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Copper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development: Role of MicroRNA-125b.

Sudhahar V, Das A, Horimatsu T, Ash D, Leanhart S, Antipova O, Vogt S, Singla B, Csanyi G, White J, Kaplan JH, Fulton D, Weintraub NL, Kim HW, Ushio-Fukai M, Fukai T.

Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2320-2337. doi: 10.1161/ATVBAHA.119.313374. Epub 2019 Sep 26.


Novel Interaction of Antioxidant-1 with TRAF4: Role in Inflammatory Responses in Endothelial Cells.

Das A, Sudhahar V, Ushio-Fukai M, Fukai T.

Am J Physiol Cell Physiol. 2019 Sep 25. doi: 10.1152/ajpcell.00264.2019. [Epub ahead of print]


Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis.

Youn SW, Li Y, Kim YM, Sudhahar V, Abdelsaid K, Kim HW, Liu Y, Fulton DJR, Ashraf M, Tang Y, Fukai T, Ushio-Fukai M.

Antioxidants (Basel). 2019 Jan 10;8(1). pii: E18. doi: 10.3390/antiox8010018.


Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffolding protein: role in PDGF-induced VSMC migration and vascular remodeling.

Ashino T, Kohno T, Sudhahar V, Ash D, Ushio-Fukai M, Fukai T.

Am J Physiol Cell Physiol. 2018 Dec 1;315(6):C850-C862. doi: 10.1152/ajpcell.00230.2018. Epub 2018 Sep 26.


Oxidant Signaling Mediated by Nox2 in Neutrophils Promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage.

Fang MM, Barman PK, Thiruppathi M, Mirza RE, McKinney RD, Deng J, Christman JW, Du X, Fukai T, Ennis WJ, Koh TJ, Ushio-Fukai M, Urao N.

J Immunol. 2018 Oct 15;201(8):2414-2426. doi: 10.4049/jimmunol.1800252. Epub 2018 Sep 10.


Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence.

Kim YM, Youn SW, Sudhahar V, Das A, Chandhri R, Cuervo Grajal H, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M.

Cell Rep. 2018 Jun 19;23(12):3565-3578. doi: 10.1016/j.celrep.2018.05.054.


Copper transporters and copper chaperones: roles in cardiovascular physiology and disease.

Fukai T, Ushio-Fukai M, Kaplan JH.

Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C186-C201. doi: 10.1152/ajpcell.00132.2018. Epub 2018 Jun 6. Review.


Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.

Sudhahar V, Okur MN, Bagi Z, O'Bryan JP, Hay N, Makino A, Patel VS, Phillips SA, Stepp D, Ushio-Fukai M, Fukai T.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):529-541. doi: 10.1161/ATVBAHA.117.309819. Epub 2018 Jan 4.


Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α.

Tsang KM, Hyun JS, Cheng KT, Vargas M, Mehta D, Ushio-Fukai M, Zou L, Pajcini KV, Rehman J, Malik AB.

Stem Cell Reports. 2017 Sep 12;9(3):796-806. doi: 10.1016/j.stemcr.2017.07.001. Epub 2017 Aug 3.


ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis.

Kim YM, Kim SJ, Tatsunami R, Yamamura H, Fukai T, Ushio-Fukai M.

Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C749-C764. doi: 10.1152/ajpcell.00346.2016. Epub 2017 Apr 19.


Short-term regular aerobic exercise reduces oxidative stress produced by acute in the adipose microvasculature.

Robinson AT, Fancher IS, Sudhahar V, Bian JT, Cook MD, Mahmoud AM, Ali MM, Ushio-Fukai M, Brown MD, Fukai T, Phillips SA.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H896-H906. doi: 10.1152/ajpheart.00684.2016. Epub 2017 Feb 24.


Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo.

Das A, Sudhahar V, Chen GF, Kim HW, Youn SW, Finney L, Vogt S, Yang J, Kweon J, Surenkhuu B, Ushio-Fukai M, Fukai T.

Sci Rep. 2016 Sep 26;6:33783. doi: 10.1038/srep33783.


Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis.

Delaney MK, Kim K, Estevez B, Xu Z, Stojanovic-Terpo A, Shen B, Ushio-Fukai M, Cho J, Du X.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):846-54. doi: 10.1161/ATVBAHA.116.307308. Epub 2016 Mar 17.


Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.

Park C, Lee TJ, Bhang SH, Liu F, Nakamura R, Oladipupo SS, Pitha-Rowe I, Capoccia B, Choi HS, Kim TM, Urao N, Ushio-Fukai M, Lee DJ, Miyoshi H, Kim BS, Lim DS, Apte RS, Ornitz DM, Choi K.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):86-96. doi: 10.1161/ATVBAHA.115.306430. Epub 2015 Nov 19.


Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function.

Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney RD, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman JW, Shantikumar S, Angelini GD, Emanueli C, Ushio-Fukai M, Fukai T.

Sci Rep. 2015 Oct 6;5:14780. doi: 10.1038/srep14780.


Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses.

Chatterjee S, Fujiwara K, Pérez NG, Ushio-Fukai M, Fisher AB.

Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1451-62. doi: 10.1152/ajpheart.00105.2015. Epub 2015 Apr 10. Review.


Novel role of reactive oxygen species-activated Trp melastatin channel-2 in mediating angiogenesis and postischemic neovascularization.

Mittal M, Urao N, Hecquet CM, Zhang M, Sudhahar V, Gao XP, Komarova Y, Ushio-Fukai M, Malik AB.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):877-87. doi: 10.1161/ATVBAHA.114.304802. Epub 2015 Feb 12.


Redox and metabolic regulation of stem/progenitor cells and their niche.

Ushio-Fukai M, Rehman J.

Antioxid Redox Signal. 2014 Oct 10;21(11):1587-90. doi: 10.1089/ars.2014.5931.


KIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2.

Yamada KH, Nakajima Y, Geyer M, Wary KK, Ushio-Fukai M, Komarova Y, Malik AB.

J Cell Sci. 2014 Oct 15;127(Pt 20):4518-30. doi: 10.1242/jcs.156109. Epub 2014 Aug 15.


P21-activated kinase in inflammatory and cardiovascular disease.

Taglieri DM, Ushio-Fukai M, Monasky MM.

Cell Signal. 2014 Sep;26(9):2060-9. doi: 10.1016/j.cellsig.2014.04.020. Epub 2014 May 2. Review.


Low-dose 6-bromoindirubin-3'-oxime induces partial dedifferentiation of endothelial cells to promote increased neovascularization.

Kohler EE, Baruah J, Urao N, Ushio-Fukai M, Fukai T, Chatterjee I, Wary KK.

Stem Cells. 2014 Jun;32(6):1538-52. doi: 10.1002/stem.1658.


Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells.

Kohler EE, Wary KK, Li F, Chatterjee I, Urao N, Toth PT, Ushio-Fukai M, Rehman J, Park C, Malik AB.

PLoS One. 2013 Dec 30;8(12):e85549. doi: 10.1371/journal.pone.0085549. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/7c0448d9-bd2c-4367-957e-779dad721c9b.


Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase.

Sudhahar V, Urao N, Oshikawa J, McKinney RD, Llanos RM, Mercer JF, Ushio-Fukai M, Fukai T.

Diabetes. 2013 Nov;62(11):3839-50. doi: 10.2337/db12-1228. Epub 2013 Jul 24.


Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice.

Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J.

Blood. 2013 Aug 8;122(6):1052-61. doi: 10.1182/blood-2013-03-492504. Epub 2013 Jun 20.


IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury.

Kohno T, Urao N, Ashino T, Sudhahar V, Inomata H, Yamaoka-Tojo M, McKinney RD, Fukai T, Ushio-Fukai M.

Am J Physiol Cell Physiol. 2013 Sep 15;305(6):C591-600. doi: 10.1152/ajpcell.00011.2013. Epub 2013 May 8.


Critical role of endothelial hydrogen peroxide in post-ischemic neovascularization.

Urao N, Sudhahar V, Kim SJ, Chen GF, McKinney RD, Kojda G, Fukai T, Ushio-Fukai M.

PLoS One. 2013;8(3):e57618. doi: 10.1371/journal.pone.0057618. Epub 2013 Mar 5.


Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.

Kohno T, Urao N, Ashino T, Sudhahar V, McKinney RD, Hamakubo T, Iwanari H, Ushio-Fukai M, Fukai T.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):805-13. doi: 10.1161/ATVBAHA.112.300862. Epub 2013 Jan 24.


Redox regulation of stem/progenitor cells and bone marrow niche.

Urao N, Ushio-Fukai M.

Free Radic Biol Med. 2013 Jan;54:26-39. doi: 10.1016/j.freeradbiomed.2012.10.532. Epub 2012 Oct 17. Review.


A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor.

Profirovic J, Strekalova E, Urao N, Krbanjevic A, Andreeva AV, Varadarajan S, Fukai T, Hen R, Ushio-Fukai M, Voyno-Yasenetskaya TA.

Angiogenesis. 2013 Jan;16(1):15-28. doi: 10.1007/s10456-012-9296-7. Epub 2012 Aug 18.


Role of copper transport protein antioxidant 1 in angiotensin II-induced hypertension: a key regulator of extracellular superoxide dismutase.

Ozumi K, Sudhahar V, Kim HW, Chen GF, Kohno T, Finney L, Vogt S, McKinney RD, Ushio-Fukai M, Fukai T.

Hypertension. 2012 Aug;60(2):476-86. doi: 10.1161/HYPERTENSIONAHA.111.189571. Epub 2012 Jul 2.


NADPH oxidase 2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells.

Urao N, McKinney RD, Fukai T, Ushio-Fukai M.

Stem Cells. 2012 May;30(5):923-34. doi: 10.1002/stem.1048.


Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells.

Oshikawa J, Kim SJ, Furuta E, Caliceti C, Chen GF, McKinney RD, Kuhr F, Levitan I, Fukai T, Ushio-Fukai M.

Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H724-32. doi: 10.1152/ajpheart.00739.2011. Epub 2011 Nov 18.


Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis.

Kaplan N, Urao N, Furuta E, Kim SJ, Razvi M, Nakamura Y, McKinney RD, Poole LB, Fukai T, Ushio-Fukai M.

Free Radic Res. 2011 Oct;45(10):1124-35. doi: 10.3109/10715762.2011.602073. Epub 2011 Jul 25.


Superoxide dismutases: role in redox signaling, vascular function, and diseases.

Fukai T, Ushio-Fukai M.

Antioxid Redox Signal. 2011 Sep 15;15(6):1583-606. doi: 10.1089/ars.2011.3999. Epub 2011 Jun 6. Review.


Endothelial progenitor cells=EPC=elemental pernicious complexity.

Brandes RP, Ushio-Fukai M.

Antioxid Redox Signal. 2011 Aug 15;15(4):911-4. doi: 10.1089/ars.2010.3803. Epub 2011 Apr 26.


IQGAP1 is involved in post-ischemic neovascularization by regulating angiogenesis and macrophage infiltration.

Urao N, Razvi M, Oshikawa J, McKinney RD, Chavda R, Bahou WF, Fukai T, Ushio-Fukai M.

PLoS One. 2010 Oct 15;5(10):e13440. doi: 10.1371/journal.pone.0013440.


Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration.

Ashino T, Sudhahar V, Urao N, Oshikawa J, Chen GF, Wang H, Huo Y, Finney L, Vogt S, McKinney RD, Maryon EB, Kaplan JH, Ushio-Fukai M, Fukai T.

Circ Res. 2010 Sep 17;107(6):787-99. doi: 10.1161/CIRCRESAHA.110.225334. Epub 2010 Jul 29.


Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice.

Oshikawa J, Urao N, Kim HW, Kaplan N, Razvi M, McKinney R, Poole LB, Fukai T, Ushio-Fukai M.

PLoS One. 2010 Apr 21;5(4):e10189. doi: 10.1371/journal.pone.0010189.


PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy.

Xiong S, Salazar G, San Martin A, Ahmad M, Patrushev N, Hilenski L, Nazarewicz RR, Ma M, Ushio-Fukai M, Alexander RW.

J Biol Chem. 2010 Jan 22;285(4):2474-87. doi: 10.1074/jbc.M109.065235. Epub 2009 Nov 23.


Vascular signaling through G protein-coupled receptors: new concepts.

Ushio-Fukai M.

Curr Opin Nephrol Hypertens. 2009 Mar;18(2):153-9. doi: 10.1097/MNH.0b013e3283252efe. Review.


Novel role of NADPH oxidase in angiogenesis and stem/progenitor cell function.

Ushio-Fukai M, Urao N.

Antioxid Redox Signal. 2009 Oct;11(10):2517-33. doi: 10.1089/ARS.2009.2582. Review.


Compartmentalization of redox signaling through NADPH oxidase-derived ROS.

Ushio-Fukai M.

Antioxid Redox Signal. 2009 Jun;11(6):1289-99. doi: 10.1089/ARS.2008.2333. Review.


Novel mechanism for regulation of extracellular SOD transcription and activity by copper: role of antioxidant-1.

Itoh S, Ozumi K, Kim HW, Nakagawa O, McKinney RD, Folz RJ, Zelko IN, Ushio-Fukai M, Fukai T.

Free Radic Biol Med. 2009 Jan 1;46(1):95-104. doi: 10.1016/j.freeradbiomed.2008.09.039. Epub 2008 Oct 21.


NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology.

Frey RS, Ushio-Fukai M, Malik AB.

Antioxid Redox Signal. 2009 Apr;11(4):791-810. doi: 10.1089/ARS.2008.2220. Review.


Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function.

Qin Z, Gongora MC, Ozumi K, Itoh S, Akram K, Ushio-Fukai M, Harrison DG, Fukai T.

Hypertension. 2008 Nov;52(5):945-51. doi: 10.1161/HYPERTENSIONAHA.108.116467. Epub 2008 Sep 2.


Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia.

Urao N, Inomata H, Razvi M, Kim HW, Wary K, McKinney R, Fukai T, Ushio-Fukai M.

Circ Res. 2008 Jul 18;103(2):212-20. doi: 10.1161/CIRCRESAHA.108.176230. Epub 2008 Jun 26.


Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells.

Nakamura Y, Patrushev N, Inomata H, Mehta D, Urao N, Kim HW, Razvi M, Kini V, Mahadev K, Goldstein BJ, McKinney R, Fukai T, Ushio-Fukai M.

Circ Res. 2008 May 23;102(10):1182-91. doi: 10.1161/CIRCRESAHA.107.167080. Epub 2008 May 1. Erratum in: Circ Res. 2013 Oct 25;113(10):e101.


Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy.

Ushio-Fukai M, Nakamura Y.

Cancer Lett. 2008 Jul 18;266(1):37-52. doi: 10.1016/j.canlet.2008.02.044. Epub 2008 Apr 10. Review.


Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation.

Itoh S, Kim HW, Nakagawa O, Ozumi K, Lessner SM, Aoki H, Akram K, McKinney RD, Ushio-Fukai M, Fukai T.

J Biol Chem. 2008 Apr 4;283(14):9157-67. doi: 10.1074/jbc.M709463200. Epub 2008 Feb 2.


Essential role of extracellular SOD in reparative neovascularization induced by hindlimb ischemia.

Kim HW, Lin A, Guldberg RE, Ushio-Fukai M, Fukai T.

Circ Res. 2007 Aug 17;101(4):409-19. Epub 2007 Jun 29.


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