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Items: 1 to 50 of 236

1.

Antibacterial Activity and Molecular Docking Studies of a Selected Series of Hydroxy-3-arylcoumarins.

Pisano MB, Kumar A, Medda R, Gatto G, Pal R, Fais A, Era B, Cosentino S, Uriarte E, Santana L, Pintus F, Matos MJ.

Molecules. 2019 Aug 1;24(15). pii: E2815. doi: 10.3390/molecules24152815.

2.

Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.

Oliveira C, Bagetta D, Cagide F, Teixeira J, Amorim R, Silva T, Garrido J, Remião F, Uriarte E, Oliveira PJ, Alcaro S, Ortuso F, Borges F.

Eur J Med Chem. 2019 Jul 15;174:116-129. doi: 10.1016/j.ejmech.2019.04.026. Epub 2019 Apr 17.

3.

Bacteremia in Systemic Lupus Erythematosus in Patients from a Spanish Registry: Risk Factors, Clinical and Microbiological Characteristics, and Outcomes.

Rúa-Figueroa I, López-Longo FJ, Del Campo V, Galindo-Izquierdo M, Uriarte E, Torre-Cisneros J, Vela P, Tomero E, Narváez J, Olivé A, Freire M, Salgado E, Andreu JL, Martínez-Taboada V, Calvo-Alén J, Hernández-Cruz B, Raya E, Quevedo V, Expósito Pérez L, Fernández-Nebro A, Ibañez M, Pascual-Valls È, Rúa-Figueroa D, Naranjo A, Pego-Reigosa JM.

J Rheumatol. 2019 Apr 15. pii: jrheum.180882. doi: 10.3899/jrheum.180882. [Epub ahead of print]

PMID:
30988123
4.

Discovery of new phthalazinones as vasodilator agents and novel pharmacological tools to study calcium channels.

Munín J, Quezada E, Viña D, Uriarte E, Delogu GL, Gil-Longo J.

Future Med Chem. 2019 Feb 25. doi: 10.4155/fmc-2018-0250. [Epub ahead of print]

PMID:
30801201
5.

Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction.

Benfeito S, Oliveira C, Fernandes C, Cagide F, Teixeira J, Amorim R, Garrido J, Martins C, Sarmento B, Silva R, Remião F, Uriarte E, Oliveira PJ, Borges F.

Eur J Med Chem. 2019 Apr 1;167:525-545. doi: 10.1016/j.ejmech.2019.01.055. Epub 2019 Feb 6.

PMID:
30784884
6.

Dual natural infection with bovine viral diarrhea virus -1 and -2 in a stillborn calf: tissue distribution and molecular characterization.

Spetter MJ, Uriarte ELL, Altamiranda EAG, Leunda MR, Pereyra SB, Verna AE, Odeón AC.

Open Vet J. 2018;8(4):493-497. doi: 10.4314/ovj.v8i4.23. Epub 2018 Dec 31.

7.

Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence.

Hajialyani M, Hosein Farzaei M, Echeverría J, Nabavi SM, Uriarte E, Sobarzo-Sánchez E.

Molecules. 2019 Feb 12;24(3). pii: E648. doi: 10.3390/molecules24030648. Review.

8.

Potent in Vitro α-Glucosidase Inhibition of Secondary Metabolites Derived from Dryopteris cycadina.

Amin S, Ullah B, Ali M, Rauf A, Khan H, Uriarte E, Sobarzo-Sánchez E.

Molecules. 2019 Jan 24;24(3). pii: E427. doi: 10.3390/molecules24030427.

9.

Quercetin and Related Chromenone Derivatives as Monoamine Oxidase Inhibitors: Targeting Neurological and Mental Disorders.

Dhiman P, Malik N, Sobarzo-Sánchez E, Uriarte E, Khatkar A.

Molecules. 2019 Jan 24;24(3). pii: E418. doi: 10.3390/molecules24030418. Review.

10.

Targeting α -(1,4)-Glucosidase in Diabetes Mellitus Type 2: The Role of New Synthetic Coumarins as Potent Inhibitors.

Figueroa-Benavides C, Matos MJ, Peñaloza-Amion M, Veas R, Valenzuela-Barra G, Zapata G, Delogu G, Uriarte E, Santana L, Olea-Azar C, Delporte C.

Curr Top Med Chem. 2018;18(27):2327-2337. doi: 10.2174/1568026619666181130113033.

PMID:
30499400
11.

PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor.

Fernandes C, Martins C, Fonseca A, Nunes R, Matos MJ, Silva R, Garrido J, Sarmento B, Remião F, Otero-Espinar FJ, Uriarte E, Borges F.

ACS Appl Mater Interfaces. 2018 Nov 21;10(46):39557-39569. doi: 10.1021/acsami.8b17224. Epub 2018 Nov 9.

PMID:
30352150
12.

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.

Reis J, Cagide F, Valencia ME, Teixeira J, Bagetta D, Pérez C, Uriarte E, Oliveira PJ, Ortuso F, Alcaro S, Rodríguez-Franco MI, Borges F.

Eur J Med Chem. 2018 Oct 5;158:781-800. doi: 10.1016/j.ejmech.2018.07.056. Epub 2018 Sep 11.

PMID:
30245401
13.

Coumarin derivatives as promising xanthine oxidase inhibitors.

Fais A, Era B, Asthana S, Sogos V, Medda R, Santana L, Uriarte E, Matos MJ, Delogu F, Kumar A.

Int J Biol Macromol. 2018 Dec;120(Pt A):1286-1293. doi: 10.1016/j.ijbiomac.2018.09.001. Epub 2018 Sep 3.

PMID:
30189275
14.

Correction to Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.

Reis J, Cagide F, Chavarria D, Silva T, Fernandes C, Gaspar A, Uriarte E, Remião F, Alcaro S, Ortuso F, Borges F.

J Med Chem. 2018 Jun 14;61(11):5054. doi: 10.1021/acs.jmedchem.8b00600. Epub 2018 May 29. No abstract available.

PMID:
29809006
15.

Aporphines and Alzheimer's Disease: Towards a Medical Approach Facing the Future.

Nabavi SM, Uriarte E, Rastrelli L, Sobarzo-Sánchez E.

Curr Med Chem. 2019;26(18):3253-3259. doi: 10.2174/0929867325666180514102933.

PMID:
29756568
16.

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors.

Oliveira C, Cagide F, Teixeira J, Amorim R, Sequeira L, Mesiti F, Silva T, Garrido J, Remião F, Vilar S, Uriarte E, Oliveira PJ, Borges F.

Front Chem. 2018 Apr 23;6:126. doi: 10.3389/fchem.2018.00126. eCollection 2018.

17.

Evaluation of Trypanocidal and Antioxidant Activities of a Selected Series of 3-amidocoumarins.

Moncada-Basualto M, Lapier M, Maya JD, Matsuhiro B, Olea-Azar C, Delogu GL, Uriarte E, Santana L, Matos MJ.

Med Chem. 2018;14(6):573-584. doi: 10.2174/1573406414666180419113437.

PMID:
29669503
18.

Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis.

Reis J, Manzella N, Cagide F, Mialet-Perez J, Uriarte E, Parini A, Borges F, Binda C.

J Med Chem. 2018 May 10;61(9):4203-4212. doi: 10.1021/acs.jmedchem.8b00357. Epub 2018 Apr 20.

PMID:
29648817
19.

In Silico Prediction of P-glycoprotein Binding: Insights from Molecular Docking Studies.

Vilar S, Sobarzo-Sánchez E, Uriarte E.

Curr Med Chem. 2019;26(10):1746-1760. doi: 10.2174/0929867325666171129121924. Review.

PMID:
29189117
20.

Ligand and Structure-based Modeling of Passive Diffusion through the Blood-Brain Barrier.

Vilar S, Sobarzo-Sanchez E, Santana L, Uriarte E.

Curr Med Chem. 2018;25(9):1073-1089. doi: 10.2174/0929867324666171106163742.

PMID:
29110594
21.

Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors.

Costas-Lago MC, Besada P, Rodríguez-Enríquez F, Viña D, Vilar S, Uriarte E, Borges F, Terán C.

Eur J Med Chem. 2017 Oct 20;139:1-11. doi: 10.1016/j.ejmech.2017.07.045. Epub 2017 Jul 25.

PMID:
28797881
22.

Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?

Fonseca A, Reis J, Silva T, Matos MJ, Bagetta D, Ortuso F, Alcaro S, Uriarte E, Borges F.

J Med Chem. 2017 Aug 24;60(16):7206-7212. doi: 10.1021/acs.jmedchem.7b00918. Epub 2017 Aug 10.

PMID:
28753307
23.

In silico genotoxicity of coumarins: application of the Phenol-Explorer food database to functional food science.

Guardado Yordi E, Matos MJ, Pérez Martínez A, Tornes AC, Santana L, Molina E, Uriarte E.

Food Funct. 2017 Aug 1;8(8):2958-2966. doi: 10.1039/c7fo00402h. Epub 2017 Jul 26.

PMID:
28745361
24.

Molecular Docking and Drug Discovery in β-Adrenergic Receptors.

Vilar S, Sobarzo-Sanchez E, Santana L, Uriarte E.

Curr Med Chem. 2017;24(39):4340-4359. doi: 10.2174/0929867324666170724101448. Review.

PMID:
28738772
25.

Coumarins and adenosine receptors: New perceptions in structure-affinity relationships.

Fonseca A, Matos MJ, Vilar S, Kachler S, Klotz KN, Uriarte E, Borges F.

Chem Biol Drug Des. 2018 Jan;91(1):245-256. doi: 10.1111/cbdd.13075. Epub 2017 Sep 4.

PMID:
28734062
26.

Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature.

Silva-Fernández L, Otón T, Askanase A, Carreira P, López-Longo FJ, Olivé A, Rúa-Figueroa Í, Narváez J, Ruiz-Lucea E, Andrés M, Calvo E, Toyos F, Alegre-Sancho JJ, Tomero E, Montilla C, Zea A, Uriarte E, Calvo-Alén J, Marras C, Martínez-Taboada VM, Belmonte-López MÁ, Rosas J, Raya E, Bonilla G, Freire M, Pego-Reigosa JM, Millán I, Hughes-Morley A, Andreu JL; from the Spanish Society for Rheumatology Systemic Autoimmune Diseases Study Group (EAS-SER).

Reumatol Clin. 2019 Jan - Feb;15(1):34-42. doi: 10.1016/j.reuma.2017.04.005. Epub 2017 May 18. English, Spanish.

27.

Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus.

Rúa-Figueroa Í, López-Longo J, Galindo-Izquierdo M, Calvo-Alén J, Del Campo V, Olivé-Marqués A, Pérez-Vicente S, Fernández-Nebro A, Andrés M, Erausquin C, Tomero E, Horcada L, Uriarte E, Freire M, Montilla C, Sánchez-Atrio A, Santos G, Boteanu A, Díez-Álvarez E, Narváez J, Martínez-Taboada V, Silva-Fernández L, Ruiz-Lucea E, Andreu JL, Hernández-Beriain JÁ, Gantes M, Hernández-Cruz B, Pérez-Venegas J, Pecondón-Español Á, Marras C, Ibáñez-Barceló M, Bonilla G, Torrente V, Castellví I, Alegre JJ, Calvet J, Marenco JL, Raya E, Vázquez T, Quevedo V, Muñoz-Fernández S, Rodríguez-Gómez M, Ibáñez J, Pego-Reigosa JM.

Semin Arthritis Rheum. 2017 Aug;47(1):38-45. doi: 10.1016/j.semarthrit.2017.01.010. Epub 2017 Jan 27.

PMID:
28259425
28.

New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies.

Pintus F, Matos MJ, Vilar S, Hripcsak G, Varela C, Uriarte E, Santana L, Borges F, Medda R, Di Petrillo A, Era B, Fais A.

Bioorg Med Chem. 2017 Mar 1;25(5):1687-1695. doi: 10.1016/j.bmc.2017.01.037. Epub 2017 Jan 31.

PMID:
28189394
29.

Synthesis, antioxidant and antichagasic properties of a selected series of hydroxy-3-arylcoumarins.

Robledo-O'Ryan N, Matos MJ, Vazquez-Rodriguez S, Santana L, Uriarte E, Moncada-Basualto M, Mura F, Lapier M, Maya JD, Olea-Azar C.

Bioorg Med Chem. 2017 Jan 15;25(2):621-632. doi: 10.1016/j.bmc.2016.11.033. Epub 2016 Nov 19.

PMID:
27908757
30.

Computational Drug Target Screening through Protein Interaction Profiles.

Vilar S, Quezada E, Uriarte E, Costanzi S, Borges F, Viña D, Hripcsak G.

Sci Rep. 2016 Nov 15;6:36969. doi: 10.1038/srep36969.

31.

Structural elucidation of a series of 6-methyl-3-carboxamidocoumarins.

Fonseca A, Gaspar A, Matos MJ, Gomes LR, Low JN, Uriarte E, Borges F.

Magn Reson Chem. 2017 Apr;55(4):373-378. doi: 10.1002/mrc.4541. Epub 2016 Nov 10. No abstract available.

PMID:
27733011
32.

Comorbidities in Patients With Primary Sjögren's Syndrome and Systemic Lupus Erythematosus: A Comparative Registries-Based Study.

Rúa-Figueroa I, Fernández Castro M, Andreu JL, Sanchez-Piedra C, Martínez-Taboada V, Olivé A, López-Longo J, Rosas J, Galindo M, Calvo-Alén J, Fernández-Nebro A, Alonso F, Rodríguez-Lozano B, Alberto García Vadillo J, Menor R, Narváez FJ, Erausquin C, García-Aparicio Á, Tomero E, Manrique-Arija S, Horcada L, Uriarte E, Gil S, Blanco R, López-González R, Boteanu A, Freire M, Galisteo C, Rodríguez-Gómez M, Díez-Álvarez E, Pego-Reigosa JM; Sjogrenser and Relesser Researchers and EAS-SER Group.

Arthritis Care Res (Hoboken). 2017 Jan;69(1):38-45. doi: 10.1002/acr.23015. Epub 2016 Nov 21.

33.

A Medical Approach to the Monoamine Oxidase Inhibition by Using 7Hbenzo[ e]perimidin-7-one Derivatives.

Bacho M, Coelho-Cerqueira E, Follmer C, Nabavi SM, Rastrelli L, Uriarte E, Sobarzo-Sanchez E.

Curr Top Med Chem. 2017;17(4):489-497.

PMID:
27558674
34.

Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity.

Silva T, Mohamed T, Shakeri A, Rao PP, Martínez-González L, Pérez DI, Martínez A, Valente MJ, Garrido J, Uriarte E, Serrão P, Soares-da-Silva P, Remião F, Borges F.

J Med Chem. 2016 Aug 25;59(16):7584-97. doi: 10.1021/acs.jmedchem.6b00666. Epub 2016 Aug 5.

PMID:
27463695
35.

Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.

Reis J, Cagide F, Chavarria D, Silva T, Fernandes C, Gaspar A, Uriarte E, Remião F, Alcaro S, Ortuso F, Borges F.

J Med Chem. 2016 Jun 23;59(12):5879-93. doi: 10.1021/acs.jmedchem.6b00527. Epub 2016 Jun 10. Erratum in: J Med Chem. 2018 Jun 14;61(11):5054.

PMID:
27244485
36.

Characterization of Patients With Lupus Nephritis Included in a Large Cohort From the Spanish Society of Rheumatology Registry of Patients With Systemic Lupus Erythematosus (RELESSER).

Galindo-Izquierdo M, Rodriguez-Almaraz E, Pego-Reigosa JM, López-Longo FJ, Calvo-Alén J, Olivé A, Fernández-Nebro A, Martinez-Taboada V, Vela-Casasempere P, Freire M, Narváez FJ, Rosas J, Ibáñez-Barceló M, Uriarte E, Tomero E, Zea A, Horcada L, Torrente V, Castellvi I, Calvet J, Menor-Almagro R, Zamorano MA, Raya E, Díez-Álvarez E, Vázquez-Rodríguez T, García de la Peña P, Movasat A, Andreu JL, Richi P, Marras C, Montilla-Morales C, Hernández-Cruz B, Marenco de la Fuente JL, Gantes M, Úcar E, Alegre-Sancho JJ, Manero J, Ibáñez-Ruán J, Rodríguez-Gómez M, Quevedo V, Hernández-Beriaín J, Silva-Fernández L, Alonso F, Pérez S, Rúa-Figueroa I; RELESSER Group, from Spanish Society of Rheumatology Systemic Autoimmune Diseases Study Group (EASSER).

Medicine (Baltimore). 2016 Mar;95(9):e2891. doi: 10.1097/MD.0000000000002891.

37.

Molecular detection of bovine Noroviruses in Argentinean dairy calves: Circulation of a tentative new genotype.

Ferragut F, Vega CG, Mauroy A, Conceição-Neto N, Zeller M, Heylen E, Uriarte EL, Bilbao G, Bok M, Matthijnssens J, Thiry E, Badaracco A, Parreño V.

Infect Genet Evol. 2016 Jun;40:144-150. doi: 10.1016/j.meegid.2016.02.034. Epub 2016 Mar 3.

PMID:
26940636
38.

Aporphines and Parkinson's Disease: Medical Tools for the Future.

Fazel Nabavi S, Uriarte E, Rastrelli L, Modak B, Sobarzo-Sánchez E.

Curr Top Med Chem. 2016;16(17):1906-9. Review.

PMID:
26845550
39.

Facing Chagas' disease: trypanocidal properties of new coumarin-chalcone scaffolds.

Vazquez-Rodriguez S, Guíñez RF, Matos MJ, Olea-Azar C, Maya JD, Uriarte E, Santana L.

Med Chem. 2016 Jan 6. [Epub ahead of print]

PMID:
26740208
40.

Randomized comparison of three transducer orientation approaches for ultrasound guided internal jugular venous cannulation.

Batllori M, Urra M, Uriarte E, Romero C, Pueyo J, López-Olaondo L, Cambra K, Ibáñez B.

Br J Anaesth. 2016 Mar;116(3):370-6. doi: 10.1093/bja/aev399. Epub 2015 Dec 24.

41.

3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases.

Matos MJ, Rodríguez-Enríquez F, Borges F, Santana L, Uriarte E, Estrada M, Rodríguez-Franco MI, Laguna R, Viña D.

ChemMedChem. 2015 Dec;10(12):2071-9. doi: 10.1002/cmdc.201500408. Epub 2015 Oct 23.

PMID:
26493007
42.

Design, synthesis and antibacterial study of new potent and selective coumarin-chalcone derivatives for the treatment of tenacibaculosis.

Vazquez-Rodriguez S, Lama López R, Matos MJ, Armesto-Quintas G, Serra S, Uriarte E, Santana L, Borges F, Muñoz Crego A, Santos Y.

Bioorg Med Chem. 2015 Nov 1;23(21):7045-52. doi: 10.1016/j.bmc.2015.09.028. Epub 2015 Sep 24.

PMID:
26433630
43.

Synthesis and pharmacological activities of non-flavonoid chromones: a patent review (from 2005 to 2015).

Matos MJ, Vazquez-Rodriguez S, Uriarte E, Santana L, Borges F.

Expert Opin Ther Pat. 2015;25(11):1285-304. doi: 10.1517/13543776.2015.1078790. Epub 2015 Aug 12. Review.

PMID:
26291463
44.

Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold.

Matos MJ, Vilar S, Kachler S, Celeiro M, Vazquez-Rodriguez S, Santana L, Uriarte E, Hripcsak G, Borges F, Klotz KN.

Bioorg Chem. 2015 Aug;61:1-6. doi: 10.1016/j.bioorg.2015.05.008. Epub 2015 May 22.

PMID:
26042529
45.

Anxiolytic-Like Effects of 7H-Benzo[e]perimidin-7-One Derivatives through Elevated Plus-Maze Test in Mice.

Nunez J, Fontenla JA, Nabavi SM, Uriarte E, Herrera A, Sobarzo-Sanchez E.

Curr Top Med Chem. 2015;15(17):1750-4.

PMID:
25915606
46.

Bioactive Coumarins from Marine Sources: Origin, Structural Features and Pharmacological Properties.

Vazquez-Rodriguez S, Matos MJ, Borges F, Uriarte E, Santana L.

Curr Top Med Chem. 2015;15(17):1755-66. Review.

PMID:
25915605
47.

Interest of antioxidant agents in parasitic diseases. The case study of coumarins.

Figueroa-Guiñez R, Matos MJ, Vazquez-Rodriguez S, Santana L, Uriarte E, Borges F, Olea-Azar C, Maya JD.

Curr Top Med Chem. 2015;15(9):850-6. Review.

PMID:
25697564
48.

Study of coumarin-resveratrol hybrids as potent antioxidant compounds.

Matos MJ, Mura F, Vazquez-Rodriguez S, Borges F, Santana L, Uriarte E, Olea-Azar C.

Molecules. 2015 Feb 16;20(2):3290-308. doi: 10.3390/molecules20023290.

49.

Oxidative stress and neurodegenerative diseases: looking for a therapeutic solution inspired on benzopyran chemistry.

Gaspar A, Milhazes N, Santana L, Uriarte E, Borges F, Matos MJ.

Curr Top Med Chem. 2015;15(5):432-45. Review.

PMID:
25658803
50.

Potential pharmacological uses of chalcones: a patent review (from June 2011 - 2014).

Matos MJ, Vazquez-Rodriguez S, Uriarte E, Santana L.

Expert Opin Ther Pat. 2015 Mar;25(3):351-66. doi: 10.1517/13543776.2014.995627. Epub 2015 Jan 19. Review.

PMID:
25598152

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