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Items: 1 to 50 of 262

1.

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.

He C, Danes JM, Hart PC, Zhu Y, Huang Y, de Abreu AL, O'Brien J, Mathison AJ, Tang B, Frasor JM, Wakefield LM, Ganini D, Stauder E, Zielonka J, Gantner BN, Urrutia RA, Gius D, Bonini MG.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201902308. doi: 10.1073/pnas.1902308116. [Epub ahead of print]

PMID:
31591207
2.

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.

Lomberk G, Dusetti N, Iovanna J, Urrutia R.

Nat Commun. 2019 Aug 28;10(1):3875. doi: 10.1038/s41467-019-11812-7. Review.

3.

ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells.

Han EH, Singh P, Lee IK, Urrutia R, Chi YI.

J Biol Chem. 2019 Sep 20;294(38):13983-13994. doi: 10.1074/jbc.RA119.009558. Epub 2019 Jul 30.

PMID:
31362984
4.

Precision Medicine and Precision Public Health: Academic Education and Community Engagement.

Meurer JR, Whittle JC, Lamb KM, Kosasih MA, Dwinell MR, Urrutia RA.

Am J Prev Med. 2019 Aug;57(2):286-289. doi: 10.1016/j.amepre.2019.03.010. No abstract available.

PMID:
31326012
5.

Fertility awareness based methods for pregnancy prevention.

Urrutia RP, Polis CB.

BMJ. 2019 Jul 11;366:l4245. doi: 10.1136/bmj.l4245. No abstract available.

PMID:
31296535
6.

Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification.

Gupta A, Zimmermann MT, Wang H, Broski SM, Sigafoos AN, Macklin SK, Urrutia RA, Clark KJ, Atwal PS, Pignolo RJ, Klee EW.

Am J Med Genet A. 2019 Sep;179(9):1764-1777. doi: 10.1002/ajmg.a.61274. Epub 2019 Jun 26.

PMID:
31240838
7.

Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1α-importin α heterodimers.

Zimmermann MT, Williams MM, Klee EW, Lomberk GA, Urrutia R.

Proteins. 2019 Nov;87(11):904-916. doi: 10.1002/prot.25752. Epub 2019 Jun 14.

8.

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA.

Cell Cycle. 2019 Jun;18(12):1407-1421. doi: 10.1080/15384101.2019.1618126. Epub 2019 May 26.

9.

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.

Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ.

JCI Insight. 2019 May 16;5. pii: 127111. doi: 10.1172/jci.insight.127111.

10.

Residues of pesticides and some metabolites in dissolved and particulate phase in surface stream water of Cachapoal River basin, central Chile.

Climent MJ, Herrero-Hernández E, Sánchez-Martín MJ, Rodríguez-Cruz MS, Pedreros P, Urrutia R.

Environ Pollut. 2019 Aug;251:90-101. doi: 10.1016/j.envpol.2019.04.117. Epub 2019 Apr 27.

PMID:
31071637
11.

Legacy and current-use pesticides (CUPs) in the atmosphere of a rural area in central Chile, using passive air samplers.

Climent MJ, Coscollà C, López A, Barra R, Urrutia R.

Sci Total Environ. 2019 Apr 20;662:646-654. doi: 10.1016/j.scitotenv.2019.01.302. Epub 2019 Jan 24.

PMID:
30703722
12.

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH.

Cell Mol Gastroenterol Hepatol. 2019;7(1):197-209. doi: 10.1016/j.jcmgh.2018.09.005. Epub 2018 Sep 15.

13.

Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.

Bamidele AO, Svingen PA, Sagstetter MR, Sarmento OF, Gonzalez M, Braga Neto MB, Kugathasan S, Lomberk G, Urrutia RA, Faubion WA Jr.

Cell Mol Gastroenterol Hepatol. 2018 Sep 14;7(1):55-71. doi: 10.1016/j.jcmgh.2018.08.009. eCollection 2019.

14.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

Santofimia-Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, Neira JL, González A, Urrutia R, Soubeyran P, Iovanna J.

Sci Rep. 2018 Nov 19;8(1):16999. doi: 10.1038/s41598-018-35020-3.

15.

Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus.

Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL.

Virology. 2019 Jan 2;526:52-60. doi: 10.1016/j.virol.2018.10.003. Epub 2018 Oct 17.

PMID:
30342302
16.

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R.

Sci Rep. 2018 Oct 10;8(1):15077. doi: 10.1038/s41598-018-33475-y.

17.

Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells.

Ebine K, Kumar K, Pham TN, Shields MA, Collier KA, Shang M, DeCant BT, Urrutia R, Hwang RF, Grimaldo S, Principe DR, Grippo PJ, Bentrem DJ, Munshi HG.

Sci Rep. 2018 Sep 5;8(1):13225. doi: 10.1038/s41598-018-31658-1.

18.

Assessing Human Genetic Variations in Glucose Transporter SLC2A10 and Their Role in Altering Structural and Functional Properties.

Zimmermann MT, Urrutia R, Cousin MA, Oliver GR, Klee EW.

Front Genet. 2018 Jul 25;9:276. doi: 10.3389/fgene.2018.00276. eCollection 2018.

19.

Epigenetics of gastrointestinal diseases: notes from a workshop.

Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME.

Epigenetics. 2018;13(4):449-457. doi: 10.1080/15592294.2018.1464351. Epub 2018 Jul 30.

20.

Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway.

Xiang X, Wang Y, Zhang H, Piao J, Muthusamy S, Wang L, Deng Y, Zhang W, Kuang R, Billadeau DD, Huang S, Lai J, Urrutia R, Kang N.

NPJ Precis Oncol. 2018 Jan 23;2(1):2. doi: 10.1038/s41698-017-0045-7. eCollection 2018.

21.

Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect?

Polonis K, Blackburn PR, Urrutia RA, Lomberk GA, Kruisselbrink T, Cousin MA, Boczek NJ, Hoppman NL, Babovic-Vuksanovic D, Klee EW, Pichurin PN.

Cold Spring Harb Mol Case Stud. 2018 Aug 1;4(4). pii: a002899. doi: 10.1101/mcs.a002899. Print 2018 Aug.

22.

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.

Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reyniès A, Dusetti N, Iovanna J, Urrutia R.

Nat Commun. 2018 May 17;9(1):1978. doi: 10.1038/s41467-018-04383-6.

23.

Organic matter geochemical signatures (TOC, TN, C/N ratio, δ13C and δ15N) of surface sediment from lakes distributed along a climatological gradient on the western side of the southern Andes.

Contreras S, Werne JP, Araneda A, Urrutia R, Conejero CA.

Sci Total Environ. 2018 Jul 15;630:878-888. doi: 10.1016/j.scitotenv.2018.02.225. Epub 2018 Mar 7.

PMID:
29499543
24.

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.

Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH, Kang N.

Gastroenterology. 2018 Jun;154(8):2209-2221.e14. doi: 10.1053/j.gastro.2018.02.015. Epub 2018 Feb 15.

25.

Effects of histone methyltransferase inhibition in endometriosis.

Colón-Caraballo M, Torres-Reverón A, Soto-Vargas JL, Young SL, Lessey B, Mendoza A, Urrutia R, Flores I.

Biol Reprod. 2018 Aug 1;99(2):293-307. doi: 10.1093/biolre/ioy030.

26.

Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms.

Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH.

JCI Insight. 2017 Dec 21;2(24). pii: 92821. doi: 10.1172/jci.insight.92821.

27.

Historical anthropogenic mercury in two lakes of Central Chile: comparison between an urban and rural lake.

Álvarez D, Torrejón F, Climent MJ, Garcia-Orellana J, Araneda A, Urrutia R.

Environ Sci Pollut Res Int. 2018 Feb;25(5):4596-4606. doi: 10.1007/s11356-017-0622-x. Epub 2017 Nov 30.

PMID:
29192400
28.

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts.

Nicolle R, Blum Y, Marisa L, Loncle C, Gayet O, Moutardier V, Turrini O, Giovannini M, Bian B, Bigonnet M, Rubis M, Elarouci N, Armenoult L, Ayadi M, Duconseil P, Gasmi M, Ouaissi M, Maignan A, Lomberk G, Boher JM, Ewald J, Bories E, Garnier J, Goncalves A, Poizat F, Raoul JL, Secq V, Garcia S, Grandval P, Barraud-Blanc M, Norguet E, Gilabert M, Delpero JR, Roques J, Calvo E, Guillaumond F, Vasseur S, Urrutia R, de Reyniès A, Dusetti N, Iovanna J.

Cell Rep. 2017 Nov 28;21(9):2458-2470. doi: 10.1016/j.celrep.2017.11.003.

29.

Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome.

Kaiwar C, Zimmermann MT, Ferber MJ, Niu Z, Urrutia RA, Klee EW, Babovic-Vuksanovic D.

Cold Spring Harb Mol Case Stud. 2017 Nov 21;3(6). pii: a002162. doi: 10.1101/mcs.a002162. Print 2017 Nov. Review.

30.

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss.

Kalinec GM, Lomberk G, Urrutia RA, Kalinec F.

Front Cell Neurosci. 2017 Jul 7;11:192. doi: 10.3389/fncel.2017.00192. eCollection 2017. Review.

31.

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

Santofimia-Castaño P, Rizzuti B, Pey ÁL, Soubeyran P, Vidal M, Urrutia R, Iovanna JL, Neira JL.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6332-E6341. doi: 10.1073/pnas.1619932114. Epub 2017 Jul 18.

32.

Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling.

Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW.

Cold Spring Harb Mol Case Stud. 2017 Jul 5;3(4). pii: a001727. doi: 10.1101/mcs.a001727. Print 2017 Jul.

33.

Evaluation of diet pattern and weight gain in postmenopausal women enrolled in the Women's Health Initiative Observational Study.

Ford C, Chang S, Vitolins MZ, Fenton JI, Howard BV, Rhee JJ, Stefanick M, Chen B, Snetselaar L, Urrutia R, Frazier-Wood AC.

Br J Nutr. 2017 Apr;117(8):1189-1197. doi: 10.1017/S0007114517000952. Epub 2017 May 16.

34.

Novel de novo variant in EBF3 is likely to impact DNA binding in a patient with a neurodevelopmental disorder and expanded phenotypes: patient report, in silico functional assessment, and review of published cases.

Blackburn PR, Barnett SS, Zimmermann MT, Cousin MA, Kaiwar C, Pinto E Vairo F, Niu Z, Ferber MJ, Urrutia RA, Selcen D, Klee EW, Pichurin PN.

Cold Spring Harb Mol Case Stud. 2017 May;3(3):a001743. doi: 10.1101/mcs.a001743.

35.

A novel de novo frameshift deletion in EHMT1 in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation.

Blackburn PR, Williams M, Cousin MA, Boczek NJ, Beek GJ, Lomberk GA, Urrutia RA, Babovic-Vuksanovic D, Klee EW.

Mol Genet Genomic Med. 2017 Jan 26;5(2):141-146. doi: 10.1002/mgg3.268. eCollection 2017 Mar.

36.

Risk of Diabetes After Hysterectomy With or Without Oophorectomy in Postmenopausal Women.

Luo J, Manson JE, Urrutia RP, Hendryx M, LeBlanc ES, Margolis KL.

Am J Epidemiol. 2017 May 1;185(9):777-785. doi: 10.1093/aje/kwx023.

37.

Organic micropollutants (OMPs) oxidation by ozone: Effect of activated carbon on toxicity abatement.

Rozas O, Baeza C, Núñez K, Rossner A, Urrutia R, Mansilla HD.

Sci Total Environ. 2017 Jul 15;590-591:430-439. doi: 10.1016/j.scitotenv.2016.12.120. Epub 2017 Mar 12.

PMID:
28292609
38.

Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy.

Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ.

JCI Insight. 2017 Mar 9;2(5):e91225. doi: 10.1172/jci.insight.91225.

39.

Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts.

Bian B, Bigonnet M, Gayet O, Loncle C, Maignan A, Gilabert M, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Nicolle R, Blum Y, Marisa L, Rubis M, Raoul JL, Bradner JE, Qi J, Lomberk G, Urrutia R, Saul A, Dusetti N, Iovanna J.

EMBO Mol Med. 2017 Apr;9(4):482-497. doi: 10.15252/emmm.201606975.

40.

Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing.

Zimmermann MT, Urrutia R, Oliver GR, Blackburn PR, Cousin MA, Bozeck NJ, Klee EW.

PLoS One. 2017 Feb 9;12(2):e0170822. doi: 10.1371/journal.pone.0170822. eCollection 2017.

41.

Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome.

Zimmermann MT, Urrutia RA, Blackburn PR, Cousin MA, Boczek NJ, Klee EW, Macmurdo C, Atwal PS.

Case Rep Genet. 2017;2017:7263780. doi: 10.1155/2017/7263780. Epub 2017 Jan 9.

42.

A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPLX Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding.

Blackburn PR, Tischer A, Zimmermann MT, Kemppainen JL, Sastry S, Knight Johnson AE, Cousin MA, Boczek NJ, Oliver G, Misra VK, Gavrilova RH, Lomberk G, Auton M, Urrutia R, Klee EW.

J Biol Chem. 2017 Mar 3;292(9):3866-3876. doi: 10.1074/jbc.M116.770545. Epub 2017 Jan 5.

43.

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion.

Jalan-Sakrikar N, De Assuncao TM, Lu J, Almada LL, Lomberk G, Fernandez-Zapico ME, Urrutia R, Huebert RC.

PLoS One. 2016 Dec 9;11(12):e0168266. doi: 10.1371/journal.pone.0168266. eCollection 2016.

44.

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).

Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA.

J Biol Chem. 2017 Jan 13;292(2):706-722. doi: 10.1074/jbc.M116.749663. Epub 2016 Dec 1.

45.

Novel roles and mechanism for Krüppel-like factor 16 (KLF16) regulation of neurite outgrowth and ephrin receptor A5 (EphA5) expression in retinal ganglion cells.

Wang J, Galvao J, Beach KM, Luo W, Urrutia RA, Goldberg JL, Otteson DC.

J Biol Chem. 2016 Oct 7;291(41):21422. No abstract available.

46.

Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth.

Saha S, Xiong X, Chakraborty PK, Shameer K, Arvizo RR, Kudgus RA, Dwivedi SK, Hossen MN, Gillies EM, Robertson JD, Dudley JT, Urrutia RA, Postier RG, Bhattacharya R, Mukherjee P.

ACS Nano. 2016 Dec 27;10(12):10636-10651. doi: 10.1021/acsnano.6b02231. Epub 2016 Oct 19.

PMID:
27758098
47.

Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

Boczek NJ, Sigafoos AN, Zimmermann MT, Maus RL, Cousin MA, Blackburn PR, Urrutia R, Clark KJ, Patterson MC, Wick MJ, Klee EW.

Clin Case Rep. 2016 Aug 15;4(9):885-95. doi: 10.1002/ccr3.655. eCollection 2016 Sep.

48.

The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation.

Loncle C, Molejon MI, Lac S, Tellechea JI, Lomberk G, Gramatica L, Fernandez Zapico MF, Dusetti N, Urrutia R, Iovanna JL.

Cell Death Dis. 2016 Jul 14;7:e2295. doi: 10.1038/cddis.2016.202.

49.

"The molecule's the thing:" the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results.

Oliver GR, Zimmermann MT, Klee EW, Urrutia RA.

Version 3. F1000Res. 2016 Apr 27 [revised 2016 Jan 1];5:766. doi: 10.12688/f1000research.8600.3. eCollection 2016.

50.

Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.

Wang J, Galvao J, Beach KM, Luo W, Urrutia RA, Goldberg JL, Otteson DC.

J Biol Chem. 2016 Aug 26;291(35):18084-95. doi: 10.1074/jbc.M116.732339. Epub 2016 Jul 11. Erratum in: J Biol Chem. 2016 Oct 7;291(41):21422.

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