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Bovine TB infection status in Great Britain in 2016.

Harris KA, Brouwer A, Upton PA, Romero Garcia MP, Gibbens JC, Dale J.

Vet Rec. 2018 May 12;182(19):538-544. doi: 10.1136/vr.k2096. No abstract available.


Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.

Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, Hodgson J, Liu B, Salmon RM, Southwood M, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Aldred M, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, MacKenzie Ross RV, Moledina S, Montani D, Newnham M, Olschewski A, Olschewski H, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Stein DF, Suntharalingam J, Swietlik EM, Toshner MR, van Heel DA, Vonk Noordegraaf A, Waisfisz Q, Wharton J, Wort SJ, Ouwehand WH, Soranzo N, Lawrie A, Upton PD, Wilkins MR, Trembath RC, Morrell NW.

Nat Commun. 2018 Apr 12;9(1):1416. doi: 10.1038/s41467-018-03672-4.


Egyptian and Jordanian nurse educators' perception of barriers preventing the implementation of evidence-based practice: A cross-sectional study.

Youssef NFA, Alshraifeen A, Alnuaimi K, Upton P.

Nurse Educ Today. 2018 May;64:33-41. doi: 10.1016/j.nedt.2018.01.035. Epub 2018 Feb 10.


Methodology and preliminary results of a systematic literature review of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis.

Downs SH, Parry JE, Upton PA, Broughan JM, Goodchild AV, Nuñez-Garcia J, Greiner M, Abernethy DA, Cameron AR, Cook AJ, de la Rua-Domenech R, Gunn J, Pritchard E, Rhodes S, Rolfe S, Sharp M, Vordermeier HM, Watson E, Welsh M, Whelan AO, Woolliams JA, More SJ, Clifton-Hadley RS.

Prev Vet Med. 2018 May 1;153:117-126. doi: 10.1016/j.prevetmed.2017.11.004. Epub 2017 Nov 9.


Achieving the four dimensions of food security for resettled refugees in Australia: A systematic review.

Lawlis T, Islam W, Upton P.

Nutr Diet. 2018 Apr;75(2):182-192. doi: 10.1111/1747-0080.12402. Epub 2017 Dec 20. Review.


Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.

Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW.

Circulation. 2017 Dec 19;136(25):2451-2467. doi: 10.1161/CIRCULATIONAHA.117.028034. Epub 2017 Sep 26.


Assessing the effects of the first 2 years of industry-led badger culling in England on the incidence of bovine tuberculosis in cattle in 2013-2015.

Brunton LA, Donnelly CA, O'Connor H, Prosser A, Ashfield S, Ashton A, Upton P, Mitchell A, Goodchild AV, Parry JE, Downs SH.

Ecol Evol. 2017 Aug 4;7(18):7213-7230. doi: 10.1002/ece3.3254. eCollection 2017 Sep.


A 3D tri-culture system reveals that activin receptor-like kinase 5 and connective tissue growth factor drive human glomerulosclerosis.

Waters JP, Richards YC, Skepper JN, Southwood M, Upton PD, Morrell NW, Pober JS, Bradley JR.

J Pathol. 2017 Nov;243(3):390-400. doi: 10.1002/path.4960. Epub 2017 Oct 3.


To embed or not to embed? A longitudinal study exploring the impact of curriculum design on the evidence-based practice profiles of UK pre-registration nursing students.

Scurlock-Evans L, Upton P, Rouse J, Upton D.

Nurse Educ Today. 2017 Nov;58:12-18. doi: 10.1016/j.nedt.2017.07.011. Epub 2017 Jul 26.


Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2.

Mitrofan CG, Appleby SL, Nash GB, Mallat Z, Chilvers ER, Upton PD, Morrell NW.

J Biol Chem. 2017 Aug 18;292(33):13714-13726. doi: 10.1074/jbc.M117.778506. Epub 2017 Jun 23.


Extreme hydrothermal conditions at an active plate-bounding fault.

Sutherland R, Townend J, Toy V, Upton P, Coussens J, Allen M, Baratin LM, Barth N, Becroft L, Boese C, Boles A, Boulton C, Broderick NGR, Janku-Capova L, Carpenter BM, Célérier B, Chamberlain C, Cooper A, Coutts A, Cox S, Craw L, Doan ML, Eccles J, Faulkner D, Grieve J, Grochowski J, Gulley A, Hartog A, Howarth J, Jacobs K, Jeppson T, Kato N, Keys S, Kirilova M, Kometani Y, Langridge R, Lin W, Little T, Lukacs A, Mallyon D, Mariani E, Massiot C, Mathewson L, Melosh B, Menzies C, Moore J, Morales L, Morgan C, Mori H, Niemeijer A, Nishikawa O, Prior D, Sauer K, Savage M, Schleicher A, Schmitt DR, Shigematsu N, Taylor-Offord S, Teagle D, Tobin H, Valdez R, Weaver K, Wiersberg T, Williams J, Woodman N, Zimmer M.

Nature. 2017 Jun 1;546(7656):137-140. doi: 10.1038/nature22355. Epub 2017 May 17.


Evaluation of the methodological quality of studies of the performance of diagnostic tests for bovine tuberculosis using QUADAS.

Downs SH, More SJ, Goodchild AV, Whelan AO, Abernethy DA, Broughan JM, Cameron A, Cook AJ, Ricardo de la Rua-Domenech R, Greiner M, Gunn J, Nuñez-Garcia J, Rhodes S, Rolfe S, Sharp M, Upton P, Watson E, Welsh M, Woolliams JA, Clifton-Hadley RS, Parry JE.

Prev Vet Med. 2018 May 1;153:108-116. doi: 10.1016/j.prevetmed.2017.03.006. Epub 2017 Mar 22.


Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland.

Nuñez-Garcia J, Downs SH, Parry JE, Abernethy DA, Broughan JM, Cameron AR, Cook AJ, de la Rua-Domenech R, Goodchild AV, Gunn J, More SJ, Rhodes S, Rolfe S, Sharp M, Upton PA, Vordermeier HM, Watson E, Welsh M, Whelan AO, Woolliams JA, Clifton-Hadley RS, Greiner M.

Prev Vet Med. 2018 May 1;153:94-107. doi: 10.1016/j.prevetmed.2017.02.017. Epub 2017 Mar 6.


Bovine TB infection status in cattle in Great Britain in 2015.

Harris KA, Brunton L, Brouwer A, Garcia MP, Gibbens JC, Smith NH, Upton PA.

Vet Rec. 2017 Feb 18;180(7):170-175. doi: 10.1136/vr.j759.


Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.

Yang P, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, Upton PD, Crosby A, Sawiak SJ, Carpenter TA, Glen RC, Morrell NW, Maguire JJ, Davenport AP.

Circulation. 2017 Mar 21;135(12):1160-1173. doi: 10.1161/CIRCULATIONAHA.116.023218. Epub 2017 Jan 30.


TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

Hurst LA, Dunmore BJ, Long L, Crosby A, Al-Lamki R, Deighton J, Southwood M, Yang X, Nikolic MZ, Herrera B, Inman GJ, Bradley JR, Rana AA, Upton PD, Morrell NW.

Nat Commun. 2017 Jan 13;8:14079. doi: 10.1038/ncomms14079.


Responses to diagnostic tests for bovine tuberculosis in dairy and non-dairy cattle naturally exposed to Mycobacterium bovis in Great Britain.

Downs SH, Broughan JM, Goodchild AV, Upton PA, Durr PA.

Vet J. 2016 Oct;216:8-17. doi: 10.1016/j.tvjl.2016.06.010. Epub 2016 Jun 28.


Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium.

Appleby SL, Mitrofan CG, Crosby A, Hoenderdos K, Lodge K, Upton PD, Yates CM, Nash GB, Chilvers ER, Morrell NW.

J Immunol. 2016 Oct 15;197(8):3302-3314. doi: 10.4049/jimmunol.1601219. Epub 2016 Sep 19.


Transverse Alpine Speciation Driven by Glaciation.

Wallis GP, Waters JM, Upton P, Craw D.

Trends Ecol Evol. 2016 Dec;31(12):916-926. doi: 10.1016/j.tree.2016.08.009. Epub 2016 Sep 15. Review.


Farm characteristics and farmer perceptions associated with bovine tuberculosis incidents in areas of emerging endemic spread.

Broughan JM, Maye D, Carmody P, Brunton LA, Ashton A, Wint W, Alexander N, Naylor R, Ward K, Goodchild AV, Hinchliffe S, Eglin RD, Upton P, Nicholson R, Enticott G.

Prev Vet Med. 2016 Jul 1;129:88-98. doi: 10.1016/j.prevetmed.2016.05.007. Epub 2016 May 14.


Supporting completion of an online continuing professional development programme for newly qualified practitioners: A qualitative evaluation.

Erol R, Upton P, Upton D.

Nurse Educ Today. 2016 Jul;42:62-8. doi: 10.1016/j.nedt.2016.04.005. Epub 2016 Apr 27.


Bovine TB surveillance in Great Britain in 2014.

Lawes JR, Harris KA, Brouwer A, Broughan JM, Smith NH, Upton PA.

Vet Rec. 2016 Mar 26;178(13):310-5. doi: 10.1136/vr.i1616.


Well-being in wounds inventory (WOWI): development of a valid and reliable measure of well-being in patients with wounds.

Upton D, Upton P, Alexander R.

J Wound Care. 2016 Mar;25(3):114, 116-20. doi: 10.12968/jowc.2016.25.3.114.


The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension.

Ormiston ML, Upton PD, Li W, Morrell NW.

Glob Cardiol Sci Pract. 2015 Nov 17;2015(4):47. doi: 10.5339/gcsp.2015.47. eCollection 2015.


Introducing the wellbeing in wounds network.

Upton D, Upton P, Dunk AM, Barker J.

Aust Nurs Midwifery J. 2015 Sep;23(3):40. No abstract available.


The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells.

Jiang H, Salmon RM, Upton PD, Wei Z, Lawera A, Davenport AP, Morrell NW, Li W.

J Biol Chem. 2016 Feb 5;291(6):2954-66. doi: 10.1074/jbc.M115.683292. Epub 2015 Dec 2.


Development of the Student Evidence-based Practice Questionnaire (S-EBPQ).

Upton P, Scurlock-Evans L, Upton D.

Nurse Educ Today. 2016 Feb;37:38-44. doi: 10.1016/j.nedt.2015.11.010. Epub 2015 Nov 18.


Farming on the edge: farmer attitudes to bovine tuberculosis in newly endemic areas.

Enticott G, Maye D, Carmody P, Naylor R, Ward K, Hinchliffe S, Wint W, Alexander N, Elgin R, Ashton A, Upton P, Nicholson R, Goodchild T, Brunton L, Broughan J.

Vet Rec. 2015 Oct 31;177(17):439. doi: 10.1136/vr.103187. Epub 2015 Oct 22.


Contribution of the Leg Club model of care to the well-being of people living with chronic wounds.

Upton D, Upton P, Alexander R.

J Wound Care. 2015 Sep;24(9):397-405. doi: 10.12968/jowc.2015.24.9.397.


Specificity of the comparative skin test for bovine tuberculosis in Great Britain.

Goodchild AV, Downs SH, Upton P, Wood JL, de la Rua-Domenech R.

Vet Rec. 2015 Sep 12;177(10):258. doi: 10.1136/vr.102961. Epub 2015 Sep 2.


Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.

Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RD, Mueller M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NW.

Nat Med. 2015 Jul;21(7):777-85. doi: 10.1038/nm.3877. Epub 2015 Jun 15.


Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension.

Soon E, Crosby A, Southwood M, Yang P, Tajsic T, Toshner M, Appleby S, Shanahan CM, Bloch KD, Pepke-Zaba J, Upton P, Morrell NW.

Am J Respir Crit Care Med. 2015 Oct 1;192(7):859-72. doi: 10.1164/rccm.201408-1509OC.


BMPR-II mutations promote pulmonary arterial hypertension via a hyperinflammatory response.

Soon E, Crosby A, Southwood M, Pepke-Zaba J, Upton P, Morrell N.

Clin Med (Lond). 2015 Jun;15 Suppl 3:s15. doi: 10.7861/clinmedicine.15-3-s15. Epub 2015 May 29. No abstract available.


Connexin-mediated regulation of the pulmonary vasculature.

Dempsie Y, Martin P, Upton PD.

Biochem Soc Trans. 2015 Jun;43(3):524-9. doi: 10.1042/BST20150030. Review.


Bovine TB infection status in cattle in Great Britain in 2013.

Broughan JM, Harris KA, Brouwer A, Downs SH, Goodchild AV, Upton PA, Smith NH.

Vet Rec. 2015 Mar 28;176(13):326-30. doi: 10.1136/vr.h1145.


Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis.

Wei Z, Salmon RM, Upton PD, Morrell NW, Li W.

J Biol Chem. 2014 Nov 7;289(45):31150-9. doi: 10.1074/jbc.M114.579771. Epub 2014 Sep 18.


The evidence-based practice profiles of academic and clinical staff involved in pre-registration nursing students' education: a cross sectional survey of US and UK staff.

Upton P, Scurlock-Evans L, Williamson K, Rouse J, Upton D.

Nurse Educ Today. 2015 Jan;35(1):80-5. doi: 10.1016/j.nedt.2014.06.006. Epub 2014 Jun 28.


Bovine TB infection status in cattle in Great Britain in 2012.

Harris KA, Downs SH, Goodchild AV, Broughan JM, Upton PA, Smith NH.

Vet Rec. 2014 Jun 14;174(24):600-4. doi: 10.1136/vr.g3644.


Family-based childhood obesity interventions in the UK: a systematic review of published studies.

Upton P, Taylor C, Erol R, Upton D.

Community Pract. 2014 May;87(5):25-9. Review.


Evidence-based practice in physiotherapy: a systematic review of barriers, enablers and interventions.

Scurlock-Evans L, Upton P, Upton D.

Physiotherapy. 2014 Sep;100(3):208-19. doi: 10.1016/ Epub 2014 Mar 12. Review.


The effects of the Food Dudes Programme on children's intake of unhealthy foods at lunchtime.

Upton P, Taylor C, Upton D.

Perspect Public Health. 2015 May;135(3):152-9. doi: 10.1177/1757913914526163. Epub 2014 Mar 20.


Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.

Toshner M, Dunmore BJ, McKinney EF, Southwood M, Caruso P, Upton PD, Waters JP, Ormiston ML, Skepper JN, Nash G, Rana AA, Morrell NW.

PLoS One. 2014 Mar 20;9(3):e91334. doi: 10.1371/journal.pone.0091334. eCollection 2014.


The reach, transferability, and impact of the Evidence-Based Practice Questionnaire: a methodological and narrative literature review.

Upton D, Upton P, Scurlock-Evans L.

Worldviews Evid Based Nurs. 2014 Feb;11(1):46-54. doi: 10.1111/wvn.12019. Epub 2014 Jan 21. Review.


Venous leg ulcers: what about well-being?

Upton D, Andrews A, Upton P.

J Wound Care. 2014 Jan;23(1):14, 16-7.


Standardization developments for large scale biobanks in smoking related diseases - a model system for blood sample processing and storage.

Malm J, Fehniger TE, Danmyr P, Végvári Á, Welinder C, Lindberg H, Upton P, Carter S, Appelqvist R, Sjödin K, Wieslander E, Dahlbäck M, Rezeli M, Erlinge D, Marko-Varga G.

Transl Respir Med. 2013 Dec;1(1):14. doi: 10.1186/2213-0802-1-14. Epub 2013 Aug 30.


Mycobacterium bovis infections in domesticated non-bovine mammalian species. Part 1: Review of epidemiology and laboratory submissions in Great Britain 2004-2010.

Broughan JM, Downs SH, Crawshaw TR, Upton PA, Brewer J, Clifton-Hadley RS.

Vet J. 2013 Nov;198(2):339-45. doi: 10.1016/j.tvjl.2013.09.006. Epub 2013 Sep 20. Review.


Can a school-based intervention increase children's fruit and vegetable consumption in the home setting?

Taylor C, Darby H, Upton P, Upton D.

Perspect Public Health. 2013 Nov;133(6):330-6. doi: 10.1177/1757913913506575.


BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia.

Wooderchak-Donahue WL, McDonald J, O'Fallon B, Upton PD, Li W, Roman BL, Young S, Plant P, Fülöp GT, Langa C, Morrell NW, Botella LM, Bernabeu C, Stevenson DA, Runo JR, Bayrak-Toydemir P.

Am J Hum Genet. 2013 Sep 5;93(3):530-7. doi: 10.1016/j.ajhg.2013.07.004. Epub 2013 Aug 22.


Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3.

Upton PD, Davies RJ, Tajsic T, Morrell NW.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1135-45. doi: 10.1165/rcmb.2012-0470OC.


Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence.

Laux DW, Young S, Donovan JP, Mansfield CJ, Upton PD, Roman BL.

Development. 2013 Aug;140(16):3403-12. doi: 10.1242/dev.095307. Epub 2013 Jul 17.

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