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Items: 1 to 50 of 160

1.

Current Landscape of Treatments for Wolfram Syndrome.

Abreu D, Urano F.

Trends Pharmacol Sci. 2019 Oct;40(10):711-714. doi: 10.1016/j.tips.2019.07.011. Epub 2019 Aug 13.

2.

Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome.

Park SJ, Kim Y, Yang SM, Henderson MJ, Yang W, Lindahl M, Urano F, Chen YM.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14154-14163. doi: 10.1073/pnas.1813580116. Epub 2019 Jun 24.

PMID:
31235574
3.

Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells.

Stone S, Abreu D, Mahadevan J, Asada R, Kries K, Graf R, Marshall BA, Hershey T, Urano F.

Sci Rep. 2019 Mar 26;9(1):5199. doi: 10.1038/s41598-019-41604-4.

4.

Novel elucidation and treatment of pancreatic chronic graft-versus-host disease in mice.

Mukai S, Ogawa Y, Urano F, Kawakami Y, Tsubota K.

R Soc Open Sci. 2018 Oct 17;5(10):181067. doi: 10.1098/rsos.181067. eCollection 2018 Oct.

5.

[Gastric tuberculosis in an elderly patient:a case report].

Kano Y, Yamamoto H, Naito T, Yamada M, Matsubara H, Sakamaki K, Maeda M, Ohashi S, Urano F.

Nihon Shokakibyo Gakkai Zasshi. 2018;115(11):985-995. doi: 10.11405/nisshoshi.115.985. Japanese.

PMID:
30416160
6.

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, Arvan P, Floyd ZE, Mauvais-Jarvis F.

Cell Rep. 2018 Jul 3;24(1):181-196. doi: 10.1016/j.celrep.2018.06.019.

7.

Understanding activity participation among individuals with Wolfram Syndrome.

Bumpus E, Hershey T, Doty T, Ranck S, Gronski M, Urano F, Foster ER.

Br J Occup Ther. 2018 Jun;81(6):348-357. doi: 10.1177/0308022618757182. Epub 2018 Apr 13.

8.

Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet-induced oxidative stress.

Abebe T, Mahadevan J, Bogachus L, Hahn S, Black M, Oseid E, Urano F, Cirulli V, Robertson RP.

JCI Insight. 2017 Dec 21;2(24). pii: 92854. doi: 10.1172/jci.insight.92854.

9.

Bisphosphonates prevent age-related weight loss in Japanese postmenopausal women.

Urano T, Shiraki M, Kuroda T, Tanaka S, Urano F, Uenishi K, Inoue S.

J Bone Miner Metab. 2018 Nov;36(6):734-740. doi: 10.1007/s00774-017-0891-y. Epub 2017 Dec 13.

PMID:
29236162
10.

Daclatasvir and asunaprevir treatment in patients infected by genotype 1b of hepatitis C virus with no or subtle resistant associated substitutions (RAS) in NS5A-Y93.

Ishigami M, Hayashi K, Honda T, Kuzuya T, Ishizu Y, Ishikawa T, Nakano I, Urano F, Kumada T, Yoshioka K, Hirooka Y, Goto H.

J Med Virol. 2018 Apr;90(4):736-744. doi: 10.1002/jmv.24978. Epub 2017 Dec 28.

PMID:
29111616
11.

Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway.

Liu H, Javaheri A, Godar RJ, Murphy J, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, McDaniel ML, Remedi MS, Razani B, Urano F, Diwan A.

Autophagy. 2017;13(11):1952-1968. doi: 10.1080/15548627.2017.1368596. Epub 2017 Nov 25.

12.

Low serum osteocalcin concentration is associated with incident type 2 diabetes mellitus in Japanese women.

Urano T, Shiraki M, Kuroda T, Tanaka S, Urano F, Uenishi K, Inoue S.

J Bone Miner Metab. 2018 Jul;36(4):470-477. doi: 10.1007/s00774-017-0857-0. Epub 2017 Aug 1.

PMID:
28766135
13.

Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.

Clark AL, Kanekura K, Lavagnino Z, Spears LD, Abreu D, Mahadevan J, Yagi T, Semenkovich CF, Piston DW, Urano F.

Sci Rep. 2017 Jul 17;7(1):5611. doi: 10.1038/s41598-017-05935-4.

14.

A case of a patient with granulocyte-colony stimulating factor-producing pancreatic cancer who responded to nab-paclitaxel plus gemcitabine.

Kataoka K, Achiwa K, Minami Y, Fujita M, Naitoh T, Yamada M, Yamamoto H, Matsubara H, Urano F.

Nihon Shokakibyo Gakkai Zasshi. 2017;114(7):1277-1284. doi: 10.11405/nisshoshi.114.1277. Review. Japanese.

PMID:
28679984
15.

Mammalian ECD Protein Is a Novel Negative Regulator of the PERK Arm of the Unfolded Protein Response.

Olou AA, Sarkar A, Bele A, Gurumurthy CB, Mir RA, Ammons SA, Mirza S, Saleem I, Urano F, Band H, Band V.

Mol Cell Biol. 2017 Aug 28;37(18). pii: e00030-17. doi: 10.1128/MCB.00030-17. Print 2017 Sep 15.

16.

Dominant ER Stress-Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts.

De Franco E, Flanagan SE, Yagi T, Abreu D, Mahadevan J, Johnson MB, Jones G, Acosta F, Mulaudzi M, Lek N, Oh V, Petz O, Caswell R, Ellard S, Urano F, Hattersley AT.

Diabetes. 2017 Jul;66(7):2044-2053. doi: 10.2337/db16-1296. Epub 2017 May 3.

17.

Analysis of the risk factors for severity in post endoscopic retrograde cholangiopancreatography pancreatitis: The indication of prophylactic treatments.

Matsubara H, Urano F, Kinoshita Y, Okamura S, Kawashima H, Goto H, Hirooka Y.

World J Gastrointest Endosc. 2017 Apr 16;9(4):189-195. doi: 10.4253/wjge.v9.i4.189.

18.

Monogenic diabetes syndromes: Locus-specific databases for Alström, Wolfram, and Thiamine-responsive megaloblastic anemia.

Astuti D, Sabir A, Fulton P, Zatyka M, Williams D, Hardy C, Milan G, Favaretto F, Yu-Wai-Man P, Rohayem J, López de Heredia M, Hershey T, Tranebjaerg L, Chen JH, Chaussenot A, Nunes V, Marshall B, McAfferty S, Tillmann V, Maffei P, Paquis-Flucklinger V, Geberhiwot T, Mlynarski W, Parkinson K, Picard V, Bueno GE, Dias R, Arnold A, Richens C, Paisey R, Urano F, Semple R, Sinnott R, Barrett TG.

Hum Mutat. 2017 Jul;38(7):764-777. doi: 10.1002/humu.23233. Epub 2017 Jun 1.

19.

Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice.

Valderrama C, Clark A, Urano F, Unanue ER, Carrero JA.

Eur J Immunol. 2017 May;47(5):830-840. doi: 10.1002/eji.201646856. Epub 2017 Apr 13.

20.

Daclatasvir and asunaprevir treatment in patients with severe liver fibrosis by hepatitis C virus genotype 1b infection: Real-world data.

Ishigami M, Hayashi K, Honda T, Kuzuya T, Ishizu Y, Ishikawa T, Nakano I, Urano F, Kumada T, Yoshioka K, Goto H, Hirooka Y.

J Gastroenterol Hepatol. 2017 Nov;32(11):1879-1886. doi: 10.1111/jgh.13779.

PMID:
28258705
21.

Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.

Mukai S, Ogawa Y, Urano F, Kudo-Saito C, Kawakami Y, Tsubota K.

Sci Rep. 2017 Feb 6;7:41939. doi: 10.1038/srep41939.

22.

Real World Data of Daclatasvir and Asunaprevir Combination Therapy for HCV Genotype 1b Infection in Patients With Renal Dysfunction.

Ishigami M, Hayashi K, Honda T, Kuzuya T, Ishizu Y, Ishikawa T, Nakano I, Urano F, Kumada T, Yoshioka K, Goto H, Hirooka Y.

Clin Gastroenterol Hepatol. 2017 May;15(5):787-788. doi: 10.1016/j.cgh.2016.12.009. Epub 2016 Dec 21. No abstract available.

PMID:
28013118
23.

Clinical efficacy of fecal occult blood test and colonoscopy for dasatinib-induced hemorrhagic colitis in CML patients.

Nishiwaki S, Maeda M, Yamada M, Okuno S, Harada Y, Suzuki K, Kurahashi S, Urano F, Okamura S, Sugiura I.

Blood. 2017 Jan 5;129(1):126-128. doi: 10.1182/blood-2016-08-734947. Epub 2016 Nov 18. No abstract available.

PMID:
27864292
24.

Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.

Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KD, Lavagnino Z, Scherrer DE, Fujiwara H, Sidhu R, Zhang J, Huang SC, Piston DW, Remedi MS, Urano F, Ory DS, Schaffer JE.

J Clin Invest. 2016 Dec 1;126(12):4616-4625. doi: 10.1172/JCI88069. Epub 2016 Nov 7.

25.

Nab-paclitaxel+gemcitabine therapy for adenosquamous carcinoma of the pancreas: an autopsy case.

Kataoka K, Matsubara H, Urano F, Okamura S, Maeda M.

Nihon Shokakibyo Gakkai Zasshi. 2016;113(10):1777-1784. Japanese.

PMID:
27725467
26.

Endoplasmic reticulum stress in beta cells and autoimmune diabetes.

Clark AL, Urano F.

Curr Opin Immunol. 2016 Dec;43:60-66. doi: 10.1016/j.coi.2016.09.006. Epub 2016 Oct 5. Review.

27.

Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases.

Kim Y, Lee H, Manson SR, Lindahl M, Evans B, Miner JH, Urano F, Chen YM.

J Am Soc Nephrol. 2016 Oct;27(10):2974-2982. Epub 2016 Mar 3.

28.

Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation.

Kanekura K, Yagi T, Cammack AJ, Mahadevan J, Kuroda M, Harms MB, Miller TM, Urano F.

Hum Mol Genet. 2016 May 1;25(9):1803-13. doi: 10.1093/hmg/ddw052. Epub 2016 Feb 29.

29.

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.

Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink DM, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, Ryoo HD, Steller H, Urano F, Chevet E, Kroemer G, Ciechanover A, Calabrese EJ, Kaufman RJ, Hetz C.

Brain Res. 2016 Oct 1;1648(Pt B):603-616. doi: 10.1016/j.brainres.2016.02.033. Epub 2016 Mar 2. Review.

30.

Neuroimaging evidence of deficient axon myelination in Wolfram syndrome.

Lugar HM, Koller JM, Rutlin J, Marshall BA, Kanekura K, Urano F, Bischoff AN, Shimony JS, Hershey T; Washington University Wolfram Syndrome Research Study Group.

Sci Rep. 2016 Feb 18;6:21167. doi: 10.1038/srep21167.

31.

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function.

Moore BD, Jin RU, Lo H, Jung M, Wang H, Battle MA, Wollheim CB, Urano F, Mills JC.

J Biol Chem. 2016 Mar 18;291(12):6146-57. doi: 10.1074/jbc.M115.685750. Epub 2016 Jan 20.

32.

Wolfram Syndrome: Diagnosis, Management, and Treatment.

Urano F.

Curr Diab Rep. 2016 Jan;16(1):6. doi: 10.1007/s11892-015-0702-6. Review.

33.

The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.

Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE.

Oncotarget. 2016 Jan 12;7(2):2080-92. doi: 10.18632/oncotarget.6712.

34.

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

Vomund AN, Zinselmeyer BH, Hughes J, Calderon B, Valderrama C, Ferris ST, Wan X, Kanekura K, Carrero JA, Urano F, Unanue ER.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5496-502. doi: 10.1073/pnas.1515954112. Epub 2015 Aug 31.

35.

Maternal uniparental disomy of chromosome 4 and homozygous novel mutation in the WFS1 gene in a paediatric patient with Wolfram syndrome.

Papadimitriou DT, Manolakos E, Bothou C, Zoupanos G, Papoulidis I, Orru S, Skarmoutsos F, Delides A, Bakoula C, Papadimitriou A, Urano F.

Diabetes Metab. 2015 Nov;41(5):433-5. doi: 10.1016/j.diabet.2015.06.003. Epub 2015 Jul 10. No abstract available.

PMID:
26169481
36.

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.

Kanekura K, Ma X, Murphy JT, Zhu LJ, Diwan A, Urano F.

Sci Signal. 2015 Jun 23;8(382):ra62. doi: 10.1126/scisignal.aaa0341.

37.

Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level.

Kanekura K, Ou J, Hara T, Zhu LJ, Urano F.

Mol Endocrinol. 2015 Mar;29(3):473-80. doi: 10.1210/me.2014-1260. Epub 2015 Jan 13.

38.

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.

Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski CM, Martinez R, Yamazaki-Inoue M, Toyoda M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, Umezawa A, Greer PA, Urano F.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5292-301. doi: 10.1073/pnas.1421055111. Epub 2014 Nov 24.

39.

[ER stress and β cell death - therapeutic approach to combat ER stress].

Hara T, Urano F.

Nihon Yakurigaku Zasshi. 2014 Aug;144(2):53-8. Japanese. No abstract available.

PMID:
25109516
40.

Effect of peginterferon alfa-2b and ribavirin on hepatocellular carcinoma prevention in older patients with chronic hepatitis C.

Honda T, Ishigami M, Masuda H, Ishizu Y, Kuzuya T, Hayashi K, Itoh A, Hirooka Y, Nakano I, Ishikawa T, Urano F, Yoshioka K, Toyoda H, Kumada T, Katano Y, Goto H.

J Gastroenterol Hepatol. 2015 Feb;30(2):321-8. doi: 10.1111/jgh.12703.

PMID:
25091027
41.

Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.

Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2319-28. doi: 10.1073/pnas.1323066111. Epub 2014 May 19.

42.

Wolfram syndrome iPS cells: the first human cell model of endoplasmic reticulum disease.

Urano F.

Diabetes. 2014 Mar;63(3):844-6. doi: 10.2337/db13-1809. No abstract available.

43.

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

Hara T, Mahadevan J, Kanekura K, Hara M, Lu S, Urano F.

Endocrinology. 2014 Mar;155(3):758-68. doi: 10.1210/en.2013-1519. Epub 2013 Jan 1.

44.

Diabetes: Targeting endoplasmic reticulum to combat juvenile diabetes.

Urano F.

Nat Rev Endocrinol. 2014 Mar;10(3):129-30. doi: 10.1038/nrendo.2013.261. Epub 2014 Jan 7.

45.

Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγ(null) mice treated with alogliptin.

Jurczyk A, Diiorio P, Brostowin D, Leehy L, Yang C, Urano F, Harlan DM, Shultz LD, Greiner DL, Bortell R.

Diabetes Metab Syndr Obes. 2013 Dec 13;6:493-9. doi: 10.2147/DMSO.S53154. eCollection 2013.

46.

Endoplasmic reticulum: an interface between the immune system and metabolism.

Unanue ER, Urano F.

Diabetes. 2014 Jan;63(1):48-9. doi: 10.2337/db13-1478. No abstract available.

47.

KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.

Jung DY, Chalasani U, Pan N, Friedline RH, Prosdocimo DA, Nam M, Azuma Y, Maganti R, Yu K, Velagapudi A, O'Sullivan-Murphy B, Sartoretto JL, Jain MK, Cooper MP, Urano F, Kim JK, Gray S.

PLoS One. 2013 Oct 22;8(10):e77851. doi: 10.1371/journal.pone.0077851. eCollection 2013.

48.
49.

Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells.

Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F.

Lab Invest. 2013 Nov;93(11):1254-8. doi: 10.1038/labinvest.2013.112. Epub 2013 Sep 16.

50.

Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation.

Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu S, Boehnke M, Urano F, Collins FS, Laakso M.

Diabetes. 2013 Nov;62(11):3943-50. doi: 10.2337/db13-0571. Epub 2013 Jul 31.

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