Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis.
He L, Liu X, Yang J, Li W, Liu S, Liu X, Yang Z, Ren J, Wang Y, Shan L, Guan C, Pei F, Lei L, Zhang Y, Yi X, Yang X, Liang J, Liu R, Sun L, Shang Y.
He L, et al.
Cell Res. 2018 Sep;28(9):934-951. doi: 10.1038/s41422-018-0079-6. Epub 2018 Aug 22.
Cell Res. 2018.
PMID: 30135474
Free PMC article.
A low level of nuclear USP43 correlates with higher histologic grades and poor prognosis. Our study identifies USP43 to be an H2BK120 deubiquitinase and a potential tumor suppressor and reveals a reciprocally inhibitory loop between USP43 and EGFR/PI3K/AKT, w …
A low level of nuclear USP43 correlates with higher histologic grades and poor prognosis. Our study identifies USP43 to be an …