Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 91

1.

Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.

Pietsch M, Viht K, Schnitzler A, Ekambaram R, Steinkrüger M, Enkvist E, Nienberg C, Nickelsen A, Lauwers M, Jose J, Uri A, Niefind K.

Bioorg Chem. 2020 Jan 23;96:103608. doi: 10.1016/j.bioorg.2020.103608. [Epub ahead of print]

PMID:
32058103
2.

SQUID-on-tip with single-electron spin sensitivity for high-field and ultra-low temperature nanomagnetic imaging.

Anahory Y, Naren HR, Lachman EO, Buhbut Sinai S, Uri A, Embon L, Yaakobi E, Myasoedov Y, Huber ME, Klajn R, Zeldov E.

Nanoscale. 2020 Feb 7;12(5):3174-3182. doi: 10.1039/c9nr08578e. Epub 2020 Jan 22.

PMID:
31967152
3.

What is the current value of fluorescence polarization assays in small molecule screening?

Uri A, Nonga OE.

Expert Opin Drug Discov. 2020 Feb;15(2):131-133. doi: 10.1080/17460441.2020.1702966. Epub 2019 Dec 13. No abstract available.

PMID:
31833421
4.

Efficient photocaging of a tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase.

Sõrmus T, Lavogina D, Enkvist E, Uri A, Viht K.

Chem Commun (Camb). 2019 Sep 21;55(74):11147-11150. doi: 10.1039/c9cc04978a. Epub 2019 Aug 29.

PMID:
31464306
5.

During acute graft versus host disease CD28 deletion in donor CD8+ , but not CD4+ , T cells maintain antileukemia responses in mice.

Uri A, Lühder F, Kerkau T, Beyersdorf N.

Eur J Immunol. 2018 Dec;48(12):2055-2067. doi: 10.1002/eji.201847669. Epub 2018 Nov 14.

6.

Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2.

Vahter J, Viht K, Uri A, Manoharan GB, Enkvist E.

Bioorg Med Chem. 2018 Oct 1;26(18):5062-5068. doi: 10.1016/j.bmc.2018.09.003. Epub 2018 Sep 5.

PMID:
30217463
7.

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo.

Langenhorst D, Haack S, Göb S, Uri A, Lühder F, Vanhove B, Hünig T, Beyersdorf N.

Front Immunol. 2018 May 16;9:1060. doi: 10.3389/fimmu.2018.01060. eCollection 2018.

8.

Imaging resonant dissipation from individual atomic defects in graphene.

Halbertal D, Ben Shalom M, Uri A, Bagani K, Meltzer AY, Marcus I, Myasoedov Y, Birkbeck J, Levitov LS, Geim AK, Zeldov E.

Science. 2017 Dec 8;358(6368):1303-1306. doi: 10.1126/science.aan0877.

PMID:
29217571
9.

A Selective Biligand Inhibitor of CK2 Increases Caspase-3 Activity in Cancer Cells and Inhibits Platelet Aggregation.

Rahnel H, Viht K, Lavogina D, Mazina O, Haljasorg T, Enkvist E, Uri A.

ChemMedChem. 2017 Oct 20;12(20):1723-1736. doi: 10.1002/cmdc.201700457. Epub 2017 Sep 26.

PMID:
28837260
10.

Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells.

Uri A, Werner S, Lühder F, Hünig T, Kerkau T, Beyersdorf N.

Front Immunol. 2017 Jun 23;8:721. doi: 10.3389/fimmu.2017.00721. eCollection 2017.

11.

Competitive ligands facilitate dissociation of the complex of bifunctional inhibitor and protein kinase.

Ivan T, Enkvist E, Sinijarv H, Uri A.

Biophys Chem. 2017 Sep;228:17-24. doi: 10.1016/j.bpc.2017.06.004. Epub 2017 Jun 20.

PMID:
28651101
12.

Binding assay for characterization of protein kinase inhibitors possessing sub-picomolar to sub-millimolar affinity.

Sinijarv H, Wu S, Ivan T, Laasfeld T, Viht K, Uri A.

Anal Biochem. 2017 Aug 15;531:67-77. doi: 10.1016/j.ab.2017.05.017. Epub 2017 May 18.

PMID:
28527909
13.

Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin.

Kestav K, Uri A, Lavogina D.

Curr Med Chem. 2017;24(21):2276-2293. doi: 10.2174/0929867324666170414155520. Review.

PMID:
28413956
14.

Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2.

Vahter J, Viht K, Uri A, Enkvist E.

Bioorg Med Chem. 2017 Apr 1;25(7):2277-2284. doi: 10.1016/j.bmc.2017.02.055. Epub 2017 Feb 28.

PMID:
28274673
15.

Slowly on, Slowly off: Bisubstrate-Analogue Conjugates of 5-Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin.

Kestav K, Viht K, Konovalov A, Enkvist E, Uri A, Lavogina D.

Chembiochem. 2017 Apr 18;18(8):790-798. doi: 10.1002/cbic.201600697. Epub 2017 Mar 21.

PMID:
28181383
16.

Nanoscale thermal imaging of dissipation in quantum systems.

Halbertal D, Cuppens J, Shalom MB, Embon L, Shadmi N, Anahory Y, Naren HR, Sarkar J, Uri A, Ronen Y, Myasoedov Y, Levitov LS, Joselevich E, Geim AK, Zeldov E.

Nature. 2016 Nov 17;539(7629):407-410. doi: 10.1038/nature19843.

PMID:
27786173
17.

Electrically Tunable Multiterminal SQUID-on-Tip.

Uri A, Meltzer AY, Anahory Y, Embon L, Lachman EO, Halbertal D, Hr N, Myasoedov Y, Huber ME, Young AF, Zeldov E.

Nano Lett. 2016 Nov 9;16(11):6910-6915. Epub 2016 Oct 13.

PMID:
27672705
18.

Correction to "Deoxygenation Increases Photoluminescence Lifetime of Protein-Responsive Organic Probes with Triplet-Singlet Resonant Energy Transfer".

Ligi K, Enkvist E, Uri A.

J Phys Chem B. 2016 Oct 6;120(39):10421. Epub 2016 Sep 23. No abstract available.

PMID:
27659703
19.

Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.

Ivan T, Enkvist E, Viira B, Manoharan GB, Raidaru G, Pflug A, Alam KA, Zaccolo M, Engh RA, Uri A.

Bioconjug Chem. 2016 Aug 17;27(8):1900-10. doi: 10.1021/acs.bioconjchem.6b00293. Epub 2016 Jul 20.

PMID:
27389935
20.

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.

Santio NM, Landor SK, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi SY, Corthals G, Varjosalo M, Manoharan GB, Uri A, Lendahl U, Sahlgren C, Koskinen PJ.

Oncotarget. 2016 Jul 12;7(28):43220-43238. doi: 10.18632/oncotarget.9215.

21.

Deoxygenation Increases Photoluminescence Lifetime of Protein-Responsive Organic Probes with Triplet-Singlet Resonant Energy Transfer.

Ligi K, Enkvist E, Uri A.

J Phys Chem B. 2016 Jun 9;120(22):4945-54. doi: 10.1021/acs.jpcb.6b03342. Epub 2016 May 31. Erratum in: J Phys Chem B. 2016 Oct 6;120(39):10421.

PMID:
27183180
22.

Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.

Lavogina D, Kestav K, Chaikuad A, Heroven C, Knapp S, Uri A.

Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):339-45. doi: 10.1107/S2053230X16004611. Epub 2016 Apr 22.

23.

Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases.

Manoharan GB, Enkvist E, Uri A.

Biophys Chem. 2016 Apr;211:39-48. doi: 10.1016/j.bpc.2016.01.004. Epub 2016 Jan 25.

PMID:
26874332
24.

Acetoxymethyl Ester of Tetrabromobenzimidazole-Peptoid Conjugate for Inhibition of Protein Kinase CK2 in Living Cells.

Viht K, Saaver S, Vahter J, Enkvist E, Lavogina D, Sinijärv H, Raidaru G, Guerra B, Issinger OG, Uri A.

Bioconjug Chem. 2015 Dec 16;26(12):2324-35. doi: 10.1021/acs.bioconjchem.5b00383. Epub 2015 Nov 12.

PMID:
26559659
25.

Fluorescent photoaffinity probes for mitotic protein kinase Aurora A.

Lavogina D, Kisand K, Raidaru G, Uri A.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3290-4. doi: 10.1016/j.bmcl.2015.05.060. Epub 2015 May 30.

PMID:
26077498
26.

FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases.

Manoharan GB, Enkvist E, Kasari M, Viht K, Zenn M, Prinz A, Filhol O, Herberg FW, Uri A.

Anal Biochem. 2015 Jul 15;481:10-7. doi: 10.1016/j.ab.2015.04.009. Epub 2015 Apr 10.

PMID:
25866074
27.

Bisubstrate inhibitor approach for targeting mitotic kinase Haspin.

Kestav K, Lavogina D, Raidaru G, Chaikuad A, Knapp S, Uri A.

Bioconjug Chem. 2015 Feb 18;26(2):225-34. doi: 10.1021/bc500464r. Epub 2015 Jan 29.

PMID:
25595038
28.

Probing dynamics and pinning of single vortices in superconductors at nanometer scales.

Embon L, Anahory Y, Suhov A, Halbertal D, Cuppens J, Yakovenko A, Uri A, Myasoedov Y, Rappaport ML, Huber ME, Gurevich A, Zeldov E.

Sci Rep. 2015 Jan 7;5:7598. doi: 10.1038/srep07598.

29.

Inhibition of CREB phosphorylation by conjugates of adenosine analogues and arginine-rich peptides, inhibitors of PKA catalytic subunit.

Kriisa M, Sinijärv H, Vaasa A, Enkvist E, Kostenko S, Moens U, Uri A.

Chembiochem. 2015 Jan 19;16(2):312-9. doi: 10.1002/cbic.201402526. Epub 2014 Dec 8.

PMID:
25487811
30.

Flow cytometric characterization of brain dendritic cell subsets after murine stroke.

Pösel C, Uri A, Schulz I, Boltze J, Weise G, Wagner DC.

Exp Transl Stroke Med. 2014 Nov 4;6(1):11. doi: 10.1186/2040-7378-6-11. eCollection 2014.

31.

Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases.

Ekambaram R, Enkvist E, Manoharan Gb, Ugandi M, Kasari M, Viht K, Knapp S, Issinger OG, Uri A.

Chem Commun (Camb). 2014 Apr 21;50(31):4096-8. doi: 10.1039/c3cc49198f.

PMID:
24619026
32.

Targeting Plasmodium falciparum protein kinases with adenosine analogue-oligoarginine conjugates.

Lavogina D, Budu A, Enkvist E, Hopp CS, Baker DA, Langsley G, Garcia CR, Uri A.

Exp Parasitol. 2014 Mar;138:55-62. doi: 10.1016/j.exppara.2014.02.001. Epub 2014 Feb 15.

PMID:
24534615
33.

Long residence times revealed by Aurora A kinase-targeting fluorescent probes derived from inhibitors MLN8237 and VX-689.

Lavogina D, Enkvist E, Viht K, Uri A.

Chembiochem. 2014 Feb 10;15(3):443-50. doi: 10.1002/cbic.201300613. Epub 2014 Jan 8.

PMID:
24403173
34.

Selective bisubstrate inhibitors with sub-nanomolar affinity for protein kinase Pim-1.

Ekambaram R, Enkvist E, Vaasa A, Kasari M, Raidaru G, Knapp S, Uri A.

ChemMedChem. 2013 Jun;8(6):909-13. doi: 10.1002/cmdc.201300042. Epub 2013 Apr 24.

PMID:
23616352
35.

Responsive microsecond-lifetime photoluminescent probes for analysis of protein kinases and their inhibitors.

Kasari M, Ligi K, Williams JA, Vaasa A, Enkvist E, Viht K, Pålsson LO, Uri A.

Biochim Biophys Acta. 2013 Jul;1834(7):1330-5. doi: 10.1016/j.bbapap.2013.02.039. Epub 2013 Mar 14.

PMID:
23499784
36.

A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.

Enkvist E, Viht K, Bischoff N, Vahter J, Saaver S, Raidaru G, Issinger OG, Niefind K, Uri A.

Org Biomol Chem. 2012 Nov 21;10(43):8645-53. doi: 10.1039/c2ob26022k.

PMID:
23032938
37.

Time-gated luminescence microscopy with responsive nonmetal probes for mapping activity of protein kinases in living cells.

Vaasa A, Ligi K, Mohandessi S, Enkvist E, Uri A, Miller LW.

Chem Commun (Camb). 2012 Sep 4;48(68):8595-7. doi: 10.1039/c2cc33565d. Epub 2012 Jul 20.

38.

Conjugates of 5-isoquinolinesulfonylamides and oligo-D-arginine possess high affinity and selectivity towards Rho kinase (ROCK).

Lavogina D, Kalind K, Bredihhina J, Hurt M, Vaasa A, Kasari M, Enkvist E, Raidaru G, Uri A.

Bioorg Med Chem Lett. 2012 May 15;22(10):3425-30. doi: 10.1016/j.bmcl.2012.03.101. Epub 2012 Apr 4.

PMID:
22521647
39.

Time-gated luminescence assay using nonmetal probes for determination of protein kinase activity-based disease markers.

Kasari M, Padrik P, Vaasa A, Saar K, Leppik K, Soplepmann J, Uri A.

Anal Biochem. 2012 Mar 15;422(2):79-88. doi: 10.1016/j.ab.2011.12.048. Epub 2012 Jan 8.

PMID:
22266208
40.

Protein-induced long lifetime luminescence of nonmetal probes.

Enkvist E, Vaasa A, Kasari M, Kriisa M, Ivan T, Ligi K, Raidaru G, Uri A.

ACS Chem Biol. 2011 Oct 21;6(10):1052-62. doi: 10.1021/cb200120v. Epub 2011 Aug 1.

PMID:
21776959
41.

Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.

Pflug A, Rogozina J, Lavogina D, Enkvist E, Uri A, Engh RA, Bossemeyer D.

J Mol Biol. 2010 Oct 15;403(1):66-77. doi: 10.1016/j.jmb.2010.08.028. Epub 2010 Aug 21.

PMID:
20732331
42.

Small-molecule FRET probes for protein kinase activity monitoring in living cells.

Vaasa A, Lust M, Terrin A, Uri A, Zaccolo M.

Biochem Biophys Res Commun. 2010 Jul 9;397(4):750-5. doi: 10.1016/j.bbrc.2010.06.026. Epub 2010 Jun 10.

PMID:
20541535
43.

Adenosine analogue-oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIalpha).

Lavogina D, Nickl CK, Enkvist E, Raidaru G, Lust M, Vaasa A, Uri A, Dostmann WR.

Biochim Biophys Acta. 2010 Sep;1804(9):1857-68. doi: 10.1016/j.bbapap.2010.04.007. Epub 2010 Apr 18.

44.

Bisubstrate fluorescent probes and biosensors in binding assays for HTS of protein kinase inhibitors.

Uri A, Lust M, Vaasa A, Lavogina D, Viht K, Enkvist E.

Biochim Biophys Acta. 2010 Mar;1804(3):541-6. doi: 10.1016/j.bbapap.2009.10.019. Epub 2009 Oct 29. Review.

PMID:
19879386
45.

Effect of the structure of adenosine mimic of bisubstrate-analog inhibitors on their activity towards basophilic protein kinases.

Enkvist E, Kriisa M, Roben M, Kadak G, Raidaru G, Uri A.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6098-101. doi: 10.1016/j.bmcl.2009.09.026. Epub 2009 Sep 12.

PMID:
19800227
46.

Bisubstrate inhibitors of protein kinases: from principle to practical applications.

Lavogina D, Enkvist E, Uri A.

ChemMedChem. 2010 Jan;5(1):23-34. doi: 10.1002/cmdc.200900252. Review.

PMID:
19774589
47.

Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases.

Lavogina D, Lust M, Viil I, König N, Raidaru G, Rogozina J, Enkvist E, Uri A, Bossemeyer D.

J Med Chem. 2009 Jan 22;52(2):308-21. doi: 10.1021/jm800797n.

PMID:
19143565
48.

High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK.

Vaasa A, Viil I, Enkvist E, Viht K, Raidaru G, Lavogina D, Uri A.

Anal Biochem. 2009 Feb 1;385(1):85-93. doi: 10.1016/j.ab.2008.10.030. Epub 2008 Oct 31.

PMID:
19017524
49.

Adenosine-oligoarginine conjugate, a novel bisubstrate inhibitor, effectively dissociates the actin cytoskeleton.

Räägel H, Lust M, Uri A, Pooga M.

FEBS J. 2008 Jul;275(14):3608-24. doi: 10.1111/j.1742-4658.2008.06506.x.

50.

Carbocyclic 3'-deoxyadenosine-based highly potent bisubstrate-analog inhibitor of basophilic protein kinases.

Enkvist E, Raidaru G, Vaasa A, Pehk T, Lavogina D, Uri A.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5336-9. Epub 2007 Aug 15.

PMID:
17716894

Supplemental Content

Support Center