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Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Turnbull AP et al. Nature. (2017)

The demographics of the ubiquitin system. Clague MJ et al. Trends Cell Biol. (2015)

Breaking the chains: structure and function of the deubiquitinases. Komander D et al. Nat Rev Mol Cell Biol. (2009)

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Items: 1 to 50 of 78


New aspects of USP30 biology in the regulation of pexophagy.

Marcassa E, Kallinos A, Jardine J, Rusilowicz-Jones EV, Clague MJ, Urbé S.

Autophagy. 2019 Sep;15(9):1634-1637. doi: 10.1080/15548627.2019.1615304. Epub 2019 Jun 9.


Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function.

Clague MJ, Urbé S, Komander D.

Nat Rev Mol Cell Biol. 2019 May;20(5):321. doi: 10.1038/s41580-019-0112-8.


Breaking the chains: deubiquitylating enzyme specificity begets function.

Clague MJ, Urbé S, Komander D.

Nat Rev Mol Cell Biol. 2019 Jun;20(6):338-352. doi: 10.1038/s41580-019-0099-1. Review. Erratum in: Nat Rev Mol Cell Biol. 2019 May;20(5):321.


A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.

Pruneda JN, Bastidas RJ, Bertsoulaki E, Swatek KN, Santhanam B, Clague MJ, Valdivia RH, Urbé S, Komander D.

Nat Microbiol. 2018 Dec;3(12):1377-1384. doi: 10.1038/s41564-018-0271-y. Epub 2018 Nov 5.


Dual role of USP30 in controlling basal pexophagy and mitophagy.

Marcassa E, Kallinos A, Jardine J, Rusilowicz-Jones EV, Martinez A, Kuehl S, Islinger M, Clague MJ, Urbé S.

EMBO Rep. 2018 Jul;19(7). pii: e45595. doi: 10.15252/embr.201745595. Epub 2018 Jun 12.


HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.

MacDonald E, Brown L, Selvais A, Liu H, Waring T, Newman D, Bithell J, Grimes D, Urbé S, Clague MJ, Zech T.

J Cell Biol. 2018 Jul 2;217(7):2549-2564. doi: 10.1083/jcb.201710051. Epub 2018 Jun 11.


The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity.

Fielding AB, Concannon M, Darling S, Rusilowicz-Jones EV, Sacco JJ, Prior IA, Clague MJ, Urbé S, Coulson JM.

Oncogene. 2018 Apr;37(17):2326-2342. doi: 10.1038/s41388-017-0092-0. Epub 2018 Feb 12.


Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D.

Nature. 2017 Oct 26;550(7677):481-486. doi: 10.1038/nature24451. Epub 2017 Oct 18.


Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.

Martinez A, Lectez B, Ramirez J, Popp O, Sutherland JD, Urbé S, Dittmar G, Clague MJ, Mayor U.

Mol Neurodegener. 2017 Apr 11;12(1):29. doi: 10.1186/s13024-017-0170-3.


Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases.

Clague MJ, Urbé S.

FEBS J. 2017 Jun;284(12):1753-1766. doi: 10.1111/febs.14007. Epub 2017 Jan 29.


The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer.

Wymant JM, Hiscox S, Westwell AD, Urbé S, Clague MJ, Jones AT.

J Cancer. 2016 Dec 9;7(15):2388-2407. eCollection 2016.


The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.

Heride C, Rigden DJ, Bertsoulaki E, Cucchi D, De Smaele E, Clague MJ, Urbé S.

J Cell Sci. 2016 Nov 1;129(21):4001-4013. Epub 2016 Sep 12.


Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6.

Perrody E, Abrami L, Feldman M, Kunz B, Urbé S, van der Goot FG.

Elife. 2016 Oct 18;5. pii: e19083. doi: 10.7554/eLife.19083.


Bimodal antagonism of PKA signalling by ARHGAP36.

Eccles RL, Czajkowski MT, Barth C, Müller PM, McShane E, Grunwald S, Beaudette P, Mecklenburg N, Volkmer R, Zühlke K, Dittmar G, Selbach M, Hammes A, Daumke O, Klussmann E, Urbé S, Rocks O.

Nat Commun. 2016 Oct 7;7:12963. doi: 10.1038/ncomms12963.


The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.

Nelson JK, Sorrentino V, Avagliano Trezza R, Heride C, Urbe S, Distel B, Zelcer N.

Circ Res. 2016 Feb 5;118(3):410-9. doi: 10.1161/CIRCRESAHA.115.307298. Epub 2015 Dec 14.


Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells.

Malec V, Coulson JM, Urbé S, Clague MJ.

J Proteome Res. 2015 Dec 4;14(12):5263-72. doi: 10.1021/acs.jproteome.5b00692. Epub 2015 Nov 16.


Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors.

Sacco JJ, Kenyani J, Butt Z, Carter R, Chew HY, Cheeseman LP, Darling S, Denny M, Urbé S, Clague MJ, Coulson JM.

Oncotarget. 2015 May 30;6(15):13757-71.


The demographics of the ubiquitin system.

Clague MJ, Heride C, Urbé S.

Trends Cell Biol. 2015 Jul;25(7):417-26. doi: 10.1016/j.tcb.2015.03.002. Epub 2015 Apr 21. Review.


USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death.

Liang JR, Martinez A, Lane JD, Mayor U, Clague MJ, Urbé S.

EMBO Rep. 2015 May;16(5):618-27. doi: 10.15252/embr.201439820. Epub 2015 Mar 4.


Plasticity of mammary cell boundaries governed by EGF and actin remodeling.

Tang WYY, Beckett AJ, Prior IA, Coulson JM, Urbé S, Clague MJ.

Cell Rep. 2014 Sep 25;8(6):1722-1730. doi: 10.1016/j.celrep.2014.08.026. Epub 2014 Sep 18.


Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP.

Nat Cell Biol. 2014 Oct;16(10):1016-26, 1-8. doi: 10.1038/ncb3028. Epub 2014 Sep 7.


USP8 controls the trafficking and sorting of lysosomal enzymes.

MacDonald E, Urbé S, Clague MJ.

Traffic. 2014 Aug;15(8):879-88. doi: 10.1111/tra.12180. Epub 2014 Jul 3.


Ubiquitin code assembly and disassembly.

Heride C, Urbé S, Clague MJ.

Curr Biol. 2014 Mar 17;24(6):R215-20. doi: 10.1016/j.cub.2014.02.002. Review.


The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells.

Sacco JJ, Yau TY, Darling S, Patel V, Liu H, Urbé S, Clague MJ, Coulson JM.

Oncogene. 2014 Aug 14;33(33):4265-72. doi: 10.1038/onc.2013.512. Epub 2013 Dec 2.


Deubiquitylases from genes to organism.

Clague MJ, Barsukov I, Coulson JM, Liu H, Rigden DJ, Urbé S.

Physiol Rev. 2013 Jul;93(3):1289-315. doi: 10.1152/physrev.00002.2013. Review.


The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit.

Faronato M, Patel V, Darling S, Dearden L, Clague MJ, Urbé S, Coulson JM.

Cell Cycle. 2013 Jun 15;12(12):1964-77. doi: 10.4161/cc.25035. Epub 2013 May 20.


Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB.

Ali N, Zhang L, Taylor S, Mironov A, Urbé S, Woodman P.

Curr Biol. 2013 Mar 18;23(6):453-61. doi: 10.1016/j.cub.2013.02.033. Epub 2013 Mar 7.


Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.

Hayes SD, Liu H, MacDonald E, Sanderson CM, Coulson JM, Clague MJ, Urbé S.

J Biol Chem. 2012 Dec 14;287(51):43007-18. doi: 10.1074/jbc.M112.386938. Epub 2012 Oct 26.


Governance of endocytic trafficking and signaling by reversible ubiquitylation.

Clague MJ, Liu H, Urbé S.

Dev Cell. 2012 Sep 11;23(3):457-67. doi: 10.1016/j.devcel.2012.08.011. Review.


Cellular functions of the DUBs.

Clague MJ, Coulson JM, Urbé S.

J Cell Sci. 2012 Jan 15;125(Pt 2):277-86. doi: 10.1242/jcs.090985. Review.


Selective protein degradation in cell signalling.

Liu H, Urbé S, Clague MJ.

Semin Cell Dev Biol. 2012 Jul;23(5):509-14. doi: 10.1016/j.semcdb.2012.01.014. Epub 2012 Feb 8. Review.


Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.

Urbé S, Liu H, Hayes SD, Heride C, Rigden DJ, Clague MJ.

Mol Biol Cell. 2012 Mar;23(6):1095-103. doi: 10.1091/mbc.E11-08-0668. Epub 2012 Feb 1.


Structural variability of the ubiquitin specific protease DUSP-UBL double domains.

Elliott PR, Liu H, Pastok MW, Grossmann GJ, Rigden DJ, Clague MJ, Urbé S, Barsukov IL.

FEBS Lett. 2011 Nov 4;585(21):3385-90. doi: 10.1016/j.febslet.2011.09.040. Epub 2011 Oct 10.


Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus.

Thorne C, Eccles RL, Coulson JM, Urbé S, Clague MJ.

Traffic. 2011 Nov;12(11):1563-74. doi: 10.1111/j.1600-0854.2011.01261.x. Epub 2011 Aug 25.


Moving in with ubiquitin.

Urbé S.

Traffic. 2011 Feb;12(2):135-6. doi: 10.1111/j.1600-0854.2010.01143.x. No abstract available.


Ubiquitin: same molecule, different degradation pathways.

Clague MJ, Urbé S.

Cell. 2010 Nov 24;143(5):682-5. doi: 10.1016/j.cell.2010.11.012. Review.


Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.

Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urbé S, Clague MJ, Tooze SA.

Autophagy. 2010 May;6(4):506-22. doi: 10.4161/auto.6.4.11863. Epub 2010 May 16.


Emerging roles of deubiquitinases in cancer-associated pathways.

Sacco JJ, Coulson JM, Clague MJ, Urbé S.

IUBMB Life. 2010 Feb;62(2):140-57. doi: 10.1002/iub.300. Review.


Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes.

Popoff V, Mardones GA, Bai SK, Chambon V, Tenza D, Burgos PV, Shi A, Benaroch P, Urbé S, Lamaze C, Grant BD, Raposo G, Johannes L.

Traffic. 2009 Dec;10(12):1868-80. doi: 10.1111/j.1600-0854.2009.00993.x. Epub 2009 Oct 5.


Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells.

Buus R, Faronato M, Hammond DE, Urbé S, Clague MJ.

Curr Biol. 2009 Sep 15;19(17):1463-6. doi: 10.1016/j.cub.2009.07.040. Epub 2009 Aug 20.


Breaking the chains: structure and function of the deubiquitinases.

Komander D, Clague MJ, Urbé S.

Nat Rev Mol Cell Biol. 2009 Aug;10(8):550-63. doi: 10.1038/nrm2731. Review.


PIKfyve regulation of endosome-linked pathways.

de Lartigue J, Polson H, Feldman M, Shokat K, Tooze SA, Urbé S, Clague MJ.

Traffic. 2009 Jul;10(7):883-93.


Regulation of ErbB2 receptor status by the proteasomal DUB POH1.

Liu H, Buus R, Clague MJ, Urbé S.

PLoS One. 2009;4(5):e5544. doi: 10.1371/journal.pone.0005544. Epub 2009 May 14.


Ab initio protein modelling reveals novel human MIT domains.

Rigden DJ, Liu H, Hayes SD, Urbé S, Clague MJ.

FEBS Lett. 2009 Mar 4;583(5):872-8. doi: 10.1016/j.febslet.2009.02.012. Epub 2009 Feb 12.


Phosphoinositides and the endocytic pathway.

Clague MJ, Urbé S, de Lartigue J.

Exp Cell Res. 2009 May 15;315(9):1627-31. doi: 10.1016/j.yexcr.2008.10.005. Epub 2008 Oct 21. Review.


Multivesicular bodies.

Clague MJ, Urbé S.

Curr Biol. 2008 May 20;18(10):R402-R404. doi: 10.1016/j.cub.2008.02.068. No abstract available.


Deciphering histone 2A deubiquitination.

Clague MJ, Coulson JM, Urbé S.

Genome Biol. 2008 Jan 23;9(1):202. doi: 10.1186/gb-2008-9-1-202. Review.


The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.

Row PE, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, Clague MJ, Sanderson CM, Urbé S.

J Biol Chem. 2007 Oct 19;282(42):30929-37. Epub 2007 Aug 21. Erratum in: J Biol Chem. 2009 Mar 20;284(12):8207.


The emerging shape of the ESCRT machinery.

Williams RL, Urbé S.

Nat Rev Mol Cell Biol. 2007 May;8(5):355-68. Review.


Control of growth factor receptor dynamics by reversible ubiquitination.

Urbé S, McCullough J, Row P, Prior IA, Welchman R, Clague MJ.

Biochem Soc Trans. 2006 Nov;34(Pt 5):754-6.


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