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Items: 1 to 50 of 101

1.

Metabolism of selective 20-epi-vitamin D3 analogs in rat osteosarcoma UMR-106 cells: Isolation and identification of four novel C-1 fatty acid esters of 1α,25-dihydroxy-16-ene-20-epi-vitamin D3.

Flarakos CC, Weiskopf A, Robinson M, Wang G, Vouros P, Sasso GJ, Uskokovic MR, Reddy GS.

Steroids. 2017 Mar;119:18-30. doi: 10.1016/j.steroids.2016.12.013. Epub 2017 Jan 12.

PMID:
28089927
2.

Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS.

J Cell Biochem. 2014 Aug;115(8):1392-402. doi: 10.1002/jcb.24789.

PMID:
24535953
3.

Novel Gemini vitamin D3 analogs: large structure/function analysis and ability to induce antimicrobial peptide.

Okamoto R, Gery S, Kuwayama Y, Borregaard N, Ho Q, Alvarez R, Akagi T, Liu GY, Uskokovic MR, Koeffler HP.

Int J Cancer. 2014 Jan 1;134(1):207-17. doi: 10.1002/ijc.28328. Epub 2013 Jul 16.

4.

Diastereotopic and deuterium effects in gemini.

Maehr H, Rochel N, Lee HJ, Suh N, Uskokovic MR.

J Med Chem. 2013 May 23;56(10):3878-88. doi: 10.1021/jm400032t. Epub 2013 May 9.

PMID:
23566225
5.

Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097.

Huet T, Maehr H, Lee HJ, Uskokovic MR, Suh N, Moras D, Rochel N.

Medchemcomm. 2011;2(5):424-429.

6.

Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis.

McNally P, Coughlan C, Bergsson G, Doyle M, Taggart C, Adorini L, Uskokovic MR, El-Nazir B, Murphy P, Greally P, Greene CM, McElvaney NG.

J Cyst Fibros. 2011 Dec;10(6):428-34. doi: 10.1016/j.jcf.2011.06.013. Epub 2011 Jul 23.

7.

A new insight into the role of rat cytochrome P450 24A1 in metabolism of selective analogs of 1α,25-dihydroxyvitamin D₃.

Rhieu SY, Annalora AJ, Gathungu RM, Vouros P, Uskokovic MR, Schuster I, Palmore GT, Reddy GS.

Arch Biochem Biophys. 2011 May 1;509(1):33-43. doi: 10.1016/j.abb.2011.02.004. Epub 2011 Feb 19.

8.

Calcitriol derivatives with two different side chains at C-20. V. Potent inhibitors of mammary carcinogenesis and inducers of leukemia differentiation.

Maehr H, Lee HJ, Perry B, Suh N, Uskokovic MR.

J Med Chem. 2009 Sep 10;52(17):5505-19. doi: 10.1021/jm900780q.

9.

Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia.

Shabtay A, Sharabani H, Barvish Z, Kafka M, Amichay D, Levy J, Sharoni Y, Uskokovic MR, Studzinski GP, Danilenko M.

Oncology. 2008;75(3-4):203-14. doi: 10.1159/000163849. Epub 2008 Oct 14.

10.

Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog.

Aparna R, Subhashini J, Roy KR, Reddy GS, Robinson M, Uskokovic MR, Venkateswara Reddy G, Reddanna P.

J Cell Biochem. 2008 Aug 1;104(5):1832-42. doi: 10.1002/jcb.21749.

PMID:
18348265
11.

Calcitriol derivatives with two different side-chains at C-20. Part 4: further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells.

Garay E, Jankowski P, Lizano P, Marczak S, Maehr H, Adorini L, Uskokovic MR, Studzinski GP.

Bioorg Med Chem. 2007 Jul 1;15(13):4444-55. Epub 2007 Apr 25.

12.

23-carboxy-24,25,26,27-tetranorvitamin D3 (calcioic acid) and 24-carboxy-25,26,27-trinorvitamin D3 (cholacalcioic acid): end products of 25-hydroxyvitamin D3 metabolism in rat kidney through C-24 oxidation pathway.

Reddy GS, Omdahl JL, Robinson M, Wang G, Palmore GT, Vicchio D, Yergey AL, Tserng KY, Uskokovic MR.

Arch Biochem Biophys. 2006 Nov 1;455(1):18-30. Epub 2006 Sep 15.

PMID:
17027908
13.

C-20 cyclopropyl vitamin D3 analogs.

Uskokovic MR, Manchand P, Marczak S, Maehr H, Jankowski P, Adorini L, Reddy GS.

Curr Top Med Chem. 2006;6(12):1289-96.

PMID:
16848742
14.

Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells.

Banwell CM, MacCartney DP, Guy M, Miles AE, Uskokovic MR, Mansi J, Stewart PM, O'Neill LP, Turner BM, Colston KW, Campbell MJ.

Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2004-13.

15.

Isolation and identification of 1alpha-hydroxy-3-epi-vitamin D3, a potent suppressor of parathyroid hormone secretion.

Brown AJ, Ritter CS, Weiskopf AS, Vouros P, Sasso GJ, Uskokovic MR, Wang G, Reddy GS.

J Cell Biochem. 2005 Oct 15;96(3):569-78.

PMID:
16088954
16.
17.

C-25 hydroxylation of 1alpha,24(R)-dihydroxyvitamin D3 is catalyzed by 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1): metabolism studies with human keratinocytes and rat recombinant CYP24A1.

Astecker N, Bobrovnikova EA, Omdahl JL, Gennaro L, Vouros P, Schuster I, Uskokovic MR, Ishizuka S, Wang G, Reddy GS.

Arch Biochem Biophys. 2004 Nov 15;431(2):261-70.

PMID:
15488475
18.

Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors.

Banwell CM, O'Neill LP, Uskokovic MR, Campbell MJ.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):245-9.

PMID:
15225779
19.

Characterization of five 19-nor-analogs of 1alpha,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic properties.

Olivera CJ, Bula CM, Bishop JE, Adorini L, Manchand P, Uskokovic MR, Norman AW.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):99-106.

PMID:
15225754
20.

Calcitriol derivatives with two different side chains at C-20. 24-hydroxy derivatives as metabolic products and molecular probes for VDR exploration.

Maehr H, Uskokovic MR, Reddy GS, Adorini L.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):35-8.

PMID:
15225743
21.

Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activity.

Weyts FA, Dhawan P, Zhang X, Bishop JE, Uskokovic MR, Ji Y, Studzinski GP, Norman AW, Christakos S.

Biochem Pharmacol. 2004 Apr 1;67(7):1327-36.

PMID:
15013848
22.
23.

1,25-(OH)2-16ene-23yne-D3 reduces secondary hyperparathyroidism in uremic rats with little calcemic effect.

Lippuner K, Perrelet R, Casez JP, Popp A, Uskokovic MR, Jaeger P.

Horm Res. 2004;61(1):7-16. Epub 2003 Nov 27.

PMID:
14646396
24.

Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation.

Banwell CM, Singh R, Stewart PM, Uskokovic MR, Campbell MJ.

Recent Results Cancer Res. 2003;164:83-98.

PMID:
12899515
25.

Structural evaluation of the agonistic action of a vitamin D analog with two side chains binding to the nuclear vitamin D receptor.

Väisänen S, Peräkylä M, Kärkkäinen JI, Uskokovic MR, Carlberg C.

Mol Pharmacol. 2003 Jun;63(6):1230-7.

PMID:
12761332
26.
28.

1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse.

Huerta S, Irwin RW, Heber D, Go VL, Koeffler HP, Uskokovic MR, Harris DM.

Cancer Res. 2002 Feb 1;62(3):741-6.

29.

Double bond in the side chain of 1alpha,25-dihydroxy-22-ene-vitamin D(3) is reduced during its metabolism: studies in chronic myeloid leukemia (RWLeu-4) cells and rat kidney.

Sunita Rao D, Balkundi D, Uskokovic MR, Tserng K, Clark JW, Horst RL, Satyanarayana Reddy G.

J Steroid Biochem Mol Biol. 2001 Aug;78(2):167-76.

PMID:
11566441
30.

Gene regulatory potential of 1alpha,25-dihydroxyvitamin D(3) analogues with two side chains.

Bury Y, Herdick M, Uskokovic MR, Carlberg C.

J Cell Biochem Suppl. 2001;Suppl 36:179-90.

PMID:
11455583
31.

Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A.

Rashid SF, Moore JS, Walker E, Driver PM, Engel J, Edwards CE, Brown G, Uskokovic MR, Campbell MJ.

Oncogene. 2001 Apr 5;20(15):1860-72.

32.
34.

Metabolism of [3alpha-3H] 25-hydroxyvitamin D2 in kidneys isolated from normal and vitamin D2-intoxicated rats.

Rao LS, Ray R, Holick MF, Horst RL, Uskokovic MR, Reddy GS.

J Nutr Sci Vitaminol (Tokyo). 2000 Oct;46(5):222-9.

PMID:
11234914
35.
36.

Highly active analogs of 1alpha,25-dihydroxyvitamin D(3) that resist metabolism through C-24 oxidation and C-3 epimerization pathways.

Uskokovic MR, Norman AW, Manchand PS, Studzinski GP, Campbell MJ, Koeffler HP, Takeuchi A, Siu-Caldera ML, Rao DS, Reddy GS.

Steroids. 2001 Mar-May;66(3-5):463-71. Review.

PMID:
11179755
37.
38.

Metabolites and analogs of 1alpha,25-dihydroxyvitamin D(3): evaluation of actions in bone.

Kadiyala S, Nagaba S, Takeuchi K, Yukihiro S, Qiu W, Eyes ST, Uskokovic MR, Posner GH, Reddy GS, Guggino SE.

Steroids. 2001 Mar-May;66(3-5):347-55.

PMID:
11179743
39.

Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D(3) analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis.

Nakagawa K, Sowa Y, Kurobe M, Ozono K, Siu-Caldera ML, Reddy GS, Uskokovic MR, Okano T.

Steroids. 2001 Mar-May;66(3-5):327-37.

PMID:
11179741
40.

Characterization of a novel analogue of 1alpha,25(OH)(2)-vitamin D(3) with two side chains: interaction with its nuclear receptor and cellular actions.

Norman AW, Manchand PS, Uskokovic MR, Okamura WH, Takeuchi JA, Bishop JE, Hisatake JI, Koeffler HP, Peleg S.

J Med Chem. 2000 Jul 13;43(14):2719-30.

PMID:
10893309
41.

Response element and coactivator-mediated conformational change of the vitamin D(3) receptor permits sensitive interaction with agonists.

Herdick M, Bury Y, Quack M, Uskokovic MR, Polly P, Carlberg C.

Mol Pharmacol. 2000 Jun;57(6):1206-17.

PMID:
10825392
42.

Induction of tissue plasminogen activator secretion from rat heart microvascular cells by fM 1,25(OH)(2)D(3).

Puri S, Bansal DD, Uskoković MR, MacGregor RR.

Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E293-301.

43.

Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity.

Siu-Caldera ML, Sekimoto H, Peleg S, Nguyen C, Kissmeyer AM, Binderup L, Weiskopf A, Vouros P, Uskoković MR, Reddy GS.

J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):111-21.

PMID:
10659699
44.

Isolation and identification of 4,25-dihydroxyvitamin D2: a novel A-ring hydroxylated metabolite of vitamin D2.

Rao DS, Dayal R, Siu-Caldera ML, Horst RL, Uskokovic MR, Tserng KY, Reddy GS.

J Steroid Biochem Mol Biol. 1999 Nov;71(1-2):63-70.

PMID:
10619358
45.

Isolation and identification of 1alpha-hydroxy-24-oxovitamin D3 and 1alpha,23-dihydroxy-24-oxovitamin D3: metabolites of 1alpha,24(R)-dihydroxyvitamin D3 produced in rat kidney.

Weinstein EA, Rao DS, Siu-Caldera ML, Tserng KY, Uskokovic MR, Ishizuka S, Reddy GS.

Biochem Pharmacol. 1999 Dec 15;58(12):1965-73.

PMID:
10591152
46.

Biological effects of 1alpha-hydroxy- and 1beta-(hydroxymethyl)-vitamin D compounds relevant for potential colorectal cancer therapy.

Hofer H, Ho Gm, Peterlik M, Uskokovic MR, Lee JK, White MC, Posner GH, Cross HS.

J Pharmacol Exp Ther. 1999 Nov;291(2):450-5.

PMID:
10525058
47.

Physiological significance of C-28 hydroxylation in the metabolism of 1alpha,25-dihydroxyvitamin D(2).

Rao DS, Siu-Caldera ML, Uskokovic MR, Horst RL, Reddy GS.

Arch Biochem Biophys. 1999 Aug 15;368(2):319-28.

PMID:
10441383
48.

Synergistic inhibition of prostate cancer cell lines by a 19-nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid.

Campbell MJ, Park S, Uskokovic MR, Dawson MI, Jong L, Koeffler HP.

Br J Cancer. 1999 Jan;79(1):101-7.

49.

Production of 1alpha,25-dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed.

Siu-Caldera ML, Sekimoto H, Weiskopf A, Vouros P, Muralidharan KR, Okamura WH, Bishop J, Norman AW, Uskoković MR, Schuster I, Reddy GS.

Bone. 1999 May;24(5):457-63.

PMID:
10321905
50.

1alpha,25-dihydroxy-3-epi-vitamin D3: in vivo metabolite of 1alpha,25-dihydroxyvitamin D3 in rats.

Sekimoto H, Siu-Caldera ML, Weiskopf A, Vouros P, Muralidharan KR, Okamura WH, Uskokovic MR, Reddy GS.

FEBS Lett. 1999 Apr 9;448(2-3):278-82.

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