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Items: 1 to 50 of 281

1.

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica.

Mühlhausen S, Schmitt HD, Pan KT, Plessmann U, Urlaub H, Hurst LD, Kollmar M.

Curr Biol. 2018 Jul 9;28(13):2046-2057.e5. doi: 10.1016/j.cub.2018.04.085. Epub 2018 Jun 18.

2.

Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.

Johannsson S, Neumann P, Wulf A, Welp LM, Gerber HD, Krull M, Diederichsen U, Urlaub H, Ficner R.

Sci Rep. 2018 Jun 11;8(1):8880. doi: 10.1038/s41598-018-27118-5.

3.

Integrative omics - from data to biology.

Dihazi H, Asif AR, Beißbarth T, Bohrer R, Feussner K, Feussner I, Jahn O, Lenz C, Majcherczyk A, Schmidt B, Schmitt K, Urlaub H, Valerius O.

Expert Rev Proteomics. 2018 Jun;15(6):463-466. doi: 10.1080/14789450.2018.1476143. Epub 2018 May 18.

PMID:
29757692
4.

Xpo7 is a broad-spectrum exportin and a nuclear import receptor.

Aksu M, Pleiner T, Karaca S, Kappert C, Dehne HJ, Seibel K, Urlaub H, Bohnsack MT, Görlich D.

J Cell Biol. 2018 Jul 2;217(7):2329-2340. doi: 10.1083/jcb.201712013. Epub 2018 May 10.

5.

The nuts and bolts of the Haloferax CRISPR-Cas system I-B.

Maier LK, Stachler AE, Brendel J, Stoll B, Fischer S, Haas KA, Schwarz TS, Alkhnbashi OS, Sharma K, Urlaub H, Backofen R, Gophna U, Marchfelder A.

RNA Biol. 2018 May 21:1-12. doi: 10.1080/15476286.2018.1460994. [Epub ahead of print]

PMID:
29649958
6.

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.

de Moura TR, Mozaffari-Jovin S, Szabó CZK, Schmitzová J, Dybkov O, Cretu C, Kachala M, Svergun D, Urlaub H, Lührmann R, Pena V.

Mol Cell. 2018 Mar 15;69(6):979-992.e6. doi: 10.1016/j.molcel.2018.02.022.

PMID:
29547724
7.

Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis.

Dickmanns A, Zschiedrich CP, Arens J, Parfentev I, Gundlach J, Hofele R, Neumann P, Urlaub H, Görke B, Ficner R, Stülke J.

J Biol Chem. 2018 Apr 20;293(16):5781-5792. doi: 10.1074/jbc.RA117.001289. Epub 2018 Mar 7.

PMID:
29514981
8.

The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR-Cas subtype III-Bv system.

Behler J, Sharma K, Reimann V, Wilde A, Urlaub H, Hess WR.

Nat Microbiol. 2018 Mar;3(3):367-377. doi: 10.1038/s41564-017-0103-5. Epub 2018 Feb 5.

PMID:
29403013
9.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Lührmann R, Stark H.

Cell. 2018 Jan 25;172(3):454-464.e11. doi: 10.1016/j.cell.2018.01.010. Epub 2018 Jan 17.

PMID:
29361316
10.

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex.

Bao P, Will CL, Urlaub H, Boon KL, Lührmann R.

Genes Dev. 2017 Dec 1;31(23-24):2416-2429. doi: 10.1101/gad.308163.117. Epub 2018 Jan 12.

11.

sRNA41 affects ribosome binding sites within polycistronic mRNAs in Methanosarcina mazei Gö1.

Buddeweg A, Sharma K, Urlaub H, Schmitz RA.

Mol Microbiol. 2018 Mar;107(5):595-609. doi: 10.1111/mmi.13900. Epub 2018 Jan 18.

PMID:
29271512
12.

Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa.

Sonnleitner E, Wulf A, Campagne S, Pei XY, Wolfinger MT, Forlani G, Prindl K, Abdou L, Resch A, Allain FH, Luisi BF, Urlaub H, Bläsi U.

Nucleic Acids Res. 2018 Feb 16;46(3):1470-1485. doi: 10.1093/nar/gkx1245.

13.

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.

Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M.

Sci Transl Med. 2017 Dec 6;9(419). pii: eaam7816. doi: 10.1126/scitranslmed.aam7816.

PMID:
29212715
14.

Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex.

Ahdash Z, Lau AM, Byrne RT, Lammens K, Stüetzer A, Urlaub H, Booth PJ, Reading E, Hopfner KP, Politis A.

Nucleic Acids Res. 2017 Nov 16;45(20):12025-12038. doi: 10.1093/nar/gkx890.

15.

Protein Profiling of Non-model Plant Cuminum cyminum by Gel-Based Proteomic Approach.

Zaman U, Urlaub H, Abbasi A.

Phytochem Anal. 2018 May;29(3):242-249. doi: 10.1002/pca.2738. Epub 2017 Nov 16.

PMID:
29148164
16.

Structures of transcription pre-initiation complex with TFIIH and Mediator.

Schilbach S, Hantsche M, Tegunov D, Dienemann C, Wigge C, Urlaub H, Cramer P.

Nature. 2017 Nov 9;551(7679):204-209. doi: 10.1038/nature24282. Epub 2017 Nov 1.

PMID:
29088706
17.

Combining cryo-electron microscopy (cryo-EM) and cross-linking mass spectrometry (CX-MS) for structural elucidation of large protein assemblies.

Schmidt C, Urlaub H.

Curr Opin Struct Biol. 2017 Oct;46:157-168. doi: 10.1016/j.sbi.2017.10.005. Epub 2017 Nov 5. Review.

PMID:
29080436
18.

Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding.

Scacioc A, Schmidt C, Hofmann T, Urlaub H, Kühnel K, Pérez-Lara Á.

Sci Rep. 2017 Oct 25;7(1):14008. doi: 10.1038/s41598-017-14337-5.

19.

Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.

Warda AS, Kretschmer J, Hackert P, Lenz C, Urlaub H, Höbartner C, Sloan KE, Bohnsack MT.

EMBO Rep. 2017 Nov;18(11):2004-2014. doi: 10.15252/embr.201744940. Epub 2017 Oct 19.

PMID:
29051200
20.

Mechanism of Transcription Anti-termination in Human Mitochondria.

Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D.

Cell. 2017 Nov 16;171(5):1082-1093.e13. doi: 10.1016/j.cell.2017.09.035. Epub 2017 Oct 12.

PMID:
29033127
21.

A new albumin-depletion strategy improves proteomic research of gingival crevicular fluid from periodontitis patients.

Batschkus S, Cingoez G, Urlaub H, Miosge N, Kirschneck C, Meyer-Marcotty P, Lenz C.

Clin Oral Investig. 2018 Apr;22(3):1375-1384. doi: 10.1007/s00784-017-2213-0. Epub 2017 Oct 9.

PMID:
28993918
22.

The SmAP2 RNA binding motif in the 3'UTR affects mRNA stability in the crenarchaeum Sulfolobus solfataricus.

Märtens B, Sharma K, Urlaub H, Bläsi U.

Nucleic Acids Res. 2017 Sep 6;45(15):8957-8967. doi: 10.1093/nar/gkx581.

23.

A new role for FBP21 as regulator of Brr2 helicase activity.

Henning LM, Santos KF, Sticht J, Jehle S, Lee CT, Wittwer M, Urlaub H, Stelzl U, Wahl MC, Freund C.

Nucleic Acids Res. 2017 Jul 27;45(13):7922-7937. doi: 10.1093/nar/gkx535.

24.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, Lührmann R, Stark H.

Cell. 2017 Aug 10;170(4):701-713.e11. doi: 10.1016/j.cell.2017.07.011. Epub 2017 Aug 3.

PMID:
28781166
25.

Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex.

Xu Y, Bernecky C, Lee CT, Maier KC, Schwalb B, Tegunov D, Plitzko JM, Urlaub H, Cramer P.

Nat Commun. 2017 Jun 6;8:15741. doi: 10.1038/ncomms15741.

26.

An activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly.

Jakhanwal S, Lee CT, Urlaub H, Jahn R.

EMBO J. 2017 Jun 14;36(12):1788-1802. doi: 10.15252/embj.201696270. Epub 2017 May 8.

27.

Structural basis for λN-dependent processive transcription antitermination.

Said N, Krupp F, Anedchenko E, Santos KF, Dybkov O, Huang YH, Lee CT, Loll B, Behrmann E, Bürger J, Mielke T, Loerke J, Urlaub H, Spahn CMT, Weber G, Wahl MC.

Nat Microbiol. 2017 Apr 28;2:17062. doi: 10.1038/nmicrobiol.2017.62.

PMID:
28452979
28.

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

Treiber T, Treiber N, Plessmann U, Harlander S, Daiß JL, Eichner N, Lehmann G, Schall K, Urlaub H, Meister G.

Mol Cell. 2017 Apr 20;66(2):270-284.e13. doi: 10.1016/j.molcel.2017.03.014.

29.

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Ströbel P, Wachter A, Beissbarth T, Schnütgen F, Cremer A, Haetscher N, Göllner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bönig H, Müller-Tidow C, Kuchenbauer F, Schütz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T.

Cancer Cell. 2017 Apr 10;31(4):549-562.e11. doi: 10.1016/j.ccell.2017.03.001.

30.

SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing.

Pozzi B, Bragado L, Will CL, Mammi P, Risso G, Urlaub H, Lührmann R, Srebrow A.

Nucleic Acids Res. 2017 Jun 20;45(11):6729-6745. doi: 10.1093/nar/gkx213.

31.

Mapping the secretome of human chondrogenic progenitor cells with mass spectrometry.

Batschkus S, Atanassov I, Lenz C, Meyer-Marcotty P, Cingöz G, Kirschneck C, Urlaub H, Miosge N.

Ann Anat. 2017 Jul;212:4-10. doi: 10.1016/j.aanat.2017.03.003. Epub 2017 Mar 30.

PMID:
28365382
32.

Adapting Data-Independent Acquisition for Mass Spectrometry-Based Protein Site-Specific N-Glycosylation Analysis.

Pan KT, Chen CC, Urlaub H, Khoo KH.

Anal Chem. 2017 Apr 18;89(8):4532-4539. doi: 10.1021/acs.analchem.6b04996. Epub 2017 Apr 7.

PMID:
28353332
33.

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

Sidarovich A, Will CL, Anokhina MM, Ceballos J, Sievers S, Agafonov DE, Samatov T, Bao P, Kastner B, Urlaub H, Waldmann H, Lührmann R.

Elife. 2017 Mar 16;6. pii: e23533. doi: 10.7554/eLife.23533.

34.

Hypoxia-stimulated membrane trafficking requires T-plastin.

Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM.

Acta Physiol (Oxf). 2017 Sep;221(1):59-73. doi: 10.1111/apha.12859. Epub 2017 Mar 23.

PMID:
28218996
35.

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, Lührmann R.

Nature. 2017 Feb 16;542(7641):318-323. doi: 10.1038/nature21079. Epub 2017 Jan 11.

PMID:
28076346
36.

HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling.

Walter R, Pan KT, Doebele C, Comoglio F, Tomska K, Bohnenberger H, Young RM, Jacobs L, Keller U, Bönig H, Engelke M, Rosenwald A, Urlaub H, Staudt LM, Serve H, Zenz T, Oellerich T.

Blood. 2017 Feb 2;129(5):598-608. doi: 10.1182/blood-2016-06-721423. Epub 2016 Nov 15.

37.

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.

Göllner S, Oellerich T, Agrawal-Singh S, Schenk T, Klein HU, Rohde C, Pabst C, Sauer T, Lerdrup M, Tavor S, Stölzel F, Herold S, Ehninger G, Köhler G, Pan KT, Urlaub H, Serve H, Dugas M, Spiekermann K, Vick B, Jeremias I, Berdel WE, Hansen K, Zelent A, Wickenhauser C, Müller LP, Thiede C, Müller-Tidow C.

Nat Med. 2017 Jan;23(1):69-78. doi: 10.1038/nm.4247. Epub 2016 Dec 12.

PMID:
27941792
38.

Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration.

Zhang JN, Michel U, Lenz C, Friedel CC, Köster S, d'Hedouville Z, Tönges L, Urlaub H, Bähr M, Lingor P, Koch JC.

Sci Rep. 2016 Nov 15;6:37050. doi: 10.1038/srep37050.

39.

The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.

Manno B, Oellerich T, Schnyder T, Corso J, Lösing M, Neumann K, Urlaub H, Batista FD, Engelke M, Wienands J.

Eur J Immunol. 2016 Nov;46(11):2520-2530. doi: 10.1002/eji.201646431. Epub 2016 Sep 14.

40.

TIM29 is a subunit of the human carrier translocase required for protein transport.

Callegari S, Richter F, Chojnacka K, Jans DC, Lorenzi I, Pacheu-Grau D, Jakobs S, Lenz C, Urlaub H, Dudek J, Chacinska A, Rehling P.

FEBS Lett. 2016 Dec;590(23):4147-4158. doi: 10.1002/1873-3468.12450. Epub 2016 Oct 26.

41.

Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum.

Martin S, Bellora N, González-Vallinas J, Irimia M, Chebli K, de Toledo M, Raabe M, Eyras E, Urlaub H, Blencowe BJ, Tazi J.

J Neurochem. 2016 Nov;139(3):349-368. doi: 10.1111/jnc.13768. Epub 2016 Oct 18.

42.

S-nitrosylation of endogenous protein tyrosine phosphatases in endothelial insulin signaling.

Hsu MF, Pan KT, Chang FY, Khoo KH, Urlaub H, Cheng CF, Chang GD, Haj FG, Meng TC.

Free Radic Biol Med. 2016 Oct;99:199-213. doi: 10.1016/j.freeradbiomed.2016.08.012. Epub 2016 Aug 10.

43.

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.

Cretu C, Schmitzová J, Ponce-Salvatierra A, Dybkov O, De Laurentiis EI, Sharma K, Will CL, Urlaub H, Lührmann R, Pena V.

Mol Cell. 2016 Oct 20;64(2):307-319. doi: 10.1016/j.molcel.2016.08.036. Epub 2016 Oct 6.

44.

Shedding light on biofilm formation of Halobacterium salinarum R1 by SWATH-LC/MS/MS analysis of planktonic and sessile cells.

Losensky G, Jung K, Urlaub H, Pfeifer F, Fröls S, Lenz C.

Proteomics. 2017 Apr;17(7). doi: 10.1002/pmic.201600111. Epub 2016 Oct 17.

PMID:
27604596
45.

Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.

Strenzke N, Chakrabarti R, Al-Moyed H, Müller A, Hoch G, Pangrsic T, Yamanbaeva G, Lenz C, Pan KT, Auge E, Geiss-Friedlander R, Urlaub H, Brose N, Wichmann C, Reisinger E.

EMBO J. 2016 Dec 1;35(23):2519-2535. Epub 2016 Oct 11.

46.

DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.

Justa-Schuch D, Silva-Garcia M, Pilla E, Engelke M, Kilisch M, Lenz C, Möller U, Nakamura F, Urlaub H, Geiss-Friedlander R.

Elife. 2016 Sep 10;5. pii: e16370. doi: 10.7554/eLife.16370.

47.

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome.

Rauhut R, Fabrizio P, Dybkov O, Hartmuth K, Pena V, Chari A, Kumar V, Lee CT, Urlaub H, Kastner B, Stark H, Lührmann R.

Science. 2016 Sep 23;353(6306):1399-1405. Epub 2016 Aug 25.

48.

LFQProfiler and RNP(xl): Open-Source Tools for Label-Free Quantification and Protein-RNA Cross-Linking Integrated into Proteome Discoverer.

Veit J, Sachsenberg T, Chernev A, Aicheler F, Urlaub H, Kohlbacher O.

J Proteome Res. 2016 Sep 2;15(9):3441-8. doi: 10.1021/acs.jproteome.6b00407. Epub 2016 Aug 10.

PMID:
27476824
49.

ATPγS stalls splicing after B complex formation but prior to spliceosome activation.

Agafonov DE, van Santen M, Kastner B, Dube P, Will CL, Urlaub H, Lührmann R.

RNA. 2016 Sep;22(9):1329-37. doi: 10.1261/rna.057810.116. Epub 2016 Jul 13.

50.

Axonopathy in the Central Nervous System Is the Hallmark of Mice with a Novel Intragenic Null Mutation of Dystonin.

Seehusen F, Kiel K, Jottini S, Wohlsein P, Habierski A, Seibel K, Vogel T, Urlaub H, Kollmar M, Baumgärtner W, Teichmann U.

Genetics. 2016 Sep;204(1):191-203. doi: 10.1534/genetics.116.186932. Epub 2016 Jul 8.

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