cao X, Ali S, Kim M, Kabir MG, Seino Y, Suzuki J, Drucker DJ.

Cell Metab. 2018 Feb 6;27(2):450-460.e6. doi: 10.1016/j.cmet.2017.11.003. Epub 2017 Dec 21.

9.

Decreased Maternal Cardiac Glucose Oxidation: Taking One for the Fetus.

Ussher JR, Lopaschuk GD.

Circ Res. 2017 Dec 8;121(12):1299-1301. doi: 10.1161/CIRCRESAHA.117.312098. No abstract available.

PMID:
29217705
10.

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice.

Baggio LL, Ussher JR, McLean BA, Cao X, Kabir MG, Mulvihill EE, Mighiu AS, Zhang H, Ludwig A, Seeley RJ, Heximer SP, Drucker DJ.

Mol Metab. 2017 Nov;6(11):1339-1349. doi: 10.1016/j.molmet.2017.08.010. Epub 2017 Sep 1.

11.

Female offspring born to obese and insulin-resistant dams are not at increased risk for obesity and metabolic dysfunction during early development.

Aburasayn H, Al Batran R, Gopal K, Almutairi M, Eshreif A, Eaton F, Ussher JR.

Can J Physiol Pharmacol. 2018 Jan;96(1):97-102. doi: 10.1139/cjpp-2017-0371. Epub 2017 Sep 8.

PMID:
28886253
12.

FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression.

Gopal K, Saleme B, Al Batran R, Aburasayn H, Eshreif A, Ho KL, Ma WK, Almutairi M, Eaton F, Gandhi M, Park EA, Sutendra G, Ussher JR.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H479-H490. doi: 10.1152/ajpheart.00191.2017. Epub 2017 Jul 7.

13.

Revisiting protein acetylation and myocardial fatty acid oxidation.

Al Batran R, Ussher JR.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H617-H619. doi: 10.1152/ajpheart.00303.2017. Epub 2017 Jun 23. No abstract available.

14.

Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway.

Yusta B, Matthews D, Flock GB, Ussher JR, Lavoie B, Mawe GM, Drucker DJ.

Mol Metab. 2017 Mar 31;6(6):503-511. doi: 10.1016/j.molmet.2017.03.006. eCollection 2017 Jun.

15.

Evolving Concepts of Myocardial Energy Metabolism: More Than Just Fats and Carbohydrates.

Lopaschuk GD, Ussher JR.

Circ Res. 2016 Nov 11;119(11):1173-1176. doi: 10.1161/CIRCRESAHA.116.310078. Review. No abstract available.

PMID:
28051784
16.

Sugar-sweetened beverages and vascular function: food for thought.

Gopal K, Ussher JR.

Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H285-H288. doi: 10.1152/ajpheart.00783.2016. Epub 2016 Dec 30. No abstract available.

17.

The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease.

Ussher JR, Elmariah S, Gerszten RE, Dyck JR.

J Am Coll Cardiol. 2016 Dec 27;68(25):2850-2870. doi: 10.1016/j.jacc.2016.09.972. Review.

18.

Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.

Mulvihill EE, Varin EM, Gladanac B, Campbell JE, Ussher JR, Baggio LL, Yusta B, Ayala J, Burmeister MA, Matthews D, Bang KWA, Ayala JE, Drucker DJ.

Cell Metab. 2017 Jan 10;25(1):152-165. doi: 10.1016/j.cmet.2016.10.007. Epub 2016 Nov 10.

19.

Targeting ceramide metabolism in obesity.

Aburasayn H, Al Batran R, Ussher JR.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E423-35. doi: 10.1152/ajpendo.00133.2016. Epub 2016 Jul 5. Review.

20.

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.

Ussher JR, Fillmore N, Keung W, Zhang L, Mori J, Sidhu VK, Fukushima A, Gopal K, Lopaschuk DG, Wagg CS, Jaswal JS, Dyck JR, Lopaschuk GD.

Diabetes. 2016 Jul;65(7):1883-91. doi: 10.2337/db15-1145. Epub 2016 May 13.

21.

Lipotoxicity in obesity and diabetes-related cardiac dysfunction.

Zlobine I, Gopal K, Ussher JR.

Biochim Biophys Acta. 2016 Oct;1861(10):1555-68. doi: 10.1016/j.bbalip.2016.02.011. Epub 2016 Feb 18. Review.

PMID:
26899197
22.

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.

Mulvihill EE, Varin EM, Ussher JR, Campbell JE, Bang KW, Abdullah T, Baggio LL, Drucker DJ.

Diabetes. 2016 Mar;65(3):742-54. doi: 10.2337/db15-1224. Epub 2015 Dec 15.

23.

TCF1 links GIPR signaling to the control of beta cell function and survival.

Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ.

Nat Med. 2016 Jan;22(1):84-90. doi: 10.1038/nm.3997. Epub 2015 Dec 7.

PMID:
26642437
24.

Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.

Fillmore N, Keung W, Kelly SE, Proctor SD, Lopaschuk GD, Ussher JR.

Exp Physiol. 2015 Jun;100(6):730-41. doi: 10.1113/EP085052. Epub 2015 May 14.

25.

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.

Ali S, Ussher JR, Baggio LL, Kabir MG, Charron MJ, Ilkayeva O, Newgard CB, Drucker DJ.

Mol Metab. 2014 Nov 29;4(2):132-43. doi: 10.1016/j.molmet.2014.11.005. eCollection 2015 Feb.

26.

Targeting microRNAs to limit myocardial lipid accumulation.

Lopaschuk GD, Ussher JR.

Circ Res. 2015 Jan 16;116(2):229-31. doi: 10.1161/CIRCRESAHA.114.305675. No abstract available.

PMID:
25593272
27.

Sweet as sugar: excessive glucose metabolism in the failing heart.

Ussher JR.

Future Cardiol. 2014 Jul;10(4):465-8. doi: 10.2217/fca.14.28. No abstract available.

PMID:
25301309
28.

Deciphering ventricular GLP-1 action: time for a change of heart.

Ussher JR.

Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1390-2. doi: 10.1152/ajpheart.00680.2014. Epub 2014 Sep 26. No abstract available.

29.

Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice.

Ussher JR, Fillmore N, Keung W, Mori J, Beker DL, Wagg CS, Jaswal JS, Lopaschuk GD.

Can J Cardiol. 2014 Aug;30(8):940-4. doi: 10.1016/j.cjca.2014.04.023. Epub 2014 Apr 29.

PMID:
25064584
30.

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection.

Ussher JR, Baggio LL, Campbell JE, Mulvihill EE, Kim M, Kabir MG, Cao X, Baranek BM, Stoffers DA, Seeley RJ, Drucker DJ.

Mol Metab. 2014 May 9;3(5):507-17. doi: 10.1016/j.molmet.2014.04.009. eCollection 2014 Aug.

31.

Cardiovascular actions of incretin-based therapies.

Ussher JR, Drucker DJ.

Circ Res. 2014 May 23;114(11):1788-803. doi: 10.1161/CIRCRESAHA.114.301958. Review.

PMID:
24855202
32.

5'-AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes.

Lee CT, Ussher JR, Mohammad A, Lam A, Lopaschuk GD.

Can J Physiol Pharmacol. 2014 Apr;92(4):307-14. doi: 10.1139/cjpp-2013-0107. Epub 2014 Feb 5.

PMID:
24708213
33.

Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.

Ussher JR, Keung W, Fillmore N, Koves TR, Mori J, Zhang L, Lopaschuk DG, Ilkayeva OR, Wagg CS, Jaswal JS, Muoio DM, Lopaschuk GD.

J Pharmacol Exp Ther. 2014 Jun;349(3):487-96. doi: 10.1124/jpet.114.214197. Epub 2014 Apr 3.

34.

The role of cardiac lipotoxicity in the pathogenesis of diabetic cardiomyopathy.

Ussher JR.

Expert Rev Cardiovasc Ther. 2014 Mar;12(3):345-58. doi: 10.1586/14779072.2014.891939. Epub 2014 Feb 19. Review.

PMID:
24552544
35.

Gut microbiota metabolism of L-carnitine and cardiovascular risk.

Ussher JR, Lopaschuk GD, Arduini A.

Atherosclerosis. 2013 Dec;231(2):456-61. doi: 10.1016/j.atherosclerosis.2013.10.013. Epub 2013 Oct 24. Review.

PMID:
24267266
36.

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation.

Masoud WG, Ussher JR, Wang W, Jaswal JS, Wagg CS, Dyck JR, Lygate CA, Neubauer S, Clanachan AS, Lopaschuk GD.

Cardiovasc Res. 2014 Jan 1;101(1):30-8. doi: 10.1093/cvr/cvt216. Epub 2013 Sep 17.

PMID:
24048945
37.

Cardiac insulin resistance: it's sweeter than you think.

Ussher JR, Lopaschuk GD.

Endocrinology. 2013 Aug;154(8):2575-8. doi: 10.1210/en.2013-1506. No abstract available.

PMID:
23873770
38.

Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy.

Zhang L, Jaswal JS, Ussher JR, Sankaralingam S, Wagg C, Zaugg M, Lopaschuk GD.

Circ Heart Fail. 2013 Sep 1;6(5):1039-48. doi: 10.1161/CIRCHEARTFAILURE.112.000228. Epub 2013 Jul 16.

PMID:
23861485
39.

The impact of current and novel anti-diabetic therapies on cardiovascular risk.

Ussher JR, Sutendra G, Jaswal JS.

Future Cardiol. 2012 Nov;8(6):895-912. doi: 10.2217/fca.12.68. Review.

PMID:
23176691
40.

Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.

Keung W, Ussher JR, Jaswal JS, Raubenheimer M, Lam VH, Wagg CS, Lopaschuk GD.

Diabetes. 2013 Mar;62(3):711-20. doi: 10.2337/db12-0259. Epub 2012 Nov 8.

41.

Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance.

Samokhvalov V, Ussher JR, Fillmore N, Armstrong IK, Keung W, Moroz D, Lopaschuk DG, Seubert J, Lopaschuk GD.

Am J Physiol Endocrinol Metab. 2012 Dec 15;303(12):E1459-68. doi: 10.1152/ajpendo.00018.2012. Epub 2012 Oct 16.

42.

Pyridine nucleotide regulation of cardiac intermediary metabolism.

Ussher JR, Jaswal JS, Lopaschuk GD.

Circ Res. 2012 Aug 17;111(5):628-41. doi: 10.1161/CIRCRESAHA.111.246371. Review.

PMID:
22904042
43.

Something old holds potential to be something new in heart failure: allopurinol revisited.

Jaswal JS, Ussher JR, Lopaschuk GD, Johnstone DE.

Can J Cardiol. 2012 Nov-Dec;28(6):626-8. doi: 10.1016/j.cjca.2012.06.001. Epub 2012 Jul 25. No abstract available.

PMID:
22841155
44.

Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

Ussher JR, Folmes CD, Keung W, Fillmore N, Jaswal JS, Cadete VJ, Beker DL, Lam VH, Zhang L, Lopaschuk GD.

PLoS One. 2012;7(5):e37703. doi: 10.1371/journal.pone.0037703. Epub 2012 May 22.

45.

An ACE up your sleeve: 2 is better than 1.

Ussher JR, Lopaschuk GD.

Circ Res. 2012 May 11;110(10):1270-2. doi: 10.1161/CIRCRESAHA.112.269951. No abstract available.

PMID:
22581918
46.

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.

Ussher JR, Wang W, Gandhi M, Keung W, Samokhvalov V, Oka T, Wagg CS, Jaswal JS, Harris RA, Clanachan AS, Dyck JR, Lopaschuk GD.

Cardiovasc Res. 2012 May 1;94(2):359-69. doi: 10.1093/cvr/cvs129. Epub 2012 Mar 21.

PMID:
22436846
47.

Cardiac hypertrophy in the newborn delays the maturation of fatty acid β-oxidation and compromises postischemic functional recovery.

Oka T, Lam VH, Zhang L, Keung W, Cadete VJ, Samokhvalov V, Tanner BA, Beker DL, Ussher JR, Huqi A, Jaswal JS, Rebeyka IM, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1784-94. doi: 10.1152/ajpheart.00804.2011. Epub 2012 Mar 9.

48.

Cardiovascular biology of the incretin system.

Ussher JR, Drucker DJ.

Endocr Rev. 2012 Apr;33(2):187-215. doi: 10.1210/er.2011-1052. Epub 2012 Feb 8. Review.

49.

Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice.

Bates HE, Campbell JE, Ussher JR, Baggio LL, Maida A, Seino Y, Drucker DJ.

Diabetes. 2012 Jan;61(1):40-8. doi: 10.2337/db11-1060. Epub 2011 Oct 31.

50.

Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart.

Jaswal JS, Keung W, Wang W, Ussher JR, Lopaschuk GD.

Biochim Biophys Acta. 2011 Jul;1813(7):1333-50. doi: 10.1016/j.bbamcr.2011.01.015. Epub 2011 Jan 20. Review.

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