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Items: 1 to 50 of 317

1.

Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.

Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Hüttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Böttcher B, Szalay AA, Cramer P, Fischer U.

Cell. 2019 Dec 12;179(7):1537-1550.e19. doi: 10.1016/j.cell.2019.11.024.

PMID:
31835032
2.

An in silico-in vitro Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients.

Mishto M, Mansurkhodzhaev A, Ying G, Bitra A, Cordfunke RA, Henze S, Paul D, Sidney J, Urlaub H, Neefjes J, Sette A, Zajonc DM, Liepe J.

Front Immunol. 2019 Nov 15;10:2572. doi: 10.3389/fimmu.2019.02572. eCollection 2019.

3.

Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP.

Gowravaram M, Schwarz J, Khilji SK, Urlaub H, Chakrabarti S.

Nat Commun. 2019 Nov 7;10(1):5054. doi: 10.1038/s41467-019-13080-x.

4.

A mass spectrometry workflow for measuring protein turnover rates in vivo.

Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF.

Nat Protoc. 2019 Dec;14(12):3333-3365. doi: 10.1038/s41596-019-0222-y. Epub 2019 Nov 4.

PMID:
31685960
5.

Mapping Cellular Microenvironments: Proximity Labeling and Complexome Profiling (Seventh Symposium of the Göttingen Proteomics Forum).

Valerius O, Asif AR, Beißbarth T, Bohrer R, Dihazi H, Feussner K, Jahn O, Majcherczyk A, Schmidt B, Schmitt K, Urlaub H, Lenz C.

Cells. 2019 Oct 2;8(10). pii: E1192. doi: 10.3390/cells8101192.

6.

Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines.

Bremmer F, Bohnenberger H, Küffer S, Oellerich T, Serve H, Urlaub H, Strauss A, Maatoug Y, Behnes CL, Oing C, Radzun HJ, Ströbel P, Balabanov S, Honecker F.

Dis Markers. 2019 Sep 3;2019:8298524. doi: 10.1155/2019/8298524. eCollection 2019.

7.

The hRPC62 subunit of human RNA polymerase III displays helicase activity.

Ayoubi LE, Dumay-Odelot H, Chernev A, Boissier F, Minvielle-Sébastia L, Urlaub H, Fribourg S, Teichmann M.

Nucleic Acids Res. 2019 Nov 4;47(19):10313-10326. doi: 10.1093/nar/gkz788.

8.

Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane.

James C, Müller M, Goldberg MW, Lenz C, Urlaub H, Kehlenbach RH.

J Biol Chem. 2019 Nov 1;294(44):16241-16254. doi: 10.1074/jbc.RA118.007283. Epub 2019 Sep 13.

PMID:
31519755
9.

The Response of Haloferax volcanii to Salt and Temperature Stress: A Proteome Study by Label-Free Mass Spectrometry.

Jevtić Ž, Stoll B, Pfeiffer F, Sharma K, Urlaub H, Marchfelder A, Lenz C.

Proteomics. 2019 Oct;19(20):e1800491. doi: 10.1002/pmic.201800491. Epub 2019 Sep 30.

PMID:
31502396
10.

Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity.

Yagensky O, Kohansal-Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, Härtig W, Urlaub H, Chua JJ.

Elife. 2019 Aug 27;8. pii: e47498. doi: 10.7554/eLife.47498.

11.

Control of p21Cip by BRAP is Critical for Cardiomyocyte Cell Cycle Progression and Survival.

Volland C, Schott P, Didié M, Männer J, Unsöld B, Toischer K, Schmidt C, Urlaub H, Nickels K, Knöll R, Schmidt A, Guan K, Hasenfuß G, Seidler T.

Cardiovasc Res. 2019 Jul 9. pii: cvz177. doi: 10.1093/cvr/cvz177. [Epub ahead of print]

PMID:
31286143
12.

Structural basis of TFIIH activation for nucleotide excision repair.

Kokic G, Chernev A, Tegunov D, Dienemann C, Urlaub H, Cramer P.

Nat Commun. 2019 Jun 28;10(1):2885. doi: 10.1038/s41467-019-10745-5.

13.

Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.

Liess AKL, Kucerova A, Schweimer K, Yu L, Roumeliotis TI, Diebold M, Dybkov O, Sotriffer C, Urlaub H, Choudhary JS, Mansfeld J, Lorenz S.

Structure. 2019 Aug 6;27(8):1195-1210.e7. doi: 10.1016/j.str.2019.05.008. Epub 2019 Jun 20.

PMID:
31230944
14.

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.

Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT.

Circulation. 2019 Aug 20;140(8):681-693. doi: 10.1161/CIRCULATIONAHA.119.039642. Epub 2019 Jun 12.

PMID:
31185731
15.

A trap mutant reveals the physiological client spectrum of TRC40.

Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B.

J Cell Sci. 2019 Jul 1;132(13). pii: jcs230094. doi: 10.1242/jcs.230094.

16.

A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria.

Callegari S, Müller T, Schulz C, Lenz C, Jans DC, Wissel M, Opazo F, Rizzoli SO, Jakobs S, Urlaub H, Rehling P, Deckers M.

J Mol Biol. 2019 Jul 12;431(15):2835-2851. doi: 10.1016/j.jmb.2019.05.015. Epub 2019 May 17.

17.

Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.

Chachami G, Stankovic-Valentin N, Karagiota A, Basagianni A, Plessmann U, Urlaub H, Melchior F, Simos G.

Mol Cell Proteomics. 2019 Jun;18(6):1197-1209. doi: 10.1074/mcp.RA119.001401. Epub 2019 Mar 29.

PMID:
30926672
18.

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.

Schroeder MP, Bastian L, Eckert C, Gökbuget N, James AR, Tanchez JO, Schlee C, Isaakidis K, Häupl B, Baum K, Migueles Lozano OA, Kouidri K, Pan KT, Urlaub H, Schwartz S, Burmeister T, von Stackelberg A, Hoelzer D, Pfeiffer H, Rieger MA, Göllner S, Oellerich T, Horstman M, Schrappe M, Wolf J, Kirschner-Schwabe R, Brüggemann M, Müller-Tidow C, Serve H, Neumann M, Baldus CD.

Sci Rep. 2019 Mar 12;9(1):4188. doi: 10.1038/s41598-019-40786-1.

19.

Human colon organoids reveal distinct physiologic and oncogenic Wnt responses.

Michels BE, Mosa MH, Grebbin BM, Yepes D, Darvishi T, Hausmann J, Urlaub H, Zeuzem S, Kvasnicka HM, Oellerich T, Farin HF.

J Exp Med. 2019 Mar 4;216(3):704-720. doi: 10.1084/jem.20180823. Epub 2019 Feb 21.

20.

Phosphoproteomic Analysis of Signaling Pathways in Lymphomas.

Häupl B, Urlaub H, Oellerich T.

Methods Mol Biol. 2019;1956:371-381. doi: 10.1007/978-1-4939-9151-8_19.

PMID:
30779046
21.

Broad range of missense error frequencies in cellular proteins.

Garofalo R, Wohlgemuth I, Pearson M, Lenz C, Urlaub H, Rodnina MV.

Nucleic Acids Res. 2019 Apr 8;47(6):2932-2945. doi: 10.1093/nar/gky1319.

22.

ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.

Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P.

J Cell Biol. 2019 Feb 4;218(2):598-614. doi: 10.1083/jcb.201806093. Epub 2018 Dec 31.

23.

Plk1/Polo Phosphorylates Sas-4 at the Onset of Mitosis for an Efficient Recruitment of Pericentriolar Material to Centrosomes.

Ramani A, Mariappan A, Gottardo M, Mandad S, Urlaub H, Avidor-Reiss T, Riparbelli M, Callaini G, Debec A, Feederle R, Gopalakrishnan J.

Cell Rep. 2018 Dec 26;25(13):3618-3630.e6. doi: 10.1016/j.celrep.2018.11.102.

24.

RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes.

Brüning L, Hackert P, Martin R, Davila Gallesio J, Aquino GRR, Urlaub H, Sloan KE, Bohnsack MT.

Nat Commun. 2018 Dec 19;9(1):5383. doi: 10.1038/s41467-018-07783-w.

25.

Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.

Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J.

EMBO J. 2019 Jan 15;38(2). pii: e99876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10.

26.

The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.

Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF.

Sci Rep. 2018 Nov 15;8(1):16913. doi: 10.1038/s41598-018-35277-8.

27.

Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum.

Özcan A, Pausch P, Linden A, Wulf A, Schühle K, Heider J, Urlaub H, Heimerl T, Bange G, Randau L.

Nat Microbiol. 2019 Jan;4(1):89-96. doi: 10.1038/s41564-018-0274-8. Epub 2018 Nov 5.

PMID:
30397343
28.

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.

Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M.

Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0.

29.

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M.

Nat Commun. 2018 Oct 12;9(1):4234. doi: 10.1038/s41467-018-06448-y.

30.

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.

Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO.

Nat Commun. 2018 Oct 12;9(1):4230. doi: 10.1038/s41467-018-06519-0.

31.

Identification of new high affinity targets for Roquin based on structural conservation.

Braun J, Fischer S, Xu ZZ, Sun H, Ghoneim DH, Gimbel AT, Plessmann U, Urlaub H, Mathews DH, Weigand JE.

Nucleic Acids Res. 2018 Dec 14;46(22):12109-12125. doi: 10.1093/nar/gky908.

32.

Stable maintenance of the rudivirus SIRV3 in a carrier state in Sulfolobus islandicus despite activation of the CRISPR-Cas immune response by a second virus SMV1.

Papathanasiou P, Erdmann S, Leon-Sobrino C, Sharma K, Urlaub H, Garrett RA, Peng X.

RNA Biol. 2019 Apr;16(4):557-565. doi: 10.1080/15476286.2018.1511674. Epub 2018 Sep 13.

33.

Structure of paused transcription complex Pol II-DSIF-NELF.

Vos SM, Farnung L, Urlaub H, Cramer P.

Nature. 2018 Aug;560(7720):601-606. doi: 10.1038/s41586-018-0442-2. Epub 2018 Aug 22.

34.

Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.

Vos SM, Farnung L, Boehning M, Wigge C, Linden A, Urlaub H, Cramer P.

Nature. 2018 Aug;560(7720):607-612. doi: 10.1038/s41586-018-0440-4. Epub 2018 Aug 22.

PMID:
30135578
35.

Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.

Bohnenberger H, Kaderali L, Ströbel P, Yepes D, Plessmann U, Dharia NV, Yao S, Heydt C, Merkelbach-Bruse S, Emmert A, Hoffmann J, Bodemeyer J, Reuter-Jessen K, Lois AM, Dröge LH, Baumeister P, Walz C, Biggemann L, Walter R, Häupl B, Comoglio F, Pan KT, Scheich S, Lenz C, Küffer S, Bremmer F, Kitz J, Sitte M, Beißbarth T, Hinterthaner M, Sebastian M, Lotz J, Schildhaus HU, Wolff H, Danner BC, Brandts C, Büttner R, Canis M, Stegmaier K, Serve H, Urlaub H, Oellerich T.

EMBO Mol Med. 2018 Sep;10(9). pii: e8428. doi: 10.15252/emmm.201708428.

36.

The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.

Lavdovskaia E, Kolander E, Steube E, Mai MM, Urlaub H, Richter-Dennerlein R.

Nucleic Acids Res. 2018 Sep 19;46(16):8471-8482. doi: 10.1093/nar/gky701.

37.

Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica.

Mühlhausen S, Schmitt HD, Pan KT, Plessmann U, Urlaub H, Hurst LD, Kollmar M.

Curr Biol. 2018 Jul 9;28(13):2046-2057.e5. doi: 10.1016/j.cub.2018.04.085. Epub 2018 Jun 18.

38.

Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.

Johannsson S, Neumann P, Wulf A, Welp LM, Gerber HD, Krull M, Diederichsen U, Urlaub H, Ficner R.

Sci Rep. 2018 Jun 11;8(1):8880. doi: 10.1038/s41598-018-27118-5.

39.

Integrative omics - from data to biology.

Dihazi H, Asif AR, Beißbarth T, Bohrer R, Feussner K, Feussner I, Jahn O, Lenz C, Majcherczyk A, Schmidt B, Schmitt K, Urlaub H, Valerius O.

Expert Rev Proteomics. 2018 Jun;15(6):463-466. doi: 10.1080/14789450.2018.1476143. Epub 2018 May 18.

PMID:
29757692
40.

Xpo7 is a broad-spectrum exportin and a nuclear import receptor.

Aksu M, Pleiner T, Karaca S, Kappert C, Dehne HJ, Seibel K, Urlaub H, Bohnsack MT, Görlich D.

J Cell Biol. 2018 Jul 2;217(7):2329-2340. doi: 10.1083/jcb.201712013. Epub 2018 May 10.

41.

The nuts and bolts of the Haloferax CRISPR-Cas system I-B.

Maier LK, Stachler AE, Brendel J, Stoll B, Fischer S, Haas KA, Schwarz TS, Alkhnbashi OS, Sharma K, Urlaub H, Backofen R, Gophna U, Marchfelder A.

RNA Biol. 2019 Apr;16(4):469-480. doi: 10.1080/15476286.2018.1460994. Epub 2018 May 21.

42.

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.

de Moura TR, Mozaffari-Jovin S, Szabó CZK, Schmitzová J, Dybkov O, Cretu C, Kachala M, Svergun D, Urlaub H, Lührmann R, Pena V.

Mol Cell. 2018 Mar 15;69(6):979-992.e6. doi: 10.1016/j.molcel.2018.02.022.

43.

Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis.

Dickmanns A, Zschiedrich CP, Arens J, Parfentev I, Gundlach J, Hofele R, Neumann P, Urlaub H, Görke B, Ficner R, Stülke J.

J Biol Chem. 2018 Apr 20;293(16):5781-5792. doi: 10.1074/jbc.RA117.001289. Epub 2018 Mar 7.

44.

The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR-Cas subtype III-Bv system.

Behler J, Sharma K, Reimann V, Wilde A, Urlaub H, Hess WR.

Nat Microbiol. 2018 Mar;3(3):367-377. doi: 10.1038/s41564-017-0103-5. Epub 2018 Feb 5.

PMID:
29403013
45.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Lührmann R, Stark H.

Cell. 2018 Jan 25;172(3):454-464.e11. doi: 10.1016/j.cell.2018.01.010. Epub 2018 Jan 17.

46.

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex.

Bao P, Will CL, Urlaub H, Boon KL, Lührmann R.

Genes Dev. 2017 Dec 1;31(23-24):2416-2429. doi: 10.1101/gad.308163.117. Epub 2018 Jan 12.

47.

sRNA41 affects ribosome binding sites within polycistronic mRNAs in Methanosarcina mazei Gö1.

Buddeweg A, Sharma K, Urlaub H, Schmitz RA.

Mol Microbiol. 2018 Mar;107(5):595-609. doi: 10.1111/mmi.13900. Epub 2018 Jan 18.

48.

Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa.

Sonnleitner E, Wulf A, Campagne S, Pei XY, Wolfinger MT, Forlani G, Prindl K, Abdou L, Resch A, Allain FH, Luisi BF, Urlaub H, Bläsi U.

Nucleic Acids Res. 2018 Feb 16;46(3):1470-1485. doi: 10.1093/nar/gkx1245.

49.

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.

Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M.

Sci Transl Med. 2017 Dec 6;9(419). pii: eaam7816. doi: 10.1126/scitranslmed.aam7816.

PMID:
29212715
50.

Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex.

Ahdash Z, Lau AM, Byrne RT, Lammens K, Stüetzer A, Urlaub H, Booth PJ, Reading E, Hopfner KP, Politis A.

Nucleic Acids Res. 2017 Nov 16;45(20):12025-12038. doi: 10.1093/nar/gkx890.

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