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Items: 1 to 50 of 167

1.

Metabolism of selective 20-epi-vitamin D3 analogs in rat osteosarcoma UMR-106 cells: Isolation and identification of four novel C-1 fatty acid esters of 1α,25-dihydroxy-16-ene-20-epi-vitamin D3.

Flarakos CC, Weiskopf A, Robinson M, Wang G, Vouros P, Sasso GJ, Uskokovic MR, Reddy GS.

Steroids. 2017 Mar;119:18-30. doi: 10.1016/j.steroids.2016.12.013. Epub 2017 Jan 12.

PMID:
28089927
2.

HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.

So JY, Wahler J, Das Gupta S, Salerno DM, Maehr H, Uskokovic M, Suh N.

J Steroid Biochem Mol Biol. 2015 Apr;148:111-21. doi: 10.1016/j.jsbmb.2014.12.013. Epub 2014 Dec 23.

3.

Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer.

Wahler J, So JY, Cheng LC, Maehr H, Uskokovic M, Suh N.

J Steroid Biochem Mol Biol. 2015 Apr;148:148-55. doi: 10.1016/j.jsbmb.2014.10.016. Epub 2014 Oct 31.

4.

Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog.

Wahler J, So JY, Kim YC, Liu F, Maehr H, Uskokovic M, Suh N.

Cancer Prev Res (Phila). 2014 Jun;7(6):617-26. doi: 10.1158/1940-6207.CAPR-13-0362. Epub 2014 Apr 1.

5.

Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS.

J Cell Biochem. 2014 Aug;115(8):1392-402. doi: 10.1002/jcb.24789.

PMID:
24535953
6.

Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.

So JY, Wahler JE, Yoon T, Smolarek AK, Lin Y, Shih WJ, Maehr H, Uskokovic M, Liby KT, Sporn MB, Suh N.

Cancer Prev Res (Phila). 2013 Sep;6(9):959-70. doi: 10.1158/1940-6207.CAPR-13-0087. Epub 2013 Jul 15.

7.

Novel Gemini vitamin D3 analogs: large structure/function analysis and ability to induce antimicrobial peptide.

Okamoto R, Gery S, Kuwayama Y, Borregaard N, Ho Q, Alvarez R, Akagi T, Liu GY, Uskokovic MR, Koeffler HP.

Int J Cancer. 2014 Jan 1;134(1):207-17. doi: 10.1002/ijc.28328. Epub 2013 Jul 16.

8.

Diastereotopic and deuterium effects in gemini.

Maehr H, Rochel N, Lee HJ, Suh N, Uskokovic MR.

J Med Chem. 2013 May 23;56(10):3878-88. doi: 10.1021/jm400032t. Epub 2013 May 9.

PMID:
23566225
9.

Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer.

So JY, Smolarek AK, Salerno DM, Maehr H, Uskokovic M, Liu F, Suh N.

PLoS One. 2013;8(1):e54020. doi: 10.1371/journal.pone.0054020. Epub 2013 Jan 11.

10.

Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097.

Huet T, Maehr H, Lee HJ, Uskokovic MR, Suh N, Moras D, Rochel N.

Medchemcomm. 2011;2(5):424-429.

11.

Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis.

McNally P, Coughlan C, Bergsson G, Doyle M, Taggart C, Adorini L, Uskokovic MR, El-Nazir B, Murphy P, Greally P, Greene CM, McElvaney NG.

J Cyst Fibros. 2011 Dec;10(6):428-34. doi: 10.1016/j.jcf.2011.06.013. Epub 2011 Jul 23.

12.

A new insight into the role of rat cytochrome P450 24A1 in metabolism of selective analogs of 1α,25-dihydroxyvitamin D₃.

Rhieu SY, Annalora AJ, Gathungu RM, Vouros P, Uskokovic MR, Schuster I, Palmore GT, Reddy GS.

Arch Biochem Biophys. 2011 May 1;509(1):33-43. doi: 10.1016/j.abb.2011.02.004. Epub 2011 Feb 19.

13.

A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer.

So JY, Lee HJ, Smolarek AK, Paul S, Wang CX, Maehr H, Uskokovic M, Zheng X, Conney AH, Cai L, Liu F, Suh N.

Mol Pharmacol. 2011 Mar;79(3):360-7. doi: 10.1124/mol.110.068403. Epub 2010 Nov 29.

14.

Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.

Lee HJ, So JY, DeCastro A, Smolarek A, Paul S, Maehr H, Uskokovic M, Suh N.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):408-12. doi: 10.1016/j.jsbmb.2010.03.053. Epub 2010 Mar 19.

15.
16.

Calcitriol derivatives with two different side chains at C-20. V. Potent inhibitors of mammary carcinogenesis and inducers of leukemia differentiation.

Maehr H, Lee HJ, Perry B, Suh N, Uskokovic MR.

J Med Chem. 2009 Sep 10;52(17):5505-19. doi: 10.1021/jm900780q.

17.

Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.

Laverny G, Penna G, Uskokovic M, Marczak S, Maehr H, Jankowski P, Ceailles C, Vouros P, Smith B, Robinson M, Reddy GS, Adorini L.

J Med Chem. 2009 Apr 23;52(8):2204-13. doi: 10.1021/jm801365a.

PMID:
19309155
18.

Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.

Lee HJ, Paul S, Atalla N, Thomas PE, Lin X, Yang I, Buckley B, Lu G, Zheng X, Lou YR, Conney AH, Maehr H, Adorini L, Uskokovic M, Suh N.

Cancer Prev Res (Phila). 2008 Nov;1(6):476-84. doi: 10.1158/1940-6207.CAPR-08-0084.

19.

Novel Gemini vitamin D(3) analogs have potent antitumor activity.

Saito T, Okamoto R, Haritunians T, O'Kelly J, Uskokovic M, Maehr H, Marczak S, Jankowski P, Badr R, Koeffler HP.

J Steroid Biochem Mol Biol. 2008 Nov;112(1-3):151-6. doi: 10.1016/j.jsbmb.2008.09.012. Epub 2008 Sep 30.

20.

Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia.

Shabtay A, Sharabani H, Barvish Z, Kafka M, Amichay D, Levy J, Sharoni Y, Uskokovic MR, Studzinski GP, Danilenko M.

Oncology. 2008;75(3-4):203-14. doi: 10.1159/000163849. Epub 2008 Oct 14.

21.

Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog.

Aparna R, Subhashini J, Roy KR, Reddy GS, Robinson M, Uskokovic MR, Venkateswara Reddy G, Reddanna P.

J Cell Biochem. 2008 Aug 1;104(5):1832-42. doi: 10.1002/jcb.21749.

PMID:
18348265
22.

Activation of bone morphogenetic protein signaling by a Gemini vitamin D3 analogue is mediated by Ras/protein kinase C alpha.

Lee HJ, Ji Y, Paul S, Maehr H, Uskokovic M, Suh N.

Cancer Res. 2007 Dec 15;67(24):11840-7.

23.

Calcitriol derivatives with two different side-chains at C-20. Part 4: further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells.

Garay E, Jankowski P, Lizano P, Marczak S, Maehr H, Adorini L, Uskokovic MR, Studzinski GP.

Bioorg Med Chem. 2007 Jul 1;15(13):4444-55. Epub 2007 Apr 25.

24.

Selective vitamin D receptor modulators and their effects on colorectal tumor growth.

Spina CS, Ton L, Yao M, Maehr H, Wolfe MM, Uskokovic M, Adorini L, Holick MF.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):757-62.

PMID:
17368190
25.

Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition.

Maehr H, Uskokovic M, Adorini L, Penna G, Mariani R, Panina P, Passini N, Bono E, Perego S, Biffi M, Holick M, Spina C, Suh N.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):277-81. Epub 2007 Jan 24.

PMID:
17254779
26.

Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol).

Adorini L, Penna G, Amuchastegui S, Cossetti C, Aquilano F, Mariani R, Fibbi B, Morelli A, Uskokovic M, Colli E, Maggi M.

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):689-93. Epub 2007 Jan 22.

PMID:
17241782
27.

23-carboxy-24,25,26,27-tetranorvitamin D3 (calcioic acid) and 24-carboxy-25,26,27-trinorvitamin D3 (cholacalcioic acid): end products of 25-hydroxyvitamin D3 metabolism in rat kidney through C-24 oxidation pathway.

Reddy GS, Omdahl JL, Robinson M, Wang G, Palmore GT, Vicchio D, Yergey AL, Tserng KY, Uskokovic MR.

Arch Biochem Biophys. 2006 Nov 1;455(1):18-30. Epub 2006 Sep 15.

PMID:
17027908
28.

Vitamin D and cancer.

Spina CS, Tangpricha V, Uskokovic M, Adorinic L, Maehr H, Holick MF.

Anticancer Res. 2006 Jul-Aug;26(4A):2515-24. Review.

29.

C-20 cyclopropyl vitamin D3 analogs.

Uskokovic MR, Manchand P, Marczak S, Maehr H, Jankowski P, Adorini L, Reddy GS.

Curr Top Med Chem. 2006;6(12):1289-96.

PMID:
16848742
30.
31.

Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway.

O'Kelly J, Uskokovic M, Lemp N, Vadgama J, Koeffler HP.

J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):107-16. Epub 2006 Jun 14.

PMID:
16777406
32.

Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer.

Lee HJ, Liu H, Goodman C, Ji Y, Maehr H, Uskokovic M, Notterman D, Reiss M, Suh N.

Biochem Pharmacol. 2006 Jul 28;72(3):332-43. Epub 2006 May 5.

PMID:
16737686
33.

Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells.

Banwell CM, MacCartney DP, Guy M, Miles AE, Uskokovic MR, Mansi J, Stewart PM, O'Neill LP, Turner BM, Colston KW, Campbell MJ.

Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2004-13.

34.

A novel vitamin D derivative activates bone morphogenetic protein signaling in MCF10 breast epithelial cells.

Lee HJ, Wislocki A, Goodman C, Ji Y, Ge R, Maehr H, Uskokovic M, Reiss M, Suh N.

Mol Pharmacol. 2006 Jun;69(6):1840-8. Epub 2006 Mar 13.

PMID:
16533909
35.

Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia.

Sharabani H, Izumchenko E, Wang Q, Kreinin R, Steiner M, Barvish Z, Kafka M, Sharoni Y, Levy J, Uskokovic M, Studzinski GP, Danilenko M.

Int J Cancer. 2006 Jun 15;118(12):3012-21.

36.

Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs.

Spina C, Tangpricha V, Yao M, Zhou W, Wolfe MM, Maehr H, Uskokovic M, Adorini L, Holick MF.

J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):111-20. Epub 2005 Sep 8.

PMID:
16154354
37.
38.

Isolation and identification of 1alpha-hydroxy-3-epi-vitamin D3, a potent suppressor of parathyroid hormone secretion.

Brown AJ, Ritter CS, Weiskopf AS, Vouros P, Sasso GJ, Uskokovic MR, Wang G, Reddy GS.

J Cell Biochem. 2005 Oct 15;96(3):569-78.

PMID:
16088954
39.

Analogs of 1alpha,25-dihydroxyvitamin D(3) as novel inhibitors of renin biosynthesis.

Qiao G, Kong J, Uskokovic M, Li YC.

J Steroid Biochem Mol Biol. 2005 Jun;96(1):59-66.

PMID:
15878826
40.
41.

C-25 hydroxylation of 1alpha,24(R)-dihydroxyvitamin D3 is catalyzed by 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1): metabolism studies with human keratinocytes and rat recombinant CYP24A1.

Astecker N, Bobrovnikova EA, Omdahl JL, Gennaro L, Vouros P, Schuster I, Uskokovic MR, Ishizuka S, Wang G, Reddy GS.

Arch Biochem Biophys. 2004 Nov 15;431(2):261-70.

PMID:
15488475
42.

Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands.

Adorini L, Penna G, Giarratana N, Roncari A, Amuchastegui S, Daniel KC, Uskokovic M.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):437-41. Review.

PMID:
15225816
43.

Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure.

Li YC, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):387-92. Review.

PMID:
15225806
44.

Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors.

Banwell CM, O'Neill LP, Uskokovic MR, Campbell MJ.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):245-9.

PMID:
15225779
45.

Characterization of five 19-nor-analogs of 1alpha,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic properties.

Olivera CJ, Bula CM, Bishop JE, Adorini L, Manchand P, Uskokovic MR, Norman AW.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):99-106.

PMID:
15225754
46.

Calcitriol derivatives with two different side chains at C-20. 24-hydroxy derivatives as metabolic products and molecular probes for VDR exploration.

Maehr H, Uskokovic MR, Reddy GS, Adorini L.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):35-8.

PMID:
15225743
47.

Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activity.

Weyts FA, Dhawan P, Zhang X, Bishop JE, Uskokovic MR, Ji Y, Studzinski GP, Norman AW, Christakos S.

Biochem Pharmacol. 2004 Apr 1;67(7):1327-36.

PMID:
15013848
48.
49.

1,25-(OH)2-16ene-23yne-D3 reduces secondary hyperparathyroidism in uremic rats with little calcemic effect.

Lippuner K, Perrelet R, Casez JP, Popp A, Uskokovic MR, Jaeger P.

Horm Res. 2004;61(1):7-16. Epub 2003 Nov 27.

PMID:
14646396
50.

A low-calcemic vitamin D analog (Ro 25-4020) inhibits the growth of LNCaP human prostate cancer cells with increased potency by producing an active 24-oxo metabolite (Ro 29-9970).

Swami S, Zhao XY, Sarabia S, Siu-Caldera ML, Uskokovic M, Reddy SG, Feldman D.

Recent Results Cancer Res. 2003;164:349-52.

PMID:
12899533

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