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Items: 38

1.

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.

He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201902308. doi: 10.1073/pnas.1902308116. [Epub ahead of print]

PMID:
31591207
2.

Precision Medicine and Precision Public Health: Academic Education and Community Engagement.

Meurer JR, Whittle JC, Lamb KM, Kosasih MA, Dwinell MR, Urrutia RA.

Am J Prev Med. 2019 Aug;57(2):286-289. doi: 10.1016/j.amepre.2019.03.010. No abstract available.

PMID:
31326012
3.

Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification.

Gupta A, Zimmermann MT, Wang H, Broski SM, Sigafoos AN, Macklin SK, Urrutia RA, Clark KJ, Atwal PS, Pignolo RJ, Klee EW.

Am J Med Genet A. 2019 Sep;179(9):1764-1777. doi: 10.1002/ajmg.a.61274. Epub 2019 Jun 26.

PMID:
31240838
4.

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA.

Cell Cycle. 2019 Jun;18(12):1407-1421. doi: 10.1080/15384101.2019.1618126. Epub 2019 May 26.

5.

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.

Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ.

JCI Insight. 2019 May 16;5. pii: 127111. doi: 10.1172/jci.insight.127111.

6.

Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.

Bamidele AO, Svingen PA, Sagstetter MR, Sarmento OF, Gonzalez M, Braga Neto MB, Kugathasan S, Lomberk G, Urrutia RA, Faubion WA Jr.

Cell Mol Gastroenterol Hepatol. 2018 Sep 14;7(1):55-71. doi: 10.1016/j.jcmgh.2018.08.009. eCollection 2019.

7.

Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect?

Polonis K, Blackburn PR, Urrutia RA, Lomberk GA, Kruisselbrink T, Cousin MA, Boczek NJ, Hoppman NL, Babovic-Vuksanovic D, Klee EW, Pichurin PN.

Cold Spring Harb Mol Case Stud. 2018 Aug 1;4(4). pii: a002899. doi: 10.1101/mcs.a002899. Print 2018 Aug.

8.

Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome.

Kaiwar C, Zimmermann MT, Ferber MJ, Niu Z, Urrutia RA, Klee EW, Babovic-Vuksanovic D.

Cold Spring Harb Mol Case Stud. 2017 Nov 21;3(6). pii: a002162. doi: 10.1101/mcs.a002162. Print 2017 Nov. Review.

9.

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss.

Kalinec GM, Lomberk G, Urrutia RA, Kalinec F.

Front Cell Neurosci. 2017 Jul 7;11:192. doi: 10.3389/fncel.2017.00192. eCollection 2017. Review.

10.

Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling.

Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW.

Cold Spring Harb Mol Case Stud. 2017 Jul 5;3(4). pii: a001727. doi: 10.1101/mcs.a001727. Print 2017 Jul.

11.

Novel de novo variant in EBF3 is likely to impact DNA binding in a patient with a neurodevelopmental disorder and expanded phenotypes: patient report, in silico functional assessment, and review of published cases.

Blackburn PR, Barnett SS, Zimmermann MT, Cousin MA, Kaiwar C, Pinto E Vairo F, Niu Z, Ferber MJ, Urrutia RA, Selcen D, Klee EW, Pichurin PN.

Cold Spring Harb Mol Case Stud. 2017 May;3(3):a001743. doi: 10.1101/mcs.a001743.

12.

A novel de novo frameshift deletion in EHMT1 in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation.

Blackburn PR, Williams M, Cousin MA, Boczek NJ, Beek GJ, Lomberk GA, Urrutia RA, Babovic-Vuksanovic D, Klee EW.

Mol Genet Genomic Med. 2017 Jan 26;5(2):141-146. doi: 10.1002/mgg3.268. eCollection 2017 Mar.

13.

Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome.

Zimmermann MT, Urrutia RA, Blackburn PR, Cousin MA, Boczek NJ, Klee EW, Macmurdo C, Atwal PS.

Case Rep Genet. 2017;2017:7263780. doi: 10.1155/2017/7263780. Epub 2017 Jan 9.

14.

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).

Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA.

J Biol Chem. 2017 Jan 13;292(2):706-722. doi: 10.1074/jbc.M116.749663. Epub 2016 Dec 1.

15.

Novel roles and mechanism for Krüppel-like factor 16 (KLF16) regulation of neurite outgrowth and ephrin receptor A5 (EphA5) expression in retinal ganglion cells.

Wang J, Galvao J, Beach KM, Luo W, Urrutia RA, Goldberg JL, Otteson DC.

J Biol Chem. 2016 Oct 7;291(41):21422. No abstract available.

16.

Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth.

Saha S, Xiong X, Chakraborty PK, Shameer K, Arvizo RR, Kudgus RA, Dwivedi SK, Hossen MN, Gillies EM, Robertson JD, Dudley JT, Urrutia RA, Postier RG, Bhattacharya R, Mukherjee P.

ACS Nano. 2016 Dec 27;10(12):10636-10651. doi: 10.1021/acsnano.6b02231. Epub 2016 Oct 19.

PMID:
27758098
17.

"The molecule's the thing:" the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results.

Oliver GR, Zimmermann MT, Klee EW, Urrutia RA.

Version 3. F1000Res. 2016 Apr 27 [revised 2016 Jan 1];5:766. doi: 10.12688/f1000research.8600.3. eCollection 2016.

18.

Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.

Wang J, Galvao J, Beach KM, Luo W, Urrutia RA, Goldberg JL, Otteson DC.

J Biol Chem. 2016 Aug 26;291(35):18084-95. doi: 10.1074/jbc.M116.732339. Epub 2016 Jul 11. Erratum in: J Biol Chem. 2016 Oct 7;291(41):21422.

19.

Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation.

Papadakis KA, Krempski J, Svingen P, Xiong Y, Sarmento OF, Lomberk GA, Urrutia RA, Faubion WA.

Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G900-9. doi: 10.1152/ajpgi.00309.2015. Epub 2015 Oct 15.

20.

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes.

De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC.

Lab Invest. 2015 Oct;95(10):1218. doi: 10.1038/labinvest.2015.99. No abstract available.

21.

Biology and pathobiology of lipid droplets and their potential role in the protection of the organ of Corti.

Urrutia RA, Kalinec F.

Hear Res. 2015 Dec;330(Pt A):26-38. doi: 10.1016/j.heares.2015.04.015. Epub 2015 May 15. Review.

22.

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes.

De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC.

Lab Invest. 2015 Jun;95(6):684-96. doi: 10.1038/labinvest.2015.51. Epub 2015 Apr 13. Erratum in: Lab Invest. 2015 Oct;95(10):1218.

23.

A novel role for KLF14 in T regulatory cell differentiation.

Sarmento OF, Svingen PA, Xiong Y, Xavier RJ, McGovern D, Smyrk TC, Papadakis KA, Urrutia RA, Faubion WA.

Cell Mol Gastroenterol Hepatol. 2015 Mar 1;1(2):188-202.e4.

24.

Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-β signaling in CD8+ T lymphocytes.

Papadakis KA, Krempski J, Reiter J, Svingen P, Xiong Y, Sarmento OF, Huseby A, Johnson AJ, Lomberk GA, Urrutia RA, Faubion WA.

Am J Physiol Cell Physiol. 2015 Mar 1;308(5):C362-71. doi: 10.1152/ajpcell.00262.2014. Epub 2014 Dec 3.

25.

Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene.

Xiong Y, Svingen PA, Sarmento OO, Smyrk TC, Dave M, Khanna S, Lomberk GA, Urrutia RA, Faubion WA Jr.

Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15;307(6):R608-20. doi: 10.1152/ajpregu.00085.2014. Epub 2014 Jun 18.

26.

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids.

de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH.

J Biol Chem. 2014 May 30;289(22):15798-809. doi: 10.1074/jbc.M113.544346. Epub 2014 Apr 23.

27.

Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.

Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog T.

PLoS One. 2013 Oct 7;8(10):e76822. doi: 10.1371/journal.pone.0076822. eCollection 2013.

28.

Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner.

Xiong Y, Khanna S, Grzenda AL, Sarmento OF, Svingen PA, Lomberk GA, Urrutia RA, Faubion WA Jr.

J Biol Chem. 2012 Oct 5;287(41):34372-85. doi: 10.1074/jbc.M111.325332. Epub 2012 Aug 15.

29.

Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts.

Kitange GJ, Mladek AC, Carlson BL, Schroeder MA, Pokorny JL, Cen L, Decker PA, Wu W, Lomberk GA, Gupta SK, Urrutia RA, Sarkaria JN.

Clin Cancer Res. 2012 Aug 1;18(15):4070-9. doi: 10.1158/1078-0432.CCR-12-0560. Epub 2012 Jun 6.

30.

Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype.

Cao Y, Szabolcs A, Dutta SK, Yaqoob U, Jagavelu K, Wang L, Leof EB, Urrutia RA, Shah VH, Mukhopadhyay D.

J Biol Chem. 2010 Oct 8;285(41):31840-8. doi: 10.1074/jbc.M110.151696. Epub 2010 Jul 30.

31.

Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis.

Huebert RC, Jagavelu K, Liebl AF, Huang BQ, Splinter PL, LaRusso NF, Urrutia RA, Shah VH.

Lab Invest. 2010 Dec;90(12):1770-81. doi: 10.1038/labinvest.2010.132. Epub 2010 Jul 19.

32.

Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors.

Bardsley MR, Horváth VJ, Asuzu DT, Lorincz A, Redelman D, Hayashi Y, Popko LN, Young DL, Lomberk GA, Urrutia RA, Farrugia G, Rubin BP, Ordog T.

Gastroenterology. 2010 Sep;139(3):942-52. doi: 10.1053/j.gastro.2010.05.083. Epub 2010 Jun 4.

33.

2007 American Pancreatic Association Presidential Address: a proud member of the APA.

Urrutia RA.

Pancreas. 2008 Nov;37(4):456-8. doi: 10.1097/MPA.0b013e31818e6c25. No abstract available.

PMID:
18953263
34.

A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome.

Nickander KK, Carlson PJ, Urrutia RA, Camilleri M, Low PA.

Auton Neurosci. 2005 Jun 15;120(1-2):97-103.

PMID:
15946904
35.

Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells.

Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD.

Cancer Res. 2005 Mar 15;65(6):2076-81.

36.

Upregulation of dynamin II expression during the acquisition of a mature pancreatic acinar cell phenotype.

Cook TA, Mesa KJ, Gebelein BA, Urrutia RA.

J Histochem Cytochem. 1996 Dec;44(12):1373-8.

PMID:
8985129
37.
38.

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