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Items: 1 to 50 of 171

1.

Programmed assembly of long DNA synthons: design, mechanism, and online monitoring.

Shchur VV, Burankova YP, Shapira MA, Klevzhits DV, Usanov SA, Yantsevich AV.

Appl Microbiol Biotechnol. 2019 Sep 12. doi: 10.1007/s00253-019-10099-4. [Epub ahead of print]

PMID:
31515595
2.

In vitro interactions of abiraterone, erythromycin, and CYP3A4: implications for drug-drug interactions.

Masamrekh RA, Kuzikov AV, Haurychenka YI, Shcherbakov KA, Veselovsky AV, Filimonov DA, Dmitriev AV, Zavialova MG, Gilep AA, Shkel TV, Strushkevich NV, Usanov SA, Archakov AI, Shumyantseva VV.

Fundam Clin Pharmacol. 2019 Jul 8. doi: 10.1111/fcp.12497. [Epub ahead of print]

PMID:
31286572
3.

Ligand-binding properties and catalytic activity of the purified human 24-hydroxycholesterol 7α-hydroxylase, CYP39A1.

Grabovec IP, Smolskaya SV, Baranovsky AV, Zhabinskii VN, Dichenko YV, Shabunya PS, Usanov SA, Strushkevich NV.

J Steroid Biochem Mol Biol. 2019 Oct;193:105416. doi: 10.1016/j.jsbmb.2019.105416. Epub 2019 Jun 24.

PMID:
31247323
4.

Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome.

Ershov PV, Mezentsev YV, Kopylov AT, Yablokov EO, Svirid AV, Lushchyk AY, Kaluzhskiy LA, Gilep AA, Usanov SA, Medvedev AE, Ivanov AS.

Biology (Basel). 2019 Jun 20;8(2). pii: E49. doi: 10.3390/biology8020049.

5.

Oligonucleotide Preparation Approach for Assembly of DNA Synthons.

Yantsevich AV, Shchur VV, Usanov SA.

SLAS Technol. 2019 Jun 5:2472630319850534. doi: 10.1177/2472630319850534. [Epub ahead of print]

PMID:
31166848
6.

A large-scale comparative analysis of affinity, thermodynamics and functional characteristics of interactions of twelve cytochrome P450 isoforms and their redox partners.

Yablokov EO, Sushko TA, Ershov PV, Florinskaya AV, Gnedenko OV, Shkel TV, Grabovec IP, Strushkevich NV, Kaluzhskiy LA, Usanov SA, Gilep AA, Ivanov AS.

Biochimie. 2019 Jul;162:156-166. doi: 10.1016/j.biochi.2019.04.020. Epub 2019 Apr 26.

PMID:
31034920
7.

[Interaction of prostacyclin synthase with cytochromes P450].

Gnedenko OV, Yablokov EO, Ershov PV, Svirid AV, Shkel TV, Haidukevich IV, Strushkevich NV, Gilep AA, Usanov SA, Ivanov AS.

Biomed Khim. 2019 Jan;65(1):63-66. doi: 10.18097/PBMC20196501063. Russian.

PMID:
30816099
8.

Assessment of electrocatalytic hydroxylase activity of cytochrome P450 3A4 (CYP3A4) by means of derivatization of 6β-hydroxycortisol by sulfuric acid for fluorimetric assay.

Kuzikov A, Masamrekh R, Shkel T, Strushkevich N, Gilep A, Usanov S, Archakov A, Shumyantseva V.

Talanta. 2019 May 1;196:231-236. doi: 10.1016/j.talanta.2018.12.041. Epub 2018 Dec 14.

PMID:
30683357
9.

Drug design strategies for Cushing's syndrome.

Usanov SA, Kliuchenovich AV, Strushkevich NV.

Expert Opin Drug Discov. 2019 Feb;14(2):143-151. doi: 10.1080/17460441.2019.1559146. Epub 2018 Dec 20.

PMID:
30572739
10.

SPR-Based study of affinity of cytochrome P450s / redox partners interactions modulated by steroidal substrates.

Ershov PV, Yablokov ЕO, Florinskaya AV, Mezentsev YV, Kaluzhskiy LА, Tumilovich AM, Gilep АА, Usanov SA, Ivanov АS.

J Steroid Biochem Mol Biol. 2019 Mar;187:124-129. doi: 10.1016/j.jsbmb.2018.11.009. Epub 2018 Nov 20.

PMID:
30468857
11.

Interaction of 17α-hydroxylase, 17(20)-lyase (CYP17A1) inhibitors - abiraterone and galeterone - with human sterol 14α-demethylase (CYP51A1).

Masamrekh R, Kuzikov A, Veselovsky A, Toropygin I, Shkel T, Strushkevich N, Gilep A, Usanov S, Archakov A, Shumyantseva V.

J Inorg Biochem. 2018 Sep;186:24-33. doi: 10.1016/j.jinorgbio.2018.05.010. Epub 2018 May 21.

PMID:
29807244
12.

Different inhibitory effects of azole-containing drugs and pesticides on CYP2C9 polymorphic forms: An in vitro study.

Haidukevich IV, Sushko TA, Tumilovich AM, Grabovec IP, Usanov SA, Gilep AA.

Toxicol In Vitro. 2018 Aug;50:249-256. doi: 10.1016/j.tiv.2018.04.002. Epub 2018 Apr 3.

PMID:
29621561
13.

[Proteomic analysis of contaminants in recombinant membrane hemeproteins expressed in E. coli and isolated by metal affinity chromatography].

Yantsevich AV, Dzichenka YV, Ivanchik AV, Shapiro MA, Trawkina M, Shkel TV, Gilep AA, Sergeev GV, Usanov SA.

Prikl Biokhim Mikrobiol. 2017 Mar-Apr;53(2):173-87. Russian.

PMID:
29508978
14.

[Study specificity of isatin interactions with P450 cytochromes].

Ershov PV, Mezentsev YV, Yablokov EO, Kalushskiy LA, Florinskaya AV, Svirid AV, Gilep AA, Usanov SA, Medvedev AE, Ivanov AS.

Biomed Khim. 2018 Jan;64(1):61-65. doi: 10.18097/PBMC20186401061. Russian.

PMID:
29460836
15.

Direct Molecular Fishing of New Protein Partners for Human Thromboxane Synthase.

Svirid AV, Ershov PV, Yablokov EO, Kaluzhskiy LA, Mezentsev YV, Florinskaya AV, Sushko TA, Strushkevich NV, Gilep AA, Usanov SA, Medvedev AE, Ivanov AS.

Acta Naturae. 2017 Oct-Dec;9(4):92-100.

16.

Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction.

Ershov P, Mezentsev Y, Gilep A, Usanov S, Buneeva O, Medvedev A, Ivanov A.

Protein Sci. 2017 Dec;26(12):2458-2462. doi: 10.1002/pro.3300. Epub 2017 Oct 9.

17.

[The effect of isatin on protein-protein interactions between cytochrome b5 and cytochromes P450].

Ershov PV, Yablokov EO, Mezentsev YV, Kalushskiy LA, Florinskaya AV, Veselovsky AV, Gnedenko OV, Gilep AA, Usanov SA, Medvedev AE, Ivanov AS.

Biomed Khim. 2017 Mar;63(2):170-175. doi: 10.18097/PBMC20176302170. Russian.

PMID:
28414290
18.

Thermodynamics of interactions between mammalian cytochromes P450 and b5.

Yablokov E, Florinskaya A, Medvedev A, Sergeev G, Strushkevich N, Luschik A, Shkel T, Haidukevich I, Gilep A, Usanov S, Ivanov A.

Arch Biochem Biophys. 2017 Apr 1;619:10-15. doi: 10.1016/j.abb.2017.02.006. Epub 2017 Feb 24.

PMID:
28238672
19.

Development of CYB5-fusion monitoring system for efficient periplasmic expression of multimeric proteins in Escherichia coli.

Dormeshkin D, Gilep A, Sergeev G, Usanov S.

Protein Expr Purif. 2016 Dec;128:60-6. doi: 10.1016/j.pep.2016.08.007. Epub 2016 Aug 12.

PMID:
27524697
20.

Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism.

Vasilevskaya AV, Yantsevich AV, Sergeev GV, Lemish AP, Usanov SA, Gilep AA.

J Steroid Biochem Mol Biol. 2017 May;169:202-209. doi: 10.1016/j.jsbmb.2016.05.021. Epub 2016 Jun 8.

PMID:
27289046
21.

Detection of microwave radiation of cytochrome CYP102 A1 solution during the enzyme reaction.

Ivanov YD, Malsagova KA, Izotov AA, Pleshakova TO, Tatur VY, Vesnin SG, Ivanova ND, Usanov SA, Archakov AI.

Biochem Biophys Rep. 2015 Dec 31;5:285-289. doi: 10.1016/j.bbrep.2015.12.013. eCollection 2016 Mar.

22.

Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.

Davydov R, Strushkevich N, Smil D, Yantsevich A, Gilep A, Usanov S, Hoffman BM.

Biochemistry. 2015 Dec 8;54(48):7089-97. doi: 10.1021/acs.biochem.5b00903. Epub 2015 Nov 25.

23.

[Protein-protein interactions of cytochromes P450 3A4 and 3A5 with their intermediate redox partners cytochromes b5].

Gnedenko OV, Ivanov AS, Yablokov EO, Usanov SA, Mukha DV, Sergeev GV, Kuzikov AV, Bulko TV, Moskaleva NE, Shumyantseva VV, Archakov AI.

Biomed Khim. 2015 Jul-Aug;61(4):468-73. doi: 10.18097/PBMC20156104468. Russian.

PMID:
26350737
24.

Computer-aided design of aptamers for cytochrome p450.

Shcherbinin DS, Gnedenko OV, Khmeleva SA, Usanov SA, Gilep AA, Yantsevich AV, Shkel TV, Yushkevich IV, Radko SP, Ivanov AS, Veselovsky AV, Archakov AI.

J Struct Biol. 2015 Aug;191(2):112-9. doi: 10.1016/j.jsb.2015.07.003. Epub 2015 Jul 10.

PMID:
26166326
25.

[An effective scheme to produce recombinant uracil-DNA glycosylase of Escherichia coli for PCR diagnostics].

Dmitrochenko AE, Turiianskaia OM, Gilep AA, Usanov SA, Iantsevich AV.

Prikl Biokhim Mikrobiol. 2014 Jul-Aug;50(4):398-407. Russian.

PMID:
25707116
26.

Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition.

Cherkesova TS, Hargrove TY, Vanrell MC, Ges I, Usanov SA, Romano PS, Lepesheva GI.

FEBS Lett. 2014 Nov 3;588(21):3878-85. doi: 10.1016/j.febslet.2014.08.030. Epub 2014 Sep 12.

27.

Highly sensitive protein detection by combination of atomic force microscopy fishing with charge generation and mass spectrometry analysis.

Ivanov YD, Pleshakova T, Malsagova K, Kozlov A, Kaysheva A, Kopylov A, Izotov A, Andreeva E, Kanashenko S, Usanov S, Archakov A.

FEBS J. 2014 Oct;281(20):4705-17. doi: 10.1111/febs.13011. Epub 2014 Oct 4.

28.

Protein interactomics based on direct molecular fishing on paramagnetic particles: practical realization and further SPR validation.

Ivanov AS, Medvedev A, Ershov P, Molnar A, Mezentsev Y, Yablokov E, Kaluzhsky L, Gnedenko O, Buneeva O, Haidukevich I, Sergeev G, Lushchyk A, Yantsevich A, Medvedeva M, Kozin S, Popov I, Novikova S, Zgoda V, Gilep A, Usanov S, Lisitsa A, Archakov A.

Proteomics. 2014 Oct;14(20):2261-74. doi: 10.1002/pmic.201400117. Epub 2014 Aug 21.

PMID:
25044858
29.

The role of cytochrome b5 structural domains in interaction with cytochromes P450.

Sergeev GV, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2014 May;79(5):406-16. doi: 10.1134/S0006297914050046.

30.

Structural characterization of human cholesterol 7α-hydroxylase.

Tempel W, Grabovec I, MacKenzie F, Dichenko YV, Usanov SA, Gilep AA, Park HW, Strushkevich N.

J Lipid Res. 2014 Sep;55(9):1925-32. doi: 10.1194/jlr.M050765. Epub 2014 Jun 13.

31.

[Role of antioxidants in electro catalytic activity of cytochrome P450 3A4].

Shumiantseva VV, Makhova AA, Bulko TV, Shikh EV, Kukes VG, Usanov SA, Archakov AI.

Biomed Khim. 2014 Mar-Apr;60(2):224-34. Russian.

PMID:
24837311
32.

[Protein-protein interactions of cytochromes P450 3A4 and 3A5 with their intermediate redox partners cytochromes b5].

Gnedenko OV, Ivanov AS, Iablokov EO, Usanov SA, Mukha DV, Sergeev GV, Kuzikov AV, Moskaleva NE, Bulko TV, Shumiantseva VV, Archakov AI.

Biomed Khim. 2014 Jan-Feb;60(1):17-27. Russian.

PMID:
24749245
33.

Photosensitized singlet oxygen luminescence from the protein matrix of Zn-substituted myoglobin.

Lepeshkevich SV, Parkhats MV, Stasheuski AS, Britikov VV, Jarnikova ES, Usanov SA, Dzhagarov BM.

J Phys Chem A. 2014 Mar 13;118(10):1864-78. doi: 10.1021/jp501615h. Epub 2014 Mar 4.

PMID:
24552592
34.

[SPR-biosensor assay for analysis of small compounds interaction with human cytochrome P450 51A1 (CYP51A1)].

Gnedenko OV, Kaluzhskiĭ LA, Mol'nar AA, Iantsevich AV, Mukha DV, Gilep AA, Usanov SA, Stonik VA, Ivanov AS, Lisitsa AV, Archakov AI.

Biomed Khim. 2013 Jul-Aug;59(4):388-98. Russian.

PMID:
24502137
35.

Human steroid and oxysterol 7α-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants.

Yantsevich AV, Dichenko YV, Mackenzie F, Mukha DV, Baranovsky AV, Gilep AA, Usanov SA, Strushkevich NV.

FEBS J. 2014 Mar;281(6):1700-13. doi: 10.1111/febs.12733. Epub 2014 Feb 20.

36.

Genetics, structure, function, mode of actions and role in cancer development of CYP17.

Sushko TA, Gilep AA, Usanov SA.

Anticancer Agents Med Chem. 2014 Jan;14(1):66-76.

PMID:
24007292
37.

Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis.

Sushko TA, Gilep AA, Yantsevich AV, Usanov SA.

Biochemistry (Mosc). 2013 Mar;78(3):282-9. doi: 10.1134/S0006297913030103.

PMID:
23586722
38.

Registration of the protein with compact disk.

Ivanov YD, Pleshakova TO, Krohin NV, Kaysheva AL, Usanov SA, Archakov AI.

Biosens Bioelectron. 2013 May 15;43:384-90. doi: 10.1016/j.bios.2012.12.039. Epub 2013 Jan 2.

PMID:
23357004
39.

Structural insights into aldosterone synthase substrate specificity and targeted inhibition.

Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov SA, Park HW.

Mol Endocrinol. 2013 Feb;27(2):315-24. doi: 10.1210/me.2012-1287. Epub 2013 Jan 15.

40.

Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies.

Davydov R, Gilep AA, Strushkevich NV, Usanov SA, Hoffman BM.

J Am Chem Soc. 2012 Oct 17;134(41):17149-56. doi: 10.1021/ja3067226. Epub 2012 Oct 5.

41.

Protein interactomics based on direct molecular fishing on paramagnetic particles: experimental simulation and SPR validation.

Ershov P, Mezentsev Y, Gnedenko O, Mukha D, Yantsevich A, Britikov V, Kaluzhskiy L, Yablokov E, Molnar A, Ivanov A, Lisitsa A, Gilep A, Usanov S, Archakov A.

Proteomics. 2012 Nov;12(22):3295-8. doi: 10.1002/pmic.201200135. Epub 2012 Nov 2.

PMID:
23001861
42.

Mechanism of intermolecular interactions of microsomal cytochrome P450s CYP17 and CYP21 involved in steroid hormone biosynthesis.

Sushko TA, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2012 Jun;77(6):585-92. doi: 10.1134/S0006297912060041.

PMID:
22817457
43.

[The influence of vitamin B group on monooxygenase activity of cytochrome P450 3A4: pharmacokinetics and electro analysis of catalytic properties].

Shumiantseva VV, Shikh EV, Makhova AA, Bylko TV, Kukes VG, Sizova OS, Ramenskaia GV, Usanov SA, Archakov AI.

Biomed Khim. 2011 May-Jun;57(3):343-54. Russian.

PMID:
21863748
44.

Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.

Strushkevich N, MacKenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10139-43. doi: 10.1073/pnas.1019441108. Epub 2011 Jun 2. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15535.

45.

Molecular modeling of human lanosterol 14α-demethylase complexes with substrates and their derivatives.

Mukha DV, Feranchuk SI, Gilep AA, Usanov SA.

Biochemistry (Mosc). 2011 Feb;76(2):175-85.

PMID:
21568850
46.

Mechanism of steroidogenic electron transport: role of conserved Glu429 in destabilization of CYP11A1-adrenodoxin complex.

Strushkevich NV, Harnastai IN, Usanov SA.

Biochemistry (Mosc). 2010 May;75(5):570-8.

PMID:
20632935
47.

At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17.

Gilep AA, Sushko TA, Usanov SA.

Biochim Biophys Acta. 2011 Jan;1814(1):200-9. doi: 10.1016/j.bbapap.2010.06.021. Epub 2010 Jul 7. Review.

PMID:
20619364
48.

Structural basis of human CYP51 inhibition by antifungal azoles.

Strushkevich N, Usanov SA, Park HW.

J Mol Biol. 2010 Apr 9;397(4):1067-78. doi: 10.1016/j.jmb.2010.01.075. Epub 2010 Feb 10.

PMID:
20149798
49.
50.

[Productive and non-productive complexes in cytochrome P450-containing system].

Ivanov IuD, Ivanov AV, Kaĭsheva AL, Zgoda VG, Usanov SA, Hui-Bon-Hoa G, Archakov AI.

Biomed Khim. 2009 May-Jun;55(3):310-30. Russian.

PMID:
19663004

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