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Page 1
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
Guan T, Li M, Song Y, Chen J, Tang J, Zhang C, Wen Y, Yang X, Huang L, Zhu Y, Wang H, Ding K, Zheng J, Zhang H, Liu T. Guan T, et al. Adv Sci (Weinh). 2023 Apr;10(11):e2205873. doi: 10.1002/advs.202205873. Epub 2023 Feb 13. Adv Sci (Weinh). 2023. PMID: 36782089 Free PMC article.
However, the mechanism by which TWIST1 is deregulated in TNBC remains elusive. Here, USP29 is identified as a bona fide deubiquitinase of TWIST1. The deubiquitination of TWIST1 catalyzed by USP29 is required for its stabilization and subsequent EMT and CSC functions …
However, the mechanism by which TWIST1 is deregulated in TNBC remains elusive. Here, USP29 is identified as a bona fide deubiquitinas …
Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.
Liu W, Tang P, Wang J, Ye W, Ge X, Rong Y, Ji C, Wang Z, Bai J, Fan J, Yin G, Cai W. Liu W, et al. J Pineal Res. 2021 Dec;71(4):e12769. doi: 10.1111/jpi.12769. Epub 2021 Oct 2. J Pineal Res. 2021. PMID: 34562326
Proteomics analysis revealed that ubiquitin-specific protease 29 (USP29) was markedly increased in MEVs, and knockdown of USP29 in MEVs (shUSP29-MEVs) abolished MEVs-mediated benefits in vitro and in vivo. We then showed that USP29 interacts with, deubiquitin …
Proteomics analysis revealed that ubiquitin-specific protease 29 (USP29) was markedly increased in MEVs, and knockdown of USP29
The emerging role of USP29 in cancer and other diseases.
Zhang R, Cai Z, Ren D, Kang Y, Zhang Q, Lu X, Tu R. Zhang R, et al. Cell Biochem Funct. 2024 Jan;42(1):e3928. doi: 10.1002/cbf.3928. Cell Biochem Funct. 2024. PMID: 38269503 Review.
Moreover, several studies have shown that deletion of Usp29 in mice does not cause visible growth and developmental defects, indicating that USP29 may be an ideal therapeutic target. In this review, we provide a comprehensive summary of the important roles and regul …
Moreover, several studies have shown that deletion of Usp29 in mice does not cause visible growth and developmental defects, indicati …
USP29 Deubiquitinates SETD8 and Regulates DNA Damage-Induced H4K20 Monomethylation and 53BP1 Focus Formation.
Hernández-Reyes Y, Paz-Cabrera MC, Freire R, Smits VAJ. Hernández-Reyes Y, et al. Cells. 2022 Aug 11;11(16):2492. doi: 10.3390/cells11162492. Cells. 2022. PMID: 36010569 Free PMC article.
We demonstrate that SETD8 binds to USP29 in vivo, and this interaction is dependent on the catalytic activity of USP29. Wildtype USP29 can deubiquitinate SETD8 in vivo, indicating that USP29 directly regulates SETD8 protein levels. ...
We demonstrate that SETD8 binds to USP29 in vivo, and this interaction is dependent on the catalytic activity of USP29. Wildty …
USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
Zhang Q, Tang Z, An R, Ye L, Zhong B. Zhang Q, et al. Cell Res. 2020 Oct;30(10):914-927. doi: 10.1038/s41422-020-0341-6. Epub 2020 May 26. Cell Res. 2020. PMID: 32457395 Free PMC article.
In addition, genetic ablation of USP29 in Trex1(-/-) mice eliminated the detectable pathological and molecular autoimmune phenotypes. ...Reconstitution of cGAS into Usp29(-/-) cells fully rescues type I IFN induction and cellular antiviral responses after HSV-1 infe …
In addition, genetic ablation of USP29 in Trex1(-/-) mice eliminated the detectable pathological and molecular autoimmune phenotypes. …
Identification of USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma through integrative analysis of multi-omics data.
Kang Y, Yu Y, Liu Y, Pan Y, Zhang R, Ren D, Cai Z, Ma J, Xiong X, Zhang Q, Zhang C, Tu R. Kang Y, et al. Cancer Biol Ther. 2023 Dec 31;24(1):2237200. doi: 10.1080/15384047.2023.2237200. Cancer Biol Ther. 2023. PMID: 37463886 Free PMC article.
In this study, we depleted endogenous USP29 in MYCN-amplified neuroblastoma SK-N-BE2 cells by sgRNAs and conducted metabolomic analysis in cells with or without USP29 depletion, we found that USP29 deficiency caused a disorder of intermediates involved in gly …
In this study, we depleted endogenous USP29 in MYCN-amplified neuroblastoma SK-N-BE2 cells by sgRNAs and conducted metabolomic analys …
Deubiquitinase USP29 correlates RORgammat expression and its association with thymoma myasthenia gravis.
Xia D, Pan L, Fu X, Meng Y, Li M, Wang W, Wang Z. Xia D, et al. Am J Transl Res. 2022 Dec 15;14(12):8632-8639. eCollection 2022. Am J Transl Res. 2022. PMID: 36628242 Free PMC article.
RESULTS: In MG-related thymomas, the mRNA and protein levels of deubiquitylases USP29 were substantially elevated. USP29 post-transcriptionally regulated RORgammat. ...Our data suggest that USP29 might take part in the regulation of RORgammat expression and T …
RESULTS: In MG-related thymomas, the mRNA and protein levels of deubiquitylases USP29 were substantially elevated. USP29 post- …
USP29 coordinates MYC and HIF1alpha stabilization to promote tumor metabolism and progression.
Tu R, Kang W, Yang M, Wang L, Bao Q, Chen Z, Dong Y, Wang J, Jiang J, Liu H, Qing G. Tu R, et al. Oncogene. 2021 Nov;40(46):6417-6429. doi: 10.1038/s41388-021-02031-w. Epub 2021 Oct 2. Oncogene. 2021. PMID: 34601505
Strikingly, mice homozygous null for the Usp29 gene are viable, fertile, and display no gross phenotypic abnormalities. Altogether, these results demonstrate that USP29 selectively coordinates MYC and HIF1alpha to integrate metabolic processes critical for cancer ce …
Strikingly, mice homozygous null for the Usp29 gene are viable, fertile, and display no gross phenotypic abnormalities. Altogether, t …
The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b.
Gao W, Wang L, Ju X, Zhao S, Li Z, Su M, Xu J, Wang P, Ding Q, Lv G, Zhang W. Gao W, et al. mBio. 2022 Jun 28;13(3):e0130022. doi: 10.1128/mbio.01300-22. Epub 2022 May 31. mBio. 2022. PMID: 35638730 Free PMC article.
We also found that ORF9b stabilization by USP29 enhanced the virulence of VSV-eGFP and transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP). Moreover, we observed that the mRNA level of USP29 in SARS-CoV-2 patients was higher than that in …
We also found that ORF9b stabilization by USP29 enhanced the virulence of VSV-eGFP and transcription and replication-competent SARS-C …
USP29-mediated HIF1alpha stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis.
Gao R, Buechel D, Kalathur RKR, Morini MF, Coto-Llerena M, Ercan C, Piscuoglio S, Chen Q, Blumer T, Wang X, Dazert E, Heim MH, Hall MN, Tang F, Christofori G. Gao R, et al. Oncogenesis. 2021 Jul 16;10(7):52. doi: 10.1038/s41389-021-00338-7. Oncogenesis. 2021. PMID: 34272356 Free PMC article.
In particular, we identified USP29 as a critical deubiquitylase (DUB) of HIF1alpha, which directly deubiquitylates and stabilizes HIF1alpha and, thus, promotes its transcriptional activity. ...Notably, the absence of USP29 and high HK2 expression levels correlate wi …
In particular, we identified USP29 as a critical deubiquitylase (DUB) of HIF1alpha, which directly deubiquitylates and stabilizes HIF …
55 results