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Items: 1 to 50 of 297

1.

Broad range of missense error frequencies in cellular proteins.

Garofalo R, Wohlgemuth I, Pearson M, Lenz C, Urlaub H, Rodnina MV.

Nucleic Acids Res. 2019 Jan 15. doi: 10.1093/nar/gky1319. [Epub ahead of print]

PMID:
30649420
2.

ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.

Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P.

J Cell Biol. 2019 Feb 4;218(2):598-614. doi: 10.1083/jcb.201806093. Epub 2018 Dec 31.

3.

Plk1/Polo Phosphorylates Sas-4 at the Onset of Mitosis for an Efficient Recruitment of Pericentriolar Material to Centrosomes.

Ramani A, Mariappan A, Gottardo M, Mandad S, Urlaub H, Avidor-Reiss T, Riparbelli M, Callaini G, Debec A, Feederle R, Gopalakrishnan J.

Cell Rep. 2018 Dec 26;25(13):3618-3630.e6. doi: 10.1016/j.celrep.2018.11.102.

4.

RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes.

Brüning L, Hackert P, Martin R, Davila Gallesio J, Aquino GRR, Urlaub H, Sloan KE, Bohnsack MT.

Nat Commun. 2018 Dec 19;9(1):5383. doi: 10.1038/s41467-018-07783-w.

5.

Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.

Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J.

EMBO J. 2019 Jan 15;38(2). pii: e99876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10.

6.

The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.

Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF.

Sci Rep. 2018 Nov 15;8(1):16913. doi: 10.1038/s41598-018-35277-8.

7.

Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum.

Özcan A, Pausch P, Linden A, Wulf A, Schühle K, Heider J, Urlaub H, Heimerl T, Bange G, Randau L.

Nat Microbiol. 2019 Jan;4(1):89-96. doi: 10.1038/s41564-018-0274-8. Epub 2018 Nov 5.

PMID:
30397343
8.

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.

Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M.

Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0.

9.

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M.

Nat Commun. 2018 Oct 12;9(1):4234. doi: 10.1038/s41467-018-06448-y.

10.

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.

Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO.

Nat Commun. 2018 Oct 12;9(1):4230. doi: 10.1038/s41467-018-06519-0.

11.

Identification of new high affinity targets for Roquin based on structural conservation.

Braun J, Fischer S, Xu ZZ, Sun H, Ghoneim DH, Gimbel AT, Plessmann U, Urlaub H, Mathews DH, Weigand JE.

Nucleic Acids Res. 2018 Dec 14;46(22):12109-12125. doi: 10.1093/nar/gky908.

12.

Stable maintenance of the rudivirus SIRV3 in a carrier state in Sulfolobus islandicus despite activation of the CRISPR-Cas immune response by a second virus SMV1.

Papathanasiou P, Erdmann S, Leon-Sobrino C, Sharma K, Urlaub H, Garrett RA, Peng X.

RNA Biol. 2018 Sep 13:1-9. doi: 10.1080/15476286.2018.1511674. [Epub ahead of print]

PMID:
30146914
13.

Structure of paused transcription complex Pol II-DSIF-NELF.

Vos SM, Farnung L, Urlaub H, Cramer P.

Nature. 2018 Aug;560(7720):601-606. doi: 10.1038/s41586-018-0442-2. Epub 2018 Aug 22.

PMID:
30135580
14.

Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.

Vos SM, Farnung L, Boehning M, Wigge C, Linden A, Urlaub H, Cramer P.

Nature. 2018 Aug;560(7720):607-612. doi: 10.1038/s41586-018-0440-4. Epub 2018 Aug 22.

PMID:
30135578
15.

Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.

Bohnenberger H, Kaderali L, Ströbel P, Yepes D, Plessmann U, Dharia NV, Yao S, Heydt C, Merkelbach-Bruse S, Emmert A, Hoffmann J, Bodemeyer J, Reuter-Jessen K, Lois AM, Dröge LH, Baumeister P, Walz C, Biggemann L, Walter R, Häupl B, Comoglio F, Pan KT, Scheich S, Lenz C, Küffer S, Bremmer F, Kitz J, Sitte M, Beißbarth T, Hinterthaner M, Sebastian M, Lotz J, Schildhaus HU, Wolff H, Danner BC, Brandts C, Büttner R, Canis M, Stegmaier K, Serve H, Urlaub H, Oellerich T.

EMBO Mol Med. 2018 Sep;10(9). pii: e8428. doi: 10.15252/emmm.201708428.

16.

The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.

Lavdovskaia E, Kolander E, Steube E, Mai MM, Urlaub H, Richter-Dennerlein R.

Nucleic Acids Res. 2018 Sep 19;46(16):8471-8482. doi: 10.1093/nar/gky701.

17.

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica.

Mühlhausen S, Schmitt HD, Pan KT, Plessmann U, Urlaub H, Hurst LD, Kollmar M.

Curr Biol. 2018 Jul 9;28(13):2046-2057.e5. doi: 10.1016/j.cub.2018.04.085. Epub 2018 Jun 18.

18.

Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.

Johannsson S, Neumann P, Wulf A, Welp LM, Gerber HD, Krull M, Diederichsen U, Urlaub H, Ficner R.

Sci Rep. 2018 Jun 11;8(1):8880. doi: 10.1038/s41598-018-27118-5.

19.

Integrative omics - from data to biology.

Dihazi H, Asif AR, Beißbarth T, Bohrer R, Feussner K, Feussner I, Jahn O, Lenz C, Majcherczyk A, Schmidt B, Schmitt K, Urlaub H, Valerius O.

Expert Rev Proteomics. 2018 Jun;15(6):463-466. doi: 10.1080/14789450.2018.1476143. Epub 2018 May 18.

PMID:
29757692
20.

Xpo7 is a broad-spectrum exportin and a nuclear import receptor.

Aksu M, Pleiner T, Karaca S, Kappert C, Dehne HJ, Seibel K, Urlaub H, Bohnsack MT, Görlich D.

J Cell Biol. 2018 Jul 2;217(7):2329-2340. doi: 10.1083/jcb.201712013. Epub 2018 May 10.

21.

The nuts and bolts of the Haloferax CRISPR-Cas system I-B.

Maier LK, Stachler AE, Brendel J, Stoll B, Fischer S, Haas KA, Schwarz TS, Alkhnbashi OS, Sharma K, Urlaub H, Backofen R, Gophna U, Marchfelder A.

RNA Biol. 2018 May 21:1-12. doi: 10.1080/15476286.2018.1460994. [Epub ahead of print]

PMID:
29649958
22.

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.

de Moura TR, Mozaffari-Jovin S, Szabó CZK, Schmitzová J, Dybkov O, Cretu C, Kachala M, Svergun D, Urlaub H, Lührmann R, Pena V.

Mol Cell. 2018 Mar 15;69(6):979-992.e6. doi: 10.1016/j.molcel.2018.02.022.

PMID:
29547724
23.

Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis.

Dickmanns A, Zschiedrich CP, Arens J, Parfentev I, Gundlach J, Hofele R, Neumann P, Urlaub H, Görke B, Ficner R, Stülke J.

J Biol Chem. 2018 Apr 20;293(16):5781-5792. doi: 10.1074/jbc.RA117.001289. Epub 2018 Mar 7.

PMID:
29514981
24.

The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR-Cas subtype III-Bv system.

Behler J, Sharma K, Reimann V, Wilde A, Urlaub H, Hess WR.

Nat Microbiol. 2018 Mar;3(3):367-377. doi: 10.1038/s41564-017-0103-5. Epub 2018 Feb 5.

PMID:
29403013
25.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Lührmann R, Stark H.

Cell. 2018 Jan 25;172(3):454-464.e11. doi: 10.1016/j.cell.2018.01.010. Epub 2018 Jan 17.

26.

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex.

Bao P, Will CL, Urlaub H, Boon KL, Lührmann R.

Genes Dev. 2017 Dec 1;31(23-24):2416-2429. doi: 10.1101/gad.308163.117. Epub 2018 Jan 12.

27.

sRNA41 affects ribosome binding sites within polycistronic mRNAs in Methanosarcina mazei Gö1.

Buddeweg A, Sharma K, Urlaub H, Schmitz RA.

Mol Microbiol. 2018 Mar;107(5):595-609. doi: 10.1111/mmi.13900. Epub 2018 Jan 18.

PMID:
29271512
28.

Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa.

Sonnleitner E, Wulf A, Campagne S, Pei XY, Wolfinger MT, Forlani G, Prindl K, Abdou L, Resch A, Allain FH, Luisi BF, Urlaub H, Bläsi U.

Nucleic Acids Res. 2018 Feb 16;46(3):1470-1485. doi: 10.1093/nar/gkx1245.

29.

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.

Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M.

Sci Transl Med. 2017 Dec 6;9(419). pii: eaam7816. doi: 10.1126/scitranslmed.aam7816.

PMID:
29212715
30.

Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex.

Ahdash Z, Lau AM, Byrne RT, Lammens K, Stüetzer A, Urlaub H, Booth PJ, Reading E, Hopfner KP, Politis A.

Nucleic Acids Res. 2017 Nov 16;45(20):12025-12038. doi: 10.1093/nar/gkx890.

31.

Protein Profiling of Non-model Plant Cuminum cyminum by Gel-Based Proteomic Approach.

Zaman U, Urlaub H, Abbasi A.

Phytochem Anal. 2018 May;29(3):242-249. doi: 10.1002/pca.2738. Epub 2017 Nov 16.

PMID:
29148164
32.

Structures of transcription pre-initiation complex with TFIIH and Mediator.

Schilbach S, Hantsche M, Tegunov D, Dienemann C, Wigge C, Urlaub H, Cramer P.

Nature. 2017 Nov 9;551(7679):204-209. doi: 10.1038/nature24282. Epub 2017 Nov 1.

33.

Combining cryo-electron microscopy (cryo-EM) and cross-linking mass spectrometry (CX-MS) for structural elucidation of large protein assemblies.

Schmidt C, Urlaub H.

Curr Opin Struct Biol. 2017 Oct;46:157-168. doi: 10.1016/j.sbi.2017.10.005. Epub 2017 Nov 5. Review.

PMID:
29080436
34.

Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding.

Scacioc A, Schmidt C, Hofmann T, Urlaub H, Kühnel K, Pérez-Lara Á.

Sci Rep. 2017 Oct 25;7(1):14008. doi: 10.1038/s41598-017-14337-5.

35.

Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.

Warda AS, Kretschmer J, Hackert P, Lenz C, Urlaub H, Höbartner C, Sloan KE, Bohnsack MT.

EMBO Rep. 2017 Nov;18(11):2004-2014. doi: 10.15252/embr.201744940. Epub 2017 Oct 19.

36.

Mechanism of Transcription Anti-termination in Human Mitochondria.

Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D.

Cell. 2017 Nov 16;171(5):1082-1093.e13. doi: 10.1016/j.cell.2017.09.035. Epub 2017 Oct 12.

37.

A new albumin-depletion strategy improves proteomic research of gingival crevicular fluid from periodontitis patients.

Batschkus S, Cingoez G, Urlaub H, Miosge N, Kirschneck C, Meyer-Marcotty P, Lenz C.

Clin Oral Investig. 2018 Apr;22(3):1375-1384. doi: 10.1007/s00784-017-2213-0. Epub 2017 Oct 9.

PMID:
28993918
38.

The SmAP2 RNA binding motif in the 3'UTR affects mRNA stability in the crenarchaeum Sulfolobus solfataricus.

Märtens B, Sharma K, Urlaub H, Bläsi U.

Nucleic Acids Res. 2017 Sep 6;45(15):8957-8967. doi: 10.1093/nar/gkx581.

39.

A new role for FBP21 as regulator of Brr2 helicase activity.

Henning LM, Santos KF, Sticht J, Jehle S, Lee CT, Wittwer M, Urlaub H, Stelzl U, Wahl MC, Freund C.

Nucleic Acids Res. 2017 Jul 27;45(13):7922-7937. doi: 10.1093/nar/gkx535.

40.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, Lührmann R, Stark H.

Cell. 2017 Aug 10;170(4):701-713.e11. doi: 10.1016/j.cell.2017.07.011. Epub 2017 Aug 3.

41.

Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex.

Xu Y, Bernecky C, Lee CT, Maier KC, Schwalb B, Tegunov D, Plitzko JM, Urlaub H, Cramer P.

Nat Commun. 2017 Jun 6;8:15741. doi: 10.1038/ncomms15741.

42.

An activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly.

Jakhanwal S, Lee CT, Urlaub H, Jahn R.

EMBO J. 2017 Jun 14;36(12):1788-1802. doi: 10.15252/embj.201696270. Epub 2017 May 8.

43.

Structural basis for λN-dependent processive transcription antitermination.

Said N, Krupp F, Anedchenko E, Santos KF, Dybkov O, Huang YH, Lee CT, Loll B, Behrmann E, Bürger J, Mielke T, Loerke J, Urlaub H, Spahn CMT, Weber G, Wahl MC.

Nat Microbiol. 2017 Apr 28;2:17062. doi: 10.1038/nmicrobiol.2017.62.

PMID:
28452979
44.

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

Treiber T, Treiber N, Plessmann U, Harlander S, Daiß JL, Eichner N, Lehmann G, Schall K, Urlaub H, Meister G.

Mol Cell. 2017 Apr 20;66(2):270-284.e13. doi: 10.1016/j.molcel.2017.03.014.

45.

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Ströbel P, Wachter A, Beissbarth T, Schnütgen F, Cremer A, Haetscher N, Göllner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bönig H, Müller-Tidow C, Kuchenbauer F, Schütz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T.

Cancer Cell. 2017 Apr 10;31(4):549-562.e11. doi: 10.1016/j.ccell.2017.03.001.

46.

SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing.

Pozzi B, Bragado L, Will CL, Mammi P, Risso G, Urlaub H, Lührmann R, Srebrow A.

Nucleic Acids Res. 2017 Jun 20;45(11):6729-6745. doi: 10.1093/nar/gkx213.

47.

Mapping the secretome of human chondrogenic progenitor cells with mass spectrometry.

Batschkus S, Atanassov I, Lenz C, Meyer-Marcotty P, Cingöz G, Kirschneck C, Urlaub H, Miosge N.

Ann Anat. 2017 Jul;212:4-10. doi: 10.1016/j.aanat.2017.03.003. Epub 2017 Mar 30.

PMID:
28365382
48.

Adapting Data-Independent Acquisition for Mass Spectrometry-Based Protein Site-Specific N-Glycosylation Analysis.

Pan KT, Chen CC, Urlaub H, Khoo KH.

Anal Chem. 2017 Apr 18;89(8):4532-4539. doi: 10.1021/acs.analchem.6b04996. Epub 2017 Apr 7.

PMID:
28353332
49.

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

Sidarovich A, Will CL, Anokhina MM, Ceballos J, Sievers S, Agafonov DE, Samatov T, Bao P, Kastner B, Urlaub H, Waldmann H, Lührmann R.

Elife. 2017 Mar 16;6. pii: e23533. doi: 10.7554/eLife.23533.

50.

Hypoxia-stimulated membrane trafficking requires T-plastin.

Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM.

Acta Physiol (Oxf). 2017 Sep;221(1):59-73. doi: 10.1111/apha.12859. Epub 2017 Mar 23.

PMID:
28218996

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