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Inhalation Devices.

Moroni-Zentgraf P, Usmani OS, Halpin DMG.

Can Respir J. 2018 Sep 18;2018:5642074. doi: 10.1155/2018/5642074. eCollection 2018. No abstract available.


Airways diseases: asthma, COPD and chronic cough highlights from the European Respiratory Society Annual Congress 2018.

Satia I, Badri H, Lahousse L, Usmani OS, Spanevello A.

J Thorac Dis. 2018 Sep;10(Suppl 25):S2992-S2997. doi: 10.21037/jtd.2018.08.23. No abstract available.


Correction: Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease.

Maneechotesuwan K, Yao X, Ito K, Jazrawi E, Usmani OS, Adcock IM, Barnes PJ.

PLoS Med. 2018 Sep 7;15(9):e1002657. doi: 10.1371/journal.pmed.1002657. eCollection 2018 Sep.


Is there room for further innovation in inhaled therapy for airways disease?

Biddiscombe MF, Usmani OS.

Breathe (Sheff). 2018 Sep;14(3):216-224. doi: 10.1183/20734735.020318. Review.


Spacer devices for inhaled therapy: why use them, and how?

Vincken W, Levy ML, Scullion J, Usmani OS, Dekhuijzen PNR, Corrigan CJ.

ERJ Open Res. 2018 Jun 18;4(2). pii: 00065-2018. doi: 10.1183/23120541.00065-2018. eCollection 2018 Apr. Review.


Functional respiratory imaging: heterogeneity of acute exacerbations of COPD.

van Geffen WH, Hajian B, Vos W, De Backer J, Cahn A, Usmani OS, Van Holsbeke C, Pistolesi M, Kerstjens HA, De Backer W.

Int J Chron Obstruct Pulmon Dis. 2018 May 30;13:1783-1792. doi: 10.2147/COPD.S152463. eCollection 2018.


Let research leave you breathless, not physical exercise!

Bonini M, Usmani OS.

ERJ Open Res. 2018 Mar 20;4(1). pii: 00010-2018. doi: 10.1183/23120541.00010-2018. eCollection 2018 Jan.


The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis.

Usmani OS, Biddiscombe MF, Yang S, Meah S, Oballa E, Simpson JK, Fahy WA, Marshall RP, Lukey PT, Maher TM.

Respir Res. 2018 Feb 6;19(1):25. doi: 10.1186/s12931-018-0732-0.


Addressing the Impact and Unmet Needs of Nonadherence in Asthma and Chronic Obstructive Pulmonary Disease: Where Do We Go From Here?

Dekhuijzen R, Lavorini F, Usmani OS, van Boven JFM.

J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):785-793. doi: 10.1016/j.jaip.2017.11.027. Epub 2018 Jan 12.


Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes.

Usmani OS, Lavorini F, Marshall J, Dunlop WCN, Heron L, Farrington E, Dekhuijzen R.

Respir Res. 2018 Jan 16;19(1):10. doi: 10.1186/s12931-017-0710-y. Review.


Harmonizing the Nomenclature for Therapeutic Aerosol Particle Size: A Proposal.

Hillyer EV, Price DB, Chrystyn H, Martin RJ, Israel E, van Aalderen WMC, Papi A, Usmani OS, Roche N.

J Aerosol Med Pulm Drug Deliv. 2018 Apr;31(2):111-113. doi: 10.1089/jamp.2017.1396. Epub 2017 Nov 28. No abstract available.


Triple therapy in COPD: new evidence with the extrafine fixed combination of beclomethasone dipropionate, formoterol fumarate, and glycopyrronium bromide.

Singh D, Corradi M, Spinola M, Papi A, Usmani OS, Scuri M, Petruzzelli S, Vestbo J.

Int J Chron Obstruct Pulmon Dis. 2017 Oct 6;12:2917-2928. doi: 10.2147/COPD.S146822. eCollection 2017. Review.


Gamma scintigraphic pulmonary deposition study of glycopyrronium/formoterol metered dose inhaler formulated using co-suspension delivery technology.

Taylor G, Warren S, Dwivedi S, Sommerville M, Mello L, Orevillo C, Maes A, Martin UJ, Usmani OS.

Eur J Pharm Sci. 2018 Jan 1;111:450-457. doi: 10.1016/j.ejps.2017.10.026. Epub 2017 Oct 18.


Novel methods for device and adherence monitoring in asthma.

Bonini M, Usmani OS.

Curr Opin Pulm Med. 2018 Jan;24(1):63-69. doi: 10.1097/MCP.0000000000000439. Review.


Extrafine Versus Fine Inhaled Corticosteroids in Relation to Asthma Control: A Systematic Review and Meta-Analysis of Observational Real-Life Studies.

Sonnappa S, McQueen B, Postma DS, Martin RJ, Roche N, Grigg J, Guilbert T, Gouder C, Pizzichini E, Niimi A, Phipatanakul W, Chisholm A, Dandurand RJ, Kaplan A, Israel E, Papi A, van Aalderen WMC, Usmani OS, Price DB.

J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):907-915.e7. doi: 10.1016/j.jaip.2017.07.032. Epub 2017 Sep 20.


Erratum to: Recent advances in capsule-based dry powder inhaler technology.

Lavorini F, Pistolesi M, Usmani OS.

Multidiscip Respir Med. 2017 Jun 23;12:19. doi: 10.1186/s40248-017-0100-9. eCollection 2017.


Risk of pneumonia in obstructive lung disease: A real-life study comparing extra-fine and fine-particle inhaled corticosteroids.

Sonnappa S, Martin R, Israel E, Postma D, van Aalderen W, Burden A, Usmani OS, Price DB; Respiratory Effectiveness Group, Small Airways Study Group.

PLoS One. 2017 Jun 15;12(6):e0178112. doi: 10.1371/journal.pone.0178112. eCollection 2017.


Recent advances in capsule-based dry powder inhaler technology.

Lavorini F, Pistolesi M, Usmani OS.

Multidiscip Respir Med. 2017 May 22;12:11. doi: 10.1186/s40248-017-0092-5. eCollection 2017. Review. Erratum in: Multidiscip Respir Med. 2017 Jun 23;12 :19.


Cough management in primary, secondary and tertiary settings.

Wang K, Milojevic N, Sheinman B, Usmani OS.

Pulm Pharmacol Ther. 2017 Dec;47:93-98. doi: 10.1016/j.pupt.2017.05.001. Epub 2017 May 2. Review.


A Randomized Pragmatic Trial of Changing to and Stepping Down Fluticasone/Formoterol in Asthma.

Usmani OS, Kemppinen A, Gardener E, Thomas V, Konduru PR, Callan C, McLoughlin A, Woodhead V, Brady A, Juniper EF, Barnes PJ, Price D.

J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1378-1387.e5. doi: 10.1016/j.jaip.2017.02.006. Epub 2017 Mar 25.


Scientific Rationale for Determining the Bioequivalence of Inhaled Drugs.

Usmani OS, Molimard M, Gaur V, Gogtay J, Singh GJP, Malhotra G, Derom E.

Clin Pharmacokinet. 2017 Oct;56(10):1139-1154. doi: 10.1007/s40262-017-0524-6. Review.


Routine Use of Budesonide/Formoterol Fixed Dose Combination in Elderly Asthmatic Patients: Practical Considerations.

Scichilone N, Braido F, Lavorini F, Levy ML, Usmani OS.

Drugs Aging. 2017 May;34(5):321-330. doi: 10.1007/s40266-017-0449-7. Review.


Asthma and gender: The female lung.

Pignataro FS, Bonini M, Forgione A, Melandri S, Usmani OS.

Pharmacol Res. 2017 May;119:384-390. doi: 10.1016/j.phrs.2017.02.017. Epub 2017 Feb 24. Review.


MyAirCoach: the use of home-monitoring and mHealth systems to predict deterioration in asthma control and the occurrence of asthma exacerbations; study protocol of an observational study.

Honkoop PJ, Simpson A, Bonini M, Snoeck-Stroband JB, Meah S, Fan Chung K, Usmani OS, Fowler S, Sont JK.

BMJ Open. 2017 Jan 24;7(1):e013935. doi: 10.1136/bmjopen-2016-013935.


Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA2LEN).

Braido F, Scichilone N, Lavorini F, Usmani OS, Dubuske L, Boulet LP, Mosges R, Nunes C, Sánchez-Borges M, Ansotegui IJ, Ebisawa M, Levi-Schaffer F, Rosenwasser LJ, Bousquet J, Zuberbier T, Canonica GW; Interasma Executive Board; WAO Board of Directors; ARIA; GA²LEN.

Asthma Res Pract. 2016 Oct 28;2:12. eCollection 2016.


Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA2LEN).

Braido F, Scichilone N, Lavorini F, Usmani OS, Dubuske L, Boulet LP, Mosges R, Nunes C, Sanchez-Borges M, Ansotegui IJ, Ebisawa M, Levi-Schaffer F, Rosenwasser LJ, Bousquet J, Zuberbier T, Canonica GW, Cruz A, Yanez A, Yorgancioglu A, Deleanu D, Rodrigo G, Berstein J, Ohta K, Vichyanond P, Pawankar R, Gonzalez-Diaz SN, Nakajima S, Slavyanskaya T, Fink-Wagner A, Loyola CB, Ryan D, Passalacqua G, Celedon J, Ivancevich JC, Dobashi K, Zernotti M, Akdis M, Benjaponpitak S, Bonini S, Burks W, Caraballo L, El-Sayed ZA, Fineman S, Greenberger P, Hossny E, Ortega-Martell JA, Saito H, Tang M, Zhang L; for Interasma Executive Board; ARIA; GA2LEN.

World Allergy Organ J. 2016 Oct 28;9(1):37. eCollection 2016.


Patients' perspectives and preferences in the choice of inhalers: the case for Respimat(®) or HandiHaler(®).

Dekhuijzen PN, Lavorini F, Usmani OS.

Patient Prefer Adherence. 2016 Aug 18;10:1561-72. doi: 10.2147/PPA.S82857. eCollection 2016. Review.


Dilemmas, Confusion, and Misconceptions Related to Small Airways Directed Therapy.

Lavorini F, Pedersen S, Usmani OS; Aerosol Drug Management Improvement Team (ADMIT).

Chest. 2017 Jun;151(6):1345-1355. doi: 10.1016/j.chest.2016.07.035. Epub 2016 Aug 11. Review.


Inhaled Aerosol Distribution in Human Airways: A Scintigraphy-Guided Study in a 3D Printed Model.

Verbanck S, Ghorbaniasl G, Biddiscombe MF, Dragojlovic D, Ricks N, Lacor C, Ilsen B, de Mey J, Schuermans D, Underwood SR, Barnes PJ, Vincken W, Usmani OS.

J Aerosol Med Pulm Drug Deliv. 2016 Dec;29(6):525-533. Epub 2016 Jun 23.


The prevalence of small airways disease in adult asthma: A systematic literature review.

Usmani OS, Singh D, Spinola M, Bizzi A, Barnes PJ.

Respir Med. 2016 Jul;116:19-27. doi: 10.1016/j.rmed.2016.05.006. Epub 2016 May 7. Review.


Inhaler technique: facts and fantasies. A view from the Aerosol Drug Management Improvement Team (ADMIT).

Levy ML, Dekhuijzen PN, Barnes PJ, Broeders M, Corrigan CJ, Chawes BL, Corbetta L, Dubus JC, Hausen T, Lavorini F, Roche N, Sanchis J, Usmani OS, Viejo J, Vincken W, Voshaar T, Crompton GK, Pedersen S.

NPJ Prim Care Respir Med. 2016 Apr 21;26:16017. doi: 10.1038/npjpcrm.2016.17. Review.


The Digital Asthma Patient: The History and Future of Inhaler Based Health Monitoring Devices.

Kikidis D, Konstantinos V, Tzovaras D, Usmani OS.

J Aerosol Med Pulm Drug Deliv. 2016 Jun;29(3):219-32. doi: 10.1089/jamp.2015.1267. Epub 2016 Feb 26. Review.


Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung.

Darquenne C, Fleming JS, Katz I, Martin AR, Schroeter J, Usmani OS, Venegas J, Schmid O.

J Aerosol Med Pulm Drug Deliv. 2016 Apr;29(2):107-26. doi: 10.1089/jamp.2015.1270. Epub 2016 Feb 1. Review.


The effect of body weight on distal airway function and airway inflammation.

van de Kant KD, Paredi P, Meah S, Kalsi HS, Barnes PJ, Usmani OS.

Obes Res Clin Pract. 2016 Sep - Oct;10(5):564-573. doi: 10.1016/j.orcp.2015.10.005. Epub 2015 Nov 24.


Oscillating Positive Expiratory Pressure on Respiratory Resistance in Chronic Obstructive Pulmonary Disease With a Small Amount of Secretion: A Randomized Clinical Trial.

Gastaldi AC, Paredi P, Talwar A, Meah S, Barnes PJ, Usmani OS.

Medicine (Baltimore). 2015 Oct;94(42):e1845. doi: 10.1097/MD.0000000000001845.


The role of the small airways in the pathophysiology of asthma and chronic obstructive pulmonary disease.

Bonini M, Usmani OS.

Ther Adv Respir Dis. 2015 Dec;9(6):281-93. doi: 10.1177/1753465815588064. Epub 2015 Jun 2. Review.


Enhancing nuclear translocation: perspectives in inhaled corticosteroid therapy.

Hakim A, Usmani OS.

Ther Deliv. 2015;6(4):443-51. doi: 10.4155/tde.15.10. Review.


Glottal Aperture and Buccal Airflow Leaks Critically Affect Forced Oscillometry Measurements.

Bikov A, Pride NB, Goldman MD, Hull JH, Horvath I, Barnes PJ, Usmani OS, Paredi P.

Chest. 2015 Sep;148(3):731-738. doi: 10.1378/chest.14-2644.


Small-airway disease in asthma: pharmacological considerations.

Usmani OS.

Curr Opin Pulm Med. 2015 Jan;21(1):55-67. doi: 10.1097/MCP.0000000000000115. Review.


Small airways dysfunction in asthma: evaluation and management to improve asthma control.

Usmani OS.

Allergy Asthma Immunol Res. 2014 Sep;6(5):376-88. doi: 10.4168/aair.2014.6.5.376. Epub 2014 Jun 18. Review.


Gabapentin as a potential treatment for cough syncope.

Wu CH, Gunasekara K, Hull JH, Bikov A, Morris AJ, Usmani OS.

Respir Care. 2015 Feb;60(2):e34-7. doi: 10.4187/respcare.03255. Epub 2014 Aug 26. No abstract available.


NEXThaler, an innovative dry powder inhaler delivering an extrafine fixed combination of beclometasone and formoterol to treat large and small airways in asthma.

Corradi M, Chrystyn H, Cosio BG, Pirozynski M, Loukides S, Louis R, Spinola M, Usmani OS.

Expert Opin Drug Deliv. 2014 Sep;11(9):1497-506. doi: 10.1517/17425247.2014.928282. Epub 2014 Jun 12. Review. Erratum in: Expert Opin Drug Deliv. 2014 Nov;11(11):1827.


New inhaler devices - the good, the bad and the ugly.

Lavorini F, Fontana GA, Usmani OS.

Respiration. 2014;88(1):3-15. doi: 10.1159/000363390. Epub 2014 May 27. Review.


New developments in inhaled drugs: within and beyond the lungs.

Usmani OS.

Respiration. 2014;88(1):1-2. doi: 10.1159/000362586. Epub 2014 Apr 30. No abstract available.


Techniques of assessing small airways dysfunction.

McNulty W, Usmani OS.

Eur Clin Respir J. 2014 Oct 17;1. doi: 10.3402/ecrj.v1.25898. eCollection 2014. Review.


Correct inhalation technique is critical in achieving good asthma control.

Lavorini F, Usmani OS.

Prim Care Respir J. 2013 Dec;22(4):385-6. doi: 10.4104/pcrj.2013.00097. No abstract available.


Inhaled long-acting β2 agonists enhance glucocorticoid receptor nuclear translocation and efficacy in sputum macrophages in COPD.

Haque R, Hakim A, Moodley T, Torrego A, Essilfie-Quaye S, Jazrawi E, Johnson M, Barnes PJ, Adcock IM, Usmani OS.

J Allergy Clin Immunol. 2013 Nov;132(5):1166-73. doi: 10.1016/j.jaci.2013.07.038. Epub 2013 Sep 23.


A novel approach to partition central and peripheral airway nitric oxide.

Paredi P, Kharitonov SA, Meah S, Barnes PJ, Usmani OS.

Chest. 2014 Jan;145(1):113-119. doi: 10.1378/chest.13-0843.


Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity.

Hakim A, Barnes PJ, Adcock IM, Usmani OS.

FASEB J. 2013 Nov;27(11):4510-9. doi: 10.1096/fj.12-222604. Epub 2013 Aug 9.


Ask the experts: the benefits and challenges of pulmonary drug delivery.

Smaldone G, Berkland C, Gonda I, Mitchell J, Usmani OS, Clark A.

Ther Deliv. 2013 Aug;4(8):905-13. doi: 10.4155/tde.13.76.


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