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Items: 1 to 50 of 114

1.

Isolation and Characterization of Lymphocytes from Human Mucosal Biopsies.

Upton NEG, Hayday TS, James LK.

Methods Mol Biol. 2019;2020:165-174. doi: 10.1007/978-1-4939-9591-2_12.

PMID:
31177499
2.

Evaluation of Selective 5-HT2C Agonists in Acute Seizure Models.

Silenieks LB, Carroll NK, Van Niekerk A, Van Niekerk E, Taylor C, Upton N, Higgins GA.

ACS Chem Neurosci. 2019 May 13. doi: 10.1021/acschemneuro.8b00739. [Epub ahead of print]

PMID:
31082204
3.

Rhinovirus induction of fractalkine (CX3CL1) in airway and peripheral blood mononuclear cells in asthma.

Upton N, Jackson DJ, Nikonova AA, Hingley-Wilson S, Khaitov M, Del Rosario A, Traub S, Trujillo-Torralbo MB, Habibi M, Elkin SL, Kon OM, Edwards MR, Mallia P, Footitt J, Macintyre J, Stanciu LA, Johnston SL, Sykes A.

PLoS One. 2017 Aug 31;12(8):e0183864. doi: 10.1371/journal.pone.0183864. eCollection 2017.

4.

Hearing loss mediates executive function impairment in sleep-disordered breathing.

Hill CM, Bucks RS, Kennedy CR, Harrison D, Carroll A, Upton N, Hogan AM.

Sleep Med. 2017 Jun;34:18-23. doi: 10.1016/j.sleep.2017.02.008. Epub 2017 Mar 7.

PMID:
28522090
5.

Ontogeny of human IgE-expressing B cells and plasma cells.

Ramadani F, Bowen H, Upton N, Hobson PS, Chan YC, Chen JB, Chang TW, McDonnell JM, Sutton BJ, Fear DJ, Gould HJ.

Allergy. 2017 Jan;72(1):66-76. doi: 10.1111/all.12911. Epub 2016 Jun 8.

6.

Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE.

Ramadani F, Upton N, Hobson P, Chan YC, Mzinza D, Bowen H, Kerridge C, Sutton BJ, Fear DJ, Gould HJ.

Allergy. 2015 Oct;70(10):1269-77. doi: 10.1111/all.12679. Epub 2015 Jul 24.

7.

Neurokinin-1 receptor antagonist orvepitant is an effective inhibitor of itch-associated response in a Mongolian gerbil model of scratching behaviour.

Trower MK, Fisher A, Upton N, Ratti E.

Exp Dermatol. 2014 Nov;23(11):858-60. doi: 10.1111/exd.12528.

PMID:
25078633
8.

Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment.

Karagiannis SN, Karagiannis P, Josephs DH, Saul L, Gilbert AE, Upton N, Gould HJ.

Microbiol Spectr. 2013 Oct;1(1). doi: 10.1128/microbiolspec.AID-0006-2012.

PMID:
26184813
9.

Receptor-interacting protein 2 gene silencing attenuates allergic airway inflammation.

Goh FY, Cook KL, Upton N, Tao L, Lah LC, Leung BP, Wong WS.

J Immunol. 2013 Sep 1;191(5):2691-9. doi: 10.4049/jimmunol.1202416. Epub 2013 Aug 5.

10.

Changes in resting connectivity with age: a simultaneous electroencephalogram and functional magnetic resonance imaging investigation.

Balsters JH, O'Connell RG, Galli A, Nolan H, Greco E, Kilcullen SM, Bokde AL, Lai R, Upton N, Robertson IH.

Neurobiol Aging. 2013 Sep;34(9):2194-207. doi: 10.1016/j.neurobiolaging.2013.03.004. Epub 2013 Apr 19.

PMID:
23608113
11.

The safety, tolerability, pharmacokinetics and cognitive effects of GSK239512, a selective histamine H₃ receptor antagonist in patients with mild to moderate Alzheimer's disease: a preliminary investigation.

Nathan PJ, Boardley R, Scott N, Berges A, Maruff P, Sivananthan T, Upton N, Lowy MT, Nestor PJ, Lai R.

Curr Alzheimer Res. 2013 Mar;10(3):240-51.

PMID:
23521503
12.

Age-related task sensitivity of frontal EEG entropy during encoding predicts retrieval.

O'Hora D, Schinkel S, Hogan MJ, Kilmartin L, Keane M, Lai R, Upton N.

Brain Topogr. 2013 Oct;26(4):547-57. doi: 10.1007/s10548-013-0278-x. Epub 2013 Mar 17.

PMID:
23504081
13.

The age-related gliosis and accompanying deficit in spatial learning are unaffected by dimebon.

Cowley TR, González-Reyes RE, Richardson JC, Virley D, Upton N, Lynch MA.

Neurochem Res. 2013 Jun;38(6):1190-5. doi: 10.1007/s11064-012-0884-0. Epub 2012 Sep 26.

PMID:
23011205
14.

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.

Callaghan CK, Hok V, Della-Chiesa A, Virley DJ, Upton N, O'Mara SM.

Neuropharmacology. 2012 Oct;63(5):890-7. doi: 10.1016/j.neuropharm.2012.06.034. Epub 2012 Jul 2.

PMID:
22766392
15.

Electrophysiological entropy in younger adults, older controls and older cognitively declined adults.

Hogan MJ, Kilmartin L, Keane M, Collins P, Staff RT, Kaiser J, Lai R, Upton N.

Brain Res. 2012 Mar 22;1445:1-10. doi: 10.1016/j.brainres.2012.01.027. Epub 2012 Jan 20.

PMID:
22342163
16.

Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.

Goh FY, Upton N, Guan S, Cheng C, Shanmugam MK, Sethi G, Leung BP, Wong WS.

Eur J Pharmacol. 2012 Mar 15;679(1-3):109-16. doi: 10.1016/j.ejphar.2012.01.002. Epub 2012 Jan 20.

PMID:
22290391
17.

A simultaneous ERP/fMRI investigation of the P300 aging effect.

O'Connell RG, Balsters JH, Kilcullen SM, Campbell W, Bokde AW, Lai R, Upton N, Robertson IH.

Neurobiol Aging. 2012 Oct;33(10):2448-61. doi: 10.1016/j.neurobiolaging.2011.12.021. Epub 2012 Jan 25.

PMID:
22277263
18.

Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus.

Ondrejcak T, Wang Q, Kew JN, Virley DJ, Upton N, Anwyl R, Rowan MJ.

Eur J Pharmacol. 2012 Feb 29;677(1-3):63-70. doi: 10.1016/j.ejphar.2011.12.008. Epub 2011 Dec 16.

PMID:
22200627
19.

Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition.

Waters KA, Stean TO, Hammond B, Virley DJ, Upton N, Kew JN, Hussain I.

Behav Brain Res. 2012 Mar 1;228(1):211-8. doi: 10.1016/j.bbr.2011.12.009. Epub 2011 Dec 16.

PMID:
22189656
20.

Behavioural and electrophysiological effects of visual paired associate context manipulations during encoding and recognition in younger adults, older adults and older cognitively declined adults.

Hogan MJ, Kenney JP, Roche RA, Keane MA, Moore JL, Kaiser J, Lai R, Upton N.

Exp Brain Res. 2012 Feb;216(4):621-33. doi: 10.1007/s00221-011-2966-7. Epub 2011 Dec 6.

PMID:
22143870
21.

Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats.

Wang BW, Hok V, Della-Chiesa A, Callaghan C, Barlow S, Tsanov M, Bechara R, Irving E, Virley DJ, Upton N, O'Mara SM.

Neurobiol Aging. 2012 Apr;33(4):835.e13-30. doi: 10.1016/j.neurobiolaging.2011.08.013. Epub 2011 Oct 4.

PMID:
21975308
22.

The neuroprotective effect of a specific P2X₇ receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells.

Murphy N, Cowley TR, Richardson JC, Virley D, Upton N, Walter D, Lynch MA.

Brain Pathol. 2012 May;22(3):295-306. doi: 10.1111/j.1750-3639.2011.00531.x. Epub 2011 Oct 27.

PMID:
21933296
23.

Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers.

Balsters JH, O'Connell RG, Martin MP, Galli A, Cassidy SM, Kilcullen SM, Delmonte S, Brennan S, Meaney JF, Fagan AJ, Bokde AL, Upton N, Lai R, Laruelle M, Lawlor B, Robertson IH.

PLoS One. 2011;6(9):e24126. doi: 10.1371/journal.pone.0024126. Epub 2011 Sep 8.

24.

Electroencephalographic coherence, aging, and memory: distinct responses to background context and stimulus repetition in younger, older, and older declined groups.

Hogan M, Collins P, Keane M, Kilmartin L, Kaiser J, Kenney J, Lai R, Upton N.

Exp Brain Res. 2011 Jul;212(2):241-55. doi: 10.1007/s00221-011-2726-8. Epub 2011 May 17.

PMID:
21584625
25.

Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls.

Devanand DP, Mikhno A, Pelton GH, Cuasay K, Pradhaban G, Dileep Kumar JS, Upton N, Lai R, Gunn RN, Libri V, Liu X, van Heertum R, Mann JJ, Parsey RV.

J Geriatr Psychiatry Neurol. 2010 Sep;23(3):185-98. doi: 10.1177/0891988710363715. Epub 2010 Apr 29.

26.

Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP.

Cowley TR, O'Sullivan J, Blau C, Deighan BF, Jones R, Kerskens C, Richardson JC, Virley D, Upton N, Lynch MA.

Neurobiol Aging. 2012 Jan;33(1):162-75. doi: 10.1016/j.neurobiolaging.2010.02.002. Epub 2010 Apr 10.

PMID:
20382448
27.

H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms.

Foley AG, Prendergast A, Barry C, Scully D, Upton N, Medhurst AD, Regan CM.

Neuropsychopharmacology. 2009 Nov;34(12):2585-600. doi: 10.1038/npp.2009.89. Epub 2009 Aug 5.

28.

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine.

Klyubin I, Wang Q, Reed MN, Irving EA, Upton N, Hofmeister J, Cleary JP, Anwyl R, Rowan MJ.

Neurobiol Aging. 2011 Apr;32(4):614-23. doi: 10.1016/j.neurobiolaging.2009.04.005. Epub 2009 May 14.

PMID:
19446369
29.

Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.

Guo RX, Anaclet C, Roberts JC, Parmentier R, Zhang M, Guidon G, Buda C, Sastre JP, Feng JQ, Franco P, Brown SH, Upton N, Medhurst AD, Lin JS.

Br J Pharmacol. 2009 May;157(1):104-17. doi: 10.1111/j.1476-5381.2009.00205.x.

30.

Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI.

Maheswaran S, Barjat H, Rueckert D, Bate ST, Howlett DR, Tilling L, Smart SC, Pohlmann A, Richardson JC, Hartkens T, Hill DL, Upton N, Hajnal JV, James MF.

Brain Res. 2009 May 13;1270:19-32. doi: 10.1016/j.brainres.2009.02.045. Epub 2009 Mar 9.

PMID:
19272356
31.

Circadian and dark-pulse activation of orexin/hypocretin neurons.

Marston OJ, Williams RH, Canal MM, Samuels RE, Upton N, Piggins HD.

Mol Brain. 2008 Dec 3;1:19. doi: 10.1186/1756-6606-1-19.

32.

Analysis of serial magnetic resonance images of mouse brains using image registration.

Maheswaran S, Barjat H, Bate ST, Aljabar P, Hill DL, Tilling L, Upton N, James MF, Hajnal JV, Rueckert D.

Neuroimage. 2009 Feb 1;44(3):692-700. doi: 10.1016/j.neuroimage.2008.10.016. Epub 2008 Oct 29.

PMID:
19015039
33.

Voxel-based analysis of 11C-PIB scans for diagnosing Alzheimer's disease.

Mikhno A, Devanand D, Pelton G, Cuasay K, Gunn R, Upton N, Lai RY, Libri V, Mann JJ, Parsey RV.

J Nucl Med. 2008 Aug;49(8):1262-9. doi: 10.2967/jnumed.107.049932. Epub 2008 Jul 16.

34.

5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease.

Upton N, Chuang TT, Hunter AJ, Virley DJ.

Neurotherapeutics. 2008 Jul;5(3):458-69. doi: 10.1016/j.nurt.2008.05.008. Review.

35.

The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.

Foley AG, Hirst WD, Gallagher HC, Barry C, Hagan JJ, Upton N, Walsh FS, Hunter AJ, Regan CM.

Neuropharmacology. 2008 Jun;54(8):1166-74. doi: 10.1016/j.neuropharm.2008.03.012. Epub 2008 Apr 1.

PMID:
18455201
36.

The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B.

Quinn LP, Crook B, Hows ME, Vidgeon-Hart M, Chapman H, Upton N, Medhurst AD, Virley DJ.

Br J Pharmacol. 2008 May;154(1):226-33. doi: 10.1038/bjp.2008.78. Epub 2008 Mar 10.

37.

Symptomatic treatment of Alzheimer's disease: identification of biomarkers to aid translation from bench to bedside.

Irving EA, Upton N.

Biomark Med. 2007 Jun;1(1):93-110. doi: 10.2217/17520363.1.1.93.

PMID:
20477463
38.

A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl.

Quinn LP, Perren MJ, Brackenborough KT, Woodhams PL, Vidgeon-Hart M, Chapman H, Pangalos MN, Upton N, Virley DJ.

J Neurosci Methods. 2007 Aug 15;164(1):43-9. Epub 2007 Apr 6. Erratum in: J Neurosci Methods. 2007 Sep 30;165(2):321.

PMID:
17498809
39.

SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.

Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS.

Neuropsychopharmacology. 2007 Oct;32(10):2163-72. Epub 2007 Mar 14.

40.

GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models.

Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, Gonzalez MI, Heslop T, Hirst WD, Jennings C, Jones DN, Lacroix LP, Martyn A, Ociepka S, Ray A, Regan CM, Roberts JC, Schogger J, Southam E, Stean TO, Trail BK, Upton N, Wadsworth G, Wald JA, White T, Witherington J, Woolley ML, Worby A, Wilson DM.

J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45. Epub 2007 Feb 27.

PMID:
17327487
41.

Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

Pugh PL, Vidgeon-Hart MP, Ashmeade T, Culbert AA, Seymour Z, Perren MJ, Joyce F, Bate ST, Babin A, Virley DJ, Richardson JC, Upton N, Sunter D.

J Neuroinflammation. 2007 Feb 26;4:8.

42.

Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.

Medhurst AD, Briggs MA, Bruton G, Calver AR, Chessell I, Crook B, Davis JB, Davis RP, Foley AG, Heslop T, Hirst WD, Medhurst SJ, Ociepka S, Ray A, Regan CM, Sargent B, Schogger J, Stean TO, Trail BK, Upton N, White T, Orlek B, Wilson DM.

Biochem Pharmacol. 2007 Apr 15;73(8):1182-94. Epub 2007 Jan 7.

PMID:
17276409
43.

Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine.

Peeters M, Gunthorpe MJ, Strijbos PJ, Goldsmith P, Upton N, James MF.

J Pharmacol Exp Ther. 2007 May;321(2):564-72. Epub 2007 Jan 31.

PMID:
17267580
44.

Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease.

Pugh PL, Richardson JC, Bate ST, Upton N, Sunter D.

Behav Brain Res. 2007 Mar 12;178(1):18-28. Epub 2007 Jan 16.

PMID:
17229472
45.

SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.

Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N.

Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19. Epub 2006 Sep 29.

PMID:
17069795
46.

Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration.

Quinn LP, Stean TO, Chapman H, Brown M, Vidgeon-Hart M, Upton N, Billinton A, Virley DJ.

J Neurosci Methods. 2006 Sep 30;156(1-2):218-27. Epub 2006 Apr 19.

PMID:
16626808
47.

The influence of social support on caregiver coping.

Upton N, Reed V.

Int J Psychiatr Nurs Res. 2006 Jan;11(2):1256-67.

PMID:
16459890
48.

What does phenomenology offer to the study of care-giving?

Upton N, Reed V.

Int J Psychiatr Nurs Res. 2006 Jan;11(2):1241-54.

PMID:
16459889
49.

The meaning of incontinence in dementia care.

Upton N, Reed V.

Int J Psychiatr Nurs Res. 2005 Sep;11(1):1200-10.

PMID:
16268229
50.

Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists.

Ahmed M, Briggs MA, Bromidge SM, Buck T, Campbell L, Deeks NJ, Garner A, Gordon L, Hamprecht DW, Holland V, Johnson CN, Medhurst AD, Mitchell DJ, Moss SF, Powles J, Seal JT, Stean TO, Stemp G, Thompson M, Trail B, Upton N, Winborn K, Witty DR.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4867-71.

PMID:
16143522

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