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Items: 12


Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation.

Hockings C, Iyer S, Uren RT, Kluck RM.

Cell Death Differ. 2019 May;26(5):794-795. doi: 10.1038/s41418-019-0284-y. Epub 2019 Feb 13. No abstract available.


Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage.

Iyer S, Uren RT, Kluck RM.

Methods Mol Biol. 2019;1877:201-216. doi: 10.1007/978-1-4939-8861-7_14.


Pore formation by dimeric Bak and Bax: an unusual pore?

Uren RT, Iyer S, Kluck RM.

Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726). pii: 20160218. doi: 10.1098/rstb.2016.0218. Review.


Disordered clusters of Bak dimers rupture mitochondria during apoptosis.

Uren RT, O'Hely M, Iyer S, Bartolo R, Shi MX, Brouwer JM, Alsop AE, Dewson G, Kluck RM.

Elife. 2017 Feb 6;6. pii: e19944. doi: 10.7554/eLife.19944.


Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

Brouwer JM, Westphal D, Dewson G, Robin AY, Uren RT, Bartolo R, Thompson GV, Colman PM, Kluck RM, Czabotar PE.

Mol Cell. 2014 Sep 18;55(6):938-946. doi: 10.1016/j.molcel.2014.07.016. Epub 2014 Aug 28.


Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.

Uren RT, Turnley AM.

Front Mol Neurosci. 2014 May 14;7:39. doi: 10.3389/fnmol.2014.00039. eCollection 2014. Review.


A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology.

Uren RT, Turbić A, Wong AW, Klein R, Murray SS, Turnley AM.

J Neurochem. 2014 May;129(4):614-27. doi: 10.1111/jnc.12671. Epub 2014 Mar 4.


Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS, Grant SG.

Mol Syst Biol. 2009;5:269. doi: 10.1038/msb.2009.27. Epub 2009 May 19.


Neurotransmitters drive combinatorial multistate postsynaptic density networks.

Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT, Swamy S, Croning MD, Choudhary JS, Grant SG.

Sci Signal. 2009 Apr 28;2(68):ra19. doi: 10.1126/scisignal.2000102.


Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM.

J Cell Biol. 2007 Apr 23;177(2):277-87.


Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes.

Uren RT, Dewson G, Bonzon C, Lithgow T, Newmeyer DD, Kluck RM.

J Biol Chem. 2005 Jan 21;280(3):2266-74. Epub 2004 Nov 9.


SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.

Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS.

Mol Cell Biol. 2002 Jul;22(13):4567-78.

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